David Siderovski

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David Siderovski, PhD

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1990 …2025

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  • Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo

    White, A. N., Gross, J. D., Kaski, S. W., Trexler, K. R., Wix, K. A., Wetsel, W. C., Kinsey, S. G., Siderovski, D. P. & Setola, V., Dec 2020, In: Journal of Psychopharmacology. 34, 12, p. 1393-1407 15 p.

    Research output: Contribution to journal › Article › peer-review

  • RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling

    Laroche, G., Giguère, P. M., Roth, B. L., Trejo, J. A. & Siderovski, D. P., Sep 2010, In: American Journal of Physiology - Cell Physiology. 299, 3, p. C654-C664

    Research output: Contribution to journal › Article › peer-review

  • RGS14 is a microtubule-associated protein

    Martin-McCaffrey, L., Willard, F. S., Pajak, A., Dagnino, L., Siderovski, D. P. & D'Souza, S. J. A., Jul 2005, In: Cell Cycle. 4, 7, p. 953-960 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization

    Paing, M. M., Johnston, C. A., Siderovski, D. P. & Trejo, J. A., Apr 2006, In: Molecular and Cellular Biology. 26, 8, p. 3231-3242 12 p.

    Research output: Contribution to journal › Article › peer-review

  • Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

    Tang, M., Wang, G., Lu, P., Karas, R. H., Aronovitz, M., Heximer, S. P., Kaltenbronn, K. M., Blumer, K. J., Siderovski, D. P., Zhu, Y. & Mendelsohn, M. E., Dec 2003, In: Nature Medicine. 9, 12, p. 1506-1512 7 p.

    Research output: Contribution to journal › Article › peer-review

  • A point mutation to Gαi selectively blocks GoLoco motif binding: Direct evidence for Gα·GoLoco complexes in mitotic spindle dynamics

    Willard, F. S., Zheng, Z., Guo, J., Digby, G. J., Kimple, A. J., Conley, J. M., Johnston, C. A., Bosch, D., Willard, M. D., Watts, V. J., Lambert, N. A., Ikeda, S. R., Du, Q. & Siderovski, D. P., 26 Dec 2008, In: Journal of Biological Chemistry. 283, 52, p. 36698-36710 13 p.

    Research output: Contribution to journal › Article › peer-review

  • LGN regulates mitotic spindle orientation during epithelial morphogenesis

    Zheng, Z., Zhu, H., Wan, Q., Liu, J., Xiao, Z., Siderovski, D. P. & Du, Q., 19 Apr 2010, In: Journal of Cell Biology. 189, 2, p. 275-288 14 p.

    Research output: Contribution to journal › Article › peer-review

  • A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits

    Snow, B. E., Krumins, A. M., Brothers, G. M., Lee, S. F., Wall, M. A., Chung, S., Mangion, J., Arya, S., Gilman, A. G. & Siderovski, D. P., 27 Oct 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 22, p. 13307-13312 6 p.

    Research output: Contribution to journal › Article › peer-review

  • Helix dipole movement and conformational variability contribute to allosteric GDP release in Gαi subunits

    Preininger, A. M., Funk, M. A., Oldham, W. M., Meier, S. M., Johnston, C. A., Adhikary, S., Kimple, A. J., Siderovski, D. P., Hamm, H. E. & Iverson, T. M., 31 Mar 2009, In: Biochemistry. 48, 12, p. 2630-2642 13 p.

    Research output: Contribution to journal › Article › peer-review

  • β 2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

    Holden, N. S., Bell, M. J., Rider, C. F., King, E. M., Gaunt, D. D., Leigh, R., Johnson, M., Siderovski, D. P., Heximer, S. P., Giembycz, M. A. & Newton, R., 6 Dec 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 49, p. 19713-19718 6 p.

    Research output: Contribution to journal › Article › peer-review

  • Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins

    Wang, H., Ng, K. H., Qian, H., Siderovski, D. P., Chia, W. & Yu, F., Nov 2005, In: Nature Cell Biology. 7, 11, p. 1091-1098 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Gα selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN

    McCudden, C. R., Willard, F. S., Kimple, R. J., Johnston, C. A., Hains, M. D., Jones, M. B. & Siderovski, D. P., 10 Sep 2005, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1745, 2, p. 254-264 11 p.

    Research output: Contribution to journal › Article › peer-review

  • A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

    Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L. & Sondek, J., 15 Mar 2002, In: EMBO Journal. 21, 6, p. 1315-1326 12 p.

    Research output: Contribution to journal › Article › peer-review

  • Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice

    Trexler, K. R., Nass, S. R., Crowe, M. S., Gross, J. D., Jones, M. S., McKitrick, A. W., Siderovski, D. P. & Kinsey, S. G., 1 Oct 2018, In: Drug and Alcohol Dependence. 191, p. 14-24 11 p.

    Research output: Contribution to journal › Article › peer-review

  • Gα12/13- and Rho-dependent activation of phospholipase C-ε by lysophosphatidic acid and thrombin receptors

    Hains, M. D., Wing, M. R., Maddileti, S., Siderovski, D. P. & Harden, T. K., 2006, In: Molecular Pharmacology. 69, 6, p. 2068-2075 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions

    Kosloff, M., Travis, A. M., Bosch, D. E., Siderovski, D. P. & Arshavsky, V. Y., Jul 2011, In: Nature Structural and Molecular Biology. 18, 7, p. 846-853 8 p.

    Research output: Contribution to journal › Article › peer-review

  • AI is a viable alternative to high throughput screening: a 318-target study

    Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H. & Ng, H. L. & 667 others, Stafford, K., Sarangapani, K., Giesler, K., Ngo, L., Mysinger, M., Ahmed, M., Anthis, N. J., Henriksen, N., Gniewek, P., Eckert, S., de Oliveira, S., Suterwala, S., PrasadPrasad, S. V. K., Shek, S., Contreras, S., Hare, S., Palazzo, T., O’Brien, T. E., Van Grack, T., Williams, T., Chern, T. R., Kenyon, V., Lee, A. H., Cann, A. B., Bergman, B., Anderson, B. M., Cox, B. D., Warrington, J. M., Sorenson, J. M., Goldenberg, J. M., Young, M. A., DeHaan, N., Pemberton, R. P., Schroedl, S., Abramyan, T. M., Gupta, T., Mysore, V., Presser, A. G., Ferrando, A. A., Andricopulo, A. D., Ghosh, A., Ayachi, A. G., Mushtaq, A., Shaqra, A. M., Toh, A. K. L., Smrcka, A. V., Ciccia, A., de Oliveira, A. S., Sverzhinsky, A., de Sousa, A. M., Agoulnik, A. I., Kushnir, A., Freiberg, A. N., Statsyuk, A. V., Gingras, A. R., Degterev, A., Tomilov, A., Vrielink, A., Garaeva, A. A., Bryant-Friedrich, A., Caflisch, A., Patel, A. K., Rangarajan, A. V., Matheeussen, A., Battistoni, A., Caporali, A., Chini, A., Ilari, A., Mattevi, A., Foote, A. T., Trabocchi, A., Stahl, A., Herr, A. B., Berti, A., Freywald, A., Reidenbach, A. G., Lam, A., Cuddihy, A. R., White, A., Taglialatela, A., Ojha, A. K., Cathcart, A. M., Motyl, A. A. L., Borowska, A., D’Antuono, A., Hirsch, A. K. H., Porcelli, A. M., Minakova, A., Montanaro, A., Müller, A., Fiorillo, A., Virtanen, A., O’Donoghue, A. J., Del Rio Flores, A., Garmendia, A. E., Pineda-Lucena, A., Panganiban, A. T., Samantha, A., Chatterjee, A. K., Haas, A. L., Paparella, A. S., John, A. L. S., Prince, A., ElSheikh, A., Apfel, A. M., Colomba, A., O’Dea, A., Diallo, B. N., Ribeiro, B. M. R. M., Bailey-Elkin, B. A., Edelman, B. L., Liou, B., Perry, B., Chua, B. S. K., Kováts, B., Englinger, B., Balakrishnan, B., Gong, B., Agianian, B., Pressly, B., Salas, B. P. M., Duggan, B. M., Geisbrecht, B. V., Dymock, B. W., Morten, B. C., Hammock, B. D., Mota, B. E. F., Dickinson, B. C., Fraser, C., Lempicki, C., Novina, C. D., Torner, C., Ballatore, C., Bon, C., Chapman, C. J., Partch, C. L., Chaton, C. T., Huang, C., Yang, C. Y., Kahler, C. M., Karan, C., Keller, C., Dieck, C. L., Huimei, C., Liu, C., Peltier, C., Mantri, C. K., Kemet, C. M., Müller, C. E., Weber, C., Zeina, C. M., Muli, C. S., Morisseau, C., Alkan, C., Reglero, C., Loy, C. A., Wilson, C. M., Myhr, C., Arrigoni, C., Paulino, C., Santiago, C., Luo, D., Tumes, D. J., Keedy, D. A., Lawrence, D. A., Chen, D., Manor, D., Trader, D. J., Hildeman, D. A., Drewry, D. H., Dowling, D. J., Hosfield, D. J., Smith, D. M., Moreira, D., Siderovski, D. P., Shum, D., Krist, D. T., Riches, D. W. H., Ferraris, D. M., Anderson, D. H., Coombe, D. R., Welsbie, D. S., Hu, D., Ortiz, D., Alramadhani, D., Zhang, D., Chaudhuri, D., Slotboom, D. J., Ronning, D. R., Lee, D., Dirksen, D., Shoue, D. A., Zochodne, D. W., Krishnamurthy, D., Duncan, D., Glubb, D. M., Gelardi, E. L. M., Hsiao, E. C., Lynn, E. G., Silva, E. B., Aguilera, E., Lenci, E., Abraham, E. T., Lama, E., Mameli, E., Leung, E., Christensen, E. M., Mason, E. R., Petretto, E., Trakhtenberg, E. F., Rubin, E. J., Strauss, E., Thompson, E. W., Cione, E., Lisabeth, E. M., Fan, E., Kroon, E. G., Jo, E., García-Cuesta, E. M., Glukhov, E., Gavathiotis, E., Yu, F., Xiang, F., Leng, F., Wang, F., Ingoglia, F., van den Akker, F., Borriello, F., Vizeacoumar, F. J., Luh, F., Buckner, F. S., Vizeacoumar, F. S., Bdira, F. B., Svensson, F., Rodriguez, G. M., Bognár, G., Lembo, G., Zhang, G., Dempsey, G., Eitzen, G., Mayer, G., Greene, G. L., Garcia, G. A., Lukacs, G. L., Prikler, G., Parico, G. C. G., Colotti, G., De Keulenaer, G., Cortopassi, G., Roti, G., Girolimetti, G., Fiermonte, G., Gasparre, G., Leuzzi, G., Dahal, G., Michlewski, G., Conn, G. L., Stuchbury, G. D., Bowman, G. R., Popowicz, G. M., Veit, G., de Souza, G. E., Akk, G., Caljon, G., Alvarez, G., Rucinski, G., Lee, G., Cildir, G., Li, H., Breton, H. E., Jafar-Nejad, H., Zhou, H., Moore, H. P., Tilford, H., Yuan, H., Shim, H., Wulff, H., Hoppe, H., Chaytow, H., Tam, H. K., Van Remmen, H., Xu, H., Debonsi, H. M., Lieberman, H. B., Jung, H., Fan, H. Y., Feng, H., Zhou, H., Kim, H. J., Greig, I. R., Caliandro, I., Corvo, I., Arozarena, I., Mungrue, I. N., Verhamme, I. M., Qureshi, I. A., Lotsaris, I., Cakir, I., Perry, J. J. P., Kwiatkowski, J., Boorman, J., Ferreira, J., Fries, J., Kratz, J. M., Miner, J., Siqueira-Neto, J. L., Granneman, J. G., Ng, J., Shorter, J., Voss, J. H., Gebauer, J. M., Chuah, J., Mousa, J. J., Maynes, J. T., Evans, J. D., Dickhout, J., MacKeigan, J. P., Jossart, J. N., Zhou, J., Lin, J., Xu, J., Wang, J., Zhu, J., Liao, J., Xu, J., Zhao, J., Lin, J., Lee, J., Reis, J., Stetefeld, J., Bruning, J. B., Bruning, J. B., Coles, J. G., Tanner, J. J., Pascal, J. M., So, J., Pederick, J. L., Costoya, J. A., Rayman, J. B., Maciag, J. J., Nasburg, J. A., Gruber, J. J., Finkelstein, J. M., Watkins, J., Rodríguez-Frade, J. M., Arias, J. A. S., Lasarte, J. J., Oyarzabal, J., Milosavljevic, J., Cools, J., Lescar, J., Bogomolovas, J., Wang, J., Kee, J. M., Liao, J., Sistla, J. C., Abrahão, J. S., Sishtla, K., Francisco, K. R., Hansen, K. B., Molyneaux, K. A., Cunningham, K. A., Martin, K. R., Gadar, K., Ojo, K. K., Wong, K. S., Wentworth, K. L., Lai, K., Lobb, K. A., Hopkins, K. M., Parang, K., Machaca, K., Pham, K., Ghilarducci, K., Sugamori, K. S., McManus, K. J., Musta, K., Faller, K. M. E., Nagamori, K., Mostert, K. J., Korotkov, K. V., Liu, K., Smith, K. S., Sarosiek, K., Rohde, K. H., Kim, K. K., Lee, K. H., Pusztai, L., Lehtiö, L., Haupt, L. M., Cowen, L. E., Byrne, L. J., Su, L., Wert-Lamas, L., Puchades-Carrasco, L., Chen, L., Malkas, L. H., Zhuo, L., Hedstrom, L., Hedstrom, L., Walensky, L. D., Antonelli, L., Iommarini, L., Whitesell, L., Randall, L. M., Fathallah, M. D., Nagai, M. H., Kilkenny, M. L., Ben-Johny, M., Lussier, M. P., Windisch, M. P., Lolicato, M., Lolli, M. L., Vleminckx, M., Caroleo, M. C., Macias, M. J., Valli, M., Barghash, M. M., Mellado, M., Tye, M. A., Wilson, M. A., Hannink, M., Ashton, M. R., Cerna, M. V. C. D., Giorgis, M., Safo, M. K., Maurice, M. S., McDowell, M. A., Pasquali, M., Mehedi, M., Serafim, M. S. M., Soellner, M. B., Alteen, M. G., Champion, M. M., Skorodinsky, M., O’Mara, M. L., Bedi, M., Rizzi, M., Levin, M., Mowat, M., Jackson, M. R., Paige, M., Al-Yozbaki, M., Giardini, M. A., Maksimainen, M. M., De