Projects per year
Personal profile
Area of Expertise
My laboratory is interested in understanding how steroid hormones like estrogen, testosterone, and natural estrogens from plants regulate brain function in injury and aging.
We use both cell and animal models to examine the underlying mechanisms of steroid action under conditions in which they are beneficial and those in which they are not in order to understand what key factors result in beneficial effects on the brain. Our goal is to determine the conditions in which these compounds can be safely and effectively used to provide ongoing brain health and treat brain injury and disease.
Additional projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
We use both cell and animal models to examine the underlying mechanisms of steroid action under conditions in which they are beneficial and those in which they are not in order to understand what key factors result in beneficial effects on the brain. Our goal is to determine the conditions in which these compounds can be safely and effectively used to provide ongoing brain health and treat brain injury and disease.
Additional projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
Education/Academic qualification
BS in Biology, Emory University
PhD in Neuroscience, University of Pittsburgh
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Projects
- 18 Finished
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Beneficial Effects of Dietary Soy Phytoestrogens on the Aging Female Brain
1/08/16 → 31/07/18
Project: Research
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Sigma 1 Receptor as a Target for Repetitive Concussive Brain Injury
Schreihofer, D., Luedtke, R. & Sumien, N.
1/08/16 → 30/04/18
Project: Research
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Repositioning Drugs to Treat Ischemic Stroke at Delayed Time Points
Schetz, J., Schreihofer, D. & Schreihofer, D.
1/07/16 → 31/12/20
Project: Research
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Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands
Dalwadi, D. A., Kim, S., Schetz, J., Schreihofer, D. A. & Kim, S., 1 Jan 2022, In: Journal of Pharmacological and Toxicological Methods. 113, 107129.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Long-term hypogonadism diminishes the neuroprotective effects of dietary genistein in young adult ovariectomized rats after transient focal ischemia
Oppong-Gyebi, A., Metzger, D., Doan, T., Han, J., Vann, P. H., Yockey, R. A., Sumien, N. & Schreihofer, D. A., Feb 2022, In: Journal of Neuroscience Research. 100, 2, p. 598-619 22 p.Research output: Contribution to journal › Article › peer-review
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Chronic Testosterone Deprivation Sensitizes the Middle-Aged Rat Brain to Damaging Effects of Testosterone Replacement
Smith, C., Contreras-Garza, J., Cunningham, R. L., Wong, J. M., Vann, P. H., Metzger, D., Kasanga, E., Oppong-Gyebi, A., Sumien, N. & Schreihofer, D. A., 1 Oct 2020, In: Neuroendocrinology. 110, 11-12, p. 914-928 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke
Schreihofer, D. & Oppong-Gyebi, A., 3 Jun 2019, In: Nutritional Neuroscience. 22, 6, p. 375-391 17 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging
Wilson, E. N., Anderson, M., Snyder, B., Duong, P., Trieu, J., Schreihofer, D. A. & Cunningham, R. L., 15 May 2018, In: Physiology and Behavior. 189, p. 64-73 10 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations