Projects per year
Personal profile
Research Interests
Stroke, Traumatic Brain injury, metabolic syndrome, Alzheimer’s disease, steroids, drug discovery
Area of Expertise
My laboratory is interested in identifying treatments for brain injury resulting from stroke, traumatic brain injury, Alzheimer Disease, and metabolic syndrome. We are particularly interested in identifying early points of intervention to reduce or prevent progression of disease. Previous studies have focused on steroid hormones and plant estrogens and current projects are focused on using novel compounds to protect and regenerate brain tissue after stroke and traumatic brain injury.
Techniques
In vivo and in vitro models of stoke, traumatic brain injury, metabolic syndrome, Alzheimer Disease; immunostaining, western blotting, PCR, fluorescent imaging, ELISA, animal behavior, gene expression, MRI.
Education/Academic qualification
BS in Biology, Emory University
PhD in Neuroscience, University of Pittsburgh
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Collaborations and top research areas from the last five years
Projects
- 20 Finished
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Early Interventions to Reduce the Effect of Metabolic Syndrome on Brain Health
Schreihofer, D. (PI)
13/03/23 → 12/03/24
Project: Research
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Brain Stem Mechanisms for Altered Autonomic Regulation of Blood Pressure in Obesity
Schreihofer, A. (PI), Sumien, N. (CoI) & Schreihofer, D. (CoI)
NHLBI: Nat Heart, Lung & Blood Institute
1/07/17 → 31/08/21
Project: Research
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Sigma 1 Receptor as a Target for Repetitive Concussive Brain Injury
Schreihofer, D. (PI), Luedtke, R. (CoI) & Sumien, N. (CoI)
1/08/16 → 30/04/18
Project: Research
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Beneficial Effects of Dietary Soy Phytoestrogens on the Aging Female Brain
Schreihofer, D. (PI)
1/08/16 → 31/07/18
Project: Research
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Repositioning Drugs to Treat Ischemic Stroke at Delayed Time Points
Schreihofer, D. (PI) & Schreihofer, D. (CoI)
NINDS: Neurological Disorders & Stroke
1/07/16 → 31/12/20
Project: Research
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Hypoxia-inducible factor and vascular endothelial growth factor are targets of dietary soy during acute stroke in female rats
Ma, Y., Lovekamp-Swan, T., Bekele, W., Dohi, A. & Schreihofer, D. A., 1 Apr 2013, In: Endocrinology. 154, 4, p. 1589-1597 9 p.Research output: Contribution to journal › Article › peer-review
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Modulation of reproductive hormone secretion by nutritional intake: Stress signals versus metabolic signals
Cameron, J. L., Helmreich, D. L. & Schreihofer, D. A., Nov 1993, In: Human Reproduction. 8, p. 162-167 6 p.Research output: Contribution to journal › Article › peer-review
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Estrogen receptor-α (ERα), but not ERβ, modulates estrogen stimulation of the ERα-truncated variant, TERP-1
Schreihofer, D. A., Rowe, D. F., Rissman, E. F., Scordalakes, E. M., Gustafsson, J. Å. & Shupnik, M. A., 1 Nov 2002, In: Endocrinology. 143, 11, p. 4196-4202 7 p.Research output: Contribution to journal › Article › peer-review
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Central inflammatory response to experimental stroke is inhibited by a neuroprotective dose of dietary soy
Shambayati, M., Patel, M., Ma, Y., Cunningham, R. L. & Schreihofer, D. A., 17 Dec 2014, In: Brain Research. 1593, p. 76-82 7 p.Research output: Contribution to journal › Article › peer-review
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Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke
Schreihofer, D. A. & Oppong-Gyebi, A., 3 Jun 2019, In: Nutritional Neuroscience. 22, 6, p. 375-391 17 p.Research output: Contribution to journal › Article › peer-review