Projects per year
Personal profile
Area of Expertise
Dr. Clark’s major research focus is to discover the molecular mechanisms involved in ocular diseases, particularly glaucoma, in order to develop disease modifying therapies for better management of ocular diseases. Glaucoma is the leading cause of irreversible vision loss and blindness in the world and is also the leading neurodegenerative disease, affecting both the eye and brain. Dr. Clark’s research includes molecular genetics, molecular biology, cell biology, physiology, pathology, and mouse models of glaucoma. A main goal in this lab is to perform translational research that eventually will help patients with glaucoma. In addition to research, he trains and mentors graduate students, postdoctoral fellows, and medical students. He also is very active in community-based vision screening events.
Education/Academic qualification
BA in Biology, Thiel College
PhD in Microbiology, Case Western Reserve University
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Projects
- 35 Finished
Novel Genome Editing for the Treatment of Glaucoma
Clark, A., Zode, G. & SHEFFIELD, V.
1/07/19 → 30/04/20
Project: Research
Research Output
CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma
Maddineni, P., Kasetti, R. B., Patel, P. D., Millar, J. C., Kiehlbauch, C., Clark, A. F. & Zode, G. S., 27 Aug 2020, In : Molecular Neurodegeneration. 15, 1, 48.Research output: Contribution to journal › Article
Open Access
Glucocorticoid-induced ocular hypertension: origins and new approaches to minimize
Yorio, T., Patel, G. C. & Clark, A. F., 1 Jan 2020, (Accepted/In press) In : Expert Review of Ophthalmology.Research output: Contribution to journal › Review article
Inducible rodent models of glaucoma
Pang, I. H. & Clark, A. F., Mar 2020, In : Progress in Retinal and Eye Research. 75, 100799.Research output: Contribution to journal › Review article
3
Scopus
citations
Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells
Lopez, N. N., Clark, A. F. & Tovar-Vidales, T., Aug 2020, In : Experimental eye research. 197, 108103.Research output: Contribution to journal › Short survey
Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation
Irnaten, M., O'Malley, G., Clark, A. F. & O'Brien, C. J., Apr 2020, In : Experimental eye research. 193, 107980.Research output: Contribution to journal › Article
Open Access