Projects per year
Personal profile
Area of Expertise
The primary focus of my research is in signal transduction, especially in the context of cancer chemotherapy. One of the major research efforts is to investigate how signal transduction pathways regulate cell survival and cell death. We have been studying how various signaling pathways, such as protein kinase C, Akt, and mechanistic target of rapamycin (mTOR)/S6 kinase (S6K), regulate apoptosis (a genetically programmed cell death), autophagy (a process by which a cell recycles its own components to survive under stressful or nutrient-derived conditions), and senescence (loss of proliferative capacity of cells).
We are using cellular, molecular, and biochemical approaches as well as state-of-the-art technologies, such as proteomics and genomics to determine how an intervention with a signaling pathway can be exploited for cancer therapy.
Another area of research is to investigate the molecular mechanism(s) of drug resistance. The ultimate goal of our research is to identify novel targets for cancer therapy, to exploit intracellular signaling systems to develop innovative strategies to treat cancer, and to identify potential biomarkers to predict patient response to cancer therapy.
We are using cellular, molecular, and biochemical approaches as well as state-of-the-art technologies, such as proteomics and genomics to determine how an intervention with a signaling pathway can be exploited for cancer therapy.
Another area of research is to investigate the molecular mechanism(s) of drug resistance. The ultimate goal of our research is to identify novel targets for cancer therapy, to exploit intracellular signaling systems to develop innovative strategies to treat cancer, and to identify potential biomarkers to predict patient response to cancer therapy.
Education/Academic qualification
MS in Biochemistry, University of Calcutta
Bachelor in Chemistry (with honors), University of Calcutta
PhD in Biochemistry, University of Pittsburgh School of Medicine
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Projects
- 10 Finished
The involvement of S6 kinase 2 in breast cancer (For: Rohan Joshi)
5/06/17 → 31/05/18
Project: Research
Role and Regulation of S6 Kinase in Breast Cancer (For: Savitha Sridharan)
1/09/13 → 31/08/14
Project: Research
Role of PKC-Epsilon in Autophagy in Breast Cancer (For: Kirti Jain)
1/09/13 → 31/08/14
Project: Research
Protein Kinase C-eta Signaling in Breast Cancer (For: Deepanwita Pal)
1/09/13 → 31/08/14
Project: Research
Research Output
Distinct roles of mTOR targets S6K1 and S6K2 in breast cancer
Sridharan, S. & Basu, A., 2 Feb 2020, In : International journal of molecular sciences. 21, 4, 1199.Research output: Contribution to journal › Review article
Open Access
Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells
Basu, A., 15 Jun 2020, In : International journal of molecular sciences. 21, 12Research output: Contribution to journal › Article
Open Access
Differential effects of protein kinase C-eta on apoptosis versus senescence
Basu, A., Pal, D. & Blaydes, R., Mar 2019, In : Cellular Signalling. 55, p. 1-7 7 p.Research output: Contribution to journal › Article
1
Scopus
citations
The emerging roles of mTORC1 in macromanaging autophagy
Dossou, A. S. & Basu, A., Oct 2019, In : Cancers. 11, 10, 1422.Research output: Contribution to journal › Review article
Open Access
3
Scopus
citations
The enigmatic protein kinase C-eta
Basu, A., Feb 2019, In : Cancers. 11, 2, 214.Research output: Contribution to journal › Review article
Open Access