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Research Output 2002 2019

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2019

Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults

Park, F. S., Kay, V. L., Sprick, J. D., Rosenberg, A. J., Anderson, G. K., Mallet, R. T. & Rickards, C. A., 1 Mar 2019, In : Experimental Biology and Medicine. 244, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Oxidative stress
Young Adult
Oxidative Stress
Hemorrhage
4 Citations (Scopus)

Ischaemic and hypoxic conditioning: potential for protection of vital organs

Sprick, J. D., Mallet, R. T., Przyklenk, K. & Rickards, C. A., 1 Mar 2019, In : Experimental physiology. 104, 3, p. 278-294 17 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Exercise
Clinical Trials
Hypoxia-Inducible Factor 1
Microglia

Responses of cerebral blood velocity and tissue oxygenation to low-frequency oscillations during simulated haemorrhagic stress in humans

Anderson, G. K., Sprick, J. D., Park, F. S., Rosenberg, A. J. & Rickards, C. A., 1 Jan 2019, In : Experimental Physiology.

Research output: Contribution to journalArticle

Arterial Pressure
Middle Cerebral Artery
Hypovolemia
Frontal Lobe
Stroke Volume
2018

Time course of compensatory physiological responses to central hypovolemia in high-and low-tolerant human subjects

Xiang, L., Hinojosa-Laborde, C., Ryan, K. L., Rickards, C. A. & Convertino, V. A., 20 Aug 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315, 2, p. R408-R416

Research output: Contribution to journalArticle

Hypovolemia
Vascular Resistance
Heart Rate
Syncope
Myocardium
2017
3 Citations (Scopus)
Hypovolemia
Cerebrovascular Circulation
Respiration
Perfusion
Electric Impedance
5 Citations (Scopus)
Ischemic Preconditioning
Exercise
Reperfusion
Arterial Pressure
Norepinephrine
6 Citations (Scopus)
Ischemic Preconditioning
Middle Cerebral Artery
Reperfusion
Norepinephrine
Arterial Pressure
2016
8 Citations (Scopus)

The effects of superimposed tilt and lower body negative pressure on anterior and posterior cerebral circulations

Tymko, M. M., Rickards, C. A., Skow, R. J., Ingram-Cotton, N. C., Howatt, M. K. & Day, T. A., 1 Sep 2016, In : Physiological Reports. 4, 17, e12957.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Lower Body Negative Pressure
Blood Volume
Intracranial Pressure
Head-Down Tilt
2 Citations (Scopus)

The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia

Sprick, J. D., Soller, B. R. & Rickards, C. A., 1 Nov 2016, In : Experimental Biology and Medicine. 241, 17, p. 2007-2013 7 p.

Research output: Contribution to journalArticle

Hypovolemia
Oxygenation
Superficial Back Muscles
Lower Body Negative Pressure
Muscle
16 Citations (Scopus)
Cerebrovascular Circulation
Central Tolerance
Lower Body Negative Pressure
Hypovolemia
Regional Blood Flow
2015
8 Citations (Scopus)

Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study

Cooke, W. H., Pokhrel, A., Dowling, C., Fogt, D. L. & Rickards, C. A., 22 Aug 2015, In : Clinical Autonomic Research. 25, 4, p. 267-270 4 p.

Research output: Contribution to journalArticle

Nicotine
Inhalation
Arterial Pressure
Posture
Longitudinal Studies
17 Citations (Scopus)

Cerebral blood-flow regulation during hemorrhage

Rickards, C. A., 1 Oct 2015, In : Comprehensive Physiology. 5, 4, p. 1585-1621 37 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Hemorrhage
Perfusion
Hemorrhagic Disorders
Brain Hypoxia-Ischemia
16 Citations (Scopus)

Cerebral blood velocity regulation during progressive blood loss compared with lower body negative pressure in humans

Rickards, C. A., Johnson, B. D., Harvey, R. E., Convertino, V. A., Joyner, M. J. & Barnes, J. N., 15 Sep 2015, In : Journal of Applied Physiology. 119, 6, p. 677-685 9 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Middle Cerebral Artery
Arterial Pressure
Central Venous Pressure
Cerebrovascular Circulation
8 Citations (Scopus)

Coupling between arterial pressure, cerebral blood velocity, and cerebral tissue oxygenation with spontaneous and forced oscillations

Rickards, C. A., Sprick, J. D., Colby, H. B., Kay, V. L. & Tzeng, Y. C., 1 Apr 2015, In : Physiological Measurement. 36, 4, p. 785-801 17 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Oxygenation
Blood pressure
Arterial Pressure
Tissue
6 Citations (Scopus)

Reproducibility of a continuous ramp lower body negative pressure protocol for simulating hemorrhage

Kay, V. L. & Rickards, C. A., 1 Nov 2015, In : Physiological Reports. 3, 11, e12640.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Architectural Accessibility
Syncope
Hemorrhage
Hypovolemia
2014
9 Citations (Scopus)

Are you bleeding? Validation of a machine-learning algorithm for determination of blood volume status: Application to remote triage

Rickards, C. A., Vyas, N., Ryan, K. L., Ward, K. R., Andre, D., Hurst, G. M., Barrera, C. R. & Convertino, V. A., 1 Mar 2014, In : Journal of Applied Physiology. 116, 5, p. 486-494 9 p.

Research output: Contribution to journalArticle

Blood Volume Determination
Lower Body Negative Pressure
Triage
Stroke Volume
Exercise
29 Citations (Scopus)

Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure-flow relation: The CARNet study

Meel-van den Abeelen, A. S. S., Simpson, D. M., Wang, L. J. Y., Slump, C. H., Zhang, R., Tarumi, T., Rickards, C. A., Payne, S., Mitsis, G. D., Kostoglou, K., Marmarelis, V., Shin, D., Tzeng, Y. C., Ainslie, P. N., Gommer, E., Müller, M., Dorado, A. C., Smielewski, P., Yelicich, B., Puppo, C. & 6 others, Liu, X., Czosnyka, M., Wang, C. Y., Novak, V., Panerai, R. B. & Claassen, J. A. H. R., 1 Jan 2014, In : Medical Engineering and Physics. 36, 5, p. 620-627 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Transfer functions
Blood Flow Velocity
Hypercapnia
Pressure
6 Citations (Scopus)

Platelet activation after presyncope by lower body negative pressure in humans

Zaar, M., Fedyk, C. G., Pidcoke, H. F., Scherer, M. R., Ryan, K. L., Rickards, C. A., Hinojosa-Laborde, C., Convertino, V. A. & Cap, A. P., 29 Dec 2014, In : PLoS ONE. 9, 12, e116174.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
platelet activation
Platelet Activation
Syncope
Platelets
2013
12 Citations (Scopus)

Heart rate variability analysis during central hypovolemia using wavelet transformation

Ji, S. Y., Belle, A., Ward, K. R., Ryan, K. L., Rickards, C. A., Convertino, V. A. & Najarian, K., 1 Jun 2013, In : Journal of Clinical Monitoring and Computing. 27, 3, p. 289-302 14 p.

Research output: Contribution to journalArticle

Wavelet Analysis
Hypovolemia
Fractals
Heart Rate
Lower Body Negative Pressure
2012
84 Citations (Scopus)

Assessment of cerebral autoregulation: The quandary of quantification

Tzeng, Y. C., Ainslie, P. N., Cooke, W. H., Peebles, K. C., Willie, C. K., MacRae, B. A., Smirl, J. D., Horsman, H. M. & Rickards, C. A., 15 Sep 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 6, p. H658-H671

Research output: Contribution to journalArticle

Homeostasis
Blood Pressure
Middle Cerebral Artery
Thigh
43 Citations (Scopus)

Autonomic mechanisms associated with heart rate and vasoconstrictor reserves

Convertino, V. A., Rickards, C. A. & Ryan, K. L., 1 Jun 2012, In : Clinical Autonomic Research. 22, 3, p. 123-130 8 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Vasoconstrictor Agents
Central Tolerance
Hypovolemia
Baroreflex
12 Citations (Scopus)

Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise

Moralez, G., Romero, S. A., Rickards, C. A., Ryan, K. L., Convertino, V. A. & Cooke, W. H., 1 Jun 2012, In : Journal of Applied Physiology. 112, 11, p. 1875-1883 9 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery
Dehydration
Arterial Pressure
Plasma Volume
Furosemide
16 Citations (Scopus)

