Projects per year
Personal profile
Area of Expertise
The strength of our research projects is using and generating genetically-engineered animal models in understanding genetic and epigenetic regulation of the T-cell immune system and its microenvironment during aging. Our aim is to determine mechanistic insights into poor (immunosenescence) and harmful (autoimmune) T-cell immunity in the elderly for developing rejuvenation strategies to combat age-related chronic inflammatory diseases and cancer recurrence.
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Education/Academic qualification
PhD in Molecular Biology & Immunology, Kyushu University
MS in Infectious Immunology, Lanzhou Medical College
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2010 2020
Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
NIAID: Allergy and Infectious Diseases
1/12/15 → 30/11/20
Project: Research
Pro-inflammatory Condition-induced Tumor Dormancy in a Pre-metastatic Reservoir: Thymus
American Association of Immunologists
1/09/17 → 31/08/18
Project: Research
Establish PCR Condition to determine p53 gene conditional deletion (For: Chandani Patel)
5/06/17 → 31/05/18
Project: Research
Genotyping of FF/FC conditional knock-out mice (For: Bunnarack Kuch)
5/06/17 → 31/05/18
Project: Research
Research Output 1995 2018
Atrophied thymus, a tumor reservoir for harboring melanoma cells
Sizova, O., Kuriatnikov, D., Liu, Y. & Su, D. M., 1 Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1652-1664 13 p.Research output: Contribution to journal › Article › Research › peer-review
Thymus Neoplasms
Melanoma
Thymus Gland
Neoplasms
Drug Therapy
4
Citations
(Scopus)
Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance
Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q. & Su, D. M., 1 Nov 2018, In : FASEB Journal. 32, 11, p. 5899-5912 14 p.Research output: Contribution to journal › Article › Research › peer-review
T-cells
Rejuvenation
Aging of materials
T-Lymphocytes
Blood
4
Citations
(Scopus)
A fine-tune role of Mir-125a-5p on Foxn1 during age-associated changes in the thymus
Xu, M., Sizova, O., Wang, L. & Su, D. M., 1 Jan 2017, In : Aging and Disease. 8, 3, p. 277-286 10 p.Research output: Contribution to journal › Article › Research › peer-review
MicroRNAs
Thymus Gland
Epithelial Cells
HEK293 Cells
3' Untranslated Regions
4
Citations
(Scopus)
Capacity of tTreg generation is not impaired in the atrophied thymus
Oh, J., Wang, W., Thomas, R. & Su, D. M., 8 Nov 2017, In : PLoS Biology. 15, 11, e2003352.Research output: Contribution to journal › Article › Research › peer-review
Thymus
T-cells
Thymus Gland
T-lymphocytes
Autoantigens
10
Citations
(Scopus)
Friend or foe: The dichotomous impact of T cells on neuro-de/ re-generation during aging
Coder, B., Wang, W., Wang, L., Wu, Z., Zhuge, Q. & Su, D. M., 1 Jan 2017, In : Oncotarget. 8, 4, p. 7116-7137 22 p.Research output: Contribution to journal › Review article › Research › peer-review
Immune System
Nervous System Trauma
T-Lymphocytes
Central Nervous System
Rejuvenation