Bruce Bunnell

2023

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Makarcyzk, M. J., Li, Z. A., Yu, I., Yagi, H., Zhang, X., Yocum, L., Li, E., Fritch, M. R., Gao, Q., Bunnell, B. A., Goodman, S. B., Tuan, R. S., Alexander, P. G. & Lin, H., Jan 2023, In: Journal of Visualized Experiments. 2023, 191, e64186.

Research output: Contribution to journal › Article › peer-review

Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential

Li, Z. A., Sant, S., Cho, S. K., Goodman, S. B., Bunnell, B. A., Tuan, R. S., Gold, M. S. & Lin, H., Apr 2023, In: Trends in Biotechnology. 41, 4, p. 511-527 17 p.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Using Microphysiological System for the Development of Treatments for Joint Inflammation and Associated Cartilage Loss—A Pilot Study

Makarczyk, M. J., Hines, S., Yagi, H., Li, Z. A., Aguglia, A. M., Zbikowski, J., Padget, A. M., Gao, Q., Bunnell, B. A., Goodman, S. B. & Lin, H., Feb 2023, In: Biomolecules. 13, 2, 384.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Aberrant Expression of COX-2 and FOXG1 in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors

O’Donnell, B. T., Monjure, T. A., Al-Ghadban, S., Ives, C. J., L’Ecuyer, M. P., Rhee, C., Romero-Lopez, M., Li, Z., Goodman, S. B., Lin, H., Tuan, R. S. & Bunnell, B. A., Aug 2022, In: Cells. 11, 15, 2367.

Research output: Contribution to journal › Article › peer-review

Open Access

Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age

Hamel, K. M., Liimatta, K. Q., Belgodere, J. A., Bunnell, B. A., Gimble, J. M. & Martin, E. C., 1 Oct 2022, In: Stem Cells and Development. 31, 19-20, p. 579-592 14 p.

Research output: Contribution to journal › Review article › peer-review

Adipose Stem Cells in Regenerative Medicine: Looking Forward

Al-Ghadban, S., Artiles, M. & Bunnell, B. A., 13 Jan 2022, In: Frontiers in Bioengineering and Biotechnology. 9, 837464.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

Breast Cancer-Stromal Interactions: Adipose-Derived Stromal/Stem Cell Age and Cancer Subtype Mediated Remodeling

Hamel, K. M., King, C. T., Cavalier, M. B., Liimatta, K. Q., Rozanski, G. L., King, T. A., Lam, M., Bingham, G. C., Byrne, C. E., Xing, D., Collins-Burow, B. M., Burow, M. E., Belgodere, J. A., Bratton, M. R., Bunnell, B. A. & Martin, E. C., 1 Oct 2022, In: Stem Cells and Development. 31, 19-20, p. 604-620 17 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing

Li, Z., Lin, Z., Liu, S., Yagi, H., Zhang, X., Yocum, L., Romero-Lopez, M., Rhee, C., Makarcyzk, M. J., Yu, I., Li, E. N., Fritch, M. R., Gao, Q., Goh, K. B., O'Donnell, B., Hao, T., Alexander, P. G., Mahadik, B., Fisher, J. P., Goodman, S. B., & 3 othersBunnell, B. A., Tuan, R. S. & Lin, H., 25 Jul 2022, In: Advanced Science. 9, 21, 2105909.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types

Matossian, M. D., Chang, T., Wright, M. K., Burks, H. E., Elliott, S., Sabol, R. A., Wathieu, H., Windsor, G. O., Alzoubi, M. S., King, C. T., Bursavich, J. B., Ham, A. M., Savoie, J. J., Nguyen, K., Baddoo, M., Flemington, E., Sirenko, O., Cromwell, E. F., Hebert, K. L., Lau, F., & 13 othersIzadpanah, R., Brown, H., Sinha, S., Zabaleta, J., Riker, A. I., Moroz, K., Miele, L., Zea, A. H., Ochoa, A., Bunnell, B. A., Collins-Burow, B. M., Martin, E. C. & Burow, M. E., Jan 2022, In: Clinical and Translational Oncology. 24, 1, p. 127-144 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Liver Kinase B1 Regulates Remodeling of the Tumor Microenvironment in Triple-Negative Breast Cancer

King, C. T., Matossian, M. D., Savoie, J. J., Nguyen, K., Wright, M. K., Byrne, C. E., Elliott, S., Burks, H. E., Bratton, M. R., Pashos, N. C., Bunnell, B. A., Burow, M. E., Collins-Burow, B. M. & Martin, E. C., 8 Jun 2022, In: Frontiers in Molecular Biosciences. 9, 847505.

