• 590 Citations
  • 13 h-Index
20012020

Research output per year

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Personal profile

Area of Expertise

Glaucoma is an eye disease commonly associated with an increase in intraocular pressure, afflicting nearly 3 million Americans and 70 million people world-wide. Current therapies are aimed at lowering intraocular pressure, however, damage to the optic nerve continues to occur despite these treatments. There is a pressing need for adjunct therapies aimed at protecting the optic nerve from further damage.
My laboratory research focuses on the development of strategies for neuroprotection in glaucoma. Specifically, we are testing various small molecules and adeno-associated viral gene therapies for their ability to attenuate neurodegeneration in animal models of glaucoma. We also aim to unravel cellular and molecular mechanisms underlying the pathophysiology of glaucoma.
Concepts/techniques: We carry out these studies using in vitro rat primary retinal ganglion cell cultures, ex vivo adult rat retinal explants, and various in vivo rodent models of glaucoma. We use visual function tests including pattern ERG and optomotor test to determine the efficacy of clinically relevant experimental pharmacotherapies.
Our ongoing studies have the potential to develop novel therapeutic agents for neuroprotection in glaucoma.

Education/Academic qualification

MS in Biochemistry & Genetics, University of Łódź

PhD in Microbiology, University of Łódź

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Projects

Research Output

  • 590 Citations
  • 13 h-Index
  • 28 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter
Open Access
  • Kynurenic acid protects against ischemia/reperfusion-induced retinal ganglion cell death in mice

    Nahomi, R. B., Nam, M. H., Rankenberg, J., Rakete, S., Houck, J. A., Johnson, G. C., Stankowska, D. L., Pantcheva, M. B., Maclean, P. S. & Nagaraj, R. H., 1 Mar 2020, In : International journal of molecular sciences. 21, 5, 1795.

    Research output: Contribution to journalArticle

    Open Access
  • Open Access
  • Open Access
  • Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

    Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations