Projects per year
Personal profile
Research Interests
Neurodegeneration, Glaucoma, Metabolism, Mitochondria
URL
Area of Expertise
My laboratory investigates the mechanisms of glaucoma, with an emphasis on how neurons and glial cells interact during the process of degeneration. Our research has implicated metabolism in the pathogenesis of glaucoma, finding that transfer of energy substrate is compromised and mitochondria are dysfunctional prior to axon loss. These observations offer new targets for therapeutic development.
Education/Academic qualification
BS in Biology, Drexel University
PhD in Neuroscience, University of Virginia
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Dive into the research topics where Denise Inman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Optic nerve head (ONH) Chips for Glaucomatous Neurodegeneration
Inman, D. (PI)
University of North Texas - Denton
30/09/22 → 31/05/25
Project: Research
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Metabolic Vulnerability as a Diseased Target for Glaucoma
Inman, D. (PI) & Prokai, L. (CoI)
30/09/21 → 31/07/26
Project: Research
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Mechanisms Underlying Endothelin Mediated Neurodegeneration in Glaucoma
Krishnamoorthy, R. (PI), Stankowska, D. (CoI) & Inman, D. (CoI)
1/06/21 → 31/08/26
Project: Research
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Neuroprotective Effect of EYS611 in Bead-Induced Rat Model of Glaucoma
Inman, D. (PI)
25/01/22 → 24/09/22
Project: Research
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Neuroprotective Effect of Transferrin in Bead-Induced Rat Model of Glaucoma
Inman, D. (PI)
15/07/21 → 31/08/21
Project: Research
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Store-operated Ca2 + entry inhibition ameliorates high glucose and ANG II-induced podocyte apoptosis and mitochondrial damage
Tao, Y., Shotorbani, P. Y., Inman, D., Das-Earl, P. & Ma, R., May 2023, In: American Journal of Physiology - Renal Physiology. 324, 5, p. F494-F504Research output: Contribution to journal › Article › peer-review
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Early Reduction of Microglia Activation by Irradiation in a Model of Chronic Glaucoma
Bosco, A., Crish, S. D., Steele, M. R., Romero, C. O., Inman, D. M., Horner, P. J., Calkins, D. J. & Vetter, M. L., 30 Aug 2012, In: PLoS ONE. 7, 8, e43602.Research output: Contribution to journal › Article › peer-review
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Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death
Nsiah, N. Y., Morgan, A. B., Donkor, N. & Inman, D. M., Dec 2023, In: Scientific Reports. 13, 1, 20541.Research output: Contribution to journal › Article › peer-review
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Ocular Hypertension Results in Hypoxia within Glia and Neurons throughout the Visual Projection
Jassim, A. H., Nsiah, N. Y. & Inman, D. M., May 2022, In: Antioxidants. 11, 5, 888.Research output: Contribution to journal › Article › peer-review
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The ketogenic diet and hypoxia promote mitophagy in the context of glaucoma
Morgan, A. B., Fan, Y. & Inman, D. M., 2024, In: Frontiers in Cellular Neuroscience. 18, 1409717.Research output: Contribution to journal › Article › peer-review