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Research Output 1967 2019

2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S. L., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticle

Lipoproteins
HDL Lipoproteins
Labeling
Imaging techniques
Acids

Identifying and targeting angiogenesis-related microRNAs in ovarian cancer

Chen, X., Mangala, L. S., Mooberry, L., Bayraktar, E., Dasari, S. K., Ma, S., Ivan, C., Court, K. A., Rodriguez-Aguayo, C., Bayraktar, R., Raut, S., Sabnis, N., Kong, X., Yang, X., Lopez-Berestein, G., Lacko, A. G. & Sood, A. K., 15 Aug 2019, In : Oncogene. 38, 33, p. 6095-6108 14 p.

Research output: Contribution to journalArticle

MicroRNAs
Ovarian Neoplasms
Neoplasms
CD36 Antigens
Vascular Endothelial Growth Factor A

The SR-B1 Receptor as a Potential Target for Treating Glioblastoma

Berney, E., Sabnis, N., Panchoo, M., Raut, S., Dickerman, R. & Lacko, A. G., 1 Jan 2019, In : Journal of Oncology. 2019, 1805841.

Research output: Contribution to journalArticle

Open Access
Scavenger Receptors
Glioblastoma
HDL Lipoproteins
Cell Cycle
Sirolimus
2018
4 Citations (Scopus)

Lipoproteins for therapeutic delivery: Recent advances and future opportunities

Raut, S., Dasseux, J. L., Sabnis, N. A., Mooberry, L. & Lacko, A., 1 Jan 2018, In : Therapeutic Delivery. 9, 4, p. 257-268 12 p.

Research output: Contribution to journalReview article

Lipoproteins
Neoplasms
Triglycerides
Therapeutics
Cholesterol
3 Citations (Scopus)

Reconstituted HDL: Drug delivery platform for overcoming biological barriers to cancer therapy

Raut, S., Mooberry, L., Sabnis, N., Garud, A., Dossou, A. S. & Lacko, A., 15 Oct 2018, In : Frontiers in Pharmacology. 9, OCT, 01154.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Neoplasms
Nanoparticles
Therapeutics
Technology
6 Citations (Scopus)
CD36 Antigens
Cell proliferation
Neuroblastoma
Cell Movement
Cell Proliferation
2017
9 Citations (Scopus)

Fluorescence properties of doxorubicin in PBS buffer and PVA films

Shah, S., Chandra, A., Kaur, A., Sabnis, N., Lacko, A., Gryczynski, Z., Fudala, R. & Gryczynski, I., 1 May 2017, In : Journal of Photochemistry and Photobiology B: Biology. 170, p. 65-69 5 p.

Research output: Contribution to journalArticle

Doxorubicin
Buffers
alcohols
buffers
Fluorescence
6 Citations (Scopus)

SR-B1-targeted nanodelivery of anti-cancer agents: A promising new approach to treat triplenegative breast cancer

Johnson, R., Sabnis, N., Sun, X. L., Ahluwalia, R. & Lacko, A. G., 2 Jun 2017, In : Breast Cancer: Targets and Therapy. 9, p. 383-392 10 p.

Research output: Contribution to journalArticle

CD36 Antigens
Triple Negative Breast Neoplasms
HDL Lipoproteins
Breast Neoplasms
Nanoparticles
13 Citations (Scopus)

Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery

Sabnis, S., Sabnis, N. A., Raut, S. & Lacko, A. G., 22 Feb 2017, In : International Journal of Nanomedicine. 12, p. 1453-1464 12 p.

Research output: Contribution to journalArticle

valrubicin
Lipoproteins
HDL Lipoproteins
Drug delivery
Nanoparticles
1 Citation (Scopus)

Ultrasound-stimulated drug delivery of reconstituted high density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake

Xiong, F., Xiong, M., Nirupama, S., Sirsi, S., Lacko, A. G. & Hoyt, K., 31 Oct 2017, 2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 8092380

Research output: Chapter in Book/Report/Conference proceedingConference contribution

lipoproteins
delivery
drugs
tumors
nanoparticles

Ultrasound-stimulated drug delivery of reconstituted high-density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake

Xiong, F., Nirupama, S., Sirsi, S. R., Lacko, A. G. & Hoyt, K., 31 Oct 2017, 2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 8092663

Research output: Chapter in Book/Report/Conference proceedingConference contribution

lipoproteins
delivery
drugs
tumors
nanoparticles
6 Citations (Scopus)

Ultrasound-stimulated drug delivery using therapeutic reconstituted high-density lipoprotein nanoparticles

Xiong, F., Nirupama, S., Sirsi, S. R., Lacko, A. & Hoyt, K., 1 Jan 2017, In : Nanotheranostics. 1, 4, p. 440-449 10 p.

