Pharmacology & Neuroscience

Research output

Research output per year 1973 2000 2001 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 115072 Citations
• 147 h-index
• 1976 Article
• 171 Review article
• 50 Chapter
• 49 Comment/debate
• 75 More
  • 26 Editorial
  • 19 Short survey
  • 13 Letter
  • 10 Conference contribution
  • 2 Book
  • 2 Foreword/postscript
  • 2 Conference article
  • 1 Paper

Research output per year

Research output per year

Search results

• Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: Insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity

  Ananthan, S., Saini, S. K., Zhou, G., Hobrath, J. V., Padmalayam, I., Zhai, L., Bostwick, J. R., Antonio, T., Reith, M. E. A., McDowell, S., Cho, E., McAleer, L., Taylor, M. & Luedtke, R. R., 28 Aug 2014, In: Journal of Medicinal Chemistry. 57, 16, p. 7042-7060 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Structure-Activity Relationship 100%
  • Dopamine 80%
  • Dopamine D3 Receptors 60%
  • Ligands 60%
  • Partial Agonist 54%

• Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D₃-Selective Antagonists

  Kim, H. Y., Lee, J. Y., Hsieh, C. J., Taylor, M., Luedtke, R. R. & Mach, R. H., Jan 2023, In: International journal of molecular sciences. 24, 1, 432.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine 100%
  • Ligands 86%
  • Scaffolds 77%
  • ligands 65%
  • benzamide 64%

• Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

  Karimi, M., Moerlein, S. M., Videen, T. O., Luedtke, R. R., Taylor, M., Mach, R. H. & Perlmutter, J. S., Jan 2011, In: Movement Disorders. 26, 1, p. 100-106 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Benperidol 100%
  • Dystonic Disorders 92%
  • Dystonia 79%
  • Dopamine Receptors 76%
  • Spiperone 70%

• Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ₁ receptors

  Wang, W., Cui, J., Lu, X., Padakanti, P. K., Xu, J., Parsons, S. M., Luedtke, R. R., Rath, N. P. & Tu, Z., 11 Aug 2011, In: Journal of Medicinal Chemistry. 54, 15, p. 5362-5372 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Vesicular Acetylcholine Transport Proteins 100%
  • Acetylcholine 68%
  • Carbon-11 33%
  • Fluorine-18 30%
  • In Vitro Techniques 27%

• Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol

  Paul, N. M., Taylor, M., Kumar, R., Deschamps, J. R., Luedtke, R. R. & Newman, A. H., 9 Oct 2008, In: Journal of Medicinal Chemistry. 51, 19, p. 6095-6109 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D2 Receptors 100%
  • Structure-Activity Relationship 99%
  • piperidine 80%
  • Dopamine 79%
  • Ligands 59%

• Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D₂ receptors: In vitro binding studies and positron emission tomography

  Mach, R. H., Nader, M. A., Ehrenkaufer, R. L. E., Line, S. W., Smith, C. R., Luedtke, R. R., Kung, M. P., Kung, H. F., Lyons, D. & Morton, T. E., Dec 1996, In: Synapse. 24, 4, p. 322-333 12 p.

  Research output: Contribution to journal › Article › peer-review

  • fluoroclebopride 100%
  • benzamide 65%
  • Fluorine-18 63%
  • Dopamine D2 Receptors 52%
  • 2,3-dimethoxy-N-(1-(4-fluorobenzyl)piperidin-4-yl)benzamide 47%

• Evaluation of N-phenyl homopiperazine analogs as potential dopamine D ₃ receptor selective ligands

  Li, A., Mishra, Y., Malik, M., Wang, Q., Li, S., Taylor, M., Reichert, D. E., Luedtke, R. R. & MacH, R. H., 1 Jun 2013, In: Bioorganic and Medicinal Chemistry. 21, 11, p. 2988-2998 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D3 Receptors 100%
  • Dopamine 65%
  • Dopamine D2 Receptors 55%
  • Ligands 49%
  • phenylpiperazine 41%

• [³H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)- butyl)benzamide: A selective radioligand for dopamine D₃ receptors. II. Quantitative analysis of dopamine D₃ and D₂ receptor density ratio in the caudate-putamen

  Xu, J., Hassanzadeh, B., Chu, W., Tu, Z., Jones, L. A., Luedtke, R. R., Perlmutter, J. S., Mintun, M. A. & Mach, R. H., Jun 2010, In: Synapse. 64, 6, p. 449-459 11 p.

