• 507 Citations
  • 12 h-Index
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Personal profile

Area of Expertise

My research interests focus on developing clinically relevant approaches that would help restore brain functions in cerebral ischemia, Alzheimer’s disease, and traumatic brain injury. During the time I worked at Buck Institute, I dealt with a wide range of subjects related to cerebral ischemia. These included the effects of ablating neuronal stem cells, of sectioning the corpus callosum, and of superimposing a contralateral cerebral lesion on stroke outcome.
At UNTHSC, I have been focusing on investigating the therapeutic effects on cerebral ischemia of a novel class of compounds, positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (α7-nAChRs). My findings that injury-elevated endogenous choline enhanced by α7-PAMs augments brain resistance to ischemia thus holds a significant therapeutic promise and can be combined with long-term bioengineering approaches utilizing stem cells and various rehabilitation programs. These intriguing and potentially clinically-relevant results provide an important conceptual support and guidance to developing novel therapeutic interventions against cerebral ischemia.

Education/Academic qualification

PhD in Neurology, Zhejiang University

MD in Clinical Medicine, Zhejiang University

Fingerprint Dive into the research topics where Fen Sun is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Stroke Medicine & Life Sciences
Middle Cerebral Artery Infarction Medicine & Life Sciences
Brain Ischemia Medicine & Life Sciences
Nicotinic Receptors Medicine & Life Sciences
Ischemia Medicine & Life Sciences
Neurogenesis Medicine & Life Sciences
neurogenesis Agriculture & Biology
ischemia Agriculture & Biology

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Research Output 2010 2017

  • 507 Citations
  • 12 h-Index
  • 18 Article
3 Citations (Scopus)

Boosting Endogenous Resistance of Brain to Ischemia

Sun, F., Johnson, S. R., Jin, K. & Uteshev, V. V., 1 Apr 2017, In : Molecular Neurobiology. 54, 3, p. 2045-2059 15 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Brain Ischemia
Wounds and Injuries
Intranasal Administration
10 Citations (Scopus)

Combining injectable plasma scaffold with mesenchymal stem/stromal cells for repairing infarct cavity after ischemic stroke

Zhang, H., Sun, F., Wang, J., Xie, L., Pan, M., Shao, B., Yang, G. Y., Yang, S. H., ZhuGe, Q. & Jin, K., 1 Jan 2017, In : Aging and Disease. 8, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Neural Stem Cells
8 Citations (Scopus)
Brain Injuries
Young Adult
10 Citations (Scopus)

Pgrmc1/BDNF signaling plays a critical role in mediating glia-neuron cross talk

Sun, F., Nguyen, T., Jin, X., Huang, R-Q., Chen, Z., Cunningham, R. L., Singh, M. & Su, C., 1 May 2016, In : Endocrinology. 157, 5, p. 2067-2079 13 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Conditioned Culture Medium
23 Citations (Scopus)

ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning

Su, C., Sun, F., Cunningham, R. L., Rybalchenko, N. & Singh, M., 1 Jan 2014, In : Age. 36, 4, 9685.

Research output: Contribution to journalArticle

Neuroprotective Agents
Nerve Growth Factor
Hydrogen Peroxide
Neuronal Apoptosis-Inhibitory Protein
Oxidative Stress