Personal profile
Area of Expertise
The main focus of my research is to discover and develop bioactive natural products from microorganisms as drugs or drug leads for the treatment of cancer, infectious diseases, or other human medical conditions. In addition, I recently initiated a collaborative project for the engineering of novel oncolytic virus for cancer chemoimmunotherapy.
Key words: anti-aging, anti-cancer, anti-infective, crowd-sourcing, crowd-funding, drug discovery, drug development, natural product, synthetic biology, chemoimmunotherapy, contract service
Education/Academic qualification
BS in Microbiology, Huazhong Agricultural University
MS in Phytochemistry, Institute of Botany of the Chinese Academy of Sciences
PhD in Botany & Microbiology, Michigan State University
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Collaborations and top research areas from the last five years
Projects
- 7 Finished
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High-Resolution Tandem Mass Spectrometer for Advanced Biomolecular Research
Prokai, L. (PI), Forster, M. (CoI) & Cheng, E. Y. (CoI)
27/01/17 → 31/01/18
Project: Research
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Discover and Engineer New Histone Deacetylase Inhibitors as Anticancer Agents
Cheng, E. Y. (PI)
NCI: National Cancer Institute
1/06/13 → 31/05/15
Project: Research
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Discover and Engineer New Histone Deacetylase Inhibitors as Anticancer Agents
Cheng, E. Y. (PI), CHENG, Y.-Q. (PI), CHENG, Y. (PI), CHENG, Y. (PI) & CHENG, Y.-Q. (PI)
1/08/10 → 30/11/15
Project: Research
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Discover and Engineer New Histone Deacetylase Inhibitors as Anticancer Agents
CHENG, Y. (PI), CHENG, Y.-Q. (CoPI) & Cheng, E. Y. (CoPI)
1/08/10 → 30/11/15
Project: Research
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Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer
Xiao, K., Li, Y. P., Wang, C., Ahmad, S., Vu, M., Kuma, K., Cheng, Y. Q. & Lam, K. S., 1 Oct 2015, In: Biomaterials. 67, p. 183-193 11 p.Research output: Contribution to journal › Article › peer-review
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Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer
Wang, B., Lo, U. G., Wu, K., Kapur, P., Liu, X., Huang, J., Chen, W., Hernandez, E., Santoyo, J., Ma, S. H., Pong, R. C., He, D., Cheng, Y. Q. & Hsieh, J. T., 15 Nov 2017, In: International Journal of Cancer. 141, 10, p. 2121-2130 10 p.Research output: Contribution to journal › Article › peer-review
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Pseudomerohedrally twinned monoclinic structure of unfolded free nona-ctin: Comparative analysis of its large conformational change upon encapsulation of alkali metal ions
Guzei, I. A., Wang, C., Zhan, Y., Dolomanov, O. V. & Cheng, Y. Q., 2009, In: Acta Crystallographica Section C: Crystal Structure Communications. 65, 10, p. o521-o524Research output: Contribution to journal › Article › peer-review
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A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis
Cheng, Y. Q. & Walton, J. D., 18 Feb 2000, In: Journal of Biological Chemistry. 275, 7, p. 4906-4911 6 p.Research output: Contribution to journal › Article › peer-review
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Extractive fermentation for enhanced production of thailandepsin A from Burkholderia thailandensis E264 using polyaromatic adsorbent resin Diaion HP-20
Liu, B., Hui, J., Cheng, Y. Q. & Zhang, X., May 2012, In: Journal of Industrial Microbiology and Biotechnology. 39, 5, p. 767-776 10 p.Research output: Contribution to journal › Article › peer-review