David Siderovski, PhD

Research output

Research output per year 1990 1998 2000 2001 2002 2004 2005 2006 2007 2008 2010 2011 2012 2024

• 141 Article
• 14 Review article
• 12 Comment/debate
• 7 Chapter
• 4 More
  • 2 Editorial
  • 1 Letter
  • 1 Short survey

Research output per year

Research output per year

Search results

• The R6A-1 peptide binds to switch II of Gα_i1 but is not a GDP-dissociation inhibitor

  Willard, F. S. & Siderovski, D. P., 27 Jan 2006, In: Biochemical and Biophysical Research Communications. 339, 4, p. 1107-1112 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanine nucleotide Dissociation Inhibitor 100%
  • GDP Dissociation Inhibitor 100%
  • Guanine 100%
  • G Protein 66%
  • Inhibitor Activity 66%

• Molecular cloning and expression analysis of rat Rgs12 and Rgs14

  Snow, B. E., Antonio, L., Suggs, S., Gutstein, H. B. & Siderovski, D. P., 28 Apr 1997, In: Biochemical and Biophysical Research Communications. 233, 3, p. 770-777 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Polypeptide 100%
  • Complementary DNA (cDNA) 100%
  • Lung 100%
  • Spleen 100%
  • Molecular Expression 100%

• G protein signaling modulator-3 inhibits the inflammasome activity of NLRP3

  Giguère, P. M., Gall, B. J., Ezekwe, E. A. D., Laroche, G., Buckley, B. K., Kebaier, C., Wilson, J. E., Ting, J. P., Siderovski, D. P. & Duncan, J. A., 28 Nov 2014, In: Journal of Biological Chemistry. 289, 48, p. 33245-33257 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Signaling Protein 100%
  • Inflammasome 100%
  • NOD-like Receptor 100%
  • Pyrin Domain 100%
  • G Protein 100%

• Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31

  Wu, H. K., Heng, H., Shi, X. M., Forsdyke, D. R., Tsui, L. C., Mak, T. W., Minden, M. D. & Siderovski, D. P., Aug 1995, In: Leukemia. 9, 8, p. 1291-1298 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoietic Cells 100%
  • Differential Expression 100%
  • Human Chromosomes 100%
  • Basic Helix-loop-helix (bHLH) 100%
  • Chronic Myeloid Leukemia 100%

• β ₂-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

  Holden, N. S., Bell, M. J., Rider, C. F., King, E. M., Gaunt, D. D., Leigh, R., Johnson, M., Siderovski, D. P., Heximer, S. P., Giembycz, M. A. & Newton, R., 6 Dec 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 49, p. 19713-19718 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS2 100%
  • Adrenoceptor Agonist 100%
  • Genomic Mechanisms 100%
  • Bronchoprotection 100%
  • Glucocorticoid 100%

• Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling

  Hains, M. D., Siderovski, D. P. & Harden, T. K., 2004, In: Methods in Enzymology. 389, p. 71-88 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Regulator of G Protein Signaling 100%
  • G Protein Selectivity 100%
  • Receptor 100%
  • Guanine Nucleotide Binding Protein 100%
  • RGS Protein 100%

• The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face

  Kimple, A. J., Willard, F. S., Giguère, P. M., Johnston, C. A., Mocanu, V. & Siderovski, D. P., Sep 2007, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 9, p. 1213-1220 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteinase Inhibitor 100%
  • Regulator of G Protein Signaling 100%
  • RGS4 100%
  • Covalent Modifier 100%
  • Protein Inhibitor 100%

• A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction

  Johnston, C. A., Willard, M. D., Kimple, A. J., Siderovski, D. P. & Willard, F. S., Dec 2008, In: Plant Signaling and Behavior. 3, 12, p. 1067-1076 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Signal Transduction 100%
  • Sweet 100%
  • G Protein 100%
  • Arabidopsis 100%
  • Guanosine Triphosphate 100%

