Ayyappa Chaturvedula, PhD

Research output

Research output per year 2003 2014 2016 2018 2019 2020 2023

• 26 Article
• 2 Chapter
• 2 Comment/debate

Research output per year

Research output per year

Search results

• Broader Implications of Modeling and Simulation (M&S) Tools in Pharmacotherapeutic Decisions: A Cautionary Optimism

  Chaturvedula, A., Palasik, B. N., Cho, H. J. & Goyal, N., 29 Apr 2020, In: Frontiers in Pharmacology. 11, 571.

  Research output: Contribution to journal › Article › peer-review

• Subcutaneous concentrations following topical iontophoretic delivery of diclofenac

  Kasha, P., Anderson, C., Morris, R., Sembrowich, W., Chaturvedula, A. & Banga, A., 2011, In: Drug Discoveries & Therapeutics. 6, 5, p. 256-262 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Diclofenac 100%
  • Subcutaneous Tissue 66%
  • Wearable Electronics 50%
  • Drug Delivery 33%
  • In(III) 16%

• In vivo iontophoretic delivery and pharmacokinetics of salmon calcitonin

  Chaturvedula, A., Joshi, D. P., Anderson, C., Morris, R. L., Sembrowich, W. L. & Banga, A. K., 13 Jun 2005, In: International Journal of Pharmaceutics. 297, 1-2, p. 190-196 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Pharmacokinetics 100%
  • Salmon Calcitonin 100%
  • Salcatonin 100%
  • Iontophoretic Patch 50%
  • Pharmacokinetic Parameters 20%

• Investigation of the dermal absorption and irritation potential of sertaconazole nitrate anhydrous gel

  Manian, M., Madrasi, K., Chaturvedula, A. & Banga, A. K., 7 Jul 2016, In: Pharmaceutics. 8, 3, 21.

  Research output: Contribution to journal › Article › peer-review

  • Dermal Absorption 100%
  • Dermal Irritation 100%
  • Absorption Potential 100%
  • Sertaconazole Nitrate 100%
  • Irritation Potential 100%

• Dermal, subdermal, and systemic concentrations of granisetron by iontophoretic delivery

  Chaturvedula, A., Joshi, D. P., Anderson, C., Morris, R., Sembrowich, W. L. & Banga, A. K., Aug 2005, In: Pharmaceutical Research. 22, 8, p. 1313-1319 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Concentration 100%
  • Granisetron Hydrochloride 100%
  • Granisetron 100%
  • Subdermal 100%
  • Iontophoretic Patch 60%

• Diversity in the era of precision medicine - From bench to bedside implementation

  Mamun, A., Nsiah, N. Y., Srinivasan, M., Chaturvedula, A., Basha, R., Cross, D., Jones, H. P., Nandy, K. & Vishwanatha, J. K., 2019, In: Ethnicity and Disease. 29, 3, p. 517-524 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Bench to Bedside 100%
  • Precision Medicine 100%
  • Personalized Medicine 100%
  • Health Disparities 83%
  • Health Disparity 83%

• Model-based predictions of protective HIV pre-exposure prophylaxis adherence levels in cisgender women

  Zhang, L., Iannuzzi, S., Chaturvedula, A., Irungu, E., Haberer, J. E., Hendrix, C. W. & von Kleist, M., Nov 2023, In: Nature Medicine. 29, 11, p. 2753-2762 10 p.

  Research output: Contribution to journal › Article › peer-review

  • AIDS/HIV 100%
  • Model Prediction 100%
  • Adherence Level 100%
  • Cisgender 100%
  • Pre-exposure Prophylaxis (PrEP) 100%

• Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling

  Cicali, B., Lingineni, K., Cristofoletti, R., Wendl, T., Hoechel, J., Wiesinger, H., Chaturvedula, A., Vozmediano, V. & Schmidt, S., Jan 2021, In: CPT: Pharmacometrics and Systems Pharmacology. 10, 1, p. 48-58 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Interactions 100%
  • Binding Partners 100%
  • Physiologically-based Pharmacokinetic Model 100%
  • Levonorgestrel 100%
  • Drug-Drug Interaction 100%

• Determining the Exposure Threshold for Levonorgestrel Efficacy Using an Integrated Model Based Meta-Analysis Approach