Lightweight noninvasive trauma monitor for early indication of central hypovolemia and tissue acidosis: A review

Soller, B. R., Zou, F., Ryan, K. L., Rickards, C. A., Ward, K. & Convertino, V. A., 1 Aug 2012, In : Journal of Trauma and Acute Care Surgery. 73, 2 SUPPL. 1, p. S106-S111

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Hypovolemia
Acidosis
Stroke Volume
Vital Signs
4 Citations (Scopus)

Progressive reduction in central blood volume is not detected by sublingual capnography

Chung, K. K., Ryan, K. L., Rickards, C. A., Hinojosa-Laborde, C., Pamplin, J. C., Patel, S. S., Herold, T. S. & Convertino, V. A., 1 Jun 2012, In : Shock. 37, 6, p. 586-591 6 p.

Research output: Contribution to journalArticle

Capnography
Blood Volume
Lower Body Negative Pressure
Hypovolemia
Blood Pressure
5 Citations (Scopus)

Simultaneous spectroscopic determination of forearm muscle pH and oxygen saturation during simulated haemorrhage

Soller, B. R., Sliwa, J., Yang, Y., Zou, F., Ryan, K. L., Rickards, C. A. & Convertino, V. A., 2 Apr 2012, In : Journal of Near Infrared Spectroscopy. 20, 1, p. 141-150 10 p.

Research output: Contribution to journalArticle

Muscle
Oxygen
Infrared radiation
Blood
Scattering
24 Citations (Scopus)

Sympathetic responses to central hypovolemia: New insights from microneurographic recordings

Ryan, K. L., Rickards, C. A., Hinojosa-Laborde, C., Cooke, W. H. & Convertino, V. A., 20 Sep 2012, In : Frontiers in Physiology. 3 APR, Article 110.

Research output: Contribution to journalArticle

Hypovolemia
Muscles
Lower Body Negative Pressure
Hemorrhage
Baroreflex
2011
21 Citations (Scopus)

Arterial pressure oscillations are not associated with muscle sympathetic nerve activity in individuals exposed to central hypovolaemia

Ryan, K. L., Rickards, C. A., Hinojosa-Laborde, C., Cooke, W. H. & Convertino, V. A., 1 Nov 2011, In : Journal of Physiology. 589, 21, p. 5311-5322 12 p.

Research output: Contribution to journalArticle

Hypovolemia
Arterial Pressure
Muscles
Lower Body Negative Pressure
Blood Pressure
18 Citations (Scopus)

Control of cerebral blood velocity with furosemide-induced hypovolemia and upright tilt

Romero, S. A., Moralez, G., Rickards, C. A., Ryan, K. L., Convertino, V. A., Fogt, D. L. & Cooke, W. H., 1 Feb 2011, In : Journal of Applied Physiology. 110, 2, p. 492-498 7 p.

Research output: Contribution to journalArticle

Hypovolemia
Furosemide
Arterial Pressure
Baroreflex
Dehydration
19 Citations (Scopus)

Heart rate variability during simulated hemorrhage with lower body negative pressure in high and low tolerant subjects

Hinojosa-Laborde, C., Rickards, C. A., Ryan, K. L. & Convertino, V. A., 1 Dec 2011, In : Frontiers in Physiology. 2 NOV, Article 85.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Heart Rate
Hemorrhage
Syncope
Hypovolemia
21 Citations (Scopus)

Improved pulse transit time estimation by system identification analysis of proximal and distal arterial waveforms

Xu, D., Ryan, K. L., Rickards, C. A., Zhang, G., Convertino, V. A. & Mukkamala, R., 1 Oct 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 4, p. H1389-H1395

Research output: Contribution to journalArticle

Pulse Wave Analysis
Impedance Cardiography
Blood Pressure
Foot
Lower Body Negative Pressure
41 Citations (Scopus)

Monitoring non-invasive cardiac output and stroke volume during experimental human hypovolaemia and resuscitation.

Reisner, A. T., Xu, D., Ryan, K. L., Convertino, V. A., Rickards, C. A. & Mukkamala, R., Jan 2011, In : British journal of anaesthesia. 106, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

Cardiac Volume
Hypovolemia
Lower Body Negative Pressure
Resuscitation
Cardiac Output
48 Citations (Scopus)

Pulse oximeter plethysmographic waveform changes in awake, spontaneously breathing, hypovolemic volunteers

McGrath, S. P., Ryan, K. L., Wendelken, S. M., Rickards, C. A. & Convertino, V. A., 1 Feb 2011, In : Anesthesia and analgesia. 112, 2, p. 368-374 7 p.

