Projects per year
Personal profile
Research Interests
Stroke, Traumatic Brain injury, metabolic syndrome, Alzheimer’s disease, steroids, drug discovery
Area of Expertise
My laboratory is interested in identifying treatments for brain injury resulting from stroke, traumatic brain injury, Alzheimer Disease, and metabolic syndrome. We are particularly interested in identifying early points of intervention to reduce or prevent progression of disease. Previous studies have focused on steroid hormones and plant estrogens and current projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
Techniques
In vivo and in vitro models of stoke, traumatic brain injury, metabolic syndrome, Alzheimer Disease; immunostaining, western blotting, PCR, fluorescent imaging, ELISA, animal behavior, gene expression, MRI.
Education/Academic qualification
BS in Biology, Emory University
PhD in Neuroscience, University of Pittsburgh
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Collaborations and top research areas from the last five years
Projects
- 20 Finished
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Early Interventions to Reduce the Effect of Metabolic Syndrome on Brain Health
Schreihofer, D. (PI)
13/03/23 → 12/03/24
Project: Research
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Brain Stem Mechanisms for Altered Autonomic Regulation of Blood Pressure in Obesity
Schreihofer, A. (PI), Sumien, N. (CoI) & Schreihofer, D. (CoI)
NHLBI: Nat Heart, Lung & Blood Institute
1/07/17 → 31/08/21
Project: Research
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Beneficial Effects of Dietary Soy Phytoestrogens on the Aging Female Brain
Schreihofer, D. (PI)
1/08/16 → 31/07/18
Project: Research
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Sigma 1 Receptor as a Target for Repetitive Concussive Brain Injury
Schreihofer, D. (PI), Luedtke, R. (CoI) & Sumien, N. (CoI)
1/08/16 → 30/04/18
Project: Research
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NINDS Schrhfr 06/18
Schreihofer, D. (PI)
NINDS: Neurological Disorders & Stroke
1/07/16 → 30/06/18
Project: Research
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Truncated estrogen receptor product-1 suppresses estrogen receptor transactivation by dimerization with estrogen receptors and β
Resnick, E. M., Schreihofer, D. A., Periasamy, A. & Shupnik, M. A., 10 Mar 2000, In: Journal of Biological Chemistry. 275, 10, p. 7158-7166 9 p.Research output: Contribution to journal › Article › peer-review
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Temporal and region-specific tau hyperphosphorylation in the medulla and forebrain coincides with development of functional changes in male obese Zucker rats
Das-Earl, P., Schreihofer, D. A., Sumien, N. & Schreihofer, A. M., Apr 2024, In: Journal of Neurophysiology. 131, 4, p. 689-708 20 p.Research output: Contribution to journal › Article › peer-review
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Adaptive cerebral neovascularization in a model of type 2 diabetes: Relevance to focal cerebral ischemia
Li, W., Prakash, R., Kelly-Cobbs, A. I., Ogbi, S., Kozak, A., El-Remessy, A. B., Schreihofer, D. A., Fagan, S. C. & Ergul, A., Jan 2010, In: Diabetes. 59, 1, p. 228-235 8 p.Research output: Contribution to journal › Article › peer-review
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Differential expression and regulation of estrogen receptors (ERs) in rat pituitary and cell lines: Estrogen decreases ERα protein and estrogen responsiveness
Schreihofer, D. A., Stoler, M. H. & Shupnik, M. A., 2000, In: Endocrinology. 141, 6, p. 2174-2184 11 p.Research output: Contribution to journal › Article › peer-review
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The authors reply
Quaynor, S. D., Schreihofer, D. A. & Layman, L. C., 2013, In: New England Journal of Medicine. 369, 17, p. 1664 1 p.Research output: Contribution to journal › Letter › peer-review