Projects per year
Personal profile
Area of Expertise
The strength of our research projects is using and generating genetically-engineered animal models in understanding genetic and epigenetic regulation of the T-cell immune system and its microenvironment during aging. Our aim is to determine mechanistic insights into poor (immunosenescence) and harmful (autoimmune) T-cell immunity in the elderly for developing rejuvenation strategies to combat age-related chronic inflammatory diseases and cancer recurrence.
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Education/Academic qualification
PhD in Molecular Biology & Immunology, Kyushu University
MS in Infectious Immunology, Lanzhou Medical College
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Projects
Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
NIAID: Allergy and Infectious Diseases
1/12/15 → 30/11/20
Project: Research
Pro-inflammatory Condition-induced Tumor Dormancy in a Pre-metastatic Reservoir: Thymus
American Association of Immunologists
1/09/17 → 31/08/18
Project: Research
Genotyping of FF/FC conditional knock-out mice (For: Bunnarack Kuch)
5/06/17 → 31/05/18
Project: Research
Establish PCR Condition to determine p53 gene conditional deletion (For: Chandani Patel)
5/06/17 → 31/05/18
Project: Research
Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
1/12/15 → 30/11/16
Project: Research
Research Output
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Thomas, R., Wang, W. & Su, D. M., 20 Jan 2020, In : Immunity and Ageing. 17, 1, 2.Research output: Contribution to journal › Review article
Open Access
6
Scopus
citations
Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity – A Mini-Review
Wang, W., Thomas, R., Sizova, O. & Su, D. M., 30 Apr 2020, In : Frontiers in Immunology. 11, 773.Research output: Contribution to journal › Review article
Open Access
Atrophied thymus, a tumor reservoir for harboring melanoma cells
Sizova, O., Kuriatnikov, D., Liu, Y. & Su, D. M., Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1652-1664 13 p.Research output: Contribution to journal › Article
2
Scopus
citations
Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance
Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q. & Su, D. M., Nov 2018, In : FASEB Journal. 32, 11, p. 5899-5912 14 p.Research output: Contribution to journal › Article
5
Scopus
citations
A fine-tune role of Mir-125a-5p on Foxn1 during age-associated changes in the thymus
Xu, M., Sizova, O., Wang, L. & Su, D. M., 1 Jan 2017, In : Aging and Disease. 8, 3, p. 277-286 10 p.Research output: Contribution to journal › Article
6
Scopus
citations