David Siderovski

Covalent immobilization of histidine-tagged proteins for surface plasmon resonance

Willard, F. S. & Siderovski, D. P., 1 Jun 2006, In: Analytical Biochemistry. 353, 1, p. 147-149 3 p.

Research output: Contribution to journal › Article › peer-review

The GoLoco motif: A Gα(i/o) binding motif and potential guanine-nucleotide exchange factor

Siderovski, D. P., Diversé-Pierluissi, M. & De Vries, L., 1 Sep 1999, In: Trends in Biochemical Sciences. 24, 9, p. 340-341 2 p.

Research output: Contribution to journal › Article › peer-review

Induction of regulator of G-protein signaling 2 expression by long-acting β₂-adrenoceptor agonists and glucocorticoids in human airway epithelial cellss

Holden, N. S., George, T., Rider, C. F., Chandrasekhar, A., Shah, S., Kaur, M., Johnson, M., Siderovski, D. P., Leigh, R., Giembycz, M. A. & Newton, R., Jan 2014, In: Journal of Pharmacology and Experimental Therapeutics. 348, 1, p. 12-24 13 p.

Research output: Contribution to journal › Article › peer-review

A P-loop mutation in Gα subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis

Bosch, D. E., Willard, F. S., Ramanujam, R., Kimple, A. J., Willard, M. D., Naqvi, N. I. & Siderovski, D. P., Feb 2012, In: PLoS Pathogens. 8, 2, e1002553.

Research output: Contribution to journal › Article › peer-review

GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg]ZO-1) domain

Snow, B. E., Hall, R. A., Krumins, A. M., Brothers, G. M., Bouchard, D., Brothers, C. A., Chung, S., Mangion, J., Gilman, A. G., Lefkowitz, R. J. & Siderovski, D. P., 10 Jul 1998, In: Journal of Biological Chemistry. 273, 28, p. 17749-17755 7 p.

Research output: Contribution to journal › Article › peer-review

A seven-transmembrane RGS protein that modulates plant cell proliferation

Chen, J. G., Willard, F. S., Huang, J., Liang, J., Chasse, S. A., Jones, A. M. & Siderovski, D. P., 19 Sep 2003, In: Science. 301, 5640, p. 1728-1731 4 p.

Research output: Contribution to journal › Article › peer-review

Selective regulation of N-type Ca channels by different combinations of G-protein β/γ subunits and RGS proteins

Zhou, J. Y., Siderovski, D. P. & Miller, R. J., 1 Oct 2000, In: Journal of Neuroscience. 20, 19, p. 7143-7148 6 p.

Research output: Contribution to journal › Article › peer-review

Structure of the Parathyroid Hormone Receptor C Terminus Bound to the G-Protein Dimer Gβ₁γ₂

Johnston, C. A., Kimple, A. J., Giguère, P. M. & Siderovski, D. P., 9 Jul 2008, In: Structure. 16, 7, p. 1086-1094 9 p.

Research output: Contribution to journal › Article › peer-review

Activator of G protein signaling 3 is a guanine dissociation inhibitor for gα subunits

De Vries, L., Fischer, T., Tronchère, H., Brothers, G. M., Strockbine, B., Siderovski, D. P. & Farquhar, M. G., 19 Dec 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 26, p. 14364-14369 6 p.

Research output: Contribution to journal › Article › peer-review

G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2)

Willard, F. S., McCudden, C. R. & Siderovski, D. P., Aug 2006, In: Cellular Signalling. 18, 8, p. 1226-1234 9 p.

Research output: Contribution to journal › Article › peer-review

RGS21, a regulator of taste and mucociliary clearance?

Kimple, A. J., Garland, A. L., Cohen, S. P., Setola, V., Willard, F. S., Zielinski, T., Lowery, R. G., Tarran, R. & Siderovski, D. P., Mar 2014, In: Laryngoscope. 124, 3, p. E56-E63

Research output: Contribution to journal › Article › peer-review

Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities

Sammond, D. W., Eletr, Z. M., Purbeck, C., Kimple, R. J., Siderovski, D. P. & Kuhlman, B., 31 Aug 2007, In: Journal of Molecular Biology. 371, 5, p. 1392-1404 13 p.

Research output: Contribution to journal › Article › peer-review

RGS12 and RGS14 GoLoco Motifs Are Gα_i Interaction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

Kimple, R. J., De Vries, L., Tronchère, H., Behe, C. I., Morris, R. A., Farquhar, M. G. & Siderovski, D. P., 3 Aug 2001, In: Journal of Biological Chemistry. 276, 31, p. 29275-29281 7 p.

Research output: Contribution to journal › Article › peer-review

HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

McMillan, N. A. J., Chun, R. F., Siderovski, D. P., Galabru, J., Toone, W. M., Samuel, C. E., Mak, T. W., Hovanessian, A. G., Jeang, K. T. & Williams, B. R. G., Nov 1995, In: Virology. 213, 2, p. 413-424 12 p., 70014.

Research output: Contribution to journal › Article › peer-review

G protein signaling modulator-3 inhibits the inflammasome activity of NLRP3

Giguère, P. M., Gall, B. J., Ezekwe, E. A. D., Laroche, G., Buckley, B. K., Kebaier, C., Wilson, J. E., Ting, J. P., Siderovski, D. P. & Duncan, J. A., 28 Nov 2014, In: Journal of Biological Chemistry. 289, 48, p. 33245-33257 13 p.

Research output: Contribution to journal › Article › peer-review

Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31

Wu, H. K., Heng, H., Shi, X. M., Forsdyke, D. R., Tsui, L. C., Mak, T. W., Minden, M. D. & Siderovski, D. P., Aug 1995, In: Leukemia. 9, 8, p. 1291-1298 8 p.

Research output: Contribution to journal › Article › peer-review

Molecular cloning and expression analysis of rat Rgs12 and Rgs14

Snow, B. E., Antonio, L., Suggs, S., Gutstein, H. B. & Siderovski, D. P., 28 Apr 1997, In: Biochemical and Biophysical Research Communications. 233, 3, p. 770-777 8 p.

Research output: Contribution to journal › Article › peer-review

β ₂-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

Holden, N. S., Bell, M. J., Rider, C. F., King, E. M., Gaunt, D. D., Leigh, R., Johnson, M., Siderovski, D. P., Heximer, S. P., Giembycz, M. A. & Newton, R., 6 Dec 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 49, p. 19713-19718 6 p.

Research output: Contribution to journal › Article › peer-review

Self-activating G protein α subunits engage seven-transmembrane regulator of G protein signaling (RGS) proteins and a Rho guanine nucleotide exchange factor effector in the amoeba Naegleria fowleri

Bosch, D. E., Jeck, W. R. & Siderovski, D. P., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102167.

Research output: Contribution to journal › Article › peer-review

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face

Kimple, A. J., Willard, F. S., Giguère, P. M., Johnston, C. A., Mocanu, V. & Siderovski, D. P., Sep 2007, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 9, p. 1213-1220 8 p.

Research output: Contribution to journal › Article › peer-review

Rgs1 regulates multiple Gα subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism

Liu, H., Suresh, A., Willard, F. S., Siderovski, D. P., Lu, S. & Naqvi, N. I., 7 Feb 2007, In: EMBO Journal. 26, 3, p. 690-700 11 p.

Research output: Contribution to journal › Article › peer-review

Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique

Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Bell, C., Nos, L., Fried, P., Pearce, D. A., Singh, S., Siderovski, D. P., Willard, F. S. & Fukuda, M., 12 Sep 2006, In: Neuropsychopharmacology. 31, 9, p. 1888-1899 12 p.

Research output: Contribution to journal › Article › peer-review

Computational design of the sequence and structure of a protein-binding peptide

Sammond, D. W., Bosch, D. E., Butterfoss, G. L., Purbeck, C., MacHius, M., Siderovski, D. P. & Kuhlman, B., 30 Mar 2011, In: Journal of the American Chemical Society. 133, 12, p. 4190-4192 3 p.

Research output: Contribution to journal › Article › peer-review

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo

Liu, Y., Snow, B. E., Hande, M. P., Yeung, D., Erdmann, N. J., Wakeham, A., Itie, A., Siderovski, D. P., Lansdorp, P. M., Robinson, M. O. & Harrington, L., 16 Nov 2000, In: Current Biology. 10, 22, p. 1459-1462 4 p.

Research output: Contribution to journal › Article › peer-review

Guanine nuoleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: Alanine-to-aspartate mutation restores function to an inactive second GoLoco motif

Kimple, R. J., Willard, F. S., Hains, M. D., Jones, M. B., Nweke, G. K. & Siderovski, D. P., 15 Mar 2004, In: Biochemical Journal. 378, 3, p. 801-808 8 p.

Research output: Contribution to journal › Article › peer-review

David Siderovski, PhD

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