• 518 Citations
  • 13 h-Index
20012020
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Personal profile

Area of Expertise

Glaucoma is an eye disease commonly associated with an increase in intraocular pressure, afflicting nearly 3 million Americans and 70 million people world-wide. Current therapies are aimed at lowering intraocular pressure, however, damage to the optic nerve continues to occur despite these treatments. There is a pressing need for adjunct therapies aimed at protecting the optic nerve from further damage.
My laboratory research focuses on the development of strategies for neuroprotection in glaucoma. Specifically, we are testing various small molecules and adeno-associated viral gene therapies for their ability to attenuate neurodegeneration in animal models of glaucoma. We also aim to unravel cellular and molecular mechanisms underlying the pathophysiology of glaucoma.
Concepts/techniques: We carry out these studies using in vitro rat primary retinal ganglion cell cultures, ex vivo adult rat retinal explants, and various in vivo rodent models of glaucoma. We use visual function tests including pattern ERG and optomotor test to determine the efficacy of clinically relevant experimental pharmacotherapies.
Our ongoing studies have the potential to develop novel therapeutic agents for neuroprotection in glaucoma.

Education/Academic qualification

PhD in Microbiology, University of Lódz

MS in Biochemistry & Genetics, University of Lódz

Fingerprint Dive into the research topics where Dorota Stankowska is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2016 2020

Research Output 2001 2019

  • 518 Citations
  • 13 h-Index
  • 26 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
Open Access
Retinal Ganglion Cells
Glaucoma
Publications
Cell Death
Animal Models

Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., 1 Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Retinal Ganglion Cells
Cell Death
Nerve Crush
Animal Models
Retina
2 Citations (Scopus)

Neuroprotective effects of inhibitors of Acid-Sensing ion channels (ASICs) in optic nerve crush model in rodents

Stankowska, D. L., Mueller, B. H., Oku, H., Ikeda, T. & Dibas, A., 2 Jan 2018, In : Current Eye Research. 43, 1, p. 84-95 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Acid Sensing Ion Channel Blockers
Nerve Crush
Neuroprotective Agents
Optic Nerve
Acid Sensing Ion Channels
4 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor
9 Citations (Scopus)

Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons

Stankowska, D. L., Krishnamoorthy, V. R., Ellis, D. Z. & Krishnamoorthy, R., 28 May 2017, In : Nutritional Neuroscience. 20, 5, p. 273-283 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Curcumin
Neuroprotective Agents
Endothelin-1
Cell Death
Neurons