Abe Clark, PhD

  • 9922 Citations
  • 53 h-Index
1979 …2020
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Personal profile

Area of Expertise

Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.

Education/Academic qualification

PhD in Microbiology, Case Western Reserve University

BA in Biology, Thiel College

Fingerprint Dive into the research topics where Abe Clark is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 12 Similar Profiles
Trabecular Meshwork Medicine & Life Sciences
Glaucoma Medicine & Life Sciences
Intraocular Pressure Medicine & Life Sciences
Ocular Hypertension Medicine & Life Sciences
Glucocorticoids Medicine & Life Sciences
Optic Disk Medicine & Life Sciences
Retinal Ganglion Cells Medicine & Life Sciences
Dexamethasone Medicine & Life Sciences

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Projects 2010 2020

Research Output 1979 2019

Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma

Daniel, S., Meyer, K. J., Clark, A., Anderson, M. G. & McDowell, C. M., 1 Aug 2019, In : Experimental eye research. 185, 107703.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Retinal Ganglion Cells
Glaucoma
Intraocular Pressure
Phenotype

Glucocorticoid receptor transactivation is required for glucocorticoid-induced ocular hypertension and glaucoma

Patel, G. C., Millar, J. C. & Clark, A., 1 May 2019, In : Investigative Ophthalmology and Visual Science. 60, 6, p. 1967-1978 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Ocular Hypertension
Trabecular Meshwork
Glucocorticoid Receptors
Glaucoma
Transcriptional Activation

RE: “Letter to the Editor concerning Webber et al. Exp Eye Res. 148:97–102, 2016”

Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. & Mao, W., 1 Jan 2019, In : Experimental eye research. 178, 1 p.

Research output: Contribution to journalLetterResearchpeer-review

3 Citations (Scopus)

Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma

Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., 1 Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium Signaling
Glaucoma
Extracellular Matrix
Calcineurin
Transforming Growth Factors
3 Citations (Scopus)

BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork

Hernandez, H., Millar, J. C., Curry, S. M., Clark, A. & McDowell, C. M., 1 Apr 2018, In : Investigative Ophthalmology and Visual Science. 59, 5, p. 2154-2166 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Activins
Bone Morphogenetic Proteins
Extracellular Matrix
Ocular Hypertension