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Personal profile

Area of Expertise

The strength of our research projects is using and generating genetically-engineered animal models in understanding genetic and epigenetic regulation of the T-cell immune system and its microenvironment during aging. Our aim is to determine mechanistic insights into poor (immunosenescence) and harmful (autoimmune) T-cell immunity in the elderly for developing rejuvenation strategies to combat age-related chronic inflammatory diseases and cancer recurrence.
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).

Education/Academic qualification

PhD in Molecular Biology & Immunology, Kyushu University

MS in Infectious Immunology, Lanzhou Medical College

Fingerprint Dive into the research topics where Dong-Ming Su is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Thymus Gland Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Thymocytes Medicine & Life Sciences
Lymphopoiesis Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
Immune System Medicine & Life Sciences
Phenotype Medicine & Life Sciences

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Projects 2010 2020

Research Output 1995 2018

  • 1442 Citations
  • 18 h-Index
  • 34 Article
  • 6 Review article
  • 1 Editorial

Atrophied thymus, a tumor reservoir for harboring melanoma cells

Sizova, O., Kuriatnikov, D., Liu, Y. & Su, D. M., 1 Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1652-1664 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Thymus Neoplasms
Melanoma
Thymus Gland
Neoplasms
Drug Therapy
4 Citations (Scopus)

Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance

Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q. & Su, D. M., 1 Nov 2018, In : FASEB Journal. 32, 11, p. 5899-5912 14 p.

Research output: Contribution to journalArticleResearchpeer-review

T-cells
Rejuvenation
Aging of materials
T-Lymphocytes
Blood
4 Citations (Scopus)

A fine-tune role of Mir-125a-5p on Foxn1 during age-associated changes in the thymus

Xu, M., Sizova, O., Wang, L. & Su, D. M., 1 Jan 2017, In : Aging and Disease. 8, 3, p. 277-286 10 p.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
Thymus Gland
Epithelial Cells
HEK293 Cells
3' Untranslated Regions
4 Citations (Scopus)

Capacity of tTreg generation is not impaired in the atrophied thymus

Oh, J., Wang, W., Thomas, R. & Su, D. M., 8 Nov 2017, In : PLoS Biology. 15, 11, e2003352.

Research output: Contribution to journalArticleResearchpeer-review

Thymus
T-cells
Thymus Gland
T-lymphocytes
Autoantigens
10 Citations (Scopus)

Friend or foe: The dichotomous impact of T cells on neuro-de/ re-generation during aging

Coder, B., Wang, W., Wang, L., Wu, Z., Zhuge, Q. & Su, D. M., 1 Jan 2017, In : Oncotarget. 8, 4, p. 7116-7137 22 p.

Research output: Contribution to journalReview articleResearchpeer-review

Immune System
Nervous System Trauma
T-Lymphocytes
Central Nervous System
Rejuvenation