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Personal profile

Area of Expertise

My laboratory investigates the mechanisms of glaucoma, with an emphasis on how neurons and glial cells interact during the process of degeneration. Our research has implicated metabolism in the pathogenesis of glaucoma, finding that transfer of energy substrate is compromised and mitochondria are dysfunctional prior to axon loss. These observations offer new targets for therapeutic development.

Education/Academic qualification

PhD in Neuroscience, University of Virginia

BS in Biology, Drexel University

Fingerprint Dive into the research topics where Denise Inman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Glaucoma Medicine & Life Sciences
Inbred DBA Mouse Medicine & Life Sciences
Optic Nerve Medicine & Life Sciences
Retinal Ganglion Cells Medicine & Life Sciences
Animal Disease Models Medicine & Life Sciences
Axons Medicine & Life Sciences
Retina Medicine & Life Sciences
Axonal Transport Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1999 2019

Evidence of hypoxic glial cells in a model of ocular hypertension

Jassim, A. H. & Inman, D. M., 1 Jan 2019, In : Investigative Ophthalmology and Visual Science. 60, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
Ocular Hypertension
Optic Nerve Diseases
Neuroglia
Astrocytes
Glutathione

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve

Jassim, A. H., Coughlin, L., Harun-Or-Rashid, M., Kang, P. T., Chen, Y. R. & Inman, D. M., 1 Oct 2019, In : Molecular Neurobiology. 56, 10, p. 7097-7112 16 p.

Research output: Contribution to journalArticle

Open Access
Glycolysis
Optic Nerve
Glaucoma
Oxygen Consumption
Respiration

Changes in ganglioside GM1 expression in glaucomic retina

Pappenhagen, N. & Inman, D. M., 1 Oct 2018, In : Journal of Neuroscience Research. 96, 10, p. 1627-1630 4 p.

Research output: Contribution to journalLetter

G(M1) Ganglioside
Retina
1 Citation (Scopus)

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

Harun-Or-Rashid, M. & Inman, D. M., 13 Nov 2018, In : Journal of neuroinflammation. 15, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Ketogenic Diet
AMP-Activated Protein Kinases
Glaucoma
Anti-Inflammatory Agents
Optic Nerve

Structural and functional rescue of chronic metabolically stressed optic nerves through respiration

Harun-Or-Rashid, M., Pappenhagen, N., Palmer, P. G., Smith, M. A., Gevorgyan, V., Wilson, G. N., Crish, S. D. & Inman, D. M., 30 May 2018, In : Journal of Neuroscience. 38, 22, p. 5122-5139 18 p.

Research output: Contribution to journalArticle

Open Access
Optic Nerve
Axons
Respiration
Glaucoma
Mitochondria