Projects per year
Personal profile
Research Interests
Eye disease; Glaucoma; molecular pathogenesis; therapeutic target discovery; molecular biology; neurodegeneration; in vitro, ex vivo, and in vivo models of disease
Area of Expertise
Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.
Techniques
Cell and molecular biology; culture of ocular cells; ex vivo perfusion organ culture; in vivo rodent models of ocular diseases; molecular genetics; genome editing
Education/Academic qualification
BA in Biology, Thiel College
PhD in Microbiology, Case Western Reserve University
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Collaborations and top research areas from the last five years
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Mechanisms Underlying Endothel
Krishnamoorthy, R. (PI), Stankowska, D. (CoI), Inman, D. (CoI) & Clark, A. (CoI)
1/06/21 → 31/08/26
Project: Research
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New Approach for Neuroprotection of Photoreceptors by Targeting TMEM97/sigma2R
Clark, A. (PI)
1/01/22 → 30/11/23
Project: Research
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Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma
Davis, R. L., Kahraman, M., Prins, T. J., Beaver, Y., Cook, T. G., Cramp, J., Cayanan, C. S., Gardiner, E. M. M., McLaughlin, M. A., Clark, A. F., Hellberg, M. R., Shiau, A. K., Noble, S. A. & Borchardt, A. J., 1 Jun 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 11, p. 3361-3366 6 p.Research output: Contribution to journal › Article › peer-review
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Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture.
Kirwan, R. P., Felice, L., Clark, A. F., O'Brien, C. J. & Leonard, M. O., Apr 2012, In: Investigative ophthalmology & visual science. 53, 4, p. 2243-2255 13 p.Research output: Contribution to journal › Article › peer-review
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Transforming growth factor-β induces extracellular matrix protein Cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells
Sethi, A., Mao, W., Wordinger, R. J. & Clark, A. F., Jul 2011, In: Investigative Ophthalmology and Visual Science. 52, 8, p. 5240-5250 11 p.Research output: Contribution to journal › Article › peer-review
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Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor β
Zhang, X., Ognibene, C. M., Clark, A. F. & Yorio, T., Feb 2007, In: Experimental eye research. 84, 2, p. 275-284 10 p.Research output: Contribution to journal › Article › peer-review
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TGFβ2 induces the formation of cross-linked actin networks (CLANs) in human trabecular meshwork cells through the smad and non-smad dependent pathways
Montecchi-Palmer, M., Bermudez, J. Y., Webber, H. C., Patel, G. C., Clark, A. F. & Mao, W., Feb 2017, In: Investigative Ophthalmology and Visual Science. 58, 2, p. 1288-1295 8 p.Research output: Contribution to journal › Article › peer-review