Research output: Contribution to journalArticle

Open Access
Lipoproteins
HDL Lipoproteins
Drug delivery
Nanoparticles
Tumors
2016
9 Citations (Scopus)

Photophysical characterization of anticancer drug valrubicin in rHDL nanoparticles and its use as an imaging agent

Shah, S., Chib, R., Raut, S. L., Bermudez, J., Sabnis, N., Duggal, D., Kimball, J. D., Lacko, A. G., Gryczynski, Z. & Gryczynski, I., 1 Feb 2016, In : Journal of Photochemistry and Photobiology B: Biology. 155, p. 60-65 6 p.

Research output: Contribution to journalArticle

valrubicin
lipoproteins
HDL Lipoproteins
Nanoparticles
drugs
27 Citations (Scopus)

Targeting the SR-B1 receptor as a gateway for cancer therapy and imaging

Mooberry, L. K., Sabnis, N. A., Panchoo, M., Nagarajan, B. & Lacko, A. G., 1 Jan 2016, In : Frontiers in Pharmacology. 7, DEC, 466.

Research output: Contribution to journalReview article

Scavenger Receptors
CD36 Antigens
Neoplasms
Therapeutics
Cholesterol Esters
2015
29 Citations (Scopus)

HDL as a drug and nucleic acid delivery vehicle

Lacko, A. G., Sabnis, N. A., Nagarajan, B. & McConathy, W. J., 1 Jan 2015, In : Frontiers in Pharmacology. 6, OCT, 1 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Nucleic Acids
Pharmaceutical Preparations
Nanoparticles
Cholesterol Esters
2014
36 Citations (Scopus)

A homodimeric BODIPY rotor as a fluorescent viscosity sensor for membrane-mimicking and cellular environments

Raut, S., Kimball, J., Fudala, R., Doan, H., Maliwal, B., Sabnis, N., Lacko, A., Gryczynski, I., Dzyuba, S. V. & Gryczynski, Z., 19 Nov 2014, In : Physical Chemistry Chemical Physics. 16, 48, p. 27037-27042 6 p.

Research output: Contribution to journalArticle

rotors
Rotors
Fluorescence
Viscosity
viscosity
12 Citations (Scopus)

Targeted nanoparticles for pediatric leukemia therapy

Basha, R., Sabnis, N., Heym, K., Bowman, W. P. & Lacko, A. G., 1 Jan 2014, In : Frontiers in Oncology. 4 MAY, 101.

Research output: Contribution to journalReview article

Nanoparticles
Leukemia
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
2013
27 Citations (Scopus)

Pre-clinical evaluation of rHDL encapsulated retinoids for the treatment of neuroblastoma

Sabnis, N., Pratap, S., Akopova, I., Bowman, P. W. & Lacko, A. G., 1 Mar 2013, In : Frontiers in Pediatrics. 1, MAR, 6.

Research output: Contribution to journalArticle

Open Access
Fenretinide
Retinoids
HDL Lipoproteins
Neuroblastoma
Nanoparticles
10 Citations (Scopus)

The potential role of nanotechnology in therapeutic approaches for triple negative breast cancer

Johnson, R., Sabnis, N., McConathy, W. J. & Lacko, A. G., 18 Jun 2013, In : Pharmaceutics. 5, 2, p. 353-370 18 p.

Research output: Contribution to journalReview article

Triple Negative Breast Neoplasms
Nanotechnology
Breast Neoplasms
Survival Rate
Therapeutics
120 Citations (Scopus)

The role of cholesterol metabolism and cholesterol transport in carcinogenesis: A review of scientific findings, relevant to future cancer therapeutics

Cruz, P. M. R., Mo, H., McConathy, W. J., Sabnis, N. & Lacko, A. G., 16 Oct 2013, In : Frontiers in Pharmacology. 4 SEP, Article 119.

Research output: Contribution to journalReview article

Carcinogenesis
Cholesterol
Neoplasms
Therapeutics
Bile Acids and Salts
2012
32 Citations (Scopus)

Drug delivery via lipoprotein-based carriers: Answering the challenges in systemic therapeutics

Sabnis, N. & Lacko, A. G., 1 May 2012, In : Therapeutic Delivery. 3, 5, p. 599-608 10 p.

