Projects per year
Personal profile
Area of Expertise
Glaucoma is an eye disease commonly associated with an increase in intraocular pressure, afflicting nearly 3 million Americans and 70 million people world-wide. Current therapies are aimed at lowering intraocular pressure, however, damage to the optic nerve continues to occur despite these treatments. There is a pressing need for adjunct therapies aimed at protecting the optic nerve from further damage.
My laboratory research focuses on the development of strategies for neuroprotection in glaucoma. Specifically, we are testing various small molecules and adeno-associated viral gene therapies for their ability to attenuate neurodegeneration in animal models of glaucoma. We also aim to unravel cellular and molecular mechanisms underlying the pathophysiology of glaucoma.
Concepts/techniques: We carry out these studies using in vitro rat primary retinal ganglion cell cultures, ex vivo adult rat retinal explants, and various in vivo rodent models of glaucoma. We use visual function tests including pattern ERG and optomotor test to determine the efficacy of clinically relevant experimental pharmacotherapies.
Our ongoing studies have the potential to develop novel therapeutic agents for neuroprotection in glaucoma.
My laboratory research focuses on the development of strategies for neuroprotection in glaucoma. Specifically, we are testing various small molecules and adeno-associated viral gene therapies for their ability to attenuate neurodegeneration in animal models of glaucoma. We also aim to unravel cellular and molecular mechanisms underlying the pathophysiology of glaucoma.
Concepts/techniques: We carry out these studies using in vitro rat primary retinal ganglion cell cultures, ex vivo adult rat retinal explants, and various in vivo rodent models of glaucoma. We use visual function tests including pattern ERG and optomotor test to determine the efficacy of clinically relevant experimental pharmacotherapies.
Our ongoing studies have the potential to develop novel therapeutic agents for neuroprotection in glaucoma.
Education/Academic qualification
MS in Biochemistry & Genetics, University of Łódź
PhD in Microbiology, University of Łódź
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Projects
- 8 Finished
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Novel hybrid molecule with both IOP lowering and neuroprotective effects for treatment of glaucoma
Stankowska, D. & ACHARYA, S.
1/09/20 → 31/08/21
Project: Research
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Novel hybrid molecule with both IOP lowering and neuroprotective effects for treatment of glaucoma
ACHARYA, S., Stankowska, D., Stankowska, D. & ACHARYA, S.
1/09/20 → 31/08/23
Project: Research
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Mechanisms Underlying Endothelin Mediated Neurodegeneration in Glaucoma
Krishnamoorthy, R., He, S. & Stankowska, D.
1/09/17 → 31/08/20
Project: Research
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Neuroprotective targets of transcription factor Brn3b (For: Alexis Seibert)
5/06/17 → 31/05/18
Project: Research
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Neuroprotective effects of inhibitors of Acid-Sensing ion channels (ASICs) in optic nerve crush model in rodents
Stankowska, D. L., Mueller, B. H., Oku, H., Ikeda, T. & Dibas, A., 2 Jan 2018, In: Current Eye Research. 43, 1, p. 84-95 12 p.Research output: Contribution to journal › Article › peer-review
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Does activation of the Fcγ RIIa play a role in the pathogenesis of the acute lung injury/acute respiratory distress syndrome?
Fudala, R., Krupa, A., Stankowska, D., Allen, T. C. & Kurdowska, A. K., 2010, In: Clinical Science. 118, 8, p. 519-526 8 p.Research output: Contribution to journal › Article › peer-review
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Involvement of AP-1 and C/EBPβ in upregulation of endothelin B (ETB) receptor expression in a rodent model of glaucoma
He, S., Minton, A. Z., Ma, H. Y., Stankowska, D. L., Sun, X. & Krishnamoorthy, R. R., 12 Nov 2013, In: PLoS ONE. 8, 11, e79183.Research output: Contribution to journal › Article › peer-review
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Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma
McGrady, N. R., Minton, A. Z., Stankowska, D. L., He, S., Jefferies, H. B. & Krishnamoorthy, R. R., 1 Mar 2017, In: BMC Neuroscience. 18, 1, 27.Research output: Contribution to journal › Article › peer-review
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Neuroprotection of Rodent and Human Retinal Ganglion Cells In Vitro/Ex Vivo by the Hybrid Small Molecule SA-2
Pham, J. H., Johnson, G. A., Rangan, R. S., Amankwa, C. E., Acharya, S. & Stankowska, D. L., Dec 2022, In: Cells. 11, 23, 3741.Research output: Contribution to journal › Article › peer-review