If you made any changes in Pure, your changes will be visible here soon.

Research Output 1995 2018

  • 1460 Citations
  • 18 h-Index
  • 34 Article
  • 6 Review article
  • 1 Editorial
2018

Atrophied thymus, a tumor reservoir for harboring melanoma cells

Sizova, O., Kuriatnikov, D., Liu, Y. & Su, D. M., 1 Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1652-1664 13 p.

Research output: Contribution to journalArticle

Thymus Neoplasms
Melanoma
Thymus Gland
Neoplasms
Drug Therapy
4 Citations (Scopus)

Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance

Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q. & Su, D. M., 1 Nov 2018, In : FASEB Journal. 32, 11, p. 5899-5912 14 p.

Research output: Contribution to journalArticle

T-cells
Rejuvenation
Aging of materials
T-Lymphocytes
Blood
2017
4 Citations (Scopus)

A fine-tune role of Mir-125a-5p on Foxn1 during age-associated changes in the thymus

Xu, M., Sizova, O., Wang, L. & Su, D. M., 1 Jan 2017, In : Aging and Disease. 8, 3, p. 277-286 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Thymus Gland
Epithelial Cells
HEK293 Cells
3' Untranslated Regions
4 Citations (Scopus)

Capacity of tTreg generation is not impaired in the atrophied thymus

Oh, J., Wang, W., Thomas, R. & Su, D. M., 8 Nov 2017, In : PLoS Biology. 15, 11, e2003352.

Research output: Contribution to journalArticle

Thymus
T-cells
Thymus Gland
T-lymphocytes
Autoantigens
10 Citations (Scopus)

Friend or foe: The dichotomous impact of T cells on neuro-de/ re-generation during aging

Coder, B., Wang, W., Wang, L., Wu, Z., Zhuge, Q. & Su, D. M., 1 Jan 2017, In : Oncotarget. 8, 4, p. 7116-7137 22 p.

Research output: Contribution to journalReview article

Immune System
Nervous System Trauma
T-Lymphocytes
Central Nervous System
Rejuvenation
8 Citations (Scopus)

Immune senescence: significance of the stromal microenvironment

Masters, A. R., Haynes, L., Su, D. M. & Palmer, D. B., 1 Jan 2017, In : Clinical and Experimental Immunology. 187, 1, p. 6-15 10 p.

Research output: Contribution to journalReview article

Immune System
Rejuvenation
Autoimmunity
Immunosenescence
Infection
13 Citations (Scopus)

Impact of aging immune system on neurodegeneration and potential immunotherapies

Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D. M. & Zhao, Y., 1 Oct 2017, In : Progress in Neurobiology. 157, p. 2-28 27 p.

Research output: Contribution to journalReview article

Immunotherapy
Immune System
Brain Injuries
Nervous System
Inflammation

MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down-or Upregulation of Transcription Factors

Xu, M., Zhang, X., Hong, R., Su, D. M. & Wang, L., 1 Jan 2017, In : Journal of Immunology Research. 2017, 2528957.

Research output: Contribution to journalReview article

MicroRNAs
Transcription Factors
Up-Regulation
Epithelium
Epithelial Cells

Soluble antigens from the neurotropic pathogen Angiostrongylus cantonensis directly induce thymus atrophy in a mouse model

Liu, Z., Su, D. M., Yu, Z. L., Wu, F., Liu, R. F., Luo, S. Q., Lv, Z. Y., Zeng, X., Sun, X. & Wu, Z. D., 1 Jan 2017, In : Oncotarget. 8, 30, p. 48575-48590 16 p.

Research output: Contribution to journalArticle

Angiostrongylus cantonensis
Thymus Gland
Atrophy
Stromal Cells
Thymocytes
2015
2 Citations (Scopus)

Cross-talk between human neural stem/progenitor cells and peripheral blood mononuclear cells in an allogeneic co-culture model

Zhang, H., Shao, B., Zhuge, Q., Wang, P., Zheng, C., Huang, W., Yang, C., Wang, B., Su, D. M. & Jin, K., 6 Feb 2015, In : PLoS ONE. 10, 2, e0117432.

