Projects per year
Personal profile
Area of Expertise
My laboratory is interested in understanding how steroid hormones like estrogen, testosterone, and natural estrogens from plants regulate brain function in injury and aging.
We use both cell and animal models to examine the underlying mechanisms of steroid action under conditions in which they are beneficial and those in which they are not in order to understand what key factors result in beneficial effects on the brain. Our goal is to determine the conditions in which these compounds can be safely and effectively used to provide ongoing brain health and treat brain injury and disease.
Additional projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
We use both cell and animal models to examine the underlying mechanisms of steroid action under conditions in which they are beneficial and those in which they are not in order to understand what key factors result in beneficial effects on the brain. Our goal is to determine the conditions in which these compounds can be safely and effectively used to provide ongoing brain health and treat brain injury and disease.
Additional projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
Education/Academic qualification
BS in Biology, Emory University
PhD in Neuroscience, University of Pittsburgh
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Projects
Beneficial Effects of Dietary Soy Phytoestrogens on the Aging Female Brain
1/08/16 → 31/07/18
Project: Research
Sigma 1 Receptor as a Target for Repetitive Concussive Brain Injury
Schreihofer, D., Luedtke, R. & Sumien, N.
1/08/16 → 30/04/18
Project: Research
Repositioning Drugs to Treat Ischemic Stroke at Delayed Time Points
Schetz, J. & Schreihofer, D.
1/07/16 → 30/06/17
Project: Research
Research Output
Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke
Schreihofer, D. & Oppong-Gyebi, A., 3 Jun 2019, In : Nutritional Neuroscience. 22, 6, p. 375-391 17 p.Research output: Contribution to journal › Article
3
Scopus
citations
Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging
Wilson, E. N., Anderson, M., Snyder, B., Duong, P., Trieu, J., Schreihofer, D. A. & Cunningham, R. L., 15 May 2018, In : Physiology and Behavior. 189, p. 64-73 10 p.Research output: Contribution to journal › Article
10
Scopus
citations
N-terminal truncations in sex steroid receptors and rapid steroid actions
Schreihofer, D. A., Duong, P. & Cunningham, R. L., May 2018, In : Steroids. 133, p. 15-20 6 p.Research output: Contribution to journal › Article
1
Scopus
citations
Duration of isoflurane-based surgical anesthesia determines severity of brain injury and neurological deficits after a transient focal ischemia in young adult rats
Gaidhani, N., Sun, F., Schreihofer, D. & Uteshev, V. V., Sep 2017, In : Brain Research Bulletin. 134, p. 168-176 9 p.Research output: Contribution to journal › Article
11
Scopus
citations
Presence of androgen receptor variant in neuronal lipid rafts
Garza-Contreras, J., Duong, P., Snyder, B. D., Schreihofer, D. A. & Cunningham, R. L., 1 Jul 2017, In : eNeuro. 4, 4, e0109-17.2017.Research output: Contribution to journal › Article
7
Scopus
citations