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Personal profile

Area of Expertise

The primary focus of my research is in signal transduction, especially in the context of cancer chemotherapy. One of the major research efforts is to investigate how signal transduction pathways regulate cell survival and cell death. We have been studying how various signaling pathways, such as protein kinase C, Akt, and mechanistic target of rapamycin (mTOR)/S6 kinase (S6K), regulate apoptosis (a genetically programmed cell death), autophagy (a process by which a cell recycles its own components to survive under stressful or nutrient-derived conditions), and senescence (loss of proliferative capacity of cells).
We are using cellular, molecular, and biochemical approaches as well as state-of-the-art technologies, such as proteomics and genomics to determine how an intervention with a signaling pathway can be exploited for cancer therapy.
Another area of research is to investigate the molecular mechanism(s) of drug resistance. The ultimate goal of our research is to identify novel targets for cancer therapy, to exploit intracellular signaling systems to develop innovative strategies to treat cancer, and to identify potential biomarkers to predict patient response to cancer therapy.

Education/Academic qualification

PhD in Biochemistry, University of Pittsburgh School of Medicine

MS in Biochemistry, University of Calcutta

Bachelor in Chemistry (with honors), University of Calcutta

Fingerprint Dive into the research topics where Alakananda Basu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Protein Kinase C Medicine & Life Sciences
Cisplatin Medicine & Life Sciences
Glucosylceramidase Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Cell death Chemical Compounds
Apoptosis Medicine & Life Sciences
Chemical activation Chemical Compounds
Down-Regulation Medicine & Life Sciences

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Projects 2012 2018

Research Output 1984 2019

1 Citation (Scopus)

Differential effects of protein kinase C-eta on apoptosis versus senescence

Basu, A., Pal, D. & Blaydes, R., 1 Mar 2019, In : Cellular Signalling. 55, p. 1-7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Apoptosis
Doxorubicin
Breast Neoplasms
protein kinase C eta
Galactosidases

The enigmatic protein kinase C-eta

Basu, A., 1 Feb 2019, In : Cancers. 11, 2, 214.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
Protein Kinase C
Neoplasms
protein kinase C eta
Glioblastoma
Renal Cell Carcinoma
2 Citations (Scopus)

Protein kinase C-eta regulates Mcl-1 level via ERK1

Pal, D. & Basu, A., 1 Dec 2017, In : Cellular Signalling. 40, p. 166-171 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Myeloid Leukemia
Myeloid Cells
Protein Kinase C
Extracellular Signal-Regulated MAP Kinases
Breast Neoplasms
6 Citations (Scopus)

Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2

Basu, A. & Sridharan, S., 1 Mar 2017, In : PLoS ONE. 12, 3, e0173854.

Research output: Contribution to journalArticleResearchpeer-review

Ribosomal Protein S6 Kinases
Myeloid Leukemia
Myeloid Cells
leukemia
phosphotransferases (kinases)

Emerging therapeutics for targeting Akt in cancer

Gdowski, A., Panchoo, M., Van Treuren, T. & Basu, A., 1 Jan 2016, In : Frontiers in Bioscience - Landmark. 21, 4, p. 757-768 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Protein Isoforms
Cells
Neoplasms
Therapeutics
Proto-Oncogene Proteins c-akt