  Research output: Contribution to journal › Article › peer-review

  • WC10 compound 100%
  • Dopamine D3 Receptors 55%
  • Dopamine D2 Receptors 45%
  • Raclopride 43%
  • Putamen 43%

• Role of activated astrocytes in neuronal damage: Potential links to HIV-1-associated dementia

  Deshpande, M., Zheng, J., Borgmann, K., Persidsky, R., Wu, L., Schellpeper, C. & Ghorpade, A., 2005, In: Neurotoxicity Research. 7, 3, p. 183-192 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurotoxicity 100%
  • Astrocytes 73%
  • HIV-1 69%
  • Dementia 66%
  • Metabolic 64%

• Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cells

  Martin, M. W., Scott, A. W., Johnston, D. E., Griffin, S. & Luedtke, R. R., 25 May 2001, In: European Journal of Pharmacology. 420, 2-3, p. 73-82 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Sf9 Cells 100%
  • Dopamine D1 Receptors 92%
  • Adenylyl Cyclases 74%
  • Antipsychotic Agents 66%
  • Flupenthixol 55%

• Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing

  Estrada-Sánchez, A. M., Rangel-Barajas, C., Howe, A. G., Barton, S. J., Mach, R. H., Luedtke, R. R. & Rebec, G. V., Jun 2023, In: International journal of molecular sciences. 24, 11, 9300.

  Research output: Contribution to journal › Article › peer-review

  • twitching 100%
  • 4-iodoamphetamine 91%
  • dopamine 79%
  • Dopamine 78%
  • Dopamine D3 Receptors 73%

• A survey of the impact of deyolking on biological processes covered by shotgun proteomic analyses of zebrafish embryos

  Rahlouni, F., Szarka, S., Shulaev, V. & Prokai, L., Dec 2015, In: Zebrafish. 12, 6, p. 398-407 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Firearms 100%
  • Proteome 91%
  • Danio rerio 90%
  • Zebrafish 89%
  • proteome 85%

• Learning deficits occur in young mice following transfer of immunity from senescent mice

  Lal, H., Bennett, M., Bennett, D., Forster, M. J. & Nandy, K., 11 Aug 1986, In: Life Sciences. 39, 6, p. 507-512 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Psychology Transfer 100%
  • Immunity 69%
  • Suspension 66%
  • Learning 62%
  • Antigen 35%

• Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles

  Shahzad, M. M. K., Mangala, L. S., Han, H. D., Lu, C., Bottsford-Miller, J., Nishimura, M., Mora, E. M., Lee, J. W., Stone, R. L., Pecot, C. V., Thanapprapasr, D., Roh, J. W., Gaur, P., Nair, M. P., Park, Y. Y., Sabnis, N., Deavers, M. T., Lee, J. S., Ellis, L. M., Lopez-Berestei, G., & 4 othersMcConathy, W. J., Prokai, L., Lacko, A. G. & Sood, A. K., Apr 2011, In: Neoplasia. 13, 4, p. 309-319 11 p.

  Research output: Contribution to journal › Article › peer-review

  • HDL Lipoproteins 100%
  • Nanoparticles 83%
  • Small Interfering RNA 79%
  • Scavenger Receptors 49%
  • Neoplasms 24%

• Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design

  Prokai-Tatrai, K., Prokai, L. & Bodor, N., 22 Nov 1996, In: Journal of Medicinal Chemistry. 39, 24, p. 4775-4782 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucine Enkephalin 100%
  • Peptides 44%
  • Peptide 40%
  • Brain 34%
  • Esters 23%

• A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

  Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L. & Ottinger, M. A., 1 Jul 2016, In: Hormones and Behavior. 83, p. 39-44 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Transgenic Mice 80%
  • Estradiol 78%
  • Alzheimer Disease 69%
  • Brain 44%
  • Hormones 15%

• Ocular-specific chemical delivery systems of betaxolol for safe local treatment of glaucoma

  Farag, H. H., Wu, W. M., Barros, M. D. C., Somogyi, G., Prokai, L. & Bodor, N., 1997, In: Drug Design and Discovery. 15, 2, p. 117-130 14 p.

