Projects per year
Personal profile
Area of Expertise
The strength of our research projects is using and generating genetically-engineered animal models in understanding genetic and epigenetic regulation of the T-cell immune system and its microenvironment during aging. Our aim is to determine mechanistic insights into poor (immunosenescence) and harmful (autoimmune) T-cell immunity in the elderly for developing rejuvenation strategies to combat age-related chronic inflammatory diseases and cancer recurrence.
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Our current NIH- & AAI-funded and potentially NIH-funded projects include: “Balance of thymic negative selection vs. Treg cell generation in the elderly (NIH-funded R01)”; “Biased Treg TCR specificity and its impact on immunity in the elderly (Potential NIH R01)”; and “Role of the central immune organ in cancer chemoimmunotherapy (AAI-funded fellowship).
Education/Academic qualification
PhD in Molecular Biology & Immunology, Kyushu University
MS in Infectious Immunology, Lanzhou Medical College
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Collaborations and top research areas from the last five years
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Projects
- 21 Finished
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Pro-inflammatory Condition-induced Tumor Dormancy in a Pre-metastatic Reservoir: Thymus
American Association of Immunologists
1/09/17 → 31/08/18
Project: Research
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Genotyping of FF/FC conditional knock-out mice (For: Bunnarack Kuch)
5/06/17 → 31/05/18
Project: Research
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Establish PCR Condition to determine p53 gene conditional deletion (For: Chandani Patel)
5/06/17 → 31/05/18
Project: Research
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Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
National Institute of Allergy and Infectious Diseases
1/12/15 → 30/11/21
Project: Research
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Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
1/12/15 → 30/11/21
Project: Research
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A fine-tune role of Mir-125a-5p on Foxn1 during age-associated changes in the thymus
Xu, M., Sizova, O., Wang, L. & Su, D. M., 2017, In: Aging and Disease. 8, 3, p. 277-286 10 p.Research output: Contribution to journal › Article › peer-review
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Cross-talk between human neural stem/progenitor cells and peripheral blood mononuclear cells in an allogeneic co-culture model
Zhang, H., Shao, B., Zhuge, Q., Wang, P., Zheng, C., Huang, W., Yang, C., Wang, B., Su, D. M. & Jin, K., 6 Feb 2015, In: PLoS ONE. 10, 2, e0117432.Research output: Contribution to journal › Article › peer-review
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Hoxa3 and Pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis
Su, D. M., Ellis, S., Napier, A., Lee, K. & Manley, N. R., 15 Aug 2001, In: Developmental Biology. 236, 2, p. 316-329 14 p.Research output: Contribution to journal › Article › peer-review
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The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells
Gui, J., Zhu, X., Dohkan, J., Cheng, L., Barnes, P. F. & Su, D. M., Oct 2007, In: International Immunology. 19, 10, p. 1201-1211 11 p.Research output: Contribution to journal › Article › peer-review
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Sex and strain differences in renal hemodynamics in mice
Tao, Y., Young-Stubbs, C., Yazdizadeh Shotorbani, P., Su, D. M., Mathis, K. W. & Ma, R., Mar 2023, In: Physiological Reports. 11, 6, e15644.Research output: Contribution to journal › Article › peer-review