Abe Clark, PhD

Research output

Research output per year 1979 1997 2001 2003 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2022

• 216 Article
• 19 Review article
• 9 Chapter
• 8 Short survey
• 13 More
  • 6 Editorial
  • 4 Comment/debate
  • 1 Book
  • 1 Foreword/postscript
  • 1 Letter

Research output per year

Research output per year

Search results

• TGFβ2 induces the formation of cross-linked actin networks (CLANs) in human trabecular meshwork cells through the smad and non-smad dependent pathways

  Montecchi-Palmer, M., Bermudez, J. Y., Webber, H. C., Patel, G. C., Clark, A. F. & Mao, W., Feb 2017, In: Investigative Ophthalmology and Visual Science. 58, 2, p. 1288-1295 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Transforming Growth Factors 78%
  • Actins 63%
  • Extracellular Signal-Regulated MAP Kinases 36%
  • JNK Mitogen-Activated Protein Kinases 28%

• Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma

  Jain, A., Liu, X., Wordinger, R. J., Yorio, T., Cheng, Y. Q. & Clark, A. F., 2013, In: Investigative Ophthalmology and Visual Science. 54, 5, p. 3137-3142 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Glaucoma 70%
  • Glucocorticoids 68%
  • Steroids 55%
  • Intraocular Pressure 32%

• Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders

  Fingert, J. H., Alward, W. L., Wang, K., Yorio, T. & Clark, A. F., 2010, In: Molecular vision. 16, p. 596-601 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Open Angle Glaucoma 100%
  • Glucocorticoid Receptors 97%
  • tacrolimus binding protein 4 75%
  • Single Nucleotide Polymorphism 73%
  • Steroids 65%

• Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice

  Sharma, T. P., McDowell, C. M., Liu, Y., Wagner, A. H., Thole, D., Faga, B. P., Wordinger, R. J., Braun, T. A. & Clark, A. F., 27 Apr 2014, In: Molecular Neurodegeneration. 9, 1, 14.

  Research output: Contribution to journal › Article › peer-review

  • Nerve Crush 100%
  • Optic Nerve 74%
  • Retina 62%
  • Gene Expression 43%
  • Nervous System Trauma 33%

• Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues

  Wordinger, R. J., Agarwal, R., Talati, M., Fuller, J., Lambert, W. & Clark, A., 1 Dec 2002, In: Molecular Vision. 8, p. 241-250 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Morphogenetic Protein Receptors 100%
  • Trabecular Meshwork 90%
  • Bone Morphogenetic Proteins 82%
  • Nerve Tissue 77%
  • Optic Disk 75%

• The similarity of protein expression in trabecular meshwork and lamina cribrosa: Implications for glaucoma

  Steely, H. T., English-Wright, S. L. & Clark, A., 1 Jan 2000, In: Experimental eye research. 70, 1, p. 17-30 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Glaucoma 70%
  • Eye 30%
  • Proteins 27%
  • Cultured Cells 21%

• Anterior chamber perfusion versus posterior chamber perfusion does not influence measurement of aqueous outflow facility in living mice by constant flow infusion

  Lopez, N. N., Patel, G. C., Raychaudhuri, U., Aryal, S., Phan, T. N., Clark, A. F. & Millar, J. C., Nov 2017, In: Experimental eye research. 164, p. 95-108 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Anterior Chamber 100%
  • Perfusion 69%
  • Tropicamide 48%
  • Eye 19%
  • Mydriatics 16%

• CRISPR-Cas9–based treatment of myocilin-associated glaucoma

  Jain, A., Zode, G., Kasetti, R. B., Ran, F. A., Yan, W., Sharma, T. P., Bugge, K., Searby, C. C., Fingert, J. H., Zhang, F., Clark, A. F. & Sheffield, V. C., 17 Oct 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11199-11204 6 p.

