Abe Clark, PhD

Research output

Research output per year 1979 1997 2001 2003 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2023

• 216 Article
• 20 Review article
• 10 Chapter
• 8 Short survey
• 13 More
  • 6 Editorial
  • 4 Comment/debate
  • 1 Book
  • 1 Foreword/postscript
  • 1 Letter

Research output per year

Research output per year

Search results

• Transcript annotation prioritization and screening system (TrAPSS) for mutation screening

  O'Leary, B. M., Davis, S. G., Smith, M. F., Brown, B., Kemp, M. B., Almabrazi, H., Grundstand, J. A., Burns, T., Leontiev, V., Andorf, J., Clark, A. F., Sheffield, V. C., Casavant, T. L., Scheetz, T. E., Stone, E. M. & Braun, T. A., Dec 2007, In: Journal of Bioinformatics and Computational Biology. 5, 6, p. 1155-1172 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Genes 100%
  • Screening 97%
  • Mutation 88%
  • Exons 54%
  • Genomics 40%

• A comparison of gene expression profiles between glucocorticoid responder and non-responder bovine trabecular meshwork cells using RNA sequencing

  Bermudez, J. Y., Webber, H. C., Brown, B., Braun, T. A., Clark, A. F. & Mao, W., Jan 2017, In: PLoS ONE. 12, 1, e0169671.

  Research output: Contribution to journal › Article › peer-review

  • RNA Sequencing 100%
  • Trabecular Meshwork 80%
  • Glucocorticoid 77%
  • Ocular 77%
  • RNA Sequence Analysis 67%

• Effect of exogenous neurotrophins on Trk receptor phosphorylation, cell proliferation, and neurotrophin secretion by cells isolated from the human lamina cribrosa

  Lambert, W. S., Clark, A. F. & Wordinger, R. J., 19 Apr 2004, In: Molecular vision. 10, p. 289-296 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Nerve Growth Factors 100%
  • Optic Disk 85%
  • Phosphorylation 64%
  • Cell Proliferation 61%
  • Astrocytes 55%

• Experimental corticosteroid myopathy: Effect on myofibrillar ATPase activity and protein degradation

  Clark, A. F. & Vignos, P. J., 1979, In: Muscle & Nerve. 2, 4, p. 265-273 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscular Diseases 100%
  • Adenosine Triphosphatases 93%
  • Proteolysis 87%
  • Adrenal Cortex Hormones 75%
  • Rabbits 66%

• Connective tissue growth factor is increased in pseudoexfoliation glaucoma

  Browne, J. G., Ho, S. L., Kane, R., Oliver, N., Clark, A. F., O'Brien, C. J. & Crean, J. K., May 2011, In: Investigative Ophthalmology and Visual Science. 52, 6, p. 3660-3666 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Connective Tissue Growth Factor 100%
  • Glaucoma 71%
  • Trabecular Meshwork 41%
  • Aqueous Humor 29%
  • Fibrillin-1 28%

• Mechanism of Action of the Angiostatic Cortisene Anecortave Acetate

  Clark, A. F., Jan 2007, In: Survey of Ophthalmology. 52, 1 SUPPL., p. S26-S34

  Research output: Contribution to journal › Article › peer-review

  • anecortave acetate 100%
  • Angiogenesis Inhibitors 61%
  • Angiogenesis Inducing Agents 38%
  • Glucocorticoids 30%
  • Acetates 16%

• Aqueous outflow-enhancing effect of tert-butylhydroquinone: Involvement of AP-1 activation and MMP-3 expression

  Pang, I. H., Fleenor, D. L., Hellberg, P. E., Stropki, K., McCartney, M. D. & Clark, A. F., 1 Aug 2003, In: Investigative Ophthalmology and Visual Science. 44, 8, p. 3502-3510 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-tert-butylhydroquinone 100%
  • Transcription Factor AP-1 65%
  • Matrix Metalloproteinases 56%
  • prostromelysin 46%
  • SR 11302 35%

• Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head

  Fuller, J. A., Brun-Zinkernagel, A. M., Clark, A. F. & Wordinger, R. J., Dec 2009, In: Investigative Ophthalmology and Visual Science. 50, 12, p. 5759-5768 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Proprotein Convertases 100%
  • Optic Disk 74%
  • Human Activities 67%
  • Retina 58%
  • Nerve Tissue 13%

• Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice

  Patel, G. C., Liu, Y., Millar, J. C. & Clark, A. F., 1 Dec 2018, In: Scientific Reports. 8, 1, 862.