Luise, M., Hussain, M. S., Christodoulides, M., Stec, N., Zelinskaya, N., Van Pelt, N., Merrill, N. M., Singh, N., Kootstra, N. A., Singh, N., Gandhi, N. S., Chan, N. L., Trinh, N. M., Schneider, N. O., Matovic, N., Horstmann, N., Longo, N., Bharambe, N., Rouzbeh, N., Mahmoodi, N., Gumede, N. J., Anastasio, N. C., Khalaf, N. B., Rabal, O., Kandror, O., Escaffre, O., Silvennoinen, O., Bishop, O. T., Iglesias, P., Sobrado, P., Chuong, P., O’Connell, P., Martin-Malpartida, P., Mellor, P., Fish, P. V., Moreira, P. O. L., Zhou, P., Liu, P., Liu, P., Wu, P., Agogo-Mawuli, P., Jones, P. L., Ngoi, P., Toogood, P., Ip, P., von Hundelshausen, P., Lee, P. H., Rowswell-Turner, R. B., Balaña-Fouce, R., Rocha, R. E. O., Guido, R. V. C., Ferreira, R. S., Agrawal, R. K., Harijan, R. K., Ramachandran, R., Verma, R., Singh, R. K., Tiwari, R. K., Mazitschek, R., Koppisetti, R. K., Dame, R. T., Douville, R. N., Austin, R. C., Taylor, R. E., Moore, R. G., Ebright, R. H., Angell, R. M., Yan, R., Kejriwal, R., Batey, R. A., Blelloch, R., Vandenberg, R. J., Hickey, R. J., Kelm, R. J., Lake, R. J., Bradley, R. K., Blumenthal, R. M., Solano, R., Gierse, R. M., Viola, R. E., McCarthy, R. R., Reguera, R. M., Uribe, R. V., do Monte-Neto, R. L., Gorgoglione, R., Cullinane, R. T., Katyal, S., Hossain, S., Phadke, S., Shelburne, S. A., Geden, S. E., Johannsen, S., Wazir, S., Legare, S., Landfear, S. M., Radhakrishnan, S. K., Ammendola, S., Dzhumaev, S., Seo, S. Y., Li, S., Zhou, S., Chu, S., Chauhan, S., Maruta, S., Ashkar, S. R., Shyng, S. L., Conticello, S. G., Buroni, S., Garavaglia, S., White, S. J., Zhu, S., Tsimbalyuk, S., Chadni, S. H., Byun, S. Y., Park, S., Xu, S. Q., Banerjee, S., Zahler, S., Espinoza, S., Gustincich, S., Sainas, S., Celano, S. L., Capuzzi, S. J., Waggoner, S. N., Poirier, S., Olson, S. H., Marx, S. O., Van Doren, S. R., Sarilla, S., Brady-Kalnay, S. M., Dallman, S., Azeem, S. M., Teramoto, T., Mehlman, T., Swart, T., Abaffy, T., Akopian, T., Haikarainen, T., Moreda, T. L., Ikegami, T., Teixeira, T. R., Jayasinghe, T. D., Gillingwater, T. H., Kampourakis, T., Richardson, T. I., Herdendorf, T. J., Kotzé, T. J., O’Meara, T. R., Corson, T. W., Hermle, T., Ogunwa, T. H., Lan, T., Su, T., Banjo, T., O’Mara, T. A., Chou, T., Chou, T. F., Baumann, U., Desai, U. R., Pai, V. P., Thai, V. C., Tandon, V., Banerji, V., Robinson, V. L., Gunasekharan, V., Namasivayam, V., Segers, V. F. M., Maranda, V., Dolce, V., Maltarollo, V. G., Scoffone, V. C., Woods, V. A., Ronchi, V. P., Van Hung Le, V., Clayton, W. B., Lowther, W. T., Houry, W. A., Li, W., Tang, W., Zhang, W., Van Voorhis, W. C., Donaldson, W. A., Hahn, W. C., Kerr, W. G., Gerwick, W. H., Bradshaw, W. J., Foong, W. E., Blanchet, X., Wu, X., Lu, X., Qi, X., Xu, X., Yu, X., Qin, X., Wang, X., Yuan, X., Zhang, X., Zhang, Y. J., Hu, Y., Aldhamen, Y. A., Chen, Y., Li, Y., Sun, Y., Zhu, Y., Gupta, Y. K., Pérez-Pertejo, Y., Li, Y., Tang, Y., He, Y., Tse-Dinh, Y. C., Sidorova, Y. A., Yen, Y., Li, Y., Frangos, Z. J., Chung, Z., Su, Z., Wang, Z., Zhang, Z., Liu, Z., Inde, Z., Artía, Z. & Heifets, A., Dec 2024, In: Scientific Reports. 14, 1, 7526.

