David Siderovski

Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein

Giguère, P. M., Laroche, G., Oestreich, E. A., Duncan, J. A. & Siderovski, D. P., 7 Sep 2012, In: Journal of Biological Chemistry. 287, 37, p. 31270-31279 10 p.

Research output: Contribution to journal › Article › peer-review

Structural basis for nucleotide exchange on Gα_i subunits and receptor coupling specificity

Johnston, C. A. & Siderovski, D. P., 6 Feb 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 2001-2006 6 p.

Research output: Contribution to journal › Article › peer-review

Minimal determinants for binding activated Gα from the structure of a Gα_il-peptide dimer

Johnston, C. A., Lobanova, E. S., Shavkunov, A. S., Low, J., Ramer, J. K., Blaesius, R., Fredericks, Z., Willard, F. S., Kuhlman, B., Arshavsky, V. Y. & Siderovski, D. P., 26 Sep 2006, In: Biochemistry. 45, 38, p. 11390-11400 11 p.

Research output: Contribution to journal › Article › peer-review

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model

Gall, B. J., Schroer, A. B., Gross, J. D., Setola, V. & Siderovski, D. P., 1 Sep 2016, In: Genes and Immunity. 17, 6, p. 321-327 7 p.

Research output: Contribution to journal › Article › peer-review

G protein signaling modulator-3 inhibits the inflammasome activity of NLRP3

Giguère, P. M., Gall, B. J., Ezekwe, E. A. D., Laroche, G., Buckley, B. K., Kebaier, C., Wilson, J. E., Ting, J. P., Siderovski, D. P. & Duncan, J. A., 28 Nov 2014, In: Journal of Biological Chemistry. 289, 48, p. 33245-33257 13 p.

Research output: Contribution to journal › Article › peer-review

5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II

McCracken, S., Fong, N., Rosonina, E., Yankulov, K., Brothers, G., Siderovski, D., Hessel, A., Foster, S., Shuman, S. & Bentley, D. L., 15 Dec 1997, In: Genes and Development. 11, 24, p. 3306-3318 13 p.

Research output: Contribution to journal › Article › peer-review

Contribution of HCN1 variant to sinus bradycardia: A case report

Yu, H., Gall, B., Newman, M., Hathaway, Q., Brundage, K., Ammer, A., Mathers, P., Siderovski, D. & Hull, R. W., Oct 2021, In: Journal of Arrhythmia. 37, 5, p. 1337-1347 11 p.

Research output: Contribution to journal › Article › peer-review

Importance of the autosomal recessive retinitis pigmentosa locus on 1q31-q32.1 (RP12) and mutation analysis of the candidate gene RGS16 (RGS-r)

Bessant, D. A. R., Payne, A. M., Snow, B. E., Antinolo, G., Mehdi, S. Q., Bird, A. C., Siderovski, D. P. & Bhattacharya, S. S., 2000, In: Journal of Medical Genetics. 37, 5, p. 384-387 4 p.

Research output: Contribution to journal › Letter › peer-review

Cooperative interaction between the DNA-binding domains of PU.1 and IRF4

Yee, A. A., Yin, P., Siderovski, D. P., Mak, T. W., Litchfield, D. W. & Arrowsmith, C. H., 26 Jun 1998, In: Journal of Molecular Biology. 279, 5, p. 1075-1083 9 p.

Research output: Contribution to journal › Article › peer-review

Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities

Sammond, D. W., Eletr, Z. M., Purbeck, C., Kimple, R. J., Siderovski, D. P. & Kuhlman, B., 31 Aug 2007, In: Journal of Molecular Biology. 371, 5, p. 1392-1404 13 p.

Research output: Contribution to journal › Article › peer-review

RIC-8 is required for GPR-1/2-dependent Gα function during asymmetric division of C. elegans embryos

Afshar, K., Willard, F. S., Colombo, K., Johnston, C. A., McCudden, C. R., Siderovski, D. P. & Gönczy, P., 15 Oct 2004, In: Cell. 119, 2, p. 219-230 12 p.

Research output: Contribution to journal › Article › peer-review

Structural basis for the selective activation of rho gtpases by dbl exchange factors

Snyder, J. T., Worthylakel, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J. & Sondek, J., 2002, In: Nature Structural Biology. 9, 6, p. 468-475 8 p.

Research output: Contribution to journal › Article › peer-review

Assays of complex formation between RGS protein Gγ subunit-like domains and Gβ subunits

Siderovski, D. P., Snow, B. E., Chung, S., Brothers, G. M., Sondek, J. & Betts, L., 2002, Methods in Enzymology. Academic Press Inc., p. 702-723 22 p. (Methods in Enzymology; vol. 344).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11

Snow, B. E., Betts, L., Mangion, J., Sondek, J. & Siderovski, D. P., 25 May 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 11, p. 6489-6494 6 p.

