Projects per year
Personal profile
Area of Expertise
My research efforts within the North Texas Eye Research Institute (NTERI) are dedicated to the investigation and further development of the mouse as a useful model for the study of aqueous humor dynamics and primary open-angle glaucoma (POAG). Areas of expertise include studies (in living animals) of: aqueous humor dynamics, intraocular pressure measurement, generation and development of transgenic models of POAG using viral vectors, visualization of the eye using spectral domain ocular coherence tomography (SD-OCT), and electroretinography. Projects currently under way include an investigation, using 5XFAD mice (which express five familial Alzheimer’s Disease (AD) mutations) into a possible connection between AD and POAG I also routinely interact with other NTERI members in a multi-disciplinary manner.
Education/Academic qualification
BS in Applied Biology, Glasgow Caledonian University
BS in Applied & Clinical Biochemistry, Glasgow Caledonian University
PhD in Pharmacology, University of Glasgow
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Projects
- 7 Finished
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Dose-Dependence Study of Dronabinol on Mouse Intraocular Pressure
25/09/17 → 31/12/17
Project: Research
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Effect of Repeated Doses of Rhodes Formulations on Mouse Intraocular Pressure
Pang, I., Millar, C. & Liu, Y.
7/06/17 → 31/12/17
Project: Research
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Preclinical Evaluation of Graybug Vision Compound
Clark, A., Tovar-Vidales, T., Liu, Y. & Millar, C.
5/06/17 → 4/06/19
Project: Research
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Effect of Shire Compound on Mouse Intraocular Pressure and Aqueous Humor Hydrodynamics
Pang, I., Millar, C. & Liu, Y.
1/10/16 → 30/09/19
Project: Research
Research Output
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ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
Kasetti, R. B., Patel, P. D., Maddineni, P., Patil, S., Kiehlbauch, C., Millar, J. C., Searby, C. C., Raghunathan, V. K., Sheffield, V. C. & Zode, G. S., 1 Dec 2020, In: Nature Communications. 11, 1, 5594.Research output: Contribution to journal › Article › peer-review
Open Access -
CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma
Maddineni, P., Kasetti, R. B., Patel, P. D., Millar, J. C., Kiehlbauch, C., Clark, A. F. & Zode, G. S., 27 Aug 2020, In: Molecular Neurodegeneration. 15, 1, 48.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of TAK-639, a novel topical C-type natriuretic peptide analog, on intraocular pressure and aqueous humor dynamics in mice
Millar, J. C., Savinainen, A., Josiah, S. & Pang, I. H., Nov 2019, In: Experimental eye research. 188, 107763.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Glucocorticoid receptor transactivation is required for glucocorticoid-induced ocular hypertension and glaucoma
Patel, G. C., Millar, J. C. & Clark, A. F., May 2019, In: Investigative Ophthalmology and Visual Science. 60, 6, p. 1967-1978 12 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Assessment of aqueous humor dynamics in the rodent by constant flow infusion
Millar, J. C., Phan, T. N. & Pang, I. H., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 109-120 12 p. (Methods in Molecular Biology; vol. 1695).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
2 Scopus citations