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Personal profile

Area of Expertise

The strength of our research projects is using and generating genetically-engineered animal models in understanding genetic and epigenetic regulation of the T-cell immune system and its microenvironment during aging. Our aim is to determine mechanistic insights into poor (immunosenescence) and harmful (autoimmune) T-cell immunity in the elderly for developing rejuvenation strategies to combat age-related chronic inflammatory diseases and cancer recurrence.
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).

Education/Academic qualification

PhD in Molecular Biology & Immunology, Kyushu University

MS in Infectious Immunology, Lanzhou Medical College

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2010 2020

Research Output 1995 2018

  • 1440 Citations
  • 18 h-Index
  • 34 Article
  • 6 Review article
  • 1 Editorial

Atrophied thymus, a tumor reservoir for harboring melanoma cells

Sizova, O., Kuriatnikov, D., Liu, Y. & Su, D. M., 1 Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1652-1664 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Thymus Neoplasms
Melanoma
Thymus Gland
Neoplasms
Drug Therapy
4 Citations (Scopus)

Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance

Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q. & Su, D. M., 1 Nov 2018, In : FASEB Journal. 32, 11, p. 5899-5912 14 p.

Research output: Contribution to journalArticleResearchpeer-review

T-cells
Rejuvenation
Aging of materials
T-Lymphocytes
Blood
4 Citations (Scopus)

A fine-tune role of Mir-125a-5p on Foxn1 during age-associated changes in the thymus

Xu, M., Sizova, O., Wang, L. & Su, D. M., 1 Jan 2017, In : Aging and Disease. 8, 3, p. 277-286 10 p.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
Thymus Gland
Epithelial Cells
HEK293 Cells
3' Untranslated Regions
4 Citations (Scopus)

Capacity of tTreg generation is not impaired in the atrophied thymus

Oh, J., Wang, W., Thomas, R. & Su, D. M., 8 Nov 2017, In : PLoS Biology. 15, 11, e2003352.

Research output: Contribution to journalArticleResearchpeer-review

Thymus
T-cells
Thymus Gland
T-lymphocytes
Autoantigens
10 Citations (Scopus)

Friend or foe: The dichotomous impact of T cells on neuro-de/ re-generation during aging

Coder, B., Wang, W., Wang, L., Wu, Z., Zhuge, Q. & Su, D. M., 1 Jan 2017, In : Oncotarget. 8, 4, p. 7116-7137 22 p.

Research output: Contribution to journalReview articleResearchpeer-review

Immune System
Nervous System Trauma
T-Lymphocytes
Central Nervous System
Rejuvenation