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Abe Clark, PhD

  • 11084 Citations
  • 58 h-Index
1979 …2020

Research output per year

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Personal profile

Area of Expertise

Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.

Education/Academic qualification

BA in Biology, Thiel College

PhD in Microbiology, Case Western Reserve University

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Projects

VisiPlate Pilot: Perfused Human Cadaver Eyes

Clark, A.

Avisi Technologies

24/09/19 → 23/09/20

Project: Research

Novel Genome Editing for the Treatment of Glaucoma

Clark, A., Zode, G. & SHEFFIELD, V.

1/07/19 → 30/04/20

Project: Research

Novel Genome Editing for the Treatment of Glaucoma

Clark, A.

University of Iowa

1/07/19 → 30/04/20

Project: Research

Evaluation of NAC, NACA and diNACA in Cultured RPE Cells and in Cultured Corneal Endothelial Cells (CECs) +/- Oxidative Stress

Clark, A. & Wu, H. (.

Nacuity Pharmaceuticals, Inc.

18/02/19 → 4/06/20

Project: Research

Glucocorticoids, Ocular Hypertension, and Glaucoma

Clark, A. & Millar, C.

NEI: National Eye Institute

30/09/18 → 31/08/19

Project: Research

Research Output

Glucocorticoid-induced ocular hypertension: origins and new approaches to minimize

Yorio, T., Patel, G. C. & Clark, A. F., 1 Jan 2020, (Accepted/In press) In : Expert Review of Ophthalmology.

Research output: Contribution to journal › Review article

    • Inducible rodent models of glaucoma

    Pang, I. H. & Clark, A. F., Mar 2020, In : Progress in Retinal and Eye Research. 75, 100799.

    Research output: Contribution to journal › Review article

    • 2 Scopus citations

    Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells

    Lopez, N. N., Clark, A. F. & Tovar-Vidales, T., Aug 2020, In : Experimental eye research. 197, 108103.

    Research output: Contribution to journal › Short survey

    • Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation

    Irnaten, M., O'Malley, G., Clark, A. F. & O'Brien, C. J., Apr 2020, In : Experimental eye research. 193, 107980.

    Research output: Contribution to journal › Article

    Open Access

    • Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma

    Daniel, S., Meyer, K. J., Clark, A. F., Anderson, M. G. & McDowell, C. M., Aug 2019, In : Experimental eye research. 185, 107703.

    Research output: Contribution to journal › Article