Projects per year
Personal profile
Area of Expertise
Glaucoma is an eye disease commonly associated with an increase in intraocular pressure, afflicting nearly 3 million Americans and 70 million people world-wide. Current therapies are aimed at lowering intraocular pressure, however, damage to the optic nerve continues to occur despite these treatments. There is a pressing need for adjunct therapies aimed at protecting the optic nerve from further damage.
My laboratory research focuses on the development of strategies for neuroprotection in glaucoma. Specifically, we are testing various small molecules and adeno-associated viral gene therapies for their ability to attenuate neurodegeneration in animal models of glaucoma. We also aim to unravel cellular and molecular mechanisms underlying the pathophysiology of glaucoma.
Concepts/techniques: We carry out these studies using in vitro rat primary retinal ganglion cell cultures, ex vivo adult rat retinal explants, and various in vivo rodent models of glaucoma. We use visual function tests including pattern ERG and optomotor test to determine the efficacy of clinically relevant experimental pharmacotherapies.
Our ongoing studies have the potential to develop novel therapeutic agents for neuroprotection in glaucoma.
My laboratory research focuses on the development of strategies for neuroprotection in glaucoma. Specifically, we are testing various small molecules and adeno-associated viral gene therapies for their ability to attenuate neurodegeneration in animal models of glaucoma. We also aim to unravel cellular and molecular mechanisms underlying the pathophysiology of glaucoma.
Concepts/techniques: We carry out these studies using in vitro rat primary retinal ganglion cell cultures, ex vivo adult rat retinal explants, and various in vivo rodent models of glaucoma. We use visual function tests including pattern ERG and optomotor test to determine the efficacy of clinically relevant experimental pharmacotherapies.
Our ongoing studies have the potential to develop novel therapeutic agents for neuroprotection in glaucoma.
Education/Academic qualification
PhD in Microbiology, University of Łódź
Award Date: 1 Jan 2001
MS in Biochemistry & Genetics, University of Łódź
Award Date: 1 Jan 2000
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Projects
Mechanisms Underlying Endothelin Mediated Neurodegeneration in Glaucoma
Krishnamoorthy, R., He, S. & Stankowska, D.
1/09/17 → 31/08/20
Project: Research
Neuroprotective targets of transcription factor Brn3b (For: Alexis Seibert)
5/06/17 → 31/05/18
Project: Research
Research Output
Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma (Cell Death Discovery, (2019), 5, 1, (112), 10.1038/s41420-019-0194-2)
Stankowska, D. L., Nam, M. H., Nahomi, R. B., Chaphalkar, R. M., Nandi, S. K., Fudala, R., Krishnamoorthy, R. & Nagaraj, R. H., 1 Dec 2019, In : Cell Death Discovery. 5, 1, 122.Research output: Contribution to journal › Comment/debate
Open Access
Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death
Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.Research output: Contribution to journal › Article
Open Access
Neuroprotective effects of inhibitors of Acid-Sensing ion channels (ASICs) in optic nerve crush model in rodents
Stankowska, D. L., Mueller, B. H., Oku, H., Ikeda, T. & Dibas, A., 2 Jan 2018, In : Current Eye Research. 43, 1, p. 84-95 12 p.Research output: Contribution to journal › Article
3
Scopus
citations
Targets of neuroprotection in glaucoma
He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.Research output: Contribution to journal › Article
6
Scopus
citations
Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons
Stankowska, D. L., Krishnamoorthy, V. R., Ellis, D. Z. & Krishnamoorthy, R. R., 28 May 2017, In : Nutritional Neuroscience. 20, 5, p. 273-283 11 p.Research output: Contribution to journal › Article
10
Scopus
citations