Projects per year
Personal profile
Research Interests
Regenerative Medicine, Tissue Engineering, Stem Cells, Microphysiological Systems
Area of Expertise
Dr. Bunnell's research program is focused on both stem cells and tissue engineering. His group focuses on both the basic science and translational applications of adult stem cells. Dr. Bunnell investigates use of mesenchymal stem cells (MSCs) isolated from the bone marrow or adipose tissue. He is particularly interested in the interactions of MSC with the immune system and how the cells inhibit robust anti-inflammatory effects in vivo. He is interested in applying these cells or products from these cells as a therapeutic intervention for both immune diseases such as Multiple Sclerosis, wound repair, and bone regeneration. He is currently working towards a human clinical trial for the treatment of osteoarthritis, rotator cuff injury and Multiple Sclerosis using autologous stem cells. He is also interested in defining the role of adipose stem cells in the manifestation of the subcutaneous adipose tissue disorder of unknown origins, called Lipedema, which is characterized by the symmetric buildup of adipose tissue (fat) in the legs and arms that is often severely painful. Dr. Bunnell has an area of focus on the development and application of engineered tissues. The approach combines scaffolds (native or lab-generated) in combination with various stem cell populations. Native scaffolds are generated by decellularizing human tissues using a combination of enzymes and salts to strip away the cells and leave an intact scaffold behind. The scaffold is then repopulated using stem cells alone or in conjunction with terminally differentiated cells in an attempt to make a functional organ. He is also developing microphysiological systems (MPS), which are bioreactor or chip-based in vitro models of complex organ systems that retain all of the functions of native organs. He is currently working as part of a team constructing an MPS of a human knee to model osteoarthritis. Once completed, the system will be used to study tissue interactions, disease mechanisms and novel therapeutics.
Techniques
Stem Cell Isolation and Culture, Organoid Culture, Microphysiological System Culture, Molecular and Cellular Analyses
Education/Academic qualification
BS, Purdue University
PhD, University of Alabama at Birmingham
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Collaborations and top research areas from the last five years
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UNTHSC Team Science - The impact of gestational PCB exposure on maternal and fetal pathophysiology
Cunningham, R. (CoPI), Bunnell, B. (CoPI), Allen, M. (CoPI) & Roberts, A. P. (CoPI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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HSC Scholars in Cancer Researc
Vishwanatha, J. (PI), Yurvati, A. (CoI), Jones, H. (CoI), Smith, M. (CoI), Berg, R. (CoI), Basha, R. (CoI), Bunnell, B. (CoI) & Mathew, S. (CoI)
Cancer Prevention & Res Inst of TX
31/08/21 → 30/08/26
Project: Research
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Use of MYR-5A nanoparticles to clear cholesterol from macrophages and foam cells in coronary heart disease
Bunnell, B. (PI)
13/03/23 → 12/03/24
Project: Research
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Erratum: Reduction in SIV replication in rhesus macaques infused with autologous lymphocytes engineered with antiviral genes (Nature Medicine (1998) 4 (181-186))
Donahue, R. E., Bunnell, B. A., Zink, M. C., Metzger, M. E., Westro, R. P., Kirby, M. R., Unangst, T., Clements, J. E. & Morgan, R., 1998, In: Nature Medicine. 4, 5, p. 633 1 p.Research output: Contribution to journal › Comment/debate
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Gender and age-related cell compositional differences in C57BL/6 murine adipose tissue stromal vascular fraction
Frazier, T., Lee, S., Bowles, A., Semon, J., Bunnell, B., Wu, X. & Gimble, J., 3 Jul 2018, In: Adipocyte. 7, 3, p. 183-189 7 p.Research output: Contribution to journal › Article › peer-review
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MSC studies in large-animal models
Bunnell, B. A., Gagliardi, C. & Dias, M. I. R., 1 Jan 2013, Mesenchymal Stromal Cells: Biology and Clinical Applications. Springer New York, p. 237-258 22 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells
Strong, A. L., Jones, R. B., Glowacki, J., Boue, S. M., Burow, M. E. & Bunnell, B. A., Jul 2017, In: Regenerative Medicine. 12, 5, p. 513-524 12 p.Research output: Contribution to journal › Article › peer-review
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Comparative characterization of mesenchymal stem cells from eGFP transgenic and non-transgenic mice
Ripoll, C. B. & Bunnell, B. A., 13 Jan 2009, In: BMC Cell Biology. 10, 3.Research output: Contribution to journal › Article › peer-review