  Lingineni, K., Chaturvedula, A., Cicali, B., Cristofoletti, R., Wendl, T., Hoechel, J., Brown, J. D., Vozmediano, V. & Schmidt, S., Feb 2022, In: Clinical Pharmacology and Therapeutics. 111, 2, p. 509-518 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Model-based Analysis 100%
  • Meta-analysis Approach 100%
  • Levonorgestrel 100%
  • Exposure Threshold 100%
  • Ethinylestradiol 44%

• Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

  Lesko, L. J., Vozmediano, V., Brown, J. D., Winterstein, A., Zhao, P., Lippert, J., Höchel, J., Chaturvedula, A., White, A. & Schmidt, S., Nov 2018, In: CPT: Pharmacometrics and Systems Pharmacology. 7, 11, p. 706-708 3 p.

  Research output: Contribution to journal › Comment/debate

  • Drug Interactions 100%
  • Multidisciplinary Framework 100%
  • Hormonal Contraception 100%
  • Drug-Drug Interaction 100%
  • Contraceptive Agent 100%

• Incorporating Pharmacometrics into Pharmacoeconomic Models: Applications from Drug Development

  Srinivasan, M., White, A., Chaturvedula, A., Vozmediano, V., Schmidt, S., Plouffe, L. & Wingate, L. M. T., 1 Oct 2020, In: PharmacoEconomics. 38, 10, p. 1031-1042 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Development 100%
  • Pharmacometrics 100%
  • Pharmacoeconomic Model 100%
  • Pharmacoeconomics 100%
  • Cost-effectiveness 50%

• Population pharmacokinetics of tenofovir and tenofovir-diphosphate in healthy women

  Burns, R. N., Hendrix, C. W. & Chaturvedula, A., 1 Jun 2015, In: Journal of Clinical Pharmacology. 55, 6, p. 629-638 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Population Pharmacokinetics 100%
  • Healthy Women 100%
  • Tenofovir 100%
  • Tenofovir Diphosphate 100%
  • Pharmacokinetics 100%

• Linking the population pharmacokinetics of tenofovir and its metabolites with its cellular uptake and metabolism

  Madrasi, K., Burns, R. N., Hendrix, C. W., Fossler, M. J. & Chaturvedula, A., 1 Jan 2014, In: CPT: Pharmacometrics and Systems Pharmacology. 3, 11, e147.

  Research output: Contribution to journal › Article › peer-review

  • Cellular Uptake 100%
  • Cellular Metabolism 100%
  • Population Pharmacokinetics 100%
  • Tenofovir 100%
  • Pharmacokinetics 100%

• Population pharmacokinetics of tenofovir, emtricitabine and intracellular metabolites in transgender women

  Tanaudommongkon, A., Chaturvedula, A., Hendrix, C. W., Fuchs, E. J., Shieh, E., Bakshi, R. P. & Marzinke, M. A., Aug 2022, In: British Journal of Clinical Pharmacology. 88, 8, p. 3674-3682 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Transgender 100%
  • Emtricitabine 100%
  • Population Pharmacokinetics 100%
  • Intracellular Metabolites 100%
  • Tenofovir 100%

• Assessment of Demographic and Socio-Behavioral Factors on Adherence to HIV Pre-Exposure Prophylaxis Using a Markov Modeling Approach

  the Partners Demonstration Project Team, 12 Jul 2019, In: Frontiers in Pharmacology. 10, 785.

  Research output: Contribution to journal › Article › peer-review

  • Odds Ratio 100%
  • AIDS/HIV 100%
  • Modeling Approach 100%
  • Pre-exposure Prophylaxis (PrEP) 100%
  • Socio-behavioral Factors 100%

• A Systematic Evaluation of Effect of Adherence Patterns on the Sample Size and Power of a Clinical Study

  Mallayasamy, S., Chaturvedula, A., Blaschke, T. & Fossler, M. J., Dec 2018, In: CPT: Pharmacometrics and Systems Pharmacology. 7, 12, p. 818-828 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Systematic Evaluation 100%
  • Adherence Pattern 100%
  • Effect Evaluation 100%
  • Clinical Trial 100%
  • Clinical Study 100%

