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Abe Clark, PhD

  • 10860 Citations
  • 57 h-Index
1979 …2020

Research output per year

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Personal profile

Area of Expertise

Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.

Education/Academic qualification

BA in Biology, Thiel College

PhD in Microbiology, Case Western Reserve University

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Projects

VisiPlate Pilot: Perfused Human Cadaver Eyes

Clark, A.

Avisi Technologies

24/09/19 → 23/09/20

Project: Research

Evaluation of NAC, NACA and diNACA in Cultured RPE Cells and in Cultured Corneal Endothelial Cells (CECs) +/- Oxidative Stress

Clark, A. & Wu, H. (.

Nacuity Pharmaceuticals, Inc.

18/02/19 → 4/06/20

Project: Research

Novel Genome Editing for the Treatment of Glaucoma

Clark, A.

University of Iowa

1/07/19 → 30/04/20

Project: Research

Novel Genome Editing for the Treatment of Glaucoma

Clark, A., Zode, G. & SHEFFIELD, V.

1/07/19 → 30/04/20

Project: Research

Glucocorticoids, Ocular Hypertension, and Glaucoma

Clark, A. & Millar, C.

NEI: National Eye Institute

30/09/18 → 31/08/19

Project: Research

Research Output

Inducible rodent models of glaucoma

Pang, I. H. & Clark, A. F., Mar 2020, In : Progress in Retinal and Eye Research. 75, 100799.

Research output: Contribution to journal › Review article

    • 1 Scopus citations

    Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma

    Daniel, S., Meyer, K. J., Clark, A. F., Anderson, M. G. & McDowell, C. M., Aug 2019, In : Experimental eye research. 185, 107703.

    Research output: Contribution to journal › Article

    • Glucocorticoid receptor transactivation is required for glucocorticoid-induced ocular hypertension and glaucoma

    Patel, G. C., Millar, J. C. & Clark, A. F., May 2019, In : Investigative Ophthalmology and Visual Science. 60, 6, p. 1967-1978 12 p.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Scopus citations

    RE: “Letter to the Editor concerning Webber et al. Exp Eye Res. 148:97–102, 2016”

    Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. F. & Mao, W., Jan 2019, In : Experimental eye research. 178, 1 p.

    Research output: Contribution to journal › Letter

    Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma

    Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.

    Research output: Contribution to journal › Article

    • 10 Scopus citations