Research output: Contribution to journalArticle

Hypovolemia
Pulse
Volunteers
Respiration
Lower Body Negative Pressure
56 Citations (Scopus)

Tolerance to central hypovolemia: the influence of oscillations in arterial pressure and cerebral blood velocity

Rickards, C. A., Ryan, K. L., Cooke, W. H. & Convertino, V. A., 1 Oct 2011, In : Journal of Applied Physiology. 111, 4, p. 1048-1058 11 p.

Research output: Contribution to journalArticle

Central Tolerance
Hypovolemia
Arterial Pressure
Lower Body Negative Pressure
Middle Cerebral Artery
2010
20 Citations (Scopus)

Characterization of common measures of heart period variability in healthy human subjects: Implications for patient monitoring

Rickards, C. A., Ryan, K. L. & Convertino, V. A., 1 Feb 2010, In : Journal of Clinical Monitoring and Computing. 24, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

Physiologic Monitoring
Healthy Volunteers
Electrocardiography
Demography
Hemorrhage
12 Citations (Scopus)

Ectopy in trauma patients: Cautions for use of heart period variability in medical monitoring

Sethuraman, G., Ryan, K. L., Rickards, C. A. & Convertino, V. A., 1 Feb 2010, In : Aviation Space and Environmental Medicine. 81, 2, p. 125-129 5 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Healthy Volunteers
Electrocardiography
Lower Body Negative Pressure
Noise
23 Citations (Scopus)

Is heart period variability associated with the administration of lifesaving interventions in individual prehospital trauma patients with normal standard vital signs?

Rickards, C. A., Ryan, K. L., Ludwig, D. A. & Convertino, V. A., Aug 2010, In : Critical Care Medicine. 38, 8, p. 1666-1673 8 p.

Research output: Contribution to journalArticle

Vital Signs
Wounds and Injuries
Aircraft
Trauma Centers
Fractals
49 Citations (Scopus)

Oxygen transport characterization of a human model of progressive hemorrhage

Ward, K. R., Tiba, M. H., Ryan, K. L., Torres Filho, I. P., Rickards, C. A., Witten, T., Soller, B. R., Ludwig, D. A. & Convertino, V. A., 1 Aug 2010, In : Resuscitation. 81, 8, p. 987-993 7 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Hemorrhage
Oxygen
Shock
Perfusion
36 Citations (Scopus)

Tracking central hypovolemia with ECG in humans: Cautions for the use of heart period variability in patient monitoring

Ryan, K. L., Rickards, C. A., Ludwig, D. A. & Convertino, V. A., 1 Jun 2010, In : Shock. 33, 6, p. 583-589 7 p.

Research output: Contribution to journalArticle

Hypovolemia
Physiologic Monitoring
Lower Body Negative Pressure
Electrocardiography
Stroke Volume
2009
28 Citations (Scopus)

Hyperventilation in response to progressive reduction in central blood volume to near syncope

Convertino, V. A., Rickards, C. A., Lurie, K. G. & Ryan, K. L., 1 Dec 2009, In : Aviation Space and Environmental Medicine. 80, 12, p. 1012-1017 6 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Hyperventilation
Syncope
Blood Volume
Hypovolemia
84 Citations (Scopus)

Muscle sympathetic nerve activity during intense lower body negative pressure to presyncope in humans

Cooke, W. H., Rickards, C. A., Ryan, K. L., Kuusela, T. A. & Convertino, V. A., 1 Oct 2009, In : Journal of Physiology. 587, 20, p. 4987-4999 13 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Syncope
Arterial Pressure
Muscles
Baroreflex
2008
30 Citations (Scopus)

Autonomic compensation to simulated hemorrhage monitored with heart period variability

Cooke, W. H., Rickards, C. A., Ryan, K. L. & Convertino, V. A., Jun 2008, In : Critical Care Medicine. 36, 6, p. 1892-1899 8 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Blood Volume
Arterial Pressure
Hemorrhage
Blood Pressure
43 Citations (Scopus)

Breathing through an inspiratory threshold device improves stroke volume during central hypovolemia in humans

Ryan, K. L., Cooke, W. H., Rickards, C. A., Lurie, K. G. & Convertino, V. A., 1 May 2008, In : Journal of Applied Physiology. 104, 5, p. 1402-1409 8 p.

