Projects per year
Personal profile
Area of Expertise
My laboratory is interested in understanding how steroid hormones like estrogen, testosterone, and natural estrogens from plants regulate brain function in injury and aging.
We use both cell and animal models to examine the underlying mechanisms of steroid action under conditions in which they are beneficial and those in which they are not in order to understand what key factors result in beneficial effects on the brain. Our goal is to determine the conditions in which these compounds can be safely and effectively used to provide ongoing brain health and treat brain injury and disease.
Additional projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
We use both cell and animal models to examine the underlying mechanisms of steroid action under conditions in which they are beneficial and those in which they are not in order to understand what key factors result in beneficial effects on the brain. Our goal is to determine the conditions in which these compounds can be safely and effectively used to provide ongoing brain health and treat brain injury and disease.
Additional projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
Education/Academic qualification
PhD in Neuroscience, University of Pittsburgh
BS in Biology, Emory University
Fingerprint Dive into the research topics where Derek Schreihofer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 12 Similar Profiles
Estrogens
Medicine & Life Sciences
Estrogen Receptors
Medicine & Life Sciences
Brain Ischemia
Medicine & Life Sciences
Stroke
Medicine & Life Sciences
Middle Cerebral Artery Infarction
Medicine & Life Sciences
Isoflavones
Medicine & Life Sciences
Luteinizing Hormone
Medicine & Life Sciences
Phytoestrogens
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2012 2018
- 9 Finished
Sigma 1 Receptor as a Target for Repetitive Concussive Brain Injury
Schreihofer, D., Luedtke, R. & Sumien, N.
1/08/16 → 31/01/18
Project: Research
Beneficial Effects of Dietary Soy Phytoestrogens on the Aging Female Brain
1/08/16 → 31/07/17
Project: Research
Pilot Study on the Risks of Testosterone Replacement to the Brain
Schreihofer, D., Sumien, N. & Cunningham, R.
NIA: National Institute on Aging
15/08/15 → 31/05/17
Project: Research
Research Output 1993 2019
Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke
Schreihofer, D. & Oppong-Gyebi, A., 3 Jun 2019, In : Nutritional Neuroscience. 22, 6, p. 375-391 17 p.Research output: Contribution to journal › Article › Research › peer-review
Genistein
Neuroprotective Agents
Stroke
Estrogens
Brain Injuries
5
Citations
(Scopus)
Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging
Wilson, E. N., Anderson, M., Snyder, B., Duong, P., Trieu, J., Schreihofer, D. & Cunningham, R. L., 15 May 2018, In : Physiology and Behavior. 189, p. 64-73 10 p.Research output: Contribution to journal › Article › Research › peer-review
Sleep Apnea Syndromes
Oxidative Stress
Testosterone
Sexual Behavior
Hypoxia
N-terminal truncations in sex steroid receptors and rapid steroid actions
Schreihofer, D., Duong, P. & Cunningham, R. L., 1 May 2018, In : Steroids. 133, p. 15-20 6 p.Research output: Contribution to journal › Article › Research › peer-review
Steroid Receptors
Steroids
Cell Membrane
Cell membranes
Caveolins
4
Citations
(Scopus)
Duration of isoflurane-based surgical anesthesia determines severity of brain injury and neurological deficits after a transient focal ischemia in young adult rats
Gaidhani, N., Sun, F., Schreihofer, D. & Uteshev-Gaard, V. V., 1 Sep 2017, In : Brain Research Bulletin. 134, p. 168-176 9 p.Research output: Contribution to journal › Article › Research › peer-review
Isoflurane
Brain Injuries
Young Adult
Ischemia
Anesthesia
5
Citations
(Scopus)
Presence of androgen receptor variant in neuronal lipid rafts
Garza-Contreras, J., Duong, P., Snyder, B. D., Schreihofer, D. & Cunningham, R. L., 1 Jul 2017, In : eNeuro. 4, 4, e0109-17.2017.Research output: Contribution to journal › Article › Research › peer-review
Androgen Receptors
Dopaminergic Neurons
Membrane Lipids
Lipids
Androgens