    Research output: Contribution to journal › Article › peer-review

  • Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits

    Soundararajan, M., Willard, F. S., Kimple, A. J., Turnbull, A. P., Ball, L. J., Schoch, G. A., Gileadi, C., Fedorov, O. Y., Dowler, E. F., Higman, V. A., Hutsell, S. Q., Sundström, M., Doyle, D. A. & Siderovski, D. P., 29 Apr 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 17, p. 6457-6462 6 p.

    Research output: Contribution to journal › Article › peer-review

  • Computational design of the sequence and structure of a protein-binding peptide

    Sammond, D. W., Bosch, D. E., Butterfoss, G. L., Purbeck, C., MacHius, M., Siderovski, D. P. & Kuhlman, B., 30 Mar 2011, In: Journal of the American Chemical Society. 133, 12, p. 4190-4192 3 p.

    Research output: Contribution to journal › Article › peer-review

  • Self-activating G protein α subunits engage seven-transmembrane regulator of G protein signaling (RGS) proteins and a Rho guanine nucleotide exchange factor effector in the amoeba Naegleria fowleri

    Bosch, D. E., Jeck, W. R. & Siderovski, D. P., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102167.

    Research output: Contribution to journal › Article › peer-review

  • The GoLoco motif: A Gα(i/o) binding motif and potential guanine-nucleotide exchange factor

    Siderovski, D. P., Diversé-Pierluissi, M. & De Vries, L., 1 Sep 1999, In: Trends in Biochemical Sciences. 24, 9, p. 340-341 2 p.

    Research output: Contribution to journal › Article › peer-review

  • Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling

    Pruitt, W. M., Karnoub, A. E., Rakauskas, A. C., Guipponi, M., Antonarakis, S. E., Kurakin, A., Kay, B. K., Sondek, J., Siderovski, D. P. & Der, C. J., 7 Apr 2003, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1640, 1, p. 61-68 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Cortical localization of the Gα protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division

    Afshar, K., Willard, F. S., Colombo, K., Siderovski, D. P. & Gönczy, P., Oct 2005, In: Development. 132, 20, p. 4449-4459 11 p.

    Research output: Contribution to journal › Article › peer-review

  • Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): Genomic structure and chromosomal localization of the human gene

    Snow, B. E., Antonio, L., Suggs, S. & Siderovski, D. P., 12 Jan 1998, In: Gene. 206, 2, p. 247-253 7 p.

    Research output: Contribution to journal › Article › peer-review

  • Structural determinants underlying the temperature-sensitive nature of a Gα mutant in asymmetric cell division of Caenorhabditis elegans

    Johnston, C. A., Afshar, K., Snyder, J. T., Tall, G. G., Gönczy, P., Siderovski, D. P. & Willard, F. S., 1 Aug 2008, In: Journal of Biological Chemistry. 283, 31, p. 21550-21558 9 p.

    Research output: Contribution to journal › Article › peer-review