  Research output: Contribution to journal › Article › peer-review

• Measurement of hydroxyl-radical formation in the rat striatum by in vivo microdialysis and GC-MS

  Nguyen, V., Bonds, D. V. & Prokai, L., Oct 2008, In: Chromatographia. 68, SUPPL. 1, p. S57-S62

  Research output: Contribution to journal › Article › peer-review

  • 2,5-dihydroxybenzoic Acid 100%
  • Microdialysis 79%
  • Hydroxyl Radical 77%
  • Ions 58%
  • 3,5-dihydroxybenzoic Acid 58%

• 17β-estradiol delivered in eye drops: Evidence of impact on protein networks and associated biological processes in the rat retina through quantitative proteomics

  Prokai, L., Zaman, K., Nguyen, V. & Prokai-Tatrai, K., Feb 2020, In: Pharmaceutics. 12, 2, 101.

  Research output: Contribution to journal › Article › peer-review

  • Eye Drop 100%
  • Ophthalmic Solutions 80%
  • Biological Phenomena 66%
  • Proteomics 62%
  • Estradiol 59%

• INVESTIGATION OF PHENOL-FORMALDEHYDE CONDENSATES BY FIELD DESORPTION MASS SPECTROMETRY.

  Prokai, L., 1986, In: Journal of Polymer Science, Part C: Polymer Letters. 24, 5, p. 223-227 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Field Desorption Mass Spectroscopy 100%
  • Mass spectrometry 87%
  • Phenols 85%
  • Formaldehyde 84%
  • Desorption 77%

• GABAergic modulation of the discriminative stimulus effects of methamphetamine

  Gatch, M. B., Selvig, M. & Forster, M. J., Jul 2005, In: Behavioural pharmacology. 16, 4, p. 261-266 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Methamphetamine 100%
  • Chlordiazepoxide 23%
  • GABA-A Receptor Antagonists 22%
  • Pentylenetetrazole 21%
  • Bicuculline 20%

• Learning and memory deficits associated with autoimmunity: Significance in aging and Alzheimer's disease

  Forster, M. J., Retz, K. C. & Lal, H., 1988, In: Drug Development Research. 15, 2-3, p. 253-273 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Memory Disorders 100%
  • Autoimmunity 91%
  • Antibody Formation 84%
  • Cognitive Dysfunction 77%
  • Alzheimer Disease 73%

• Proteomic analysis of the synaptic plasma membrane fraction isolated from rat forebrain

  Stevens, S. M., Zharikova, A. D. & Prokai, L., 7 Oct 2003, In: Molecular Brain Research. 117, 2, p. 116-128 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Synaptic Membranes 100%
  • Prosencephalon 80%
  • Proteomics 69%
  • Cell Membrane 55%
  • Membrane Proteins 46%

• Reversed-phase high-performance liquid chromatography-thermospray mass spectrometry of alprenolol and its ketoxime analogues

  Prokai, L. & Bodor, N., 1991, In: Journal of Chromatography A. 541, C, p. 474-479 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Alprenolol 100%
  • Oximes 87%
  • Ketoxime 85%
  • Reverse-Phase Chromatography 79%
  • Oxime 61%

• Conversion of 3-nitrotyrosine to 3-aminotyrosine residues facilitates mapping of tyrosine nitration in proteins by electrospray ionization-tandem mass spectrometry using electron capture dissociation

  Guo, J. & Prokai, L., Dec 2012, In: Journal of Mass Spectrometry. 47, 12, p. 1601-1611 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-Nitrotyrosine 100%
  • Electron-Capture Dissociation 93%
  • Nitrotyrosine 68%
  • Tyrosine 59%
  • Mass Spectrometry 43%