My research interests involve the study of the brain renin-angiotensin system and the role it plays in neural plasticity. Currently, my work focuses on understanding the mechanisms that regulate the synthesis and release of angiotensin II within the brain in response to chronic intermittent hypoxia, an animal model that simulates the hypoxemia associated with sleep apnea. Furthermore, I investigate how dysregulation of angiotensin signaling can contribute to pathogenesis such as the development of hypertension commonly associated with sleep apnea. In my research group, we have developed the use of sniffer cell line to detect the spontaneous and evoked release of angiotensin II in an in vitro preparation. Additionally, our research group has shown that angiotensin II signaling can influence the excitability of neurons in the median preoptic nucleus, an integrative brain structure that contributes to the sustained hypertension associated with sleep apnea, through the regulation of potassium-chloride co-transporters.