• 9875 Citations
  • 53 h-Index
1979 …2020
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Personal profile

Area of Expertise

Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.

Education/Academic qualification

PhD in Microbiology, Case Western Reserve University

BA in Biology, Thiel College

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2010 2020

Research Output 1979 2019

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

Patel, G. C., Millar, J. C. & Clark, A., 1 May 2019, In : Investigative ophthalmology & visual science. 60, 6, p. 1967-1978 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Ocular Hypertension
Glucocorticoid Receptors
Transcriptional Activation

RE: “Letter to the Editor concerning Webber et al. Exp Eye Res. 148:97–102, 2016”

Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. & Mao, W., 1 Jan 2019, In : Experimental eye research. 178, 1 p.

Research output: Contribution to journalLetterResearchpeer-review

3 Citations (Scopus)

Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma

Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., 1 Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium Signaling
Extracellular Matrix
Transforming Growth Factors
3 Citations (Scopus)

BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork

Hernandez, H., Millar, J. C., Curry, S. M., Clark, A. & McDowell, C. M., 1 Apr 2018, In : Investigative Ophthalmology and Visual Science. 59, 5, p. 2154-2166 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Bone Morphogenetic Proteins
Extracellular Matrix
Ocular Hypertension
4 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 othersKnepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure