Projects per year
Personal profile
Research Interests
Eye disease; Glaucoma; molecular pathogenesis; therapeutic target discovery; molecular biology; neurodegeneration; in vitro, ex vivo, and in vivo models of disease
Area of Expertise
Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.
Techniques
Cell and molecular biology; culture of ocular cells; ex vivo perfusion organ culture; in vivo rodent models of ocular diseases; molecular genetics; genome editing
Education/Academic qualification
BA in Biology, Thiel College
PhD in Microbiology, Case Western Reserve University
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Collaborations and top research areas from the last five years
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Targeting FMNL2/Rho-GTPase Pat
Clark, A. (CoI), Millar, C. (PI), Millar, C. (CoI) & Ellis, D. (CoI)
1/01/24 → 31/12/25
Project: Research
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Mechanisms Underlying Endothel
Krishnamoorthy, R. (PI), Stankowska, D. (CoI), Inman, D. (CoI) & Clark, A. (CoI)
1/06/21 → 31/08/26
Project: Research
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New Approach for Neuroprotection of Photoreceptors by Targeting TMEM97/sigma2R
Clark, A. (PI)
1/01/22 → 30/11/23
Project: Research
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The role of proteases in experimental glucocorticoid myopathy
Clark, A. F. & Vignos, P. J., 1981, In: Muscle & Nerve. 4, 3, p. 219-222 4 p.Research output: Contribution to journal › Article › peer-review
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Erratum: Reduced oxidative phosphorylation and increased glycolysis in human glaucoma lamina cribrosa cells ((Invest Ophthalmol Vis Sci. (2020) 61:13 (4) DOI: 10.1167/iovs.61.13.4)
Kamel, K., O'Brien, C. J., Zhdanov, A. V., Papkovsky, D. B., Clark, A. F., Stamer, W. D. & Irnaten, M., Jan 2021, In: Investigative Ophthalmology and Visual Science. 62, 1, p. 1 1 p.Research output: Contribution to journal › Comment/debate
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The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity
Penn, J. S., Rajaratnam, V. S., Collier, R. J. & Clark, A. F., 2001, In: Investigative Ophthalmology and Visual Science. 42, 1, p. 283-290 8 p.Research output: Contribution to journal › Article › peer-review
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The Eye as a Drug Target
Yorio, T., Clark, A. F. & Wax, M. B., 2008, Ocular Therapeutics. Elsevier Ltd, p. 3-6 4 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Microfilament structure and microfilament protein expression in cultured dex ameth asonetreated and glaucomatous human trabecular meshwork (TM) cells
Clark, A. F., Aboul-Ela, N. & English-Wright, S., 1997, In: Investigative Ophthalmology and Visual Science. 38, 4, p. S489Research output: Contribution to journal › Article › peer-review