Projects per year
Personal profile
Research Interests
Signal Transduction, Cancer Biology, Protein kinase C. Akt, S6 kinase, Breast Cancer
Area of Expertise
We are using cellular, molecular, and biochemical approaches as well as state-of-the-art technologies, such as proteomics and genomics to determine how an intervention with a signaling pathway can be exploited for cancer therapy.
Another area of research is to investigate the molecular mechanism(s) of drug resistance. The ultimate goal of our research is to identify novel targets for cancer therapy, to exploit intracellular signaling systems to develop innovative strategies to treat cancer, and to identify potential biomarkers to predict patient response to cancer therapy.
Education/Academic qualification
MS in Biochemistry, University of Calcutta
Bachelor in Chemistry (with honors), University of Calcutta
PhD in Biochemistry, University of Pittsburgh School of Medicine
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Collaborations and top research areas from the last five years
Projects
- 13 Finished
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The involvement of S6 kinase 2 in breast cancer (For: Rohan Joshi)
Basu, A. (PI)
5/06/17 → 31/05/18
Project: Research
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Role of PKC-Epsilon in Autophagy in Breast Cancer (For: Kirti Jain)
Basu, A. (PI)
1/09/13 → 31/08/14
Project: Research
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Protein Kinase C-eta Signaling in Breast Cancer (For: Deepanwita Pal)
Basu, A. (PI)
1/09/13 → 31/08/14
Project: Research
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Role and Regulation of S6 Kinase in Breast Cancer (For: Savitha Sridharan)
Basu, A. (PI)
1/09/13 → 31/08/14
Project: Research
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Chapter 8 Manipulation of PKC Isozymes by RNA Interference and Inducible Expression of PKC Constructs
Basu, A., Persaud, S. D. & Sivaprasad, U., 2008, Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B. Khosravi-Far, R., Zakeri, Z., Lockshin, R. & Piacentini, M. (eds.). p. 141-157 17 p. (Methods in Enzymology; vol. 446).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Suppression of Dexamethasone-induced Metallothionein Expression and as-Diamminedichloroplatinum(II) Resistance by V-mos
Basu, A. & Lazo, J. S., Feb 1991, In: Cancer Research. 51, 3, p. 893-896 4 p.Research output: Contribution to journal › Article › peer-review
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Deregulation of PKB influences antiapoptotic signaling by PKC in breast cancer cells.
Lu, D., Huang, J. & Basu, A., 2004, In: International journal of oncology. 25, 3, p. 671-676 6 p.Research output: Contribution to journal › Article › peer-review
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Down-regulation of caspase-2 by rottlerin via protein kinase C-δ-independent pathway
Basu, A., Adkins, B. & Basu, C., 15 Apr 2008, In: Cancer Research. 68, 8, p. 2795-2802 8 p.Research output: Contribution to journal › Article › peer-review
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Regulation of caspase activation and cis-diamminedichloroplatinum(II)- induced cell death by protein kinase C
Basu, A. & Akkaraju, G. R., 6 Apr 1999, In: Biochemistry. 38, 14, p. 4245-4251 7 p.Research output: Contribution to journal › Article › peer-review