Projects per year
Personal profile
Research Interests
Neurodegeneration, Glaucoma, Metabolism, Mitochondria
URL
Area of Expertise
My laboratory investigates the mechanisms of glaucoma, with an emphasis on how neurons and glial cells interact during the process of degeneration. Our research has implicated metabolism in the pathogenesis of glaucoma, finding that transfer of energy substrate is compromised and mitochondria are dysfunctional prior to axon loss. These observations offer new targets for therapeutic development.
Education/Academic qualification
BS in Biology, Drexel University
PhD in Neuroscience, University of Virginia
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Dive into the research topics where Denise Inman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Metabolic Vulnerability as a Diseased Target for Glaucoma
INMAN, D., INMAN, D. & Inman, D.
1/04/16 → 31/07/24
Project: Research
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Metabolic vulnerability as a disease target for glaucoma
Inman, D. & INMAN, D.
1/04/16 → 31/03/21
Project: Research
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Changes in ganglioside GM1 expression in glaucomic retina
Pappenhagen, N. & Inman, D. M., Oct 2018, In: Journal of Neuroscience Research. 96, 10, p. 1627-1630 4 p.Research output: Contribution to journal › Letter › peer-review
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Stretch stress propels glutamine dependency and glycolysis in optic nerve head astrocytes
Pappenhagen, N., Yin, E., Morgan, A. B., Kiehlbauch, C. C. & Inman, D. M., 5 Aug 2022, In: Frontiers in Neuroscience. 16, 957034.Research output: Contribution to journal › Article › peer-review
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Transcorneal Electrical Stimulation Reduces Neurodegenerative Process in a Mouse Model of Glaucoma
Jassim, A. H., Cavanaugh, M. K., Shah, J. S., Willits, R. & Inman, D. M., Feb 2021, In: Annals of Biomedical Engineering. 49, 2, p. 858-870 13 p.Research output: Contribution to journal › Article › peer-review
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Distal axonopathy with structural persistence in glaucomatous neurodegeneration
Crish, S. D., Sappington, R. M., Inman, D. M., Horner, P. J. & Calkins, D. J., 16 Mar 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 5196-5201 6 p.Research output: Contribution to journal › Article › peer-review
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Decreased energy capacity and increased autophagic activity in optic nerve axons with defective anterograde transport
Kleesattel, D., Crish, S. D. & Inman, D. M., 1 Dec 2015, In: Investigative Ophthalmology and Visual Science. 56, 13, p. 8215-8227 13 p.Research output: Contribution to journal › Article › peer-review