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Personal profile

Area of Expertise

My laboratory is interested in understanding how steroid hormones like estrogen, testosterone, and natural estrogens from plants regulate brain function in injury and aging.
We use both cell and animal models to examine the underlying mechanisms of steroid action under conditions in which they are beneficial and those in which they are not in order to understand what key factors result in beneficial effects on the brain. Our goal is to determine the conditions in which these compounds can be safely and effectively used to provide ongoing brain health and treat brain injury and disease.
Additional projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.

Education/Academic qualification

PhD in Neuroscience, University of Pittsburgh

BS in Biology, Emory University

Fingerprint Dive into the research topics where Derek Schreihofer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 12 Similar Profiles
Estrogens Medicine & Life Sciences
Estrogen Receptors Medicine & Life Sciences
Brain Ischemia Medicine & Life Sciences
Stroke Medicine & Life Sciences
Middle Cerebral Artery Infarction Medicine & Life Sciences
Isoflavones Medicine & Life Sciences
Luteinizing Hormone Medicine & Life Sciences
Phytoestrogens Medicine & Life Sciences

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Projects 2012 2018

Research Output 1993 2019

Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke

Schreihofer, D. & Oppong-Gyebi, A., 3 Jun 2019, In : Nutritional Neuroscience. 22, 6, p. 375-391 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Genistein
Neuroprotective Agents
Stroke
Estrogens
Brain Injuries
5 Citations (Scopus)

Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging

Wilson, E. N., Anderson, M., Snyder, B., Duong, P., Trieu, J., Schreihofer, D. & Cunningham, R. L., 15 May 2018, In : Physiology and Behavior. 189, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Sleep Apnea Syndromes
Oxidative Stress
Testosterone
Sexual Behavior
Hypoxia

N-terminal truncations in sex steroid receptors and rapid steroid actions

Schreihofer, D., Duong, P. & Cunningham, R. L., 1 May 2018, In : Steroids. 133, p. 15-20 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Steroid Receptors
Steroids
Cell Membrane
Cell membranes
Caveolins
4 Citations (Scopus)
Isoflurane
Brain Injuries
Young Adult
Ischemia
Anesthesia
5 Citations (Scopus)

Presence of androgen receptor variant in neuronal lipid rafts

Garza-Contreras, J., Duong, P., Snyder, B. D., Schreihofer, D. & Cunningham, R. L., 1 Jul 2017, In : eNeuro. 4, 4, e0109-17.2017.

Research output: Contribution to journalArticleResearchpeer-review

Androgen Receptors
Dopaminergic Neurons
Membrane Lipids
Lipids
Androgens