Abe Clark, PhD

  • 9973 Citations
  • 53 h-Index
1979 …2020
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Personal profile

Area of Expertise

Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.

Education/Academic qualification

PhD in Microbiology, Case Western Reserve University

BA in Biology, Thiel College

Fingerprint Dive into the research topics where Abe Clark is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Trabecular Meshwork Medicine & Life Sciences
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Retinal Ganglion Cells Medicine & Life Sciences
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Projects 2010 2020

Research Output 1979 2019

Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma

Daniel, S., Meyer, K. J., Clark, A., Anderson, M. G. & McDowell, C. M., 1 Aug 2019, In : Experimental eye research. 185, 107703.

Research output: Contribution to journalArticle

Ocular Hypertension
Retinal Ganglion Cells
Glaucoma
Intraocular Pressure
Phenotype
1 Citation (Scopus)
Open Access
Ocular Hypertension
Trabecular Meshwork
Glucocorticoid Receptors
Glaucoma
Transcriptional Activation

Inducible rodent models of glaucoma

Pang, I. H. & Clark, A. F., 1 Jan 2019, (Accepted/In press) In : Progress in Retinal and Eye Research. 100799.

Research output: Contribution to journalArticle

Glaucoma
Rodentia
Pressure
Intraocular Pressure
Low Tension Glaucoma

RE: “Letter to the Editor concerning Webber et al. Exp Eye Res. 148:97–102, 2016”

Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. & Mao, W., 1 Jan 2019, In : Experimental eye research. 178, 1 p.

Research output: Contribution to journalLetter

3 Citations (Scopus)

Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma

Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., 1 Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.

Research output: Contribution to journalArticle

Calcium Signaling
Glaucoma
Extracellular Matrix
Calcineurin
Transforming Growth Factors