• Rgs1 regulates multiple Gα subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism

  Liu, H., Suresh, A., Willard, F. S., Siderovski, D. P., Lu, S. & Naqvi, N. I., 7 Feb 2007, In: EMBO Journal. 26, 3, p. 690-700 11 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS1 100%
  • Thigmotropism 100%
  • Magnaporthe 100%
  • Appressorium 100%
  • Appressoria 100%

• Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique

  Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Bell, C., Nos, L., Fried, P., Pearce, D. A., Singh, S., Siderovski, D. P., Willard, F. S. & Fukuda, M., 12 Sep 2006, In: Neuropsychopharmacology. 31, 9, p. 1888-1899 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Frontal Cortex 100%
  • Olanzapine 100%
  • Microarray Experiment 100%
  • Gene Differential Expression 100%
  • DNA Microarray 100%

• Computational design of the sequence and structure of a protein-binding peptide

  Sammond, D. W., Bosch, D. E., Butterfoss, G. L., Purbeck, C., MacHius, M., Siderovski, D. P. & Kuhlman, B., 30 Mar 2011, In: Journal of the American Chemical Society. 133, 12, p. 4190-4192 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Binding 100%
  • Binding Peptide 100%
  • Computational Design 100%
  • Conformation 100%
  • Binding Protein 100%

• The GoLoco motif: heralding a new tango between G protein signaling and cell division.

  Kimple, R. J., Willard, F. S. & Siderovski, D. P., Apr 2002, In: Molecular interventions. 2, 2, p. 88-100 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cell Division 100%
  • G Protein Signaling 100%
  • Tango 100%
  • Signaling Protein 100%
  • GoLoco Motif 100%

• Self-activating G protein α subunits engage seven-transmembrane regulator of G protein signaling (RGS) proteins and a Rho guanine nucleotide exchange factor effector in the amoeba Naegleria fowleri

  Bosch, D. E., Jeck, W. R. & Siderovski, D. P., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102167.

  Research output: Contribution to journal › Article › peer-review

  • Regulator of G Protein Signaling 100%
  • G Protein Subunit 100%
  • Transmembrane Regulator 100%
  • Amoeba 100%
  • Naegleria Fowleri 100%

• Activator of G protein signaling 3 is a guanine dissociation inhibitor for gα subunits

  De Vries, L., Fischer, T., Tronchère, H., Brothers, G. M., Strockbine, B., Siderovski, D. P. & Farquhar, M. G., 19 Dec 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 26, p. 14364-14369 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanine 100%
  • Dissociation 100%
  • Activator of G-protein Signaling 3 100%
  • Signaling Protein 100%
  • G Protein 100%

• G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2)

  Willard, F. S., McCudden, C. R. & Siderovski, D. P., Aug 2006, In: Cellular Signalling. 18, 8, p. 1226-1234 9 p.

  Research output: Contribution to journal › Article › peer-review

  • GoLoco Motif 100%
  • Protein Motif 100%
  • Alpha Chain 100%
  • Purkinje Cell 100%
  • G Protein 100%

• RGS21, a regulator of taste and mucociliary clearance?

  Kimple, A. J., Garland, A. L., Cohen, S. P., Setola, V., Willard, F. S., Zielinski, T., Lowery, R. G., Tarran, R. & Siderovski, D. P., Mar 2014, In: Laryngoscope. 124, 3, p. E56-E63

  Research output: Contribution to journal › Article › peer-review

  • Regulator of G Protein Signaling 100%
  • Mucociliary Clearance 100%
  • RGS Protein 100%
  • Sinonasal mucosa 66%
  • Mucosa 57%

• HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

  McMillan, N. A. J., Chun, R. F., Siderovski, D. P., Galabru, J., Toone, W. M., Samuel, C. E., Mak, T. W., Hovanessian, A. G., Jeang, K. T. & Williams, B. R. G., Nov 1995, In: Virology. 213, 2, p. 413-424 12 p., 70014.

  Research output: Contribution to journal › Article › peer-review

  • Interferon-α (IFN-α) 100%
  • HIV-1 Tat 100%
  • Exon 100%
  • RNA-dependent 100%
  • Double-stranded RNA 100%

• Recent Advances in Nanosensors for Therapeutic Drug Monitoring (TDM)

  Agogo-Mawuli, P. S. & Siderovski, D. P., 1 Jan 2022, Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology. Springer International Publishing, p. 233-253 21 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Recent Advances 100%
  • Therapeutic Drug Monitoring 100%
  • Nanomaterials 100%
  • Nanosensor 100%
  • Nanomaterial 100%

• Development of full sweet, umami, and bitter taste responsiveness requires Regulator of G protein Signaling-21 (RGS21)

  Schroer, A. B., Gross, J. D., Kaski, S. W., Wix, K., Siderovski, D. P., Vandenbeuch, A. & Setola, V., 23 May 2018, In: Chemical Senses. 43, 5, p. 367-378 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Regulator of G Protein Signaling 100%
  • Sweet Taste 100%
  • Taste Responsiveness 100%
  • Bitter Taste 100%
  • Tastants 100%

• PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-κB activation

  Nakamura, K., Kimple, A. J., Siderovski, D. P. & Johnson, G. L., 15 Jan 2010, In: Journal of Biological Chemistry. 285, 3, p. 2077-2089 13 p.

  Research output: Contribution to journal › Article › peer-review

  • NF-B 100%
  • Domain-domain Interaction 100%
  • SQSTM1 100%
  • MEKK3 100%
  • PB1 Domain 100%

• Structural determinants underlying the temperature-sensitive nature of a Gα mutant in asymmetric cell division of Caenorhabditis elegans

  Johnston, C. A., Afshar, K., Snyder, J. T., Tall, G. G., Gönczy, P., Siderovski, D. P. & Willard, F. S., 1 Aug 2008, In: Journal of Biological Chemistry. 283, 31, p. 21550-21558 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Caenorhabditis Elegans 100%
  • Asymmetric Cell Division 100%
  • Temperature Sensitivity 100%
  • Pulling Force 75%
  • Spindle 50%

• Structural determinants of rgs-rhogef signaling critical to entamoeba histolytica pathogenesis

  Bosch, D. E., Kimple, A. J., Manning, A. J., Muller, R. E., Willard, F. S., MacHius, M., Rogers, S. L. & Siderovski, D. P., 8 Jan 2013, In: Structure. 21, 1, p. 65-75 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Entamoeba Histolytica 100%
  • RhoGEF 100%
  • Rho Guanine Nucleotide Exchange Factor 100%
  • G Protein 66%
  • Guanine Nucleotide Binding Protein 50%

• Inhibition of Dopamine Transporter Activity by G Protein βγ Subunits

  Garcia-Olivares, J., Torres-Salazar, D., Owens, W. A., Baust, T., Siderovski, D. P., Amara, S. G., Zhu, J., Daws, L. C. & Torres, G. E., 26 Mar 2013, In: PLoS ONE. 8, 3, e59788.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine Transporter 100%
  • G Protein Subunit 100%
  • Transporter Activity 100%
  • G Protein 100%
  • Protein Subunit 100%

• Erratum: Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): Genomic structure and chromosomal localization of the human gene (Gene (1998) 206 (247-253) SO378111997005933))

  Snow, B. E., Antonio, L., Suggs, S. & Siderovski, D. P., 15 Jun 1998, In: Gene. 213, 1-2, p. 223 1 p.

  Research output: Contribution to journal › Comment/debate

• Structural basis for nucleotide exchange on Gái subunits and receptor coupling specificity (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 6 (2001-2006) 10.1073/pnas. 0608599104)

  Johnston, C. A. & Siderovski, D. P., 31 Jan 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1808 1 p.

  Research output: Contribution to journal › Comment/debate