Pharmacology & Neuroscience

Research output

Research output per year 1973 2000 2001 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 114956 Citations
• 147 h-index
• 1977 Article
• 171 Review article
• 50 Chapter
• 49 Comment/debate
• 76 More
  • 27 Editorial
  • 19 Short survey
  • 13 Letter
  • 10 Conference contribution
  • 2 Book
  • 2 Foreword/postscript
  • 2 Conference article
  • 1 Paper

Research output per year

Research output per year

Search results

• GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling

  Johnston, C. A., Taylor, J. P., Gao, Y., Kimple, A. J., Grigston, J. C., Chen, J. G., Siderovski, D. P., Jones, A. M. & Willard, F. S., 30 Oct 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 44, p. 17317-17322 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Arabidopsis Proteins 100%
  • Heterotrimeric GTP-Binding Proteins 76%
  • GTP Phosphohydrolases 65%
  • Guanosine Triphosphate 60%
  • GTP-Binding Proteins 56%

• G protein signaling modulator-3 inhibits the inflammasome activity of NLRP3

  Giguère, P. M., Gall, B. J., Ezekwe, E. A. D., Laroche, G., Buckley, B. K., Kebaier, C., Wilson, J. E., Ting, J. P., Siderovski, D. P. & Duncan, J. A., 28 Nov 2014, In: Journal of Biological Chemistry. 289, 48, p. 33245-33257 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Pyrin Domain 100%
  • NLR Proteins 98%
  • Inflammasomes 80%
  • GTP-Binding Proteins 67%
  • Interleukin-1 46%

• Structural determinants of G-protein α subunit selectivity by regulator of G-protein signaling 2 (RGS2)

  Kimple, A. J., Soundararajan, M., Hutsell, S. Q., Roos, A. K., Urban, D. J., Setola, V., Temple, B. R. S., Roth, B. L., Knapp, S., Willard, F. S. & Siderovski, D. P., 17 Jul 2009, In: Journal of Biological Chemistry. 284, 29, p. 19402-19411 10 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Protein Subunits 76%
  • GTP-Binding Proteins 66%
  • Vasoconstrictive 39%
  • Protein 27%

• The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells

  Sambi, B. S., Hains, M. D., Waters, C. M., Connell, M. C., Willard, F. S., Kimple, A. J., Pyne, S., Siderovski, D. P. & Pyne, N. J., Jul 2006, In: Cellular Signalling. 18, 7, p. 971-981 11 p.

  Research output: Contribution to journal › Article › peer-review

  • PDZ Domains 100%
  • Platelet-Derived Growth Factor Receptors 95%
  • Mitogen-Activated Protein Kinase 1 81%
  • Mitogen-Activated Protein Kinase 3 21%
  • Smooth Muscle Myocytes 15%

• Selective regulation of N-type Ca channels by different combinations of G-protein β/γ subunits and RGS proteins

  Zhou, J. Y., Siderovski, D. P. & Miller, R. J., 1 Oct 2000, In: Journal of Neuroscience. 20, 19, p. 7143-7148 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • Protein Subunits 73%
  • GTP-Binding Proteins 64%
  • HEK293 Cells 23%
  • Nervous System 17%

• Genistein directly inhibits native and recombinant NMDA receptors

  Huang, R., Singh, M. & Dillon, G. H., Jun 2010, In: Neuropharmacology. 58, 8, p. 1246-1251 6 p.

  Research output: Contribution to journal › Article › peer-review

  • aspartic acid receptor 100%
  • Genistein 98%
  • Aspartic Acid 75%
  • Protein-Tyrosine Kinases 47%
  • Protein Kinase Inhibitors 21%

• Gα selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN

  McCudden, C. R., Willard, F. S., Kimple, R. J., Johnston, C. A., Hains, M. D., Jones, M. B. & Siderovski, D. P., 10 Sep 2005, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1745, 2, p. 254-264 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanine Nucleotide Dissociation Inhibitors 100%
  • Amino Acid Motifs 81%
  • Tetratricopeptide Repeat 19%
  • Surface Plasmon Resonance 16%
  • Spindle Apparatus 15%

• Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes

  Trantow, C. M., Hedberg-Buenz, A., Iwashita, S., Moore, S. A. & Anderson, M. G., Jul 2010, In: PLoS Genetics. 6, 7, p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  • modifiers (genes) 100%
  • phenotype 86%
  • mutant 84%
  • Iris 59%
  • membrane 54%

• Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling

  Su, C., Cunningham, R. L., Rybalchenko, N. & Singh, M., 1 Sep 2012, In: Endocrinology. 153, 9, p. 4389-4400 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain-Derived Neurotrophic Factor 100%
  • Progesterone Receptors 99%
  • Progesterone 88%
  • Neuroglia 83%
  • Membranes 56%

• A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation

  Zha, Z., Han, X., Smith, M. D., Liu, Y., Giguère, P. M., Kopanja, D., Raychaudhuri, P., Siderovski, D. P., Guan, K. L., Lei, Q. Y. & Xiong, Y., 4 Jun 2015, In: Molecular Cell. 58, 5, p. 794-803 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin-Protein Ligases 100%
  • Ubiquitination 94%
  • G-Protein-Coupled Receptors 88%
  • GTP-Binding Proteins 65%
  • Protein Subunits 50%

• Application of a brain specific chemical delivery system approach to tranylcypromine

  Pop, E., Prokai-Tatrai, K., Anderson, W., Lin, J. L., Brewster, M. E. & Bodor, N., 1990, In: European Journal of Pharmacology. 183, 5, p. 1909 1 p.

  Research output: Contribution to journal › Article › peer-review

• RAMHA: A PC-based Monte-Carlo simulation of random saturation mutagenesis

  Siderovski, D. P. & Mak, T. W., Nov 1993, In: Computers in Biology and Medicine. 23, 6, p. 463-474 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutagenesis 100%
  • Polypeptides 40%
  • Nucleotides 31%
  • phosphoramidite 23%
  • Nucleosides 23%

• Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia

  Cohen, S. P., Buckley, B. K., Kosloffs, M., Garland, A. L., Bosch, D. E., Cheng, G., Radhakrishna, H., Brown, M. D., Willard, F. S., Arshavsky, V. Y., Tarran, R., Siderovski, D. P. & Kimple, A. J., 7 Dec 2012, In: Journal of Biological Chemistry. 287, 50, p. 41706-41719 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Lingual 100%
  • GTP-Binding Protein Regulators 86%
  • Tongue 54%
  • Epithelium 44%
  • Signal Transduction 25%

• Detection of axonal degeneration in a mouse model of Huntington’s disease: comparison between diffusion tensor imaging and anomalous diffusion metrics

  Gatto, R. G., Ye, A. Q., Colon-Perez, L., Mareci, T. H., Lysakowski, A., Price, S. D., Brady, S. T., Karaman, M., Morfini, G. & Magin, R. L., