Pharmacology & Neuroscience

Research output

Research output per year 1973 2000 2001 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 115070 Citations
• 147 h-index
• 1976 Article
• 171 Review article
• 50 Chapter
• 49 Comment/debate
• 75 More
  • 26 Editorial
  • 19 Short survey
  • 13 Letter
  • 10 Conference contribution
  • 2 Book
  • 2 Foreword/postscript
  • 2 Conference article
  • 1 Paper

Research output per year

Research output per year

Search results

• Identification and characterization of the human and mouse SLC19A3 gene: A novel member of the reduced folate family of micronutrient transporter genes

  Eudy, J. D., Spiegelstein, O., Barber, R. C., Wlodarczyk, B. J., Talbot, J. & Finnell, R. H., 2000, In: Molecular Genetics and Metabolism. 71, 4, p. 581-590 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Micronutrient 100%
  • Forensic Anthropology 92%
  • Folate 85%
  • Micronutrients 81%
  • Folic Acid 70%

• Association of mitochondrial allele 4216c with increased risk for sepsis-related organ dysfunction and shock after burn injury

  Huebinger, R. M., Gomez, R., McGee, D., Chang, L. Y., Bender, J. E., O'Keeffe, T., Burris, A. M., Friese, S. M., Purdue, G. F., Hunt, J. L., Arnoldo, B. D., Horton, J. W. & Barber, R. C., Jan 2010, In: Shock. 33, 1, p. 19-23 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Shock 100%
  • Sepsis 91%
  • Alleles 83%
  • Wounds and Injuries 55%
  • Burns 46%

• N -(3-Fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl) arylcarboxamides as selective dopamine D3 receptor ligands: Critical role of the carboxamide linker for d3 receptor selectivity

  Banala, A. K., Levy, B. A., Khatri, S. S., Furman, C. A., Roof, R. A., Mishra, Y., Griffin, S. A., Sibley, D. R., Luedtke, R. R. & Newman, A. H., 26 May 2011, In: Journal of Medicinal Chemistry. 54, 10, p. 3581-3594 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D3 Receptors 100%
  • Piperazine 99%
  • Amides 82%
  • Carboxamide 80%
  • Dopamine 65%

• Synthesis and evaluation of cyclic diamino benzamide based D₃ receptor ligands

  Blass, B. E., Chen, P. J., Taylor, M., Griffin, S. A., Gordon, J. C. & Luedtke, R. R., Mar 2022, In: Medicinal Chemistry Research. 31, 3, p. 446-461 16 p.

  Research output: Contribution to journal › Article › peer-review

  • benzamide 100%
  • Benzamide 80%
  • Dopamine 64%
  • Pharmacological Phenomena 53%
  • Ligands 48%

• Structure-activity relationship studies of N-(9-benzyl)-9- azabicyclo[3.3.1]nonan-3-β-yl benzamide analogues for dopamine D₂ and D₃ receptors

  Mach, R. H., Hammond, P. S., Huang, Y., Yang, B., Xu, Y., Cheney, J. T., Freeman, R. & Luedtke, R. R., 1999, In: Medicinal Chemistry Research. 9, 6, p. 355-373 19 p.

  Research output: Contribution to journal › Article › peer-review

  • benzamide 100%
  • Dopamine D3 Receptors 97%
  • Benzamide 80%
  • Dopamine D2 Receptors 80%
  • Structure-Activity Relationship 80%

• Characterization of binding sites for [³H]spiroperidol

  Luedtke, R. R. & Molinoff, P. B., 1 Oct 1987, In: Biochemical Pharmacology. 36, 19, p. 3255-3264 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Spiperone 100%
  • Binding Sites 55%
  • Binding Site 51%
  • Antagonist 48%
  • Digitonin 28%

• Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in rats

  Kumar, R., Riddle, L., Griffin, S. A., Grundt, P., Newman, A. H. & Luedtke, R. R., May 2009, In: Neuropharmacology. 56, 6-7, p. 944-955 12 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-pyridine-2-ylbenzamide 100%
  • Dihydroxyphenylalanine 62%
  • Dopamine Antagonists 59%
  • Dyskinesias 53%
  • Benserazide 10%

• Characterization of membrane-bound and soluble D2 receptors in canine caudate using [¹²⁵I]IBZM

  Schonwetter, B. S., Luedtke, R. R., King, M. P., Billings, J., Kung, H. F. & Molinoff, P. B., 1989, In: Journal of Pharmacology and Experimental Therapeutics. 250, 1, p. 110-116 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide 100%
  • Canidae 50%
  • Membranes 34%
  • Detergents 26%
  • Binding Sites 14%

• Development of polyclonal anti-D2 dopamine receptor antibodies using sequence-specific peptides

  Boundy, V. A., Luedtke, R. R., Artymyshyn, R. P., Filtz, T. M. & Molinoff, P. B., 1993, In: Molecular Pharmacology. 43, 5, p. 666-676 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D2 Receptors 100%
  • Immune Sera 67%
  • NCQ 298 62%
  • Peptides 54%
  • Antibodies 46%

• Structural basis for the preferential association of autologous immunoglobulin subunits: Role of the J region of the light chain

  Hamel, P. A., Isenman, D. E., Klein, M. H., Luedtke, R. & Dorrington, K. J., Apr 1984, In: Molecular Immunology. 21, 4, p. 277-283 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin Subunits 100%
  • Genetic Recombination 58%
  • Light 43%
  • Gene Rearrangement 17%

• HIV-1 and IL-1β regulate Fas ligand expression in human astrocytes through the NF-κB pathway

  Ghorpade, A., Holter, S., Borgmann, K., Persidsky, R. & Wu, L., Aug 2003, In: Journal of Neuroimmunology. 141, 1-2, p. 141-149 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Fas Ligand Protein 100%
  • Interleukin-1 82%
  • Astrocytes 75%
  • HIV-1 71%
  • Dementia 45%

• Pharmacological survey of medicinal plants for activity at ligand-gated ion channels: Selective interaction with 5-HT3 receptors

  Luedtke, R. R., Bell-Horner, C. L., Volk, M., Reinecke, M. G. & Dillon, G. H., Feb 2004, In: Pharmaceutical Biology. 42, 1, p. 73-82 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Xanthium 100%
  • Ligand-Gated Ion Channels 74%
  • Receptors, Serotonin, 5-HT3 71%
  • Senecio 70%
  • Medicinal Plants 58%

• Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis

  Barber, R. C. & O'Keefe, G. E., 15 May 2003, In: American Journal of Respiratory and Critical Care Medicine. 167, 10, p. 1316-1320 5 p.

  Research output: Contribution to journal › Article › peer-review

  • lipopolysaccharide-binding protein 100%
  • Single Nucleotide Polymorphism 57%
  • Sepsis 54%
  • N-(2-aminoethyl)-4-(5-(4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 32%
  • Amino Acid Substitution 29%

• Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compound

  Vangveravong, S., Zhang, Z., Taylor, M., Bearden, M., Xu, J., Cui, J., Wang, W., Luedtke, R. R. & MacH, R. H., 1 Jun 2011, In: Bioorganic and Medicinal Chemistry. 19, 11, p. 3502-3511 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Aripiprazole 100%
  • 7-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one 78%
  • Dopamine D2 Receptors 71%
  • Benperidol 59%
  • Oxalate 59%

• Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl) piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor

  Grundt, P., Carlson, E. E., Cao, J., Bennett, C. J., McElveen, E., Taylor, M., Luedtke, R. R. & Newman, A. H., 10 Feb 2005, In: Journal of Medicinal Chemistry. 48, 3, p. 839-848 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Alkenes 100%
  • Dopamine D3 Receptors 91%
  • Amides 75%
  • Dopamine 60%
  • Receptor Binding Affinity 58%

• Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats

  Cheung, T. H. C., Nolan, B. C., Hammerslag, L. R., Weber, S. M., Durbin, J. P., Peartree, N. A., MacH, R. H., Luedtke, R. R. & Neisewander, J. L., Dec 2012, In: Neuropharmacology. 63, 8, p. 1346-1359 14 p.

  Research output: Contribution to journal › Article › peer-review

  • phenylpiperazine 100%
  • Dopamine D3 Receptors 80%
  • Self Administration 67%
  • Cocaine 56%
  • Psychology Reinforcement 20%

• Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds

  Luedtke, R. R., Mishra, Y., Wang, Q., Griffin, S. A., Bell-Horner, C., Taylor, M., Vangveravong, S., Dillon, G. H., Huang, R. Q., Reichert, D. E. & MacH, R. H., 19 Dec 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1050-1062 13 p.

  Research output: Contribution to journal › Article › peer-review

  • 1-((5-methoxy-1H-indol-3-yl)methyl)-4-(4-(methylthio)phenyl)piperidin-4-ol 100%
  • Dopamine D3 Receptors 58%
  • Dopamine D2 Receptors 48%
  • Dopamine 38%
  • 7-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one 35%

• Genetic polymorphisms at the rat and murine loci coding for dopamine D2-like receptors

  Scott, A. W., Griffin, S. A. & Luedtke, R. R., Apr 1995, In: Molecular Brain Research. 29, 2, p. 347-357 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D2 Receptors 100%
  • Dopamine D4 Receptors 95%
  • Dopamine D3 Receptors 90%
  • Genetic Polymorphisms 88%
  • Inbred Strains Rats 31%

• Quantitative changes in Gαolf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants

  Corvol, J. C., Valjent, E., Pascoli, V., Robin, A., Stipanovich, A., Luedtke, R. R., Belluscio, L., Girault, J. A. & Hervé, D., 24 May 2007, In: Neuropsychopharmacology. 32, 5, p. 1109-1121 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Golf 100%
  • Amphetamine 63%
  • Cocaine 29%
  • Proteins 24%
  • Corpus Striatum 18%

• The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D₃ and D₂ receptors

  Silvano, E., Millan, M. J., La Cour, C. M., Han, Y., Duan, L., Griffin, S. A., Luedtke, R. R., Aloisi, G., Rossi, M., Zazzeroni, F., Javitch, J. A. & Maggio, R., Nov 2010, In: Molecular Pharmacology. 78, 5, p. 925-934 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 1H-indole-2-carboxylic acid (4-(2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl)cyclohexyl)amide 100%
  • 1,2,3,4-tetrahydroisoquinoline 68%
  • Dopamine D3 Receptors 59%
  • Dopamine D2 Receptors 49%
  • Dopamine 14%

• Antibody Interaction with a Membrane-Bound Fluorescent Ligand on Synthetic Lipid Vesicles

  Luedtke, R., Karush, F. & Luedtke, R., 1982, In: Biochemistry. 21, 23, p. 5738-5744 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ligands 100%
  • Lipid 97%
  • Cholesterol 95%
  • Lipids 92%
  • Fluorescence 86%

• Synthesis and in vitro binding of N-alkyl-2,3- dimethoxy[3.3.1]azabicyclononane benzamides at dopamine D₂ and D₃ receptors

  Yang, B., Johnston, D. E., Luedtke, R. R., Hammond, P. S. & Mach, R. H., 1998, In: Medicinal Chemistry Research. 8, 3, p. 115-131 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Benzamides 100%
  • Dopamine D3 Receptors 85%
  • Dopamine D2 Receptors 70%
  • Dopamine 55%
  • benzamide 43%

• Isolation and HIV-1 infection of primary human microglia from fetal and adult tissue.

  Borgmann, K., Gendelman, H. E. & Ghorpade, A., 2005, In: Methods in molecular biology (Clifton, N.J.). 304, p. 49-70 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Microglia 100%
  • HIV Infections 87%
  • HIV-1 85%
  • Fetus 78%
  • Virus Diseases 36%

• Effect of cyclosporin A on the uptake of D₃-selective PET radiotracers in rat brain

  Tu, Z., Li, S., Xu, J., Chu, W., Jones, L. A., Luedtke, R. R. & Mach, R. H., Jul 2011, In: Nuclear Medicine and Biology. 38, 5, p. 725-739 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclosporine 100%
  • benzamide 93%
  • Electrons 84%
  • Brain 52%
  • ATP-Binding Cassette Transporters 50%

• Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci

  Alzheimer's Disease Genetics Consortium (ADGC), Feb 2016, In: PLoS ONE. 11, 2, e0148717.

  Research output: Contribution to journal › Article › peer-review

  • Genome-Wide Association Study 100%
  • Alzheimer Disease 74%
  • Single Nucleotide Polymorphism 60%
  • Gene Expression 57%
  • Quantitative Trait Loci 30%