Personal profile
Research Interests
Stroke, Traumatic Brain injury, metabolic syndrome, Alzheimer’s disease, steroids, drug discovery
Area of Expertise
My laboratory is interested in identifying treatments for brain injury resulting from stroke, traumatic brain injury, Alzheimer Disease, and metabolic syndrome. We are particularly interested in identifying early points of intervention to reduce or prevent progression of disease. Previous studies have focused on steroid hormones and plant estrogens and current projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
Techniques
In vivo and in vitro models of stoke, traumatic brain injury, metabolic syndrome, Alzheimer Disease; immunostaining, western blotting, PCR, fluorescent imaging, ELISA, animal behavior, gene expression, MRI.
Education/Academic qualification
BS in Biology, Emory University
PhD in Neuroscience, University of Pittsburgh
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Collaborations and top research areas from the last five years
Projects
- 21 Finished
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Early Interventions to Reduce the Effect of Metabolic Syndrome on Brain Health
Schreihofer, D. (PI)
13/03/23 → 12/03/24
Project: Research
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Discovery of Functionally Sele
Luedtke, R. (PI) & Schreihofer, D. (PI)
NIA: National Institute on Aging
15/09/17 → 31/05/25
Project: Research
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Brain Stem Mechanisms for Altered Autonomic Regulation of Blood Pressure in Obesity
Schreihofer, A. (PI), Sumien, N. (CoI) & Schreihofer, D. (CoI)
NHLBI: Nat Heart, Lung & Blood Institute
1/07/17 → 31/08/23
Project: Research
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Beneficial Effects of Dietary Soy Phytoestrogens on the Aging Female Brain
Schreihofer, D. (PI)
1/08/16 → 31/12/19
Project: Research
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Sigma 1 Receptor as a Target for Repetitive Concussive Brain Injury
Schreihofer, D. (PI), Luedtke, R. (CoI) & Sumien, N. (CoI)
1/08/16 → 31/08/20
Project: Research
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Loss of gonadal steroids as a negative conditioner for neurological disease
Sun, F., Oppong-Gyebi, A. & Schreihofer, D., 2019, In: Conditioning Medicine.Research output: Contribution to journal › Article › peer-review
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Insights into a successful dual scientific career and partnership.
Schreihofer, A. & Schreihofer, D., Jun 2012, In: The Physiologist. 55, 3, p. 94-95 2 p.Research output: Contribution to journal › Article › peer-review
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A high soy diet reduces programmed cell death and enhances bcl-xL expression in experimental stroke
Lovekamp-Swan, T., Glendenning, M. & Schreihofer, D. A., 7 Sep 2007, In: Neuroscience. 148, 3, p. 644-652 9 p.Research output: Contribution to journal › Article › peer-review
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Ligand-independent activation of pituitary ER: Dependence on PKA-stimulated pathways
Schreihofer, D. A., Resnick, E. M., Lin, V. Y. & Shupnik, M. A., 2001, In: Endocrinology. 142, 8, p. 3361-3368 8 p.Research output: Contribution to journal › Article › peer-review
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Duration of isoflurane-based surgical anesthesia determines severity of brain injury and neurological deficits after a transient focal ischemia in young adult rats
Gaidhani, N., Sun, F., Schreihofer, D. & Uteshev, V. V., Sep 2017, In: Brain Research Bulletin. 134, p. 168-176 9 p.Research output: Contribution to journal › Article › peer-review