Abe Clark, PhD

Research output

Research output per year 1979 1997 2001 2003 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2025

• 220 Article
• 20 Review article
• 11 Chapter
• 8 Short survey
• 13 More
  • 6 Editorial
  • 4 Comment/debate
  • 1 Book
  • 1 Foreword/postscript
  • 1 Letter

Research output per year

Research output per year

Search results

• Viral vector induced ocular hypertension in mice. Chapter 9, Retinal Ganglion Cells: Methods and Protocols

  Millar, C., Sundaresan, Y., Zode, G. S. & Clark, A., 10 Aug 2023, In: Methods in molecular biology (Clifton, N.J.). 2708, p. 77-79 3 p., Chapter 9.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Ocular Hypertension 100%
  • Viral Vectors 100%
  • Retinal Ganglion Cells 100%
  • Cell-based 100%

• Gene expression profile of the adult human retinal ganglion cell layer

  Kim, C. Y., Kuehn, M. H., Clark, A. F. & Kwon, Y. H., 22 Dec 2006, In: Molecular vision. 12, p. 1640-1648 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ganglion Cell-inner Plexiform Layer (GC-IPL) 100%
  • Gene Expression Profile 100%
  • Retinal Ganglion Cell Layer 100%
  • Adult Humans 100%
  • Retinal Ganglion Cell 100%

• Viral Vector-Induced Ocular Hypertension in Mice

  Millar, J. C., Sundaresan, Y., Zode, G. S. & Clark, A. F., 2023, Methods in Molecular Biology. Humana Press Inc., p. 77-97 21 p. (Methods in Molecular Biology; vol. 2708).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Trabecular Meshwork 100%
  • Ocular Hypertension 100%
  • Viral Vectors 100%
  • Aqueous Humor Outflow 100%
  • Virus Vector 100%

• Disproportionate reduction of actin synthesis in hearts of starved rats

  Clark, A. F. & Wildenthal, K., 1986, In: Journal of Biological Chemistry. 261, 28, p. 13168-13172 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Actin 100%
  • Starvation 83%
  • Protein Synthesis 37%
  • Myosin Heavy Chain (MyHC) 33%
  • Cardiac Actin 33%

• Evaluation of Cross-Linked Actin Networks (CLANs) in Human Trabecular Meshwork Cells and Tissues

  Patel, P. D. & Clark, A. F., 2025, Methods in Molecular Biology. Humana Press Inc., p. 1-15 15 p. (Methods in Molecular Biology; vol. 2858).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Actin 100%
  • Intraocular Pressure 33%
  • Aqueous Humor Outflow 22%
  • Cell Rearrangement 14%
  • Prevalence 11%

• Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells

  Shepard, A. R., Jacobson, N., Fingert, J. H., Stone, E. M., Sheffield, V. C. & Clark, A. F., 2001, In: Investigative Ophthalmology and Visual Science. 42, 13, p. 3173-3181 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork Cells 100%
  • Myocilin 100%
  • Glucocorticoid Responsiveness 100%
  • Glucocorticoid 100%
  • Trabecular Meshwork 100%

• Inhibition of intraocular tumor growth by topical application of the angiostatic steroid anecortave acetate

  Clark, A. F., Mellon, J., Li, X. Y., Ma, D., Leher, H., Apte, R., Alizadeh, H., Hegde, S., McLenaghan, A., Mayhew, E., D'Orazio, T. J. & Niederkorn, J. Y., Aug 1999, In: Investigative Ophthalmology and Visual Science. 40, 9, p. 2158-2162 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Growth 100%
  • Acetate 100%
  • Angiostatic 100%
  • Topical Application 100%
  • Intraocular Tumor 100%

• Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization

  Swiderski, R. E., Ross, J. L., Fingert, J. H., Clark, A. F., Alward, W. L. M., Stone, E. M. & Sheffield, V. C., 2000, In: Investigative Ophthalmology and Visual Science. 41, 11, p. 3420-3428 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Myocilin 100%
  • Optic Nerve 100%
  • Human Eye 100%
  • In Situ Hybridization 100%
  • Gene Expression 100%

