Projects per year
Personal profile
Area of Expertise
My goal is to better understand how the brain controls blood pressure, both under normal conditions and in the presence of disorders that raise blood pressure. Currently, my laboratory focuses on two conditions that lead to high blood pressure: obesity and sleep apnea. Both of these conditions change how the brain controls blood pressure, but the mechanisms are not well understood. Although, ideally, obesity and sleep apnea can be managed, many find it difficult to control body weight in the long term and not may tolerate current treatments for sleep apnea. As these conditions continue to become more prevalent, the cardiovascular disease that accompanies them also becomes a major health issue nationwide. The current treatments for high blood pressure are numerous, and many medications act within the brain to control blood pressure.
Our work examines which treatments are ideal for management of cardiovascular disease with these conditions by determining how the brain changes with obesity and sleep apnea and whether current medications can reverse these changes. Because high blood pressure has many causes, treatments should be individually optimized to best manage control of blood pressure in the context of the conditions that accompany it.
Our work examines which treatments are ideal for management of cardiovascular disease with these conditions by determining how the brain changes with obesity and sleep apnea and whether current medications can reverse these changes. Because high blood pressure has many causes, treatments should be individually optimized to best manage control of blood pressure in the context of the conditions that accompany it.
Education/Academic qualification
BS in Psychology, Emory University
PhD in Neuroscience, University of Pittsburgh
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Projects
- 18 Finished
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Brain Stem Mechanisms for Altered Autonomic Regulation of Blood Pressure in Obesity
NHLBI: Nat Heart, Lung & Blood Institute
1/07/17 → 31/08/21
Project: Research
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Mechanisms for impaired short-term control of blood pressure with obesity
Schreihofer, A. & SCHREIHOFER, A.
1/07/17 → 31/08/21
Project: Research
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Mechanisms for impaired short-term control of blood pressure with obesity
Schreihofer, A. & SCHREIHOFER, A.
National Heart, Lung, and Blood Institute
1/07/17 → 31/08/21
Project: Research
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Preserved glycemic control and baroreflex efficacy in young adult hypertensive female obese Zucker rats
Chaudhary, P., Das-Earl, P. & Schreihofer, A. M., Jun 2021, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 321, 1, p. 62-78 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Improved glucose homeostasis in male obese zucker rats coincides with enhanced baroreflexes and activation of the nucleus tractus solitarius
Chaudhary, P. & Schreihofer, A. M., Dec 2018, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315, 6, p. R1195-R1209Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Exaggerated sympathoexcitatory reflexes develop with changes in the rostral ventrolateral medulla in obese Zucker rats
Huber, D. A. & Schreihofer, A. M., Aug 2016, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 2, p. R243-R253Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Development of attenuated baroreflexes in obese Zucker rats coincides with impaired activation of nucleus tractus solitarius
Guimaraes, P. S., Huber, D. A., Campagnole-Santos, M. J. & Schreihofer, A. M., 1 May 2014, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 306, 9, p. R681-R692Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Increasing angiotensin-(1-7) levels in the brain attenuates metabolic syndrome-related risks in fructose-fed rats
Guimaraes, P. S., Oliveira, M. F., Braga, J. F., Nadu, A. P., Schreihofer, A., Santos, R. A. S. & Campagnole-Santos, M. J., May 2014, In: Hypertension. 63, 5, p. 1078-1085 8 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations