• 6363 Citations
  • 33 h-Index
1984 …2020

Research output per year

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Personal profile

Area of Expertise

The primary focus of my research is in signal transduction, especially in the context of cancer chemotherapy. One of the major research efforts is to investigate how signal transduction pathways regulate cell survival and cell death. We have been studying how various signaling pathways, such as protein kinase C, Akt, and mechanistic target of rapamycin (mTOR)/S6 kinase (S6K), regulate apoptosis (a genetically programmed cell death), autophagy (a process by which a cell recycles its own components to survive under stressful or nutrient-derived conditions), and senescence (loss of proliferative capacity of cells).
We are using cellular, molecular, and biochemical approaches as well as state-of-the-art technologies, such as proteomics and genomics to determine how an intervention with a signaling pathway can be exploited for cancer therapy.
Another area of research is to investigate the molecular mechanism(s) of drug resistance. The ultimate goal of our research is to identify novel targets for cancer therapy, to exploit intracellular signaling systems to develop innovative strategies to treat cancer, and to identify potential biomarkers to predict patient response to cancer therapy.

Education/Academic qualification

MS in Biochemistry, University of Calcutta

Bachelor in Chemistry (with honors), University of Calcutta

PhD in Biochemistry, University of Pittsburgh School of Medicine

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Research Output

Distinct roles of mTOR targets S6K1 and S6K2 in breast cancer

Sridharan, S. & Basu, A., 2 Feb 2020, In : International journal of molecular sciences. 21, 4, 1199.

Research output: Contribution to journalReview article

Open Access
  • 2 Scopus citations

    Regulation of autophagy by protein kinase C-ε in breast cancer cells

    Basu, A., 2 Jun 2020, In : International journal of molecular sciences. 21, 12, p. 1-11 11 p., 4247.

    Research output: Contribution to journalArticle

    Open Access
  • Differential effects of protein kinase C-eta on apoptosis versus senescence

    Basu, A., Pal, D. & Blaydes, R., Mar 2019, In : Cellular Signalling. 55, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    The emerging roles of mTORC1 in macromanaging autophagy

    Dossou, A. S. & Basu, A., Oct 2019, In : Cancers. 11, 10, 1422.

    Research output: Contribution to journalReview article

    Open Access
  • 11 Scopus citations

    The enigmatic protein kinase C-eta

    Basu, A., Feb 2019, In : Cancers. 11, 2, 214.

    Research output: Contribution to journalReview article

    Open Access