• 1617 Citations
  • 20 h-Index
19952020

Research output per year

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Personal profile

Area of Expertise

The strength of our research projects is using and generating genetically-engineered animal models in understanding genetic and epigenetic regulation of the T-cell immune system and its microenvironment during aging. Our aim is to determine mechanistic insights into poor (immunosenescence) and harmful (autoimmune) T-cell immunity in the elderly for developing rejuvenation strategies to combat age-related chronic inflammatory diseases and cancer recurrence.
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).

Education/Academic qualification

PhD in Molecular Biology & Immunology, Kyushu University

MS in Infectious Immunology, Lanzhou Medical College

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Projects

Research Output

  • 1617 Citations
  • 20 h-Index
  • 34 Article
  • 8 Review article
  • 1 Editorial

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Thomas, R., Wang, W. & Su, D. M., 20 Jan 2020, In : Immunity and Ageing. 17, 1, 2.

Research output: Contribution to journalReview article

Open Access
  • 6 Scopus citations

    Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity – A Mini-Review

    Wang, W., Thomas, R., Sizova, O. & Su, D. M., 30 Apr 2020, In : Frontiers in Immunology. 11, 773.

    Research output: Contribution to journalReview article

    Open Access
  • Atrophied thymus, a tumor reservoir for harboring melanoma cells

    Sizova, O., Kuriatnikov, D., Liu, Y. & Su, D. M., Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1652-1664 13 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance

    Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q. & Su, D. M., Nov 2018, In : FASEB Journal. 32, 11, p. 5899-5912 14 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    A fine-tune role of Mir-125a-5p on Foxn1 during age-associated changes in the thymus

    Xu, M., Sizova, O., Wang, L. & Su, D. M., 1 Jan 2017, In : Aging and Disease. 8, 3, p. 277-286 10 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations