Projects per year
Personal profile
Research Interests
Eye disease; Glaucoma; molecular pathogenesis; therapeutic target discovery; molecular biology; neurodegeneration; in vitro, ex vivo, and in vivo models of disease
Area of Expertise
Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.
Techniques
Cell and molecular biology; culture of ocular cells; ex vivo perfusion organ culture; in vivo rodent models of ocular diseases; molecular genetics; genome editing
Education/Academic qualification
BA in Biology, Thiel College
PhD in Microbiology, Case Western Reserve University
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Collaborations and top research areas from the last five years
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Targeting FMNL2/Rho-GTPase Pathway for IOP Regulation in Glaucoma
Ellis, D. (PI) & Clark, A. (CoI)
1/01/24 → 31/12/25
Project: Research
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Glucocorticoids, Ocular Hypertension and Glaucoma
Clark, A. (PI) & Millar, C. (CoI)
30/09/20 → 31/08/25
Project: Research
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New Approach for Neuroprotection of Photoreceptors by Targeting TMEM97/sigma2R
Clark, A. (PI)
1/01/22 → 30/11/23
Project: Research
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Glucocorticoids, ocular hypertension and glaucoma
Clark, A. (PI) & GEISERT, E. (CoPI)
30/09/20 → 31/08/21
Project: Research
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Glucocorticoids, ocular hypertension and glaucoma
GEISERT, E. (CoPI), GEISERT, E. (CoPI), Clark, A. (CoPI), Clark, A. (PI) & Clark, A. (PI)
30/09/20 → 31/08/24
Project: Research
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FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor β and glucocorticoid responsiveness
Zhang, X., Clark, A. F. & Yorio, T., Mar 2008, In: Investigative Ophthalmology and Visual Science. 49, 3, p. 1037-1047 11 p.Research output: Contribution to journal › Article › peer-review
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Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage
Pang, I. H., Johnson, E. C., Jia, L., Cepurna, W. O., Shepard, A. R., Hellberg, M. R., Clark, A. F. & Morrison, J. C., Apr 2005, In: Investigative Ophthalmology and Visual Science. 46, 4, p. 1313-1321 9 p.Research output: Contribution to journal › Article › peer-review
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Effects of muscarinic agents on cultured human trabecular meshwork cells
Shade, D. L., Clark, A. F. & Pang, I. H., Mar 1996, In: Experimental eye research. 62, 3, p. 201-210 10 p.Research output: Contribution to journal › Article › peer-review
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Fractionation and quantification of calcium-dependent proteinase activity from small tissue samples
Clark, A. F., DeMartino, G. N. & Croall, D. E., 1986, In: Biochemical Journal. 235, 1, p. 279-282 4 p.Research output: Contribution to journal › Article › peer-review
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Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells
Shepard, A. R., Jacobson, N., Fingert, J. H., Stone, E. M., Sheffield, V. C. & Clark, A. F., 2001, In: Investigative Ophthalmology and Visual Science. 42, 13, p. 3173-3181 9 p.Research output: Contribution to journal › Article › peer-review