Research output: Contribution to journalReview article

Lipoproteins
Pharmaceutical Preparations
Therapeutics
Neoplasms
Drug Carriers
36 Citations (Scopus)

Enhanced solubility and functionality of valrubicin (AD-32) against cancer cells upon encapsulation into biocompatible nanoparticles

Sabnis, N., Nair, M., Israel, M., McConathy, W. J. & Lacko, A. G., 5 Dec 2012, In : International Journal of Nanomedicine. 7, p. 975-983 9 p.

Research output: Contribution to journalArticle

valrubicin
Lipoproteins
Encapsulation
Nanoparticles
Solubility
Lipoproteins
Pharmaceutical Preparations
Therapeutics
2011
140 Citations (Scopus)

Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles

Shahzad, M. M. K., Mangala, L. S., Han, H. D., Lu, C., Bottsford-Miller, J., Nishimura, M., Mora, E. M., Lee, J. W., Stone, R. L., Pecot, C. V., Thanapprapasr, D., Roh, J. W., Gaur, P., Nair, M. P., Park, Y. Y., Sabnis, N., Deavers, M. T., Lee, J. S., Ellis, L. M., Lopez-Berestei, G. & 4 others, McConathy, W. J., Prokai, L., Lacko, A. G. & Sood, A. K., 1 Jan 2011, In : Neoplasia. 13, 4, p. 309-319 11 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Nanoparticles
Small Interfering RNA
Scavenger Receptors
Neoplasms
10 Citations (Scopus)

Validation of the reconstituted high-density lipoprotein (rHDL) drug delivery platform using dilauryl fluorescein (DLF)

McConathy, W. J., Paranjape, S., Mooberry, L., Buttreddy, S., Nair, M. & Lacko, A. G., 1 Apr 2011, In : Drug Delivery and Translational Research. 1, 2, p. 113-120 8 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Fluorescein
Pharmaceutical Preparations
Hydrolysis
lauric acid
2010
86 Citations (Scopus)

Receptor mediated uptake of paclitaxel from a synthetic high density lipoprotein nanocarrier

Mooberry, L. K., Nair, M. P., Paranjape, S., McConathy, W. J. & Lacko, A. G., 1 Jan 2010, In : Journal of Drug Targeting. 18, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Paclitaxel
Scavenger Receptors
Nanoparticles
Pharmaceutical Preparations
7 Citations (Scopus)

Studies on solvatochromic properties of aminophenylstyryl-quinolinum dye, LDS 798, and its application in studying submicron lipid based structure

Sarkar, P., Luchowski, R., Raut, S. L., Sabnis, N., Remaley, A., Lacko, A. G., Thamake, S., Gryczynski, Z. & Gryczynski, I., 1 Dec 2010, In : Biophysical Chemistry. 153, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

Coloring Agents
Lipids
Unilamellar Liposomes
Fluorescence Spectrometry
Nanoparticles
2008
10 Citations (Scopus)
Anilino Naphthalenesulfonates
Phosphatidylcholine-Sterol O-Acyltransferase
cholesterol
Fluorescence
fluorescence
96 Citations (Scopus)

Evaluation of synthetic/reconstituted high-density lipoproteins as delivery vehicles for paclitaxel

McConathy, W. J., Nair, M. P., Paranjape, S., Mooberry, L. & Lacko, A. G., 1 Feb 2008, In : Anti-Cancer Drugs. 19, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Paclitaxel
Nanoparticles
Ultracentrifugation
Inhibitory Concentration 50
2007
27 Citations (Scopus)

Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer

Singhal, S. S., Singhal, J., Nair, M. P., Lacko, A. G., Awasthi, Y. C. & Awasthi, S., 1 Mar 2007, In : International Journal of Oncology. 30, 3, p. 717-725 9 p.

Research output: Contribution to journalArticle

Doxorubicin
Lung Neoplasms
Breast Neoplasms
Cell Line
Small Cell Lung Carcinoma
61 Citations (Scopus)

Prospects and challenges of the development of lipoprotein-based formulations for anti-cancer drugs

Lacko, A. G., Nair, M. P., Prokai, L. & McConarthy, W. J., 1 Nov 2007, In : Expert Opinion on Drug Delivery. 4, 6, p. 665-675 11 p.

Research output: Contribution to journalReview article

Lipoproteins
Pharmaceutical Preparations
Neoplasms
Drug Compounding
Drug Carriers
4 Citations (Scopus)

Recent developments and patenting of lipoprotein based formulations.

Lacko, A. G., Stewart, D. R., McClain, R., Prokai, L. & McConathy, W. J., 1 Jan 2007, In : Recent patents on drug delivery & formulation. 1, 2, p. 143-145 3 p.

Research output: Contribution to journalReview article

Lipoproteins
Drug delivery
Pharmaceutical Preparations
Solubility
Chemotherapy
2006
4 Citations (Scopus)

Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase

Reshetnyak, Y., Tchedre, K. T., Nair, M. P., Pritchard, P. H. & Lacko, A. G., Aug 2006, In : Journal of Biomolecular Structure and Dynamics. 24, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Lecithin Cholesterol Acyltransferase Deficiency
Phosphatidylcholine-Sterol O-Acyltransferase
HDL Lipoproteins
Tryptophan
Acrylamide
26 Citations (Scopus)

Trojan horse meets magic bullet to spawn a novel, highly effective drug delivery model

Lacko, A. G., Nair, M. P., Paranjape, S., Mooberry, L. & McConathy, W. J., 1 Jun 2006, In : Chemotherapy. 52, 4, p. 171-173 3 p.

Research output: Contribution to journalArticle

Magic
HDL Lipoproteins
Pharmaceutical Preparations
2004
6 Citations (Scopus)

ApoA-1 Milano and Regression of Atherosclerosis [1] (multiple letters)

Kim, H., Jacobson, E. L., Jacobson, M. K., Lacko, A. G., Sirtori, C. R. & Nissen, S. E., 17 Mar 2004, In : Journal of the American Medical Association. 291, 11, p. 1319-1320 2 p.

Research output: Contribution to journalLetter

Apolipoprotein A-I
HDL Lipoproteins
Phosphatidylcholines
Coronary Artery Disease
Atherosclerosis
21 Citations (Scopus)

Cardiovascular risk factors in Mexican-American children at risk for type 2 diabetes mellitus (T2DM)

Urrutia-Rojas, X., Menchaca, J., Wadley, W., Ahmad, N., Lacko, A. G., Bae, S., Spellman, C., Kudchodkar, B., Kudolo, G. & McConathy, W., 1 Apr 2004, In : Journal of Adolescent Health. 34, 4, p. 290-299 10 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Cardiovascular Diseases
Acanthosis Nigricans
Body Mass Index
Siblings
5 Citations (Scopus)

Characterization of lecithin:cholesterol acyltransferase expressed in a human lung cell line

Lane, S. B., Tchedre, K. T., Nair, M. P., Thigpen, A. E. & Lacko, A. G., 1 Aug 2004, In : Protein Expression and Purification. 36, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Phosphatidylcholine-Sterol O-Acyltransferase
Cell Line
Lung
Enzyme Replacement Therapy
Lecithin Cholesterol Acyltransferase Deficiency
2002
78 Citations (Scopus)

High density lipoprotein complexes as delivery vehicles for anticancer drugs

Lacko, A. G., Nair, M. P., Paranjape, S., Johnson, S. & McConathy, W. J., 19 Aug 2002, In : Anticancer Research. 22, 4, p. 2045-2049 5 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Pharmaceutical Preparations
Cholesterol Esters
Paclitaxel
Scavenger Receptors
2001
14 Citations (Scopus)

High cholesterol diet down regulates the activity of activator protein-1 but not nuclear factor-kappa B in rabbit brain

Kálmán, J., Kudchodkar, B. J., Krishnamoorthy, R., Dory, L., Lacko, A. G. & Agarwal, N., 16 Feb 2001, In : Life Sciences. 68, 13, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

NF-kappa B
Transcription Factor AP-1
Nutrition
Brain
Down-Regulation
7 Citations (Scopus)

Probing the 121-136 domain of lecithin:cholesterol acyltransferase using antibodies

Murray, K. R., Nair, M. P., Ayyobi, A. F., Hill, J. S., Pritchard, P. H. & Lacko, A. G., 15 Jan 2001, In : Archives of Biochemistry and Biophysics. 385, 2, p. 267-275 9 p.

Research output: Contribution to journalArticle

Phosphatidylcholine-Sterol O-Acyltransferase
Antibodies
Enzymes
Mutation
Immunoassay
2000
70 Citations (Scopus)

Apolipoprotein D in the aging brain and in Alzheimer's dementia

Kalman, J., McConathy, W., Araoz, C., Kasa, P. & Lacko, A. G., 1 Jan 2000, In : Neurological Research. 22, 4, p. 330-336 7 p.

