Projects per year
Personal profile
Area of Expertise
Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.
Education/Academic qualification
PhD in Microbiology, Case Western Reserve University
BA in Biology, Thiel College
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2010 2020
Preclinical Evaluation of Graybug Vision Compound
Clark, A., Tovar-Vidales, T., Liu, Y. & Millar, C.
5/06/17 → 4/06/19
Project: Research
Research Output 1979 2019
Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma
Patel, G. C., Millar, J. C. & Clark, A., 1 May 2019, In : Investigative ophthalmology & visual science. 60, 6, p. 1967-1978 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Ocular Hypertension
Glucocorticoid Receptors
Glaucoma
Transcriptional Activation
Glucocorticoids
RE: “Letter to the Editor concerning Webber et al. Exp Eye Res. 148:97–102, 2016”
Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. & Mao, W., 1 Jan 2019, In : Experimental eye research. 178, 1 p.Research output: Contribution to journal › Letter › Research › peer-review
3
Citations
(Scopus)
Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma
Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., 1 Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.Research output: Contribution to journal › Article › Research › peer-review
Calcium Signaling
Glaucoma
Extracellular Matrix
Calcineurin
Transforming Growth Factors
3
Citations
(Scopus)
BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork
Hernandez, H., Millar, J. C., Curry, S. M., Clark, A. & McDowell, C. M., 1 Apr 2018, In : Investigative Ophthalmology and Visual Science. 59, 5, p. 2154-2166 13 p.Research output: Contribution to journal › Article › Research › peer-review
Trabecular Meshwork
Activins
Bone Morphogenetic Proteins
Extracellular Matrix
Ocular Hypertension
4
Citations
(Scopus)
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture
Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.Research output: Contribution to journal › Short survey › Research › peer-review
Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure