Projects per year
Personal profile
Area of Expertise
My research efforts within the North Texas Eye Research Institute (NTERI) are dedicated to the investigation and further development of the mouse as a useful model for the study of aqueous humor dynamics and primary open-angle glaucoma (POAG). Areas of expertise include studies (in living animals) of: aqueous humor dynamics, intraocular pressure measurement, generation and development of transgenic models of POAG using viral vectors, visualization of the eye using spectral domain ocular coherence tomography (SD-OCT), and electroretinography. Projects currently under way include an investigation, using 5XFAD mice (which express five familial Alzheimer’s Disease (AD) mutations) into a possible connection between AD and POAG I also routinely interact with other NTERI members in a multi-disciplinary manner.
Education/Academic qualification
BS in Applied Biology, Glasgow Caledonian University
BS in Applied & Clinical Biochemistry, Glasgow Caledonian University
PhD in Pharmacology, University of Glasgow
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Projects
- 7 Finished
Dose-Dependence Study of Dronabinol on Mouse Intraocular Pressure
25/09/17 → 31/12/17
Project: Research
Effect of Repeated Doses of Rhodes Formulations on Mouse Intraocular Pressure
Pang, I., Millar, C. & Liu, Y.
7/06/17 → 31/12/17
Project: Research
Preclinical Evaluation of Graybug Vision Compound
Clark, A., Tovar-Vidales, T., Liu, Y. & Millar, C.
5/06/17 → 4/06/19
Project: Research
Effect of Shire Compound on Mouse Intraocular Pressure and Aqueous Humor Hydrodynamics
Pang, I., Millar, C. & Liu, Y.
1/10/16 → 30/09/19
Project: Research
Research Output
CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma
Maddineni, P., Kasetti, R. B., Patel, P. D., Millar, J. C., Kiehlbauch, C., Clark, A. F. & Zode, G. S., 27 Aug 2020, In : Molecular Neurodegeneration. 15, 1, 48.Research output: Contribution to journal › Article
Open Access
Effects of TAK-639, a novel topical C-type natriuretic peptide analog, on intraocular pressure and aqueous humor dynamics in mice
Millar, J. C., Savinainen, A., Josiah, S. & Pang, I. H., Nov 2019, In : Experimental eye research. 188, 107763.Research output: Contribution to journal › Article
2
Scopus
citations
Glucocorticoid receptor transactivation is required for glucocorticoid-induced ocular hypertension and glaucoma
Patel, G. C., Millar, J. C. & Clark, A. F., May 2019, In : Investigative Ophthalmology and Visual Science. 60, 6, p. 1967-1978 12 p.Research output: Contribution to journal › Article
Open Access
3
Scopus
citations
Assessment of aqueous humor dynamics in the rodent by constant flow infusion
Millar, J. C., Phan, T. N. & Pang, I. H., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 109-120 12 p. (Methods in Molecular Biology; vol. 1695).Research output: Chapter in Book/Report/Conference proceeding › Chapter
2
Scopus
citations
BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork
Hernandez, H., Cameron Millar, J., Curry, S. M., Clark, A. F. & McDowell, C. M., Apr 2018, In : Investigative Ophthalmology and Visual Science. 59, 5, p. 2154-2166 13 p.Research output: Contribution to journal › Article
14
Scopus
citations