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Personal profile

Area of Expertise

My laboratory focuses on the development of research/therapeutic strategies to slow premature brain aging resulting from a chronic use of drugs of dependence such as benzodiazepine (BZD, an antianxiety medication) and alcohol, and withdrawal stress from the substances.
Currently, we investigate whether BZD administration to mice elevates/alters the production of neurotoxic amyloid beta, amyloid beta-producing gamma-secretase, and peripheral BZD receptors. We also investigate whether these changes mediate aging-like behavioral signs such as movement and cognition deficits. We are planning to test whether the aging-like effects of BZD will be attenuated by training mice with moderately low oxygen. Our study may help understand how to minimize accelerated brain aging associated with substance misuse.

Education/Academic qualification

PhD in Pharmacology, UNT Health Science Center

MS in Pharmacology, UNT Health Science Center

MS in Pharmacy, Ewha University

BS in Pharmacy, Ewha University

Fingerprint Dive into the research topics where Eunsun (Marianna) Jung is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2010 2018

Research Output 1995 2018

  • 566 Citations
  • 15 h-Index
  • 33 Article
  • 4 Review article
  • 1 Short survey
1 Citation (Scopus)

Chronic benzodiazepine suppresses translocator protein and elevates amyloid β in mice

Tan, S., Metzger, D. B. & Jung, E., 1 Sep 2018, In : Pharmacology Biochemistry and Behavior. 172, p. 59-67 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloidogenic Proteins
Presenilin-1
Benzodiazepines
Neprilysin
Membranes
4 Citations (Scopus)

Intermittent hypoxia training: Powerful, non-invasive cerebroprotection against ethanol withdrawal excitotoxicity

Jung, E. & Mallet, R. T., 1 Oct 2018, In : Respiratory Physiology and Neurobiology. 256, p. 67-78 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Ethanol
Amyloid
Glutamic Acid
Oxidative Stress
Adenosine Triphosphate
5 Citations (Scopus)
Presenilin-1
Amyloid
Ethanol
Amyloid Precursor Protein Secretases
Heat-Shock Proteins
6 Citations (Scopus)

A sex difference in oxidative stress and behavioral suppression induced by ethanol withdrawal in rats

Jung, E. & Metzger, D. B., 1 Nov 2016, In : Behavioural Brain Research. 314, p. 199-214 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex Characteristics
Oxidative Stress
Ethanol
Hippocampus
Electron Transport Complex IV
2 Citations (Scopus)

The role of presenilin-1 in the excitotoxicity of ethanol withdrawal

Jung, E., Metzger, D. B. & Das, H., 1 Sep 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 516-526 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Presenilin-1
Ethanol
Glutamic Acid
Dizocilpine Maleate
Amyloid Precursor Protein Secretases