Research output: Contribution to journalArticle

Neural Stem Cells
coculture
mononuclear leukocytes
Coculture Techniques
Stem cells
10 Citations (Scopus)

Thymic involution beyond T-cell insufficiency

Coder, B. & Su, D. M., 1 Jan 2015, In : Oncotarget. 6, 26, p. 21777-21778 2 p.

Research output: Contribution to journalEditorial

Thymus Gland
Immunity
Inflammation
T-Lymphocytes
22 Citations (Scopus)

Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation

Coder, B. D., Wang, H., Ruan, L. & Su, D. M., 15 Jun 2015, In : Journal of Immunology. 194, 12, p. 5825-5837 13 p.

Research output: Contribution to journalArticle

Inflammation
T-Lymphocytes
Regulatory T-Lymphocytes
Knockout Mice
Lymphoid Tissue
2014
8 Citations (Scopus)

Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice

Ruan, L., Zhang, Z., Mu, L., Burnley, P., Wang, L., Coder, B., Zhuge, Q. & Su, D. M., 1 Jan 2014, In : Cell Death and Disease. 5, 10, e1457.

Research output: Contribution to journalArticle

Lymphopoiesis
Epithelial Cells
Skin
Mutation
Thymus Gland
70 Citations (Scopus)

MTOR Signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia

Xie, L., Sun, F., Wang, J., Mao, X. O., Xie, L., Yang, S., Su, D. M., Simpkins, J. W., Greenberg, D. A. & Jin, K., 15 Jun 2014, In : Journal of Immunology. 192, 12, p. 6009-6019 11 p.

Research output: Contribution to journalArticle

Microglia
Regulatory T-Lymphocytes
Sirolimus
Ischemia
Macrophages
31 Citations (Scopus)

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke

Wang, L. Q., Lin, Z. Z., Zhang, H. X., Shao, B., Xiao, L., Jiang, H. G., Zhuge, Q. C., Xie, L. K., Wang, B., Su, D. M. & Jin, K., 1 Jan 2014, In : CNS Neuroscience and Therapeutics. 20, 4, p. 317-326 10 p.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Bone Marrow
Stroke
Mesenchymal Stromal Cells
Ischemia
2013
18 Citations (Scopus)

Immunosenescence: A product of the environment?

Su, D. M., Aw, D. & Palmer, D. B., 1 Aug 2013, In : Current Opinion in Immunology. 25, 4, p. 498-503 6 p.

Research output: Contribution to journalReview article

Immune System
Rejuvenation
Infection
Vaccination
Immunosenescence
27 Citations (Scopus)

Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

Burnley, P., Rahman, M., Wang, H., Zhang, Z., Sun, X. L., Zhuge, Q. & Su, D. M., 1 Nov 2013, In : Cell Death and Disease. 4, 11, e932.

Research output: Contribution to journalArticle

Homeostasis
Epithelial Cells
Cell Aging
Cell Differentiation
Complementary DNA
2012
18 Citations (Scopus)

Age-related disruption of steady-state thymic medulla provokes autoimmune phenotype via perturbing negative selection

Xia, J., Wang, H., Guo, J., Zhang, Z., Coder, B. & Su, D. M., 1 Jan 2012, In : Aging and Disease. 3, 3, p. 248-259 12 p.

Research output: Contribution to journalArticle

Central Tolerance
Mediastinal Cyst
Phenotype
Genetic Selection
Regulatory T-Lymphocytes
12 Citations (Scopus)

Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus

Sun, L., Brown, R., Chen, S., Zhuge, Q. & Su, D. M., 1 Jan 2012, In : Aging. 4, 9, p. 606-619 14 p.

Research output: Contribution to journalArticle

Lymphopoiesis
Hematopoietic Stem Cells
Thymus Gland
Bone Marrow
Stem Cell Niche
15 Citations (Scopus)

Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging

Guo, J., Feng, Y., Barnes, P., Huang, F. F., Idell, S., Su, D. M. & Shams, H., 13 Apr 2012, In : PLoS ONE. 7, 4, e34681.