Research output: Contribution to journal › Article › peer-review

A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization

Muller, R. E., Klein, K. R., Hutsell, S. Q., Siderovski, D. P. & Kimple, A. J., 1 Oct 2010, In: Assay and Drug Development Technologies. 8, 5, p. 621-624 4 p.

Research output: Contribution to journal › Article › peer-review

Regulation of T cell activation, anxiety, and male aggression by RGS2

Oliveira-dos-Santos, A. J., Matsumoto, G., Snow, B. E., Bai, D., Houston, F. P., Whishaw, I. Q., Mariathasan, S., Sasaki, T., Wakeham, A., Ohashi, P. S., Roder, J. C., Barnes, C. A., Siderovski, D. P. & Penninger, J. M., 24 Oct 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 22, p. 12272-12277 6 p.

Research output: Contribution to journal › Article › peer-review

Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ₁₃

Blake, B. L., Wing, M. R., Zhou, J. Y., Lei, Q., Hillmann, J. R., Behe, C. I., Morris, R. A., Harden, T. K., Bayliss, D. A., Miller, R. J. & Siderovski, D. P., 28 Dec 2001, In: Journal of Biological Chemistry. 276, 52, p. 49267-49274 8 p.

Research output: Contribution to journal › Article › peer-review

Molecular Modeling and In Vitro Functional Analysis of the RGS12 PDZ Domain Variant Associated with High-Penetrance Familial Bipolar Disorder

Agogo-Mawuli, P. S., Mendez, J., Oestreich, E. A., Bosch, D. E. & Siderovski, D. P., Nov 2024, In: International journal of molecular sciences. 25, 21, 11431.

Research output: Contribution to journal › Article › peer-review

GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg]ZO-1) domain

Snow, B. E., Hall, R. A., Krumins, A. M., Brothers, G. M., Bouchard, D., Brothers, C. A., Chung, S., Mangion, J., Gilman, A. G., Lefkowitz, R. J. & Siderovski, D. P., 10 Jul 1998, In: Journal of Biological Chemistry. 273, 28, p. 17749-17755 7 p.

Research output: Contribution to journal › Article › peer-review

RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote

Martin-McCaffrey, L., Willard, F. S., Oliveira-dos-Santos, A. J., Natale, D. R. C., Snow, B. E., Kimple, R. J., Pajak, A., Watson, A. J., Dagnino, L., Penninger, J. M., Siderovski, D. P. & D'Souza, S. J. A., Nov 2004, In: Developmental Cell. 7, 5, p. 763-769 7 p.

Research output: Contribution to journal › Article › peer-review

Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes

Guipponi, M., Santoni, F. A., Setola, V., Gehrig, C., Rotharmel, M., Cuenca, M., Guillin, O., Dikeos, D., Georgantopoulos, G., Papadimitriou, G., Curtis, L., Méary, A., Schürhoff, F., Jamain, S., Avramopoulos, D., Leboyer, M., Rujescu, D., Pulver, A., Campion, D. & Siderovski, D. P. & 1 others, Antonarakis, S. E., 24 Nov 2014, In: PLoS ONE. 9, 11, e112745.

Research output: Contribution to journal › Article › peer-review

Erratum: Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes (PLoS ONE 9:11 (e112745) DOI 10.1371/journal.pone.0112745)

Guipponi, M., Santoni, F. A., Setola, V., Gehrig, C., Rotharmel, M., Cuenca, M., Guillin, O., Dikeos, D., Georgantopoulos, G., Papadimitriou, G., Curtis, L., Méary, A., Schürhoff, F., Jamain, S., Avramopoulos, D., Leboyer, M., Rujescu, D., Pulver, A., Campion, D. & Siderovski, D. P. & 1 others, Antonarakis, S. E., 21 Oct 2015, In: PLoS ONE. 10, 10, e0141630.

Research output: Contribution to journal › Comment/debate

Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane

Dho, S. E., Trejo, J. A., Siderovski, D. P. & McGlade, C. J., Sep 2006, In: Molecular Biology of the Cell. 17, 9, p. 4142-4155 14 p.

Research output: Contribution to journal › Article › peer-review

Whither goest the RGS proteins?

Siderovski, D. P., Strockbine, B. & Behe, C. I., 1999, In: Critical Reviews in Biochemistry and Molecular Biology. 34, 4, p. 215-251 37 p.

Research output: Contribution to journal › Review article › peer-review

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses

Tarrant, T. K., Billard, M. J., Timoshchenko, R. G., McGinnis, M. W., Stephen Serafin, D., Foreman, O., Esserman, D. A., Chao, N. J., Lento, W. E., Lee, D. M., Patel, D. & Siderovski, D. P., Dec 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1243-1251 9 p.

Research output: Contribution to journal › Article › peer-review

David Siderovski, PhD

Research output

Search results