Research output: Contribution to journalArticle

Apolipoproteins D
Alzheimer Disease
Brain
Astrocytes
Oligodendroglia
9 Citations (Scopus)

Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source

Ayyobi, A. F., Lacko, A. G., Murray, K., Nair, M. P., Li, M., Molhuizen, H. O. F. & Pritchard, P. H., 24 Feb 2000, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1484, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Phosphatidylcholine-Sterol O-Acyltransferase
Liver
Cricetinae
Glycoproteins
Oligosaccharides
66 Citations (Scopus)

Dietary fat modulates serum paraoxonase 1 activity in rats

Kudchodkar, B. J., Lacko, A. G., Dory, L. & Fungwe, T. V., 13 Oct 2000, In : Journal of Nutrition. 130, 10, p. 2427-2433 7 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Dietary Fats
Serum
Diet
Lipids
46 Citations (Scopus)

Hyperbaric oxygen reduces the progression and accelerates the regression of atherosclerosis in rabbits

Kudchodkar, B. J., Wilson, J., Lacko, A. G. & Dory, L., 1 Jan 2000, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 20, 6, p. 1637-1643 7 p.

Research output: Contribution to journalArticle

Atherosclerosis
Oxygen
Rabbits
Cholesterol
Aryldialkylphosphatase
10 Citations (Scopus)

International symposium on basic aspects of HDL metabolism and disease prevention

Lacko, A. G., Barter, P., Ehnholm, C. & Van Tol, A., 24 Oct 2000, In : Journal of Lipid Research. 41, 10, p. 1695-1699 5 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
RNA-Binding Proteins
Gene Expression Regulation
HDL Lipoproteins
Carrier Proteins
1999

Enzyme linked immunoassay (ELISA) for lecithin:cholesterol acyltransferase (LCAT)

Murray, K. R., Nair, M. P., McConathy, W. J. & Lacko, A. G., 1 Jan 1999, In : Analytical Letters. 32, 8, p. 1553-1564 12 p.

Research output: Contribution to journalArticle

Phosphatidylcholine-Sterol O-Acyltransferase
Lecithin
Cholesterol
Immunoenzyme Techniques
Immunoassay
26 Citations (Scopus)

Evaluation of serum-lipid-related cardiovascular risk factors in Alzheimer's disease

Kálmán, J., Kudchodkar, B. J., Murray, K., McConathy, W. J., Juhász, A., Janka, Z. & Lacko, A. G., 12 Nov 1999, In : Dementia and Geriatric Cognitive Disorders. 10, 6, p. 488-493 6 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Lipids
Serum
Oxidants
HDL Cholesterol
1998
13 Citations (Scopus)

Characterization of recombinant human plasma lecithin: Cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties

Lacko, A. G., Reason, A. J., Nuckolls, C., Kudchodkar, B. J., Nair, M. P., Sundarrajan, G., Pritchard, P. H., Morris, H. R. & Dell, A., 1 Apr 1998, In : Journal of Lipid Research. 39, 4, p. 807-820 14 p.

Research output: Contribution to journalArticle

Plasma (human)
Phosphatidylcholine-Sterol O-Acyltransferase
Carbohydrates
Polysaccharides
Oligosaccharides

Decrease in high density lipoprotein cholesterol (HDL-C) levels following gemfibrozil therapy

Lacko, A. G., Kudchodkar, B. J., Loney, W. W., Clearfield, M. B. & Weis, S., 28 Aug 1998, In : Clinical Chemistry and Laboratory Medicine. 36, 6, p. 389-392 4 p.

Research output: Contribution to journalArticle

Gemfibrozil
HDL Cholesterol
HDL Lipoproteins
Lipoproteins
Triglycerides
15 Citations (Scopus)

Fatty acids modulate lecithin:cholesterol acyltransferase secretion independently of effects on triglyceride secretion in primary rat hepatocytes

Fungwe, T. V., Kudchodkar, B. J., Lacko, A. G. & Dory, L., 1 Aug 1998, In : Journal of Nutrition. 128, 8, p. 1270-1275 6 p.

Research output: Contribution to journalArticle

Phosphatidylcholine-Sterol O-Acyltransferase
Hepatocytes
Triglycerides
Fatty Acids
Apolipoprotein A-I