Research output: Contribution to journalArticle

Hypovolemia
Electric Impedance
Stroke Volume
Respiration
Equipment and Supplies
18 Citations (Scopus)

Changes in pulse character and mental status are late responses to central hypovolemia

Ryan, K. L., Batchinsky, A., McManus, J. G., Rickards, C. A. & Convertino, V. A., 1 Apr 2008, In : Prehospital Emergency Care. 12, 2, p. 192-198 7 p.

Research output: Contribution to journalArticle

Hypovolemia
Pulse
Blood Pressure
Lower Body Negative Pressure
Stroke Volume
15 Citations (Scopus)

Combat stress or hemorrhage? Evidence for a decision-assist algorithm for remote triage

Rickards, C. A., Ryan, K. L., Cooke, W. H., Romero, S. A. & Convertino, V. A., 1 Jul 2008, In : Aviation Space and Environmental Medicine. 79, 7, p. 670-676 7 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Triage
Military Personnel
Exercise
Hemorrhage
16 Citations (Scopus)

Inspiratory resistance, cerebral blood flow velocity, and symptoms of acute hypotension

Rickards, C. A., Cohen, K. D., Bergeron, L. L., Burton, L., Khatri, P. J., Lee, C. T., Ryan, K. L., Cooke, W. H., Doerr, D. F., Lurie, K. G. & Convertino, V. A., 1 Jun 2008, In : Aviation Space and Environmental Medicine. 79, 6, p. 557-564 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Blood Flow Velocity
Electric Impedance
Hypotension
Equipment and Supplies
13 Citations (Scopus)

Limitations of end-tidal CO2 as an early indicator of central hypovolemia in humans

McManus, J. G., Ryan, K. L., Morton, M. J., Rickards, C. A., Cooke, W. H. & Convertino, V. A., 1 Apr 2008, In : Prehospital Emergency Care. 12, 2, p. 199-205 7 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Hypovolemia
Lung
Stroke Volume
Respiratory Rate
53 Citations (Scopus)

Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans

Soller, B. R., Yang, Y., Soyemi, O. O., Ryan, K. L., Rickards, C. A., Walz, J. M., Heard, S. O. & Convertino, V. A., 1 Feb 2008, In : Journal of Applied Physiology. 104, 2, p. 475-481 7 p.

Research output: Contribution to journalArticle

Hypovolemia
Stroke Volume
Lower Body Negative Pressure
Oxygen
Blood Volume
55 Citations (Scopus)

Oxygen saturation determined from deep muscle, not thenar tissue, is an early indicator of central hypovolemia in humans

Soller, B. R., Ryan, K. L., Rickards, C. A., Cooke, W. H., Yang, Y., Soyemi, O. O., Crookes, B. A., Heard, S. O. & Convertino, V. A., Jan 2008, In : Critical Care Medicine. 36, 1, p. 176-182 7 p.

Research output: Contribution to journalArticle

Lower Body Negative Pressure
Hypovolemia
Oxygen
Muscles
Forearm
87 Citations (Scopus)

Physiological and medical monitoring for en route care of combat casualties

Convertino, V. A., Ryan, K. L., Rickards, C. A., Salinas, J., McManus, J. G., Cooke, W. H. & Holcomb, J. B., 1 Apr 2008, In : Journal of Trauma - Injury, Infection and Critical Care. 64, SUPPL. 4, p. S342-S353

Research output: Contribution to journalArticle

Physiologic Monitoring
Vital Signs
Oxygen
Wounds and Injuries
Lower Body Negative Pressure
8 Citations (Scopus)

Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy

Lee, J., Kim, J. G., Mahon, S., Tromberg, B. J., Ryan, K. L., Convertino, V. A., Rickards, C. A., Osann, K. & Brenner, M., 1 Dec 2008, In : Journal of Biomedical Optics. 13, 6, 064027.

Research output: Contribution to journalArticle

hypovolemia
lower body negative pressure
Hemoglobin
hemoglobin
Hemoglobins