Eric Y. Cheng

¹³C labeling indicates that the epoxide-containing amino acid of HC- toxin is biosynthesized by head-to-tail condensation of acetate

Cheng, Y. Q., Le, L. D., Walton, J. D. & Bishop, K. D., 1999, In: Journal of Natural Products. 62, 1, p. 143-145 3 p.

Research output: Contribution to journal › Article › peer-review

Leinamycin Biosynthesis Revealing Unprecedented Architectural Complexity for a Hybrid Polyketide Synthase and Nonribosomal Peptide Synthetase

Tang, G. L., Cheng, Y. Q. & Shen, B., Jan 2004, In: Chemistry and Biology. 11, 1, p. 33-45 13 p.

Research output: Contribution to journal › Article › peer-review

Corrigendum to: Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment [Surgery. 2020 Jan;167(1):189-196. doi: 10.1016/j.surg.2019.05.092. Epub 2019 Oct 16.PMID: 31629542] (Surgery (2020) 167(1) (189–196), (S0039606019305835), (10.1016/j.surg.2019.05.092))

Guenter, R., Aweda, T., Carmona Matos, D. M., Jang, S., Whitt, J., Cheng, Y. Q., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jul 2021, In: Surgery (United States). 170, 1, p. 351 1 p.

Research output: Contribution to journal › Comment/debate

KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy

Chen, G., Jaskula-Sztul, R., Harrison, A., Dammalapati, A., Xu, W., Cheng, Y., Chen, H. & Gong, S., 1 Aug 2016, In: Biomaterials. 97, p. 22-33 12 p.

Research output: Contribution to journal › Article › peer-review

The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor

Thomy, D., Culp, E., Adamek, M., Cheng, E. Y., Ziemert, N., Wright, G. D., Sass, P. & Brötz-Oesterhelt, H., 2019, In: Applied and Environmental Microbiology. 85, 20, e01292-19.

Research output: Contribution to journal › Article › peer-review

Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y. Q., Bosch, J., Townsend, C. A. & Dimopoulos, G., 1 Dec 2018, In: Scientific Reports. 8, 1, 6176.

Research output: Contribution to journal › Article › peer-review

New insights into the genetic organization of the FK228 biosynthetic gene cluster in chromobacterium violaceum No. 968

Potharla, V. Y., Wesener, S. R. & Cheng, Y. Q., Feb 2011, In: Applied and Environmental Microbiology. 77, 4, p. 1508-1511 4 p.

Research output: Contribution to journal › Article › peer-review

Thailandepsin A

Wang, C. & Cheng, Y. Q., Nov 2011, In: Acta Crystallographica Section E: Structure Reports Online. 67, 11, p. o2948-o2949

Research output: Contribution to journal › Article › peer-review

Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitors

Guenter, R. E., Aweda, T., Matos, D. M. C., Whitt, J., Chang, A. W., Cheng, E. Y., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jun 2019, In: Cancers. 11, 6, 767.

Research output: Contribution to journal › Article › peer-review

Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

Chaudhari, K., Wang, J., Xu, Y., Winters, A., Wang, L., Dong, X., Cheng, E. Y., Liu, R. & Yang, S. H., Jun 2020, In: PLoS ONE. 15, 6, e0234571.

Research output: Contribution to journal › Article › peer-review

Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report

Shen, B., Cheng, Y. Q., Christenson, S. D., Jiang, H., Ju, J., Kwon, H. J., Lim, S. K., Liu, W., Nonaka, K., Seo, J. W., Smith, W. C., Standage, S., Tang, G. L., Van Lanen, S. & Zhang, J., 2007, Polyketides Biosynthesis, Biological Activity, and Genetic Engineering. Rimando, A. & Baerson, S. (eds.). p. 154-166 13 p. (ACS Symposium Series; vol. 955).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis

Cheng, Y. Q. & Walton, J. D., 18 Feb 2000, In: Journal of Biological Chemistry. 275, 7, p. 4906-4911 6 p.

