Personal profile
Research Interests
Neurodegeneration, Glaucoma, Metabolism, Mitochondria
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Area of Expertise
My laboratory investigates the mechanisms of glaucoma, with an emphasis on how neurons and glial cells interact during the process of degeneration. Our research has implicated metabolism in the pathogenesis of glaucoma, finding that transfer of energy substrate is compromised and mitochondria are dysfunctional prior to axon loss. These observations offer new targets for therapeutic development.
Education/Academic qualification
BS in Biology, Drexel University
PhD in Neuroscience, University of Virginia
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mechanisms Underlying Endothel
Krishnamoorthy, R. (PI), Stankowska, D. (CoI), Inman, D. (CoI) & Clark, A. (CoI)
1/06/21 → 31/08/26
Project: Research
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Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma
Smith, M. A., Xia, C. Z., Dengler-Crish, C. M., Fening, K. M., Inman, D. M., Schofield, B. R. & Crish, S. D., 1 Dec 2016, In: Journal of Comparative Neurology. 524, 17, p. 3503-3517 15 p.Research output: Contribution to journal › Article › peer-review
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Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma
Wilson, G. N., Inman, D. M., Denger-Crish, C. M., Smith, M. A. & Crish, S. D., 17 Sep 2015, In: Journal of neuroinflammation. 12, 1, 176.Research output: Contribution to journal › Article › peer-review
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Transcorneal Electrical Stimulation Reduces Neurodegenerative Process in a Mouse Model of Glaucoma
Jassim, A. H., Cavanaugh, M. K., Shah, J. S., Willits, R. & Inman, D. M., Feb 2021, In: Annals of Biomedical Engineering. 49, 2, p. 858-870 13 p.Research output: Contribution to journal › Article › peer-review
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Decreased energy capacity and increased autophagic activity in optic nerve axons with defective anterograde transport
Kleesattel, D., Crish, S. D. & Inman, D. M., 1 Dec 2015, In: Investigative Ophthalmology and Visual Science. 56, 13, p. 8215-8227 13 p.Research output: Contribution to journal › Article › peer-review
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Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons
Uo, T., Dworzak, J., Kinoshita, C., Inman, D. M., Kinoshita, Y., Horner, P. J. & Morrison, R. S., Aug 2009, In: Experimental Neurology. 218, 2, p. 274-285 12 p.Research output: Contribution to journal › Article › peer-review