Research output: Contribution to journalArticle

T-cells
Keratin-14
epithelium
Epithelium
T-lymphocytes
18 Citations (Scopus)

Insights on Foxn1 biological significance and usages of the "nude" mouse in studies of T-Lymphopoiesis

Zhang, Z., Burnley, P., Coder, B. & Su, D. M., 24 Sep 2012, In : International Journal of Biological Sciences. 8, 8, p. 1156-1167 12 p.

Research output: Contribution to journalArticle

Lymphopoiesis
Nude Mice
animal models
Gene Knockout Techniques
mice
18 Citations (Scopus)

Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis

Rahman, M., Zhang, Z., Mody, A. A., Su, D. M. & Das, H., 11 Apr 2012, In : Brain Research. 1448, p. 117-128 12 p.

Research output: Contribution to journalArticle

Presenilin-1
JNK Mitogen-Activated Protein Kinases
Intraperitoneal Injections
Apoptosis
Brain
80 Citations (Scopus)

Thymus size and age-related thymic involution: Early programming, sexual dimorphism, progenitors and stroma

Gui, J., Mustachio, L. M., Su, D. M. & Craig, R. W., 1 Jan 2012, In : Aging and Disease. 3, 3, p. 280-290 11 p.

Research output: Contribution to journalReview article

Sex Characteristics
Thymus Gland
T-Lymphocytes
Immune System
Immunity
2011
15 Citations (Scopus)

Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium

Guo, J., Rahman, M., Cheng, L., Zhang, S., Tvinnereim, A. & Su, D. M., 1 Mar 2011, In : Journal of Molecular Medicine. 89, 3, p. 263-277 15 p.

Research output: Contribution to journalArticle

Claudin-3
Claudin-4
Morphogenesis
Thymus Gland
Mediastinal Cyst
2010
5 Citations (Scopus)

A new avenue to cure cancer by turning adaptive immune T cells to innate immune NK cells via reprogramming

Su, D. M. & Vankayalapati, R., 1 Dec 2010, In : Journal of Molecular Cell Biology. 2, 5, p. 237-239 3 p.

Research output: Contribution to journalArticle

Natural Killer Cells
T-Lymphocytes
Thymocytes
Neoplasms
Thymus Gland
37 Citations (Scopus)

Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution

Sun, L., Guo, J., Brown, R., Amagai, T., Zhao, Y. & Su, D. M., 1 Jun 2010, In : Aging Cell. 9, 3, p. 347-357 11 p.

Research output: Contribution to journalArticle

Epithelial Cells
Genes
Transgenes
Thymus Gland
Complementary DNA
67 Citations (Scopus)

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy

Cheng, L., Guo, J., Sun, L., Fu, J., Barnes, P. F., Metzger, D., Chambon, P., Oshima, R. G., Amagai, T. & Su, D. M., 19 Feb 2010, In : Journal of Biological Chemistry. 285, 8, p. 5836-5847 12 p.

Research output: Contribution to journalArticle

Atrophy
Transcription Factors
Epithelial Cells
Tissue
Organogenesis
2008
126 Citations (Scopus)

Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis

Zhang, P., Su, D. M., Liang, M. & Fu, J., 1 Mar 2008, In : Molecular Immunology. 45, 5, p. 1470-1476 7 p.

Research output: Contribution to journalArticle

CD274 Antigen
Apoptosis
Breast Neoplasms
Ligands
T-Lymphocytes
12 Citations (Scopus)

T cell development from kit-negative progenitors in the Foxn1 Δ/Δ mutant thymus

Xiao, S., Su, D. M. & Manley, N. R., 15 Jan 2008, In : Journal of Immunology. 180, 2, p. 914-921 8 p.

Research output: Contribution to journalArticle

Thymus Gland
T-Lymphocytes
Phenotype
Bone Marrow Cells
Cell Differentiation
2007
10 Citations (Scopus)

Atypical memory phenotype T cells with low homeostatic potential and impaired TCR signaling and regulatory T cell function in Foxn1 Δ/Δ mutant mice

Xiao, S., Su, D. M. & Manley, N. R., 15 Dec 2007, In : Journal of Immunology. 179, 12, p. 8153-8163 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
T-Lymphocytes
Phenotype
Thymocytes
Thymus Gland
60 Citations (Scopus)

Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involution

Zhu, X., Gui, J., Dohkan, J., Cheng, L., Barnes, P. F. & Su, D. M., 1 Oct 2007, In : Aging Cell. 6, 5, p. 663-672 10 p.

