Projects per year
Personal profile
Research Interests
Eye disease; Glaucoma; molecular pathogenesis; therapeutic target discovery; molecular biology; neurodegeneration; in vitro, ex vivo, and in vivo models of disease
Area of Expertise
Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.
Techniques
Cell and molecular biology; culture of ocular cells; ex vivo perfusion organ culture; in vivo rodent models of ocular diseases; molecular genetics; genome editing
Education/Academic qualification
BA in Biology, Thiel College
PhD in Microbiology, Case Western Reserve University
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Collaborations and top research areas from the last five years
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Discovery of novel disease mod
Clark, A. (PI) & Siderovski, D. (CoI)
1/09/24 → 31/08/26
Project: Research
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Mechanisms Underlying Endothel
Krishnamoorthy, R. (PI), Stankowska, D. (CoI), Inman, D. (CoI) & Clark, A. (CoI)
1/06/21 → 31/08/26
Project: Research
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Targeting FMNL2/Rho-GTPase Pat
Clark, A. (CoI), Millar, C. (PI), Millar, C. (CoI) & Ellis, D. (CoI)
1/01/24 → 31/12/25
Project: Research
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New Approach for Neuroprotection of Photoreceptors by Targeting TMEM97/sigma2R
Clark, A. (PI)
1/01/22 → 30/11/23
Project: Research
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Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma
Davis, R. L., Kahraman, M., Prins, T. J., Beaver, Y., Cook, T. G., Cramp, J., Cayanan, C. S., Gardiner, E. M. M., McLaughlin, M. A., Clark, A. F., Hellberg, M. R., Shiau, A. K., Noble, S. A. & Borchardt, A. J., 1 Jun 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 11, p. 3361-3366 6 p.Research output: Contribution to journal › Article › peer-review
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Steroid-induced ocular hypertension and effects of glucocorticoids on the trabecular meshwork
Sethi, A. & Clark, A. F., 1 Jan 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd., p. 219-223 5 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Steroid-induced glaucoma
Clark, A. F., Zhang, X. & Yorio, T., 2010, Ocular Disease: Mechanisms and Management. Elsevier Inc., p. 146-152 7 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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AL-3789: A novel ophthalmic angiostatic steroid
Clark, A. F., 1997, In: Expert Opinion on Investigational Drugs. 6, 12, p. 1867-1877 11 p.Research output: Contribution to journal › Article › peer-review
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Expression of tgf-β isoforms and their receptor mRNA'S in cultured human lamina cribrosa cells
Lambert, W., Agarwal, R., Clark, A. F. & Wordingcr, R. J., 1997, In: Investigative Ophthalmology and Visual Science. 38, 4, p. S162Research output: Contribution to journal › Article › peer-review