Research output: Contribution to journal › Article › peer-review

Open Access

Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study

Frazier, T., March, K., Garza, J. R., Bunnell, B. A., Darr, K. F., Rogers, E., Hamel, K. & Gimble, J. M., Dec 2022, In: Bone Reports. 17, 101601.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

Short-Term Autophagy Preconditioning Upregulates the Expression of COX2 and PGE2 and Alters the Immune Phenotype of Human Adipose-Derived Stem Cells In Vitro

Wise, R. M., Al-Ghadban, S., Harrison, M. A. A., Sullivan, B. N., Monaco, E. R., Aleman, S. J., Donato, U. M. & Bunnell, B. A., 1 May 2022, In: Cells. 11, 9, 1376.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer

Bunnell, B. A., Martin, E. C., Matossian, M. D., Brock, C. K., Nguyen, K., Collins-Burow, B. & Burow, M. E., Sep 2022, In: Cancer and Metastasis Reviews. 41, 3, p. 549-573 25 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

The role of MEK1/2 and MEK5 in melatonin-mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation

Munmun, F., Mohiuddin, O. A., Hoang, V. T., Burow, M. E., Bunnell, B. A., Sola, V. M., Carpentieri, A. R. & Witt-Enderby, P. A., Sep 2022, In: Journal of Pineal Research. 73, 2, e12814.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2021

Adipose-derived stem cells from obese donors polarize macrophages and microglia toward a pro-inflammatory phenotype

Harrison, M. A. A., Wise, R. M., Benjamin, B. P., Hochreiner, E. M., Mohiuddin, O. A. & Bunnell, B. A., Jan 2021, In: Cells. 10, 1, p. 1-15 15 p., 26.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Adipose tissue-derived mesenchymal stem cells

Bunnell, B. A., Dec 2021, In: Cells. 10, 12, 3433.

Research output: Contribution to journal › Editorial

Open Access

14 Scopus citations

A Role for Adipocytes and Adipose Stem Cells in the Breast Tumor Microenvironment and Regenerative Medicine

Brock, C. K., Hebert, K. L., Artiles, M., Wright, M. K., Cheng, T., Windsor, G. O., Nguyen, K., Alzoubi, M. S., Collins-Burow, B. M., Martin, E. C., Lau, F. H., Bunnell, B. A. & Burow, M. E., 29 Nov 2021, In: Frontiers in Physiology. 12, 751239.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Comparative Analysis of Human Adipose-Derived Stromal/Stem Cells and Dermal Fibroblasts

Zanata, F., Curley, L., Martin, E., Bowles, A., Bunnell, B. A., Wu, X., Ferreira, L. M. & Gimble, J. M., 1 Dec 2021, In: Stem Cells and Development. 30, 23, p. 1171-1178 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Current Models for Development of Disease-Modifying Osteoarthritis Drugs

Makarczyk, M. J., Gao, Q., He, Y., Li, Z., Gold, M. S., Hochberg, M. C., Bunnell, B. A., Tuan, R. S., Goodman, S. B. & Lin, H., 1 Feb 2021, In: Tissue Engineering - Part C: Methods. 27, 2, p. 124-138 15 p.

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Erratum: Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor (PLoS ONE (2020) 15:10 (e0226464) DOI: 10.1371/journal.pone.0226464)

Chang, T. C., Matossian, M. D., Elliott, S., Burks, H. E., Sabol, R. A., Ucar, D. A., Wathieu, H., Zabaleta, J., Valle, L. D., Gill, S., Martin, E., Riker, A. I., Miele, L., Bunnell, B. A., Burow, M. E. & Collins-Burow, B. M., Apr 2021, In: PLoS ONE. 16, 4 April, e0251106.

