Keyphrases
Histone Deacetylase Inhibitor (HDACi)
100%
Thailandepsin A
98%
FK228
86%
Burkholderia Thailandensis
63%
Streptomyces
50%
Polyketide Synthase
43%
Biosynthetic Gene Clusters
41%
Gene Cluster
40%
Leinamycin
37%
ClpP
31%
Cochliobolus
29%
Chromobacterium Violaceum
29%
Nonribosomal Peptide Synthetase
28%
Acyldepsipeptide
26%
Nonribosomal Peptides
24%
Thailanstatin
23%
Type I Polyketide Synthase
22%
Somatostatin Receptor 2 (SSTR2)
22%
Neuroendocrine Cancer
22%
Guided Discovery
22%
Antiproliferative Activity
21%
Acyltransferase
21%
Toxin Biosynthesis
20%
Antibiotics
19%
Overexpression
19%
Natural Products
18%
Neuroendocrine Tumor
17%
Biosynthetic Pathway
16%
Romidepsin
16%
Small Molecules
16%
Anticancer
15%
Cancer Therapy
15%
Clp Protease
15%
Histone Deacetylase 1 (HDAC1)
15%
Valinomycin
14%
Polyketide Biosynthesis
14%
DOTATATE
14%
Trabecular Meshwork
14%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
14%
Unimolecular Micelles
14%
Axial Channel
14%
Inhibitory Activity
13%
Depsipeptide
13%
Hydrogen Bonds (H-bonds)
12%
Genome Sequencing
12%
Motility
12%
Biosynthetic Genes
12%
Fatty Acid Synthase
11%
Cyclic Peptide
11%
TOX2
11%
Biochemistry, Genetics and Molecular Biology
Anabolism
99%
Romidepsin
69%
Gene Cluster
60%
Streptomyces
50%
Polyketide Synthase
49%
Nonribosomal Peptide
46%
Histone Deacetylase
45%
Burkholderia thailandensis
30%
Chromobacterium violaceum
28%
Anticancer
27%
Cochliobolus carbonum
25%
Conformation
22%
Endopeptidase Clp
22%
Amino Acids
21%
Acyltransferase
21%
N-Acetyltransferase
21%
N-Terminus
18%
Protease
16%
Depsipeptide
16%
Oxidoreductase
15%
Valinomycin
14%
Fatty Acid Synthase
14%
Enzyme
13%
Escherichia coli
13%
Precursor
12%
Polyketide
12%
Adenosine Triphosphate
12%
Protein Sequencing
12%
Intraocular Pressure
11%
Disulfide Bond
10%
Genetics
9%
Disulfide
9%
Molecular Genetics
9%
Antiproliferative Activity
9%
Metabolic Engineering
9%
Adenylylation
9%
Cytochrome P450
9%
Titer
8%
Crystal Structure
8%
Liquid Chromatography-Mass Spectrometry
8%
Small Molecule
8%
Carrier Protein
8%
HDAC3
8%
Retention Time
8%
Nicotinamide Adenine Dinucleotide Phosphate
8%
Wild Type
7%
Deletion Mutant
7%
Polyketide Biosynthesis
7%
Oxidase
7%
Conformational Change
7%
Pharmacology, Toxicology and Pharmaceutical Science
Histone Deacetylase Inhibitor
79%
Burkholderia thailandensis
40%
Malignant Neoplasm
35%
Romidepsin
32%
Polyketide Synthase
25%
Streptomyces
23%
Polyketide
22%
Micelle
22%
Antiproliferative Activity
21%
Histone Deacetylase
20%
Cancer Growth
15%
Glaucoma
14%
Breast Cancer
14%
Natural Product
13%
Amino Acid
12%
Hydrogen Bond
11%
Nonribosomal Peptide Synthetase
11%
Histone
11%
Cochliobolus carbonum
11%
Leinamycin
10%
Cytotoxicity
10%
Depsipeptide
10%
IC50
9%
Proteinase
9%
Somatostatin Receptor
9%
Preclinical Study
9%
Acyltransferase
8%
Cyclodepsipeptide
8%
Antibiotics
8%
Ovary Cancer
8%
Receptor
8%
Histone Deacetylase 3
8%
Anticarcinogen
8%
Octreotide
8%
SARS Coronavirus
7%
Valinomycin
7%
Castration Resistant Prostate Cancer
7%
Androgen Receptor
7%
Carcinoid
7%
Glucocorticoid
7%
Antineoplastic Antibiotic
7%
Chromobacterium
7%
Plasmodium
7%
Alanine Racemase
7%
Endopeptidase Clp
7%
Branched Chain Amino Acid
7%
Epoxide
7%
Proline Derivative
7%
Carbon 13
7%
Biodistribution
7%