Research output: Contribution to journal › Article › peer-review

A putative branched-chain-amino-acid transaminase gene required for HC-toxin biosynthesis and pathogenicity in Cochliobolus carbonum

Cheng, Y. Q., Ahn, J. H. & Walton, J. D., Dec 1999, In: Microbiology. 145, 12, p. 3539-3546 8 p.

Research output: Contribution to journal › Article › peer-review

HDAC inhibitor-mediated epigenetic regulation of glaucoma-associated TGFβ2 in the trabecular meshwork

Bermudez, J. Y., Webber, H. C., Patel, G. C., Liu, X., Cheng, Y. Q., Clark, A. F. & Mao, W., Jul 2016, In: Investigative Ophthalmology and Visual Science. 57, 8, p. 3698-3707 10 p.

Research output: Contribution to journal › Article › peer-review

Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228

Liu, X., Xie, F., Doughty, L. B., Wang, Q., Zhang, L., Liu, X. & Cheng, Y. Q., Dec 2018, In: Synthetic and Systems Biotechnology. 3, 4, p. 268-274 7 p.

Research output: Contribution to journal › Article › peer-review

Thailandepsins: Bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities

Wang, C., Henkes, L. M., Doughty, L. B., He, M., Wang, D., Meyer-Almes, F. J. & Cheng, Y. Q., 28 Oct 2011, In: Journal of Natural Products. 74, 10, p. 2031-2038 8 p.

Research output: Contribution to journal › Article › peer-review

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A. & Hadjithomas, M. & 134 others, Haines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. & Glöckner, F. O., 18 Aug 2015, In: Nature Chemical Biology. 11, 9, p. 625-631 7 p.

Research output: Contribution to journal › Review article › peer-review

Target engagement and drug residence time can be observed in living cells with BRET

Robers, M. B., Dart, M. L., Woodroofe, C. C., Zimprich, C. A., Kirkland, T. A., Machleidt, T., Kupcho, K. R., Levin, S., Hartnett, J. R., Zimmerman, K., Niles, A. L., Ohana, R. F., Daniels, D. L., Slater, M., Wood, M. G., Cong, M., Cheng, Y. Q. & Wood, K. V., 3 Dec 2015, In: Nature Communications. 6, 10091.

Research output: Contribution to journal › Article › peer-review

Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141

Cheng, Y. Q., Mar 2006, In: ChemBioChem. 7, 3, p. 471-477 7 p.

Research output: Contribution to journal › Article › peer-review

Origin and bioactivities of thiosulfinated FK228

Liu, X., Currens, G. C., Xue, L. & Cheng, Y. Q., 2019, In: MedChemComm. 10, 4, p. 538-542 5 p.

Research output: Contribution to journal › Article › peer-review

Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140

Cheng, Y. Q., Tang, G. L. & Shen, B., Dec 2002, In: Journal of Bacteriology. 184, 24, p. 7013-7024 12 p.

Research output: Contribution to journal › Article › peer-review

FK228 from Burkholderia thailandensis MSMB43

Liu, X. Y., Wang, C. & Cheng, Y. Q., Sep 2012, In: Acta Crystallographica Section E: Structure Reports Online. 68, 9, p. o2757-o2758

Research output: Contribution to journal › Article › peer-review

Thailandepsins are new small molecule class i HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: A preclinical study of epigenetic ovarian cancer therapy

Wilson, A. J., Cheng, Y. Q. & Khabele, D., 2012, In: Journal of Ovarian Research. 5, 1, 12.

Research output: Contribution to journal › Article › peer-review

The structural basis of an NADP⁺-independent dithiol oxidase in FK228 biosynthesis

Li, J., Wang, C., Zhang, Z. M., Cheng, Y. Q. & Zhou, J., 20 Feb 2014, In: Scientific Reports. 4, 4145.

Research output: Contribution to journal › Article › peer-review

Cyclo(-l-prolyl-l-valinyl-) from Burkholderia thailandensis MSMB43

Liu, X. Y., Wang, C. & Cheng, Y. Q., Nov 2012, In: Acta Crystallographica Section E: Structure Reports Online. 68, 11, p. o3182-o3183

Research output: Contribution to journal › Article › peer-review

Eric Y. Cheng, PhD

Research output

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