  Research output: Contribution to journal › Article › peer-review

  • trabecular meshwork-induced glucocorticoid response protein 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 69%
  • Glaucoma 57%
  • Gene Editing 55%
  • Open Angle Glaucoma 51%

• Increased global DNA methylation and decreased TGFβ1 promoter methylation in glaucomatous lamina cribrosa cells

  McDonnell, F. S., Mcnally, S. A., Clark, A. F., O'brien, C. J. & Wallace, D. M., 1 Oct 2016, In: Journal of Glaucoma. 25, 10, p. e834-e842

  Research output: Contribution to journal › Article › peer-review

  • Transforming Growth Factors 100%
  • DNA Methylation 93%
  • Methylation 86%
  • Glaucoma 45%
  • Fibrosis 26%

• Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol

  Clark, A., Lane, D., Wilson, K., Miggans, S. T. & McCartney, M. D., 23 Apr 1996, In: Investigative Ophthalmology and Visual Science. 37, 5, p. 805-813 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Tetrahydrocortisol 100%
  • Trabecular Meshwork 77%
  • Dexamethasone 53%
  • Glucocorticoids 26%
  • Glucocorticoid Receptors 24%

• Optimal procedure for extracting RNA from human ocular tissues and expression profiling of the congenital glaucoma gene FOXCI using quantitative RT-PCR

  Wang, W. H., McNatt, L. G., Shepard, A. R., Jacobson, N., Nishimura, D. Y., Stone, E. M., Sheffield, V. C. & Clark, A. F., 2001, In: Molecular vision. 7, p. 89-94 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Glaucoma 100%
  • RNA 73%
  • Eye 65%
  • Polymerase Chain Reaction 62%
  • Genes 42%

• Animal models of glucocorticoid-induced glaucoma

  Overby, D. R. & Clark, A. F., 13 Apr 2015, In: Experimental eye research. 141, p. 15-22 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Glaucoma 100%
  • Glucocorticoids 96%
  • Animal Models 76%
  • Ocular Hypertension 75%
  • Open Angle Glaucoma 51%

• Basic sciences in clinical glaucoma: Steroids, ocular hypertension, and glaucoma

  Clark, A., 1 Jan 1995, In: Journal of Glaucoma. 4, 5, p. 354-369 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Ocular Hypertension 100%
  • Glaucoma 75%
  • Glucocorticoids 72%
  • Steroids 59%
  • Trabecular Meshwork 35%

• Anterior Juxtascleral Delivery of Anecortave Acetate in Eyes with Primary Open-Angle Glaucoma: A Pilot Investigation

  Robin, A. L., Clark, A. F., Covert, D. W., Krueger, S., Bergamini, M. V. W., Landry, T. A., Dickerson, J. E., Scheib, S. A., Realini, T., Defaller, J. M. & Cagle, G. D., Jan 2009, In: American Journal of Ophthalmology. 147, 1, p. 45-50.e2

  Research output: Contribution to journal › Article › peer-review

  • anecortave acetate 100%
  • Open Angle Glaucoma 58%
  • Intraocular Pressure 49%
  • Eye 31%
  • Injections 8%

• Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor β

  Zhang, X., Ognibene, C. M., Clark, A. F. & Yorio, T., Feb 2007, In: Experimental eye research. 84, 2, p. 275-284 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Cytophagocytosis 97%
  • Glucocorticoid Receptors 83%
  • Dexamethasone 68%
  • Glucocorticoids 11%

• Crosstalk between transforming growth factor beta-2 and toll-like receptor 4 in the trabecular meshwork

  Hernandez, H., Medina-Ortiz, W. E., Luan, T., Clark, A. F. & McDowell, C. M., Mar 2017, In: Investigative Ophthalmology and Visual Science. 58, 3, p. 1811-1823 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Toll-Like Receptor 4 86%
  • Transforming Growth Factor beta 68%
  • Fibronectins 29%
  • Ocular Hypertension 28%

• Intra-cellular calcium signaling pathways (Pkc, ras/raf/mapk, pi3k) in lamina cribrosa cells in glaucoma

  Irnaten, M., Duff, A., Clark, A. & O’brien, C., Jan 2021, In: Journal of Clinical Medicine. 10, 1, p. 1-14 14 p., 62.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Signaling 100%
  • Glaucoma 80%
  • Protein Kinase C 53%
  • Mitogen-Activated Protein Kinase 1 47%
  • Phosphatidylinositol 3-Kinases 41%

• Mechanism of Action of the Angiostatic Cortisene Anecortave Acetate

  Clark, A. F., Jan 2007, In: Survey of Ophthalmology. 52, 1 SUPPL., p. S26-S34

  Research output: Contribution to journal › Article › peer-review

  • anecortave acetate 100%
  • Angiogenesis Inhibitors 61%
  • Angiogenesis Inducing Agents 38%
  • Glucocorticoids 30%
  • Acetates 16%

• Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice

  McDowell, C. M., Tebow, H. E., Wordinger, R. J. & Clark, A. F., Nov 2013, In: Experimental eye research. 116, p. 419-423 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Transforming Growth Factor beta2 100%
  • Trabecular Meshwork 83%
  • Ocular Hypertension 78%
  • Fibronectins 36%
  • Intraocular Pressure 36%

• Activation of stretch-activated channels and maxi-K⁺ channels by membrane stress of human lamina cribrosa cells

  Irnaten, M., Barry, R. C., Quill, B., Clark, A. F., Harvey, B. J. P. & O'Brien, C. J., Jan 2009, In: Investigative Ophthalmology and Visual Science. 50, 1, p. 194-202 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Large-Conductance Calcium-Activated Potassium Channels 100%
  • Membranes 42%
  • Cell Membrane 13%
  • Cell Size 12%
  • Ion Channels 11%

• Preclinical Efficacy of Anecortave Acetate

  Clark, A. F., 1 Jan 2007, In: Survey of Ophthalmology. 52, 1 SUPPL., p. S41-S48

  Research output: Contribution to journal › Article › peer-review

  • anecortave acetate 100%
  • Choroidal Neovascularization 31%
  • Macular Degeneration 26%
  • Eye 15%

• Human optic nerve head astrocytes as a target for endothelin-1

  Prasanna, G., Krishnamoorthy, R., Clark, A. F., Wordinger, R. J. & Yorio, T., 2002, In: Investigative Ophthalmology and Visual Science. 43, 8, p. 2704-2713 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Optic Disk 100%
  • Endothelin-1 97%
  • Astrocytes 82%
  • BQ 610 29%
  • BQ 788 24%

• Fractionation and quantification of calcium-dependent proteinase activity from small tissue samples

  Clark, A. F., DeMartino, G. N. & Croall, D. E., 1986, In: Biochemical Journal. 235, 1, p. 279-282 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytidine Diphosphate 100%
  • Fractionation 56%
  • Peptide Hydrolases 54%
  • Calcium 44%
  • Affinity Chromatography 31%

• Gremlin induces ocular hypertension in mice through Smad3-dependent signaling

  McDowell, C. M., Hernandez, H., Mao, W. & Clark, A. F., 2015, In: Investigative Ophthalmology and Visual Science. 56, 9, p. 5485-5492 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Ocular Hypertension 94%
  • Fibronectins 27%
  • Bone Morphogenetic Proteins 22%
  • Extracellular Matrix Proteins 20%

• Assessment of blood-born biochemical markers in primary open angle glaucoma

  Goode, S., Lane, D., McNatt, L. & Clark, A., 15 Feb 1996, In: Investigative Ophthalmology and Visual Science. 37, 3

  Research output: Contribution to journal › Article › peer-review

  • Open Angle Glaucoma 100%
  • Hydroxysteroid Dehydrogenases 59%
  • Biomarkers 57%
  • Leukocytes 34%
  • Ouabain 33%