  Research output: Contribution to journal › Article › peer-review

  • Ocular Hypertension 100%
  • Glucocorticoid Receptors 88%
  • Glucocorticoids 72%
  • Trabecular Meshwork 58%
  • Eye 16%

• Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture.

  Kirwan, R. P., Felice, L., Clark, A. F., O'Brien, C. J. & Leonard, M. O., Apr 2012, In: Investigative ophthalmology & visual science. 53, 4, p. 2243-2255 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Optic Nerve 100%
  • Hypoxia 76%
  • Cell Culture Techniques 73%
  • Extracellular Matrix 40%
  • Genes 38%

• Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

  Murphy, R., Irnaten, M., Hopkins, A., O'Callaghan, J., Stamer, W. D., Clark, A. F., Wallace, D. & O'Brien, C. J., Jan 2022, In: Investigative Ophthalmology and Visual Science. 63, 1, 16.

  Research output: Contribution to journal › Article › peer-review

  • Human YAP1 (Yes-associated) protein 100%
  • Glaucoma 45%
  • Proteins 17%
  • Verteporfin 13%
  • alpha 1 chain collagen type I 5%

• Existence of the canonical wnt signaling pathway in the human trabecular meshwork

  Mao, W., Cameron Millar, J., Wang, W. H., Silverman, S. M., Liu, Y., Wordinger, R. J., Rubin, J. S., Pang, I. H. & Clark, A. F., Oct 2012, In: Investigative Ophthalmology and Visual Science. 53, 11, p. 7043-7051 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Wnt Signaling Pathway 85%
  • frizzled related protein-1 58%
  • Luciferases 19%
  • Catenins 17%

• Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma

  Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., Feb 2018, In: Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Signaling 100%
  • transcription factor NF-AT c3 81%
  • Glaucoma 80%
  • Extracellular Matrix 27%
  • Calcineurin 16%

• Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol

  Clark, A., Lane, D., Wilson, K., Miggans, S. T. & McCartney, M. D., 23 Apr 1996, In: Investigative Ophthalmology and Visual Science. 37, 5, p. 805-813 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Tetrahydrocortisol 100%
  • Trabecular Meshwork 77%
  • Dexamethasone 53%
  • Glucocorticoids 26%
  • Glucocorticoid Receptors 24%

• Soluble CD44 Is cytotoxic to trabecular meshwork and retinal ganglion cells in vitro

  Choi, J., Miller, A. M., Nolan, M. J., Yue, B. Y. J. T., Thotz, S. T., Clark, A. F., Agarwal, N. & Knepper, P. A., Jan 2005, In: Investigative Ophthalmology and Visual Science. 46, 1, p. 214-222 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Retinal Ganglion Cells 85%
  • In Vitro Techniques 32%
  • Cell Survival 25%
  • Caspase Inhibitors 20%

• Glucocorticoid receptor transactivation is required for glucocorticoid-induced ocular hypertension and glaucoma

  Patel, G. C., Millar, J. C. & Clark, A. F., May 2019, In: Investigative Ophthalmology and Visual Science. 60, 6, p. 1967-1978 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ocular Hypertension 100%
  • Trabecular Meshwork 90%
  • Glucocorticoid Receptors 88%
  • Glaucoma 75%
  • Glucocorticoids 72%

• Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization

  Swiderski, R. E., Ross, J. L., Fingert, J. H., Clark, A. F., Alward, W. L. M., Stone, E. M. & Sheffield, V. C., 2000, In: Investigative Ophthalmology and Visual Science. 41, 11, p. 3420-3428 9 p.

  Research output: Contribution to journal › Article › peer-review

  • trabecular meshwork-induced glucocorticoid response protein 100%
  • Optic Nerve 62%
  • In Situ Hybridization 55%
  • Eye 37%
  • Sclera 31%

• Acute effects of glaucoma medications on rat intraocular pressure

  Pang, I-H., Wang, W. H. & Clark, A., 1 Feb 2005, In: Experimental eye research. 80, 2, p. 207-214 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Intraocular Pressure 100%
  • Glaucoma 96%
  • Latanoprost 27%
  • Betaxolol 20%
  • Topical Administration 16%

• Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

  McDowell, C. M., Kizhatil, K., Elliott, M. H., Overby, D. R., van Batenburg-Sherwood, J., Cameron Millar, J., Kuehn, M. H., Zode, G., Acott, T. S., Anderson, M. G., Bhattacharya, S. K., Bertrand, J. A., Borras, T., Bovenkamp, D. E., Cheng, L., Danias, J., De Ieso, M. L., Du, Y., Faralli, J. A., Fuchshofer, R., & 60 othersGanapathy, P. S., Gong, H., Herberg, S., Hernandez, H., Humphries, P., John, S. W. M., Kaufman, P. L., Keller, K. E., Kelley, M. J., Kelly, R. A., Krizaj, D., Kumar, A., Leonard, B. C., Lieberman, R. L., Liton, P., Liu, Y., Liu, K. C., Lopez, N. N., Mao, W., Mavlyutov, T., McDonnell, F., McLellan, G. J., Mzyk, P., Nartey, A., Pasquale, L. R., Patel, G. C., Pattabiraman, P. P., Peters, D. M., Raghunathan, V., Rao, P. V., Rayana, N., Raychaudhuri, U., Reina-Torres, E., Ren, R., Rhee, D., Chowdhury, U. R., Samples, J. R., Griffen Samples, E., Sharif, N., Schuman, J. S., Sheffield, V. C., Stevenson, C. H., Soundararajan, A., Subramanian, P., Sugali, C. K., Sun, Y., Toris, C. B., Torrejon, K. Y., Vahabikashi, A., Vranka, J. A., Wang, T., Willoughby, C. E., Xin, C., Yun, H., Zhang, H. F., Fautsch, M. P., Tamm, E. R., Clark, A. F., Ross Ethier, C. & Daniel Stamer, W., Feb 2022, In: Investigative Ophthalmology and Visual Science. 63, 2, 12.

  Research output: Contribution to journal › Article › peer-review

  • Ocular Hypertension 100%
  • Aqueous Humor 94%
  • Intraocular Pressure 19%
  • Anatomy 16%
  • Homeostasis 14%

• Ocular hypotensive and aqueous outflow-enhancing effects of AL-3037A (Sodium ferri ethylenediaminetetraacetate)

  Pang, I. H., Moll, H., McLaughlin, M. A., Knepper, P. A., De Santis, L., Epstein, D. L. & Clark, A. F., 2001, In: Experimental eye research. 73, 6, p. 815-825 11 p.

  Research output: Contribution to journal › Article › peer-review

  • AL3037A 100%
  • Intraocular Pressure 33%
  • Eye 24%
  • Perfusion 10%
  • Rabbits 10%

• Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells

  Sethi, A., Wordinger, R. J. & Clark, A. F., Aug 2013, In: Experimental eye research. 113, p. 117-127 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein-Lysine 6-Oxidase 100%
  • Trabecular Meshwork 92%
  • Genes 27%
  • p38 Mitogen-Activated Protein Kinases 26%
  • Intraocular Pressure 25%

• Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage

  Pang, I. H., Johnson, E. C., Jia, L., Cepurna, W. O., Shepard, A. R., Hellberg, M. R., Clark, A. F. & Morrison, J. C., Apr 2005, In: Investigative Ophthalmology and Visual Science. 46, 4, p. 1313-1321 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Optic Nerve Diseases 100%
  • Optic Disk 89%
  • Nitric Oxide Synthase Type II 84%
  • Optic Nerve 83%
  • Pressure 52%

• Corticosteroid-induced ocular hypertension in cynomolgus monkeys

  Clark, A. F., McLaughlin, M. A., Tuttle, L. & Chandler, M. L., 15 Feb 1996, In: Investigative Ophthalmology and Visual Science. 37, 3, p. S202

  Research output: Contribution to journal › Article › peer-review

  • Ocular Hypertension 100%
  • Macaca fascicularis 97%
  • Ophthalmic Administration 86%
  • Haplorhini 73%
  • Topical Administration 68%

• Histopathologic analysis of experimental autoimmune uveitis attenuated by intracameral injection of s-antigen

  Mizuno, K., Altman, N. F., Clark, A. F. & Streilein, J. W., 1989, In: Current Eye Research. 8, 1, p. 113-121 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Uveitis 100%
  • Antigens 56%
  • Injections 51%
  • Eye 31%
  • Immune Privilege 18%

• Cultured human trabecular meshwork cells express functional growth factor receptors

  Wordinger, R. J., Clark, A. F., Agarwal, R., McNatt, L., Wilson, S. E., Qu, E. & Fung, B. K. K., 1 Dec 1997, In: Investigative Ophthalmology and Visual Science. 38, 4, p. S562

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Growth Factor Receptors 88%
  • Fibroblast Growth Factor 2 22%
  • Cell Proliferation 21%
  • Intercellular Signaling Peptides and Proteins 17%