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A new approach involving drug delivery to cancerous breast tumors is proposed. The method involves the encapsulation of an anti-cancer agent (such as taxol [pacliataxel]) into artificial cholesterol complexes as novel delivery vehicles. These complexes resemble high density lipoproteins (good cholesterol carriers, HDL) and they markedly improve the solubility and transportability of otherwise poorly soluble drugs. The proposed studies include: Testing of the HDL/drug complexes against several breast tumor cells, by comparing their killing potential to that of the free drug and testing the efficacy of the HDL/drug preparation against breast tumors carried by mice (in vivo). Future studies would include clinical trials with appropriate formulations.
If successful, these studies will establish a new generation of chemotherapeutic agents against breast cancer and thus substantially enhance the quality of life and the survival of patients. Furthermore, the proposed formulation may provide an improved treatment modality for breast cancer as the encapsulated drug preparation is expected to have reduced toxicity against normal cells and tissues (particularly heart tissue). This approach has the potential to markedly improve the delivery of anticancer drugs to target tissues and thus improve the chemotherapy and may even provide a cure for breast cancer.

Education/Academic qualification

PhD in Biochemistry, University of Washington

MS in Microbiology, University of British Columbia

BS in Food Technology, University of British Columbia

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Projects 2010 2018

Research Output 1967 2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S. L., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoproteins
HDL Lipoproteins
Labeling
Imaging techniques
Acids
2 Citations (Scopus)

Lipoproteins for therapeutic delivery: Recent advances and future opportunities

Raut, S. L., Dasseux, J. L., Sabnis, N. A., Mooberry, L. & Lacko, A. G., 1 Jan 2018, In : Therapeutic Delivery. 9, 4, p. 257-268 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Lipoproteins
Neoplasms
Triglycerides
Therapeutics
Cholesterol
1 Citation (Scopus)

Reconstituted HDL: Drug delivery platform for overcoming biological barriers to cancer therapy

Raut, S. L., Mooberry, L., Sabnis, N., Garud, A., Dossou, A. S. & Lacko, A. G., 15 Oct 2018, In : Frontiers in Pharmacology. 9, OCT, 01154.

Research output: Contribution to journalReview articleResearchpeer-review

Pharmaceutical Preparations
Neoplasms
Nanoparticles
Therapeutics
Technology
5 Citations (Scopus)

Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion

Panchoo, M. & Lacko, A. G., 1 Jan 2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 614-620 7 p.

Research output: Contribution to journalArticleResearchpeer-review

CD36 Antigens
Cell proliferation
Neuroblastoma
Cell Movement
Cell Proliferation
5 Citations (Scopus)

Fluorescence properties of doxorubicin in PBS buffer and PVA films

Shah, S., Chandra, A., Kaur, A., Sabnis, N., Lacko, A. G., Gryczynski, Z., Fudala, R. & Gryczynski, I., 1 May 2017, In : Journal of Photochemistry and Photobiology B: Biology. 170, p. 65-69 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Doxorubicin
Buffers
alcohols
buffers
Fluorescence