Research output: Contribution to journal › Comment/debate

Open Access

Establishing the adipose stem cell identity: Characterization assays and functional properties

Harrison, M. A. A., Al-Ghadban, S. I., O’Donnell, B. T., Mohiuddin, O. A., Wise, R. M., Sullivan, B. N. & Bunnell, B. A., 1 Jan 2021, Scientific Principles of Adipose Stem Cells. Elsevier, p. 23-56 34 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Evaluation of Extracellular Matrix Composition to Improve Breast Cancer Modeling

Byrne, C. E., Decombe, J. B., Bingham, G. C., Remont, J., Miller, L. G., Khalif, L., King, C. T., Hamel, K., Bunnell, B. A., Burow, M. E. & Martin, E. C., Apr 2021, In: Tissue Engineering - Part A. 27, 7-8, p. 500-511 12 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Excision of latent HIV-1: CRISPR technology overcomes viral strain diversity

Bunnell, B. A., Dec 2021, In: EBioMedicine. 74, 103720.

Research output: Contribution to journal › Comment/debate

Open Access

Illuminating the Regenerative Properties of Stem Cells In Vivo with Bioluminescence Imaging

Madsen, S. D., Giler, M. K., Bunnell, B. A. & O'Connor, K. C., Mar 2021, In: Biotechnology Journal. 16, 3, 2000248.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

International Federation for Adipose Therapeutics and Science and Stem Cells and Development: A Long-Term Relationship That Has Been Growing in Plain Sight

Gimble, J. M., Blunk, T., Rodriguez, R., Rubin, J. P. & Bunnell, B. A., 1 Dec 2021, In: Stem Cells and Development. 30, 23, p. 1139-1140 2 p.

Research output: Contribution to journal › Editorial

In Vitro Culture Expansion Shifts the Immune Phenotype of Human Adipose-Derived Mesenchymal Stem Cells

Jeske, R., Yuan, X., Fu, Q., Bunnell, B. A., Logan, T. M. & Li, Y., 10 Mar 2021, In: Frontiers in Immunology. 12, 621744.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Macrophages modulate the function of msc-and ipsc-derived fibroblasts in the presence of polyethylene particles

Gao, Q., Li, Z., Rhee, C., Xiang, S., Maruyama, M., Huang, E. E., Yao, Z., Bunnell, B. A., Tuan, R. S., Lin, H., Gold, M. S. & Goodman, S. B., 1 Dec 2021, In: International journal of molecular sciences. 22, 23, 12837.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment

Bagdasarian, F. A., Yuan, X., Athey, J., Bunnell, B. A. & Grant, S. C., Dec 2021, In: Magnetic Resonance in Medicine. 86, 6, p. 3211-3223 13 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Obesity modulates the gut microbiome in triple-negative breast cancer

Hossain, F., Majumder, S., David, J., Bunnell, B. A. & Miele, L., Oct 2021, In: Nutrients. 13, 10, 3656.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

The effects of macrophage phenotype on osteogenic differentiation of mscs in the presence of polyethylene particles

Gao, Q., Rhee, C., Maruyama, M., Li, Z., Shen, H., Zhang, N., Utsunomiya, T., Huang, E. E., Yao, Z., Bunnell, B. A., Lin, H., Tuan, R. S. & Goodman, S. B., 2021, In: Biomedicines. 9, 5, 499.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Therapeutic Potential of Adipose Stem Cells

Sabol, R. A., Bowles, A. C., Côté, A., Wise, R., Pashos, N. & Bunnell, B. A., 2021, Advances in Experimental Medicine and Biology. Springer, p. 15-25 11 p. (Advances in Experimental Medicine and Biology; vol. 1341).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

18 Scopus citations

Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model

Caronna, V. C., Rosenberg, A. F., Graham, D. M., Heim, W. M., Grasperge, B. F., Sullivan, S. K., Chaffin, A. E., Bunnell, B. A. & Pashos, N. C., Dec 2021, In: Scientific Reports. 11, 1, 15085.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2020