Research output: Contribution to journalArticle

Lymphopoiesis
T-Lymphocytes
Thymus Gland
Thymocytes
Hematopoietic Stem Cells
62 Citations (Scopus)

Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus

Gordon, J., Xiao, S., Hughes, B., Su, D. M., Navarre, S. P., Condie, B. G. & Manley, N. R., 11 Jul 2007, In : BMC Developmental Biology. 7, 69.

Research output: Contribution to journalArticle

Gene Targeting
Epithelial Cells
Alleles
Thymus Gland
3' Untranslated Regions
63 Citations (Scopus)

The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells

Gui, J., Zhu, X., Dohkan, J., Cheng, L., Barnes, P. F. & Su, D. M., 1 Oct 2007, In : International Immunology. 19, 10, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

Thymus Gland
Epithelial Cells
Stem Cells
Thymocytes
T-Lymphocytes
2005
88 Citations (Scopus)

Ontogeny and regulation of IL-7-expressing thymic epithelial cells

Zamisch, M., Moore-Scott, B., Su, D. M., Lucas, P. J., Manley, N. & Richie, E. R., 1 Jan 2005, In : Journal of Immunology. 174, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Interleukin-7
Epithelial Cells
Thymocytes
Thymus Gland
Keratin-5
2003
114 Citations (Scopus)

A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation

Su, D. M., Navarre, S., Oh, W. J., Condie, B. G. & Manley, N. R., 1 Nov 2003, In : Nature Immunology. 4, 11, p. 1128-1135 8 p.

Research output: Contribution to journalArticle

Thymus Gland
Cell Differentiation
Epithelial Cells
Alleles
T-Lymphocytes
2002
14 Citations (Scopus)
Thymocytes
Epithelial Cells
Interleukin-7
Thymus Gland
Cell Differentiation
2001
112 Citations (Scopus)

Hoxa3 and Pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis

Su, D. M., Ellis, S., Napier, A., Lee, K. & Manley, N. R., 15 Aug 2001, In : Developmental Biology. 236, 2, p. 316-329 14 p.

Research output: Contribution to journalArticle

Organogenesis
Thymus Gland
Cell Death
Epithelial Cells
Cell Proliferation
178 Citations (Scopus)

γ-Secretase inhibitors repress thymocyte development

Hadland, B. K., Manley, N. R., Su, D. M., Longmore, G. D., Moore, C. L., Wolfe, M. S., Schroeter, E. H. & Kopan, R., 19 Jun 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 13, p. 7487-7491 5 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Thymocytes
Multiprotein Complexes
Aptitude
Organ Culture Techniques
2000
58 Citations (Scopus)

Hoxa3 and Pax1 transcription factors regulate the ability of fetal thymic epithelial cells to promote thymocyte development

Su, D. M. & Manley, N. R., 1 Jan 2000, In : Journal of Immunology. 164, 11, p. 5753-5760 8 p.

Research output: Contribution to journalArticle

Thymocytes
Transcription Factors
Epithelial Cells
Adoptive Transfer
Stromal Cells
1997
34 Citations (Scopus)

Interferons α/β inhibit IL-7-induced proliferation of CD4- CD8- CD3- CD44+ CD25+ thymocytes, but do not inhibit that of CD4- CD8- CD3- CD44- CD25- thymocytes

Su, D. M., Wang, J., Lin, Q., Cooper, M. D. & Watanabe, T., 1 Jan 1997, In : Immunology. 90, 4, p. 543-549 7 p.

Research output: Contribution to journalArticle

Interleukin-7
Thymocytes
Interferons
Interferon Type I
Thymus Gland
1995
13 Citations (Scopus)

A novel cell surface antigen, immature thymocyte antigen-1, is involved in the differentiation of murine thymocytes

Kishi, H., Su, D. M., Muraguchi, A. & Watanabe, T., 1 Jan 1995, In : Journal of Immunology. 155, 2, p. 568-577 10 p.

Research output: Contribution to journalArticle

Thymocytes
Surface Antigens
Antigens
Thymus Gland
Hot Temperature