David Siderovski

Regulators of G-protein signalling as new central nervous system drug targets

Neubig, R. R. & Siderovski, D. P., Mar 2002, In: Nature Reviews Drug Discovery. 1, 3, p. 187-197 11 p.

Research output: Contribution to journal › Review article › peer-review

A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation

Schroer, A. B., Mohamed, J. S., Willard, M. D., Setola, V., Oestreich, E. & Siderovski, D. P., 1 Aug 2019, In: PLoS ONE. 14, 8, e0216167.

Research output: Contribution to journal › Article › peer-review

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses

Tarrant, T. K., Billard, M. J., Timoshchenko, R. G., McGinnis, M. W., Stephen Serafin, D., Foreman, O., Esserman, D. A., Chao, N. J., Lento, W. E., Lee, D. M., Patel, D. & Siderovski, D. P., Dec 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1243-1251 9 p.

Research output: Contribution to journal › Article › peer-review

Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

Schiff, M. L., Siderovski, D. P., Jordan, J. D., Brothers, G., Snow, B., De Vries, L., Ortiz, D. F. & Diversé-Pierluissi, M., 7 Dec 2000, In: Nature. 408, 6813, p. 723-727 5 p.

Research output: Contribution to journal › Article › peer-review

Structural basis for the selective activation of rho gtpases by dbl exchange factors

Snyder, J. T., Worthylakel, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J. & Sondek, J., 2002, In: Nature Structural Biology. 9, 6, p. 468-475 8 p.

Research output: Contribution to journal › Article › peer-review

Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities

Sammond, D. W., Eletr, Z. M., Purbeck, C., Kimple, R. J., Siderovski, D. P. & Kuhlman, B., 31 Aug 2007, In: Journal of Molecular Biology. 371, 5, p. 1392-1404 13 p.

Research output: Contribution to journal › Article › peer-review

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

Kimple, A. J., Yasgar, A., Hughes, M., Jadhav, A., Willard, F. S., Muller, R. E., Austin, C. P., Inglese, J., Ibeanu, G. C., Siderovski, D. P. & Simeonov, A., Jun 2008, In: Combinatorial Chemistry and High Throughput Screening. 11, 5, p. 396-409 14 p.

Research output: Contribution to journal › Review article › peer-review

D2 dopamine receptor activation of potassium channels is selectively decoupled by Gα_i-specific GoLoco motif peptides

Webb, C. K., McCudden, C. R., Willard, F. S., Kimple, R. J., Siderovski, D. P. & Oxford, G. S., Mar 2005, In: Journal of Neurochemistry. 92, 6, p. 1408-1418 11 p.

Research output: Contribution to journal › Article › peer-review

RGS12 interacts with the SNARE-binding region of the Ca_v2.2 calcium channel

Richman, R. W., Strock, J., Hains, M. D., Cabanilla, N. J., Lau, K. K., Siderovski, D. P. & Diversé-Pierluissi, M., 14 Jan 2005, In: Journal of Biological Chemistry. 280, 2, p. 1521-1528 8 p.

Research output: Contribution to journal › Article › peer-review

Structure of the Parathyroid Hormone Receptor C Terminus Bound to the G-Protein Dimer Gβ₁γ₂

Johnston, C. A., Kimple, A. J., Giguère, P. M. & Siderovski, D. P., 9 Jul 2008, In: Structure. 16, 7, p. 1086-1094 9 p.

Research output: Contribution to journal › Article › peer-review

Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins

Willard, F. S., Low, A. B., McCudden, C. R. & Siderovski, D. P., Feb 2007, In: Cellular Signalling. 19, 2, p. 428-438 11 p.

Research output: Contribution to journal › Article › peer-review

The RGS Protein Superfamily

Siderovski, D. P. & Harden, T. K., 1 Jan 2003, Handbook of Cell Signaling: Volume 1-3. Elsevier, Vol. 1-3. p. 631-638 8 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction

Johnston, C. A., Willard, M. D., Kimple, A. J., Siderovski, D. P. & Willard, F. S., Dec 2008, In: Plant Signaling and Behavior. 3, 12, p. 1067-1076 10 p.

Research output: Contribution to journal › Review article › peer-review

Erratum: Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): Genomic structure and chromosomal localization of the human gene (Gene (1998) 206 (247-253) SO378111997005933))

Snow, B. E., Antonio, L., Suggs, S. & Siderovski, D. P., 15 Jun 1998, In: Gene. 213, 1-2, p. 223 1 p.

Research output: Contribution to journal › Comment/debate

Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling

Pruitt, W. M., Karnoub, A. E., Rakauskas, A. C., Guipponi, M., Antonarakis, S. E., Kurakin, A., Kay, B. K., Sondek, J., Siderovski, D. P. & Der, C. J., 7 Apr 2003, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1640, 1, p. 61-68 8 p.

Research output: Contribution to journal › Article › peer-review

Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes

Guipponi, M., Santoni, F. A., Setola, V., Gehrig, C., Rotharmel, M., Cuenca, M., Guillin, O., Dikeos, D., Georgantopoulos, G., Papadimitriou, G., Curtis, L., Méary, A., Schürhoff, F., Jamain, S., Avramopoulos, D., Leboyer, M., Rujescu, D., Pulver, A., Campion, D. & Siderovski, D. P. & 1 others, Antonarakis, S. E., 24 Nov 2014, In: PLoS ONE. 9, 11, e112745.

Research output: Contribution to journal › Article › peer-review

Structural determinants underlying the temperature-sensitive nature of a Gα mutant in asymmetric cell division of Caenorhabditis elegans

Johnston, C. A., Afshar, K., Snyder, J. T., Tall, G. G., Gönczy, P., Siderovski, D. P. & Willard, F. S., 1 Aug 2008, In: Journal of Biological Chemistry. 283, 31, p. 21550-21558 9 p.

Research output: Contribution to journal › Article › peer-review

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model

Gall, B. J., Schroer, A. B., Gross, J. D., Setola, V. & Siderovski, D. P., 1 Sep 2016, In: Genes and Immunity. 17, 6, p. 321-327 7 p.

Research output: Contribution to journal › Article › peer-review

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

Kaski, S. W., White, A. N., Gross, J. D., Trexler, K. R., Wix, K., Harland, A. A., Prisinzano, T. E., Aubé, J., Kinsey, S. G., Kenakin, T., Siderovski, D. P. & Setola, V., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 487-499 13 p.

Research output: Contribution to journal › Article › peer-review

RGS12 and RGS14 GoLoco Motifs Are Gα_i Interaction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

Kimple, R. J., De Vries, L., Tronchère, H., Behe, C. I., Morris, R. A., Farquhar, M. G. & Siderovski, D. P., 3 Aug 2001, In: Journal of Biological Chemistry. 276, 31, p. 29275-29281 7 p.

Research output: Contribution to journal › Article › peer-review

David Siderovski, PhD

Regulators of G-protein signalling as new central nervous system drug targets

A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses

Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

Structural basis for the selective activation of rho gtpases by dbl exchange factors

Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

D2 dopamine receptor activation of potassium channels is selectively decoupled by Gα_i-specific GoLoco motif peptides

RGS12 interacts with the SNARE-binding region of the Ca_v2.2 calcium channel

Structure of the Parathyroid Hormone Receptor C Terminus Bound to the G-Protein Dimer Gβ₁γ₂

Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins

The RGS Protein Superfamily

A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction

Erratum: Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): Genomic structure and chromosomal localization of the human gene (Gene (1998) 206 (247-253) SO378111997005933))

Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling

Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes

Structural determinants underlying the temperature-sensitive nature of a Gα mutant in asymmetric cell division of Caenorhabditis elegans

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model

Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review

Structural determinants of G-protein α subunit selectivity by regulator of G-protein signaling 2 (RGS2)

Computational design of the sequence and structure of a protein-binding peptide

Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation

PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-κB activation

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

RGS12 and RGS14 GoLoco Motifs Are Gα_i Interaction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

David Siderovski, PhD

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