3d spheroids derived from human lipedema ascs demonstrated similar adipogenic differentiation potential and ecm remodeling to non-lipedema ascs in vitro

Al-Ghadban, S., Pursell, I. A., Diaz, Z. T., Herbst, K. L. & Bunnell, B. A., 1 Nov 2020, In: International journal of molecular sciences. 21, 21, p. 1-14 14 p., 8350.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Acellular Biologic Nipple-Areolar Complex Graft: In Vivo Murine and Nonhuman Primate Host Response Evaluation

Pashos, N. C., Graham, D. M., Burkett, B. J., O'Donnell, B., Sabol, R. A., Helm, J., Martin, E. C., Bowles, A. C., Heim, W. M., Caronna, V. C., Miller, K. S., Grasperge, B., Sullivan, S., Chaffin, A. E. & Bunnell, B. A., Aug 2020, In: Tissue Engineering - Part A. 26, 15-16, p. 872-885 14 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Adipose tissue-derived stem cells: Immunomodulatory effects and therapeutic potential

Al-Ghadban, S. & Bunnell, B. A., 2020, In: Physiology. 35, 2, p. 125-133 9 p.

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Adipose tissue-derived stem cells retain their adipocyte differentiation potential in three-dimensional hydrogels and bioreactors

O’donnell, B. T., Al-Ghadban, S., Ives, C. J., L’ecuyer, M. P., Monjure, T. A., Romero-Lopez, M., Li, Z., Goodman, S. B., Lin, H., Tuan, R. S. & Bunnell, B. A., Jul 2020, In: Biomolecules. 10, 7, p. 1-16 16 p., 1070.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies

O'Keefe, R. J., Tuan, R. S., Lane, N. E., Awad, H. A., Barry, F., Bunnell, B. A., Colnot, C., Drake, M. T., Drissi, H., Dyment, N. A., Fortier, L. A., Guldberg, R. E., Kandel, R., Little, D. G., Marshall, M. F., Mao, J. J., Nakamura, N., Proffen, B. L., Rodeo, S. A., Rosen, V., & 3 othersThomopoulos, S., Schwarz, E. M. & Serra, R., 1 Jan 2020, In: Journal of Bone and Mineral Research. 35, 1, p. 3-17 15 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies – Secondary Publication

O'Keefe, R. J., Tuan, R. S., Lane, N. E., Awad, H. A., Barry, F., Bunnell, B. A., Colnot, C., Drake, M. T., Drissi, H., Dyment, N. A., Fortier, L. A., Guldberg, R. E., Kandel, R., Little, D. G., Marshall, M. F., Mao, J. J., Nakamura, N., Proffen, B. L., Rodeo, S. A., Rosen, V., & 3 othersThomopoulos, S., Schwarz, E. M. & Serra, R., 1 Mar 2020, In: Journal of Orthopaedic Research. 38, 3, p. 485-502 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways

Matossian, M. D., Burks, H. E., Elliott, S., Hoang, V. T., Zuercher, W. J., Wells, C., Drewry, D. H., Kapadia, N., Chang, T., Yan, T., Windsor, G. O., Nguyen, K., Fang, F., Nephew, K. P., Buechlein, A., Rusch, D. B., Sabol, R. A., Ucar, D. A., Zabaleta, J., Miele, L., & 3 othersBunnell, B. A., Collins-Burow, B. M. & Burow, M. E., 1 Sep 2020, In: Anti-Cancer Drugs. p. 759-775 17 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

A novel tissue culture model for evaluating the effect of aging on stem cell fate in adult microvascular networks

Azimi, M. S., Motherwell, J. M., Dutreil, M., Fishel, R. L., Nice, M., Hodges, N. A., Bunnell, B. A., Katz, A. & Murfee, W. L., 1 Apr 2020, In: GeroScience. 42, 2, p. 515-526 12 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Arguments for a different regulatory categorization and framework for stromal vascular fraction

Rodriguez, R. L., Frazier, T., Bunnell, B. A., Mouton, C. A., March, K. L., Katz, A. J., Rubin, J. P., Llull, R., Sørensen, J. A. & Gimble, J. M., 1 Mar 2020, In: Stem Cells and Development. 29, 5, p. 257-262 6 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Characterization and Proteomic Analysis of Decellularized Adipose Tissue Hydrogels Derived from Lean and Overweight/Obese Human Donors