• Prioritizing regions of candidate genes for efficient mutation screening

  Braun, T. A., Shankar, S. P., Davis, S., O'Leary, B., Scheetz, T. E., Clark, A. F., Sheffield, V. C., Casavant, T. L. & Stone, E. M., Feb 2006, In: Human Mutation. 27, 2, p. 195-200 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Cause of Disease 100%
  • Mutation Screening 100%
  • Candidate Gene 100%
  • Coding Region 50%
  • Disease-associated 50%

• Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes

  Clark, A. F., Wilson, K., De Kater, A. W., Allingham, R. R. & McCartney, M. D., 1995, In: Investigative Ophthalmology and Visual Science. 36, 2, p. 478-489 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Intraocular Pressure 100%
  • Ocular Hypertension 100%
  • Perfusion 100%
  • Human Eye 100%
  • Dexamethasone 100%

• Increased expression of serum amyloid A in glaucoma and its effect on intraocular pressure

  Wang, W. H., McNatt, L. G., Pang, I. H., Hellberg, P. E., Fingert, J. H., McCartney, M. D. & Clark, A. F., Apr 2008, In: Investigative Ophthalmology and Visual Science. 49, 5, p. 1916-1923 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Intraocular Pressure 100%
  • Glaucoma 100%
  • Serum Amyloid A 100%
  • Trabecular Meshwork 100%
  • Trabecular Meshwork Cells 42%

• Cytoskeletal changes in cultured human glaucoma trabecular meshwork cells

  Clark, A. F., Miggans, S. T., Wilson, K., Browder, S. & McCartney, M. D., Jun 1995, In: Journal of Glaucoma. 4, 3, p. 183-188 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork Cells 100%
  • Human Glaucoma 100%
  • Cytoskeletal Changes 100%
  • Trabecular Meshwork 100%
  • Glaucoma 100%

• Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells

  Clark, A. F., Wilson, K., McCartney, M. D., Miggans, S. T., Kunkle, M. & Howe, W., 1994, In: Investigative Ophthalmology and Visual Science. 35, 1, p. 281-294 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork Cells 100%
  • Glucocorticoid-induced 100%
  • Cross-linked Actin Networks 100%
  • Trabecular Meshwork 100%
  • Glucocorticoid 100%

• Anterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport

  Gabelt, B. T., Wiederholt, M., Clark, A. F. & Kaufman, P. L., Aug 1997, In: Investigative Ophthalmology and Visual Science. 38, 9, p. 1700-1707 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Anterior Segment 100%
  • K-Cl Cotransporter 100%
  • Bumetanide 100%
  • Na-K 100%
  • Trabecular Meshwork 40%

• Role of the alternatively spliced glucocorticoid receptor isoform GRβ in steroid responsiveness and glaucoma

  Jain, A., Wordinger, R. J., Yorio, T. & Clark, A. F., 1 Mar 2014, In: Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 121-127 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Trabecular Meshwork 100%
  • Steroid-induced Glaucoma 100%
  • Steroid Responsiveness 100%
  • Alternative Splicing 100%
  • Glucocorticoid Receptor Isoforms 100%

• Effect of immunomodulation with anti-CD40L antibody on adenoviral-mediated transgene expression in mouse anterior segment

  Cameron Millar, J., Pang, I. H., Wang, W. H., Wang, Y. & Clark, A. F., 9 Jan 2008, In: Molecular vision. 14, p. 10-19 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Anterior Segment 100%
  • Adenoviral 100%
  • Transgene Expression 100%
  • Immunomodulation 100%
  • Green Fluorescent Protein Expression 100%

• Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

  Zode, G. S., Kuehn, M. H., Nishimura, D. Y., Searby, C. C., Mohan, K., Grozdanic, S. D., Bugge, K., Anderson, M. G., Clark, A. F., Stone, E. M. & Sheffield, V. C., 1 Sep 2011, In: Journal of Clinical Investigation. 121, 9, p. 3542-3553 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Open-angle Glaucoma 100%
  • Endoplasmic Reticulum Stress (ER stress) 100%
  • Disease Phenotype 100%
  • Mouse Model 100%
  • Myocilin 100%

• Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration

  Libby, R. T., Anderson, M. G., Pang, I. H., Robinson, Z. H., Savinova, O. V., Cosma, I. M., Snow, A., Wilson, L. A., Smith, R. S., Clark, A. F. & John, S. W. M., Sep 2005, In: Visual Neuroscience. 22, 5, p. 637-648 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glaucoma 100%
  • Disease Pattern 100%
  • Neurodegeneration 100%
  • Intraocular Pressure 80%
  • Elevated Intraocular Pressure 66%

• The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells

  Quill, B., Docherty, N. G., Clark, A. F. & O'Brien, C. J., Mar 2011, In: Investigative Ophthalmology and Visual Science. 52, 3, p. 1908-1915 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Extracellular Matrix 100%
  • Gene Expression Profile 100%
  • Lamina Cribrosa Cells 100%
  • Cyclic Stretching 100%
  • Gene Expression 100%

• Increased substrate stiffness elicits a myofibroblastic phenotype in human lamina cribrosa cells

  Liu, B., Kilpatrick, J. I., Lukasz, B., Jarvis, S. P., McDonnell, F., Wallace, D. M., Clar, A. F. & O’Brien, C. J., Feb 2018, In: Investigative Ophthalmology and Visual Science. 59, 2, p. 803-814 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Lamina Cribrosa Cells 100%
  • Substrate Stiffness 100%
  • Myofibroblastic Phenotype 100%
  • Adhesion Formation 100%
  • Atomic Force Microscopy 100%

• Transforming Growth factor-β-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells

  Kirwan, R. P., Leonard, M. O., Murphy, M., Clark, A. F. & O'Brien, C. J., Dec 2005, In: GLIA. 52, 4, p. 309-324 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Transcription 100%
  • Protein Expression 100%
  • Transforming Growth Factor-β 100%
  • Transcription Expression 100%
  • Lamina Cribrosa Cells 100%

• Anti-connective tissue growth factor antibody treatment reduces Extracellular matrix production in Trabecular meshwork and Lamina Cribrosa cells

  Wallace, D. M., Clark, A. F., Lipson, K. E., Andrews, D., Crean, J. K. & O'Brien, C. J., 7 Nov 2013, In: Investigative Ophthalmology and Visual Science. 54, 13, p. 7836-7848 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Lamina Cribrosa Cells 100%
  • Connective Tissue Growth Factor 100%
  • Extracellular Matrix Deposition 100%
  • Antibody Treatment 100%

• Age-related permeability changes in rabbit corneas

  Ke, T. L., Clark, A. F. & Gracy, R. W., Dec 1999, In: Journal of Ocular Pharmacology and Therapeutics. 15, 6, p. 513-523 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Age-related 100%
  • Rabbit Cornea 100%
  • Cornea 100%
  • Permeability Change 100%
  • Steady State 100%

• Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells

  Zode, G. S., Clark, A. F. & Wordinger, R. J., Nov 2007, In: Investigative Ophthalmology and Visual Science. 48, 11, p. 5058-5067 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Signaling Pathway 100%
  • Bone Morphogenetic Protein 100%
  • Optic Nerve Head 100%
  • Lamina Cribrosa Cells 100%
  • Optic Nerve Head Astrocytes 100%

• Cells of the human optic nerve head express glial cell-line derived neurotrophic factor (GDNF) and the GDNF receptor complex

  Wordinger, R. J., Lambert, W., Agarwal, R., Liu, X. & Clark, A. F., 2003, In: Molecular vision. 9, p. 249-256 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor Complex 100%
  • Optic Nerve Head 100%
  • Glial Cell Line-derived Neurotrophic Factor 100%
  • Optic Nerve 100%
  • Glial Cell Line Derived Neurotrophic Factor Receptor 100%