• Genetic algorithm guided population pharmacokinetic model development for simvastatin, concurrently or non-concurrently co-administered with amlodipine

  Chaturvedul, A., Sale, M. E. & Lee, H., Feb 2014, In: Journal of Clinical Pharmacology. 54, 2, p. 141-149 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Simvastatin 100%
  • Model-driven Development 100%
  • Population Pharmacokinetic Model 100%
  • Genetic Algorithm 100%
  • Hybrid Genetic Algorithm 100%

• Transdermal delivery of methotrexate for pediatrics using silicon microneedles

  Abla, M. J., Chaturvedula, A., O'Mahony, C. & Banga, A. K., May 2013, In: Therapeutic Delivery. 4, 5, p. 543-551 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Methotrexate 100%
  • Pediatric 100%
  • Transdermal Delivery 100%
  • Silicon Microneedles 100%
  • Plasma Concentration 66%

• Population pharmacokinetics of tenofovir in HIV-1-uninfected members of serodiscordant couples and effect of dose reporting methods

  Lu, Y., Goti, V., Chaturvedula, A., Haberer, J. E., Fossler, M. J., Sale, M. E., Bangsberg, D., Baeten, J. M., Celum, C. L. & Hendrix, C. W., 1 Sep 2016, In: Antimicrobial agents and chemotherapy. 60, 9, p. 5379-5386 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Immunodeficiency Virus Type 1 (HIV-1) 100%
  • Population Pharmacokinetics 100%
  • Tenofovir 100%
  • Dosing Information 100%
  • Reporting Methods 100%

• Hospitalized Patients with and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis

  Goti, V., Chaturvedula, A., Fossler, M. J., Mok, S. & Jacob, J. T., 1 Apr 2018, In: Therapeutic drug monitoring. 40, 2, p. 212-221 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemodialysis 100%
  • Hospitalized Patients 100%
  • Model-based Analysis 100%
  • Nomogram 100%
  • Population Pharmacokinetic Model 100%

• Iontophoretic in vivo transdermal delivery of β-blockers in hairless rats and reduced skin irritation by liposomal formulation

  Conjeevaram, R., Chaturvedula, A., Betageri, G. V., Sunkara, G. & Banga, A. K., 1 Sep 2003, In: Pharmaceutical Research. 20, 9, p. 1496-1501 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Beta-blockers 100%
  • Transdermal Delivery 100%
  • Liposomal Formulation 100%
  • Hairless Rat 100%
  • Skin Irritation 100%

• Markov Mixed Effects Modeling Using Electronic Adherence Monitoring Records Identifies Influential Covariates to HIV Preexposure Prophylaxis

  Madrasi, K., Chaturvedula, A., Haberer, J. E., Sale, M., Fossler, M. J., Bangsberg, D., Baeten, J. M., Celum, C. & Hendrix, C. W., May 2017, In: Journal of Clinical Pharmacology. 57, 5, p. 606-615 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Markov Model 100%
  • Markov 100%
  • Mixed-effects Model 100%
  • HIV Pre-exposure Prophylaxis 100%
  • Electronic Adherence Monitoring 100%

• Estimation of tenofovir's population pharmacokinetic parameters without reliable dosing histories and application to tracing dosing history using simulation strategies

  Chaturvedula, A., Fossler, M. J. & Hendrix, C. W., Feb 2014, In: Journal of Clinical Pharmacology. 54, 2, p. 150-160 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Pharmacokinetic Parameters 100%
  • Population Pharmacokinetics 100%
  • Tenofovir 100%
  • Simulation Strategy 100%
  • Pharmacokinetic Parameter 100%

• Population pharmacokinetics

  Chaturvedula, A., 1 Jan 2016, Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents. Springer International Publishing, p. 71-90 20 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Population Pharmacokinetics 100%
  • Pharmacokinetics 100%
  • Drug Development 85%
  • Drug Exposure 40%
  • NONMEM 40%

• In vitro-in vivo correlation: Transdermal drug delivery systems

  Chaturvedula, A. & Banga, A. K., 12 Feb 2007, Pharmaceutical Product Development: In Vitro-In Vivo Correlation. CRC Press, p. 153-176 24 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review