Projects per year
Personal profile
Area of Expertise
Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.
Education/Academic qualification
BA in Biology, Thiel College
PhD in Microbiology, Case Western Reserve University
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Glucocorticoids, ocular hypertension and glaucoma
Clark, A., GEISERT, E. & GEISERT, E.
30/09/20 → 31/08/22
Project: Research
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Glucocorticoids, ocular hypertension and glaucoma
Clark, A. & GEISERT, E.
30/09/20 → 31/08/21
Project: Research
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Novel Genome Editing for the Treatment of Glaucoma
Clark, A., Zode, G. & SHEFFIELD, V.
1/07/19 → 30/04/22
Project: Research
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Novel Genome Editing for the Treatment of Glaucoma
Clark, A., Zode, G. & SHEFFIELD, V.
1/07/19 → 30/04/22
Project: Research
Research output
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Erratum: Reduced oxidative phosphorylation and increased glycolysis in human glaucoma lamina cribrosa cells ((Invest Ophthalmol Vis Sci. (2020) 61:13 (4) DOI: 10.1167/iovs.61.13.4)
Kamel, K., O'Brien, C. J., Zhdanov, A. V., Papkovsky, D. B., Clark, A. F., Stamer, W. D. & Irnaten, M., Jan 2021, In: Investigative Ophthalmology and Visual Science. 62, 1, p. 1 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
ID1 and ID3 are negative regulators of TGFβ2-induced ocular hypertension and compromised aqueous humor outflow facility in mice
Mody, A. A., Cameron Millar, J. & Clark, A. F., 2021, In: Investigative Ophthalmology and Visual Science. 62, 6, A2.Research output: Contribution to journal › Article › peer-review
Open Access -
Intra-cellular calcium signaling pathways (Pkc, ras/raf/mapk, pi3k) in lamina cribrosa cells in glaucoma
Irnaten, M., Duff, A., Clark, A. & O’brien, C., Jan 2021, In: Journal of Clinical Medicine. 10, 1, p. 1-14 14 p., 62.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Mirna expression in glaucomatous and tgfβ2 treated lamina cribrosa cells
Lopez, N. N., Rangan, R., Clark, A. F. & Tovar-Vidales, T., 2 Jun 2021, In: International journal of molecular sciences. 22, 12, 6178.Research output: Contribution to journal › Article › peer-review
Open Access -
The Canonical Wnt Signaling Pathway Inhibits the Glucocorticoid Receptor Signaling Pathway in the Trabecular Meshwork
Sugali, C. K., Rayana, N. P., Dai, J., Peng, M., Harris, S. L., Webber, H. C., Liu, S., Dixon, S. G., Parekh, P. H., Martin, E. A., Cantor, L. B., Fellman, R. L., Godfrey, D. G., Butler, M. R., Emanuel, M. E., Grover, D. S., Smith, O. U., Clark, A. F., Raghunathan, V. K. & Mao, W., Jun 2021, In: American Journal of Pathology. 191, 6, p. 1020-1035 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations