Projects per year
Personal profile
Area of Expertise
The strength of our research projects is using and generating genetically-engineered animal models in understanding genetic and epigenetic regulation of the T-cell immune system and its microenvironment during aging. Our aim is to determine mechanistic insights into poor (immunosenescence) and harmful (autoimmune) T-cell immunity in the elderly for developing rejuvenation strategies to combat age-related chronic inflammatory diseases and cancer recurrence.
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Education/Academic qualification
PhD in Molecular Biology & Immunology, Kyushu University
MS in Infectious Immunology, Lanzhou Medical College
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Projects
- 21 Finished
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Pro-inflammatory Condition-induced Tumor Dormancy in a Pre-metastatic Reservoir: Thymus
American Association of Immunologists
1/09/17 → 31/08/18
Project: Research
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Genotyping of FF/FC conditional knock-out mice (For: Bunnarack Kuch)
5/06/17 → 31/05/18
Project: Research
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Establish PCR Condition to determine p53 gene conditional deletion (For: Chandani Patel)
5/06/17 → 31/05/18
Project: Research
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Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
NIAID: Allergy and Infectious Diseases
1/12/15 → 30/11/20
Project: Research
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Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
National Institute of Allergy and Infectious Diseases
1/12/15 → 30/11/21
Project: Research
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Thymic aging may be associated with covid-19 pathophysiology in the elderly
Wang, W., Thomas, R., Oh, J. & Su, D. M., Mar 2021, In: Cells. 10, 3, p. 1-15 15 p., 628.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
Thymic atrophy creates holes in Treg-mediated immuno-regulation via impairment of an antigen-specific clone
Thomas, R., Oh, J., Wang, W. & Su, D. M., Aug 2021, In: Immunology. 163, 4, p. 478-492 15 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Thomas, R., Wang, W. & Su, D. M., 20 Jan 2020, In: Immunity and Ageing. 17, 1, 2.Research output: Contribution to journal › Review article › peer-review
Open Access92 Scopus citations -
Editorial: New Insights Into Thymic Functions During Stress, Aging, and in Disease Settings
van Oers, N. S. C., Su, D. M., Chidgey, A. P. & Dudakov, J., 22 Oct 2020, In: Frontiers in Immunology. 11, 591936.Research output: Contribution to journal › Editorial
Open Access -
Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity – A Mini-Review
Wang, W., Thomas, R., Sizova, O. & Su, D. M., 30 Apr 2020, In: Frontiers in Immunology. 11, 773.Research output: Contribution to journal › Review article › peer-review
Open Access13 Scopus citations