Mohiuddin, O. A., Motherwell, J. M., Rogers, E., Bratton, M. R., Zhang, Q., Wang, G., Bunnell, B., Hayes, D. J. & Gimble, J. M., 1 Oct 2020, In: Advanced Biosystems. 4, 10, 2000124.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

CRISPR based editing of SIV proviral DNA in ART treated non-human primates

Mancuso, P., Chen, C., Kaminski, R., Gordon, J., Liao, S., Robinson, J. A., Smith, M. D., Liu, H., Sariyer, I. K., Sariyer, R., Peterson, T. A., Donadoni, M., Williams, J. B., Siddiqui, S., Bunnell, B. A., Ling, B., MacLean, A. G., Burdo, T. H. & Khalili, K., Dec 2020, In: Nature Communications. 11, 1, 6065.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Decellularized Adipose Tissue: Biochemical Composition, in vivo Analysis and Potential Clinical Applications

Mohiuddin, O. A., Campbell, B., Poche, J. N., Thomas-Porch, C., Hayes, D. A., Bunnell, B. A. & Gimble, J. M., 2020, Advances in Experimental Medicine and Biology. Springer, p. 57-70 14 p. (Advances in Experimental Medicine and Biology; vol. 1212).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

26 Scopus citations

Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor

Chang, T. C., Matossian, M. D., Elliott, S., Burks, H. E., Sabol, R. A., Ucar, D. A., Wathieu, H., Zabaleta, J., De Valle, L., Gill, S., Martin, E., Riker, A. I., Miele, L., Bunnell, B. A., Burow, M. E. & Collins-Burow, B. M., Oct 2020, In: PLoS ONE. 15, 10 October, e0226464.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Increase in Leptin and PPAR-γ Gene Expression in Lipedema Adipocytes Differentiated in vitro from Adipose-Derived Stem Cells

Al-Ghadban, S., Diaz, Z. T., Singer, H. J., Mert, K. B. & Bunnell, B. A., 12 Feb 2020, In: Cells. 9, 2

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Macrophage effects on mesenchymal stem cell osteogenesis in a three-dimensional in vitro bone model

Romero-López, M., Li, Z., Rhee, C., Maruyama, M., Pajarinen, J., O'Donnell, B., Lin, T. H., Lo, C. W., Hanlon, J., Dubowitz, R., Yao, Z., Bunnell, B. A., Lin, H., Tuan, R. S. & Goodman, S. B., Oct 2020, In: Tissue Engineering - Part A. 26, 19-20, p. 1099-1111 13 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Obesity-altered adipose stem cells promote radiation resistance of estrogen receptor positive breast cancer through paracrine signaling

Sabol, R. A., Villela, V. A., Denys, A., Freeman, B. T., Hartono, A. B., Wise, R. M., Harrison, M. A. A., Sandler, M. B., Hossain, F., Miele, L. & Bunnell, B. A., 2 Apr 2020, In: International journal of molecular sciences. 21, 8, 2722.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

Rogers, C. J., Harman, R. J., Bunnell, B. A., Schreiber, M. A., Xiang, C., Wang, F. S., Santidrian, A. F. & Minev, B. R., 18 May 2020, In: Journal of Translational Medicine. 18, 1, 203.

Research output: Contribution to journal › Review article › peer-review

Open Access

71 Scopus citations

Safety and Efficacy of Human Adipose-Derived Stromal/Stem Cell Therapy in an Immunocompetent Murine Pressure Ulcer Model

Bukowska, J., Alarcon Uquillas, A., Wu, X., Frazier, T., Walendzik, K., Vanek, M., Gaupp, DI., Bunnell, B. A., Kosnik, P., Mehrara, B., Katz, A. J., Gawronska-Kozak, B. & Gimble, J. M., 1 Apr 2020, In: Stem Cells and Development. 29, 7, p. 440-451 12 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Bruce Bunnell, PhD

Research output

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