• 548 Citations
  • 12 h-Index
20102017

Research output per year

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Personal profile

Area of Expertise

My research interests focus on developing clinically relevant approaches that would help restore brain functions in cerebral ischemia, Alzheimer’s disease, and traumatic brain injury. During the time I worked at Buck Institute, I dealt with a wide range of subjects related to cerebral ischemia. These included the effects of ablating neuronal stem cells, of sectioning the corpus callosum, and of superimposing a contralateral cerebral lesion on stroke outcome.
At UNTHSC, I have been focusing on investigating the therapeutic effects on cerebral ischemia of a novel class of compounds, positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (α7-nAChRs). My findings that injury-elevated endogenous choline enhanced by α7-PAMs augments brain resistance to ischemia thus holds a significant therapeutic promise and can be combined with long-term bioengineering approaches utilizing stem cells and various rehabilitation programs. These intriguing and potentially clinically-relevant results provide an important conceptual support and guidance to developing novel therapeutic interventions against cerebral ischemia.

Education/Academic qualification

MD in Clinical Medicine, Zhejiang University

PhD in Neurology, Zhejiang University

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Research Output

  • 548 Citations
  • 12 h-Index
  • 18 Article

Boosting Endogenous Resistance of Brain to Ischemia

Sun, F., Johnson, S. R., Jin, K. & Uteshev, V. V., 1 Apr 2017, In : Molecular Neurobiology. 54, 3, p. 2045-2059 15 p.

Research output: Contribution to journalArticle

  • 4 Scopus citations

    Combining injectable plasma scaffold with mesenchymal stem/stromal cells for repairing infarct cavity after ischemic stroke

    Zhang, H., Sun, F., Wang, J., Xie, L., Pan, M., Shao, B., Yang, G. Y., Yang, S. H., ZhuGe, Q. & Jin, K., 1 Jan 2017, In : Aging and Disease. 8, 2, p. 203-214 12 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations
  • 10 Scopus citations

    Pgrmc1/BDNF signaling plays a critical role in mediating glia-neuron cross talk

    Sun, F., Nguyen, T., Jin, X., Huang, R., Chen, Z., Cunningham, R. L., Singh, M. & Su, C., May 2016, In : Endocrinology. 157, 5, p. 2067-2079 13 p.

    Research output: Contribution to journalArticle

  • 13 Scopus citations

    ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning

    Su, C., Sun, F., Cunningham, R. L., Rybalchenko, N. & Singh, M., 1 Jan 2014, In : Age. 36, 4, 9685.

    Research output: Contribution to journalArticle

  • 24 Scopus citations