• Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
20102017

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Personal profile

Area of Expertise

My research interests focus on developing clinically relevant approaches that would help restore brain functions in cerebral ischemia, Alzheimer’s disease, and traumatic brain injury. During the time I worked at Buck Institute, I dealt with a wide range of subjects related to cerebral ischemia. These included the effects of ablating neuronal stem cells, of sectioning the corpus callosum, and of superimposing a contralateral cerebral lesion on stroke outcome.
At UNTHSC, I have been focusing on investigating the therapeutic effects on cerebral ischemia of a novel class of compounds, positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (α7-nAChRs). My findings that injury-elevated endogenous choline enhanced by α7-PAMs augments brain resistance to ischemia thus holds a significant therapeutic promise and can be combined with long-term bioengineering approaches utilizing stem cells and various rehabilitation programs. These intriguing and potentially clinically-relevant results provide an important conceptual support and guidance to developing novel therapeutic interventions against cerebral ischemia.

Education/Academic qualification

MD in Clinical Medicine, Zhejiang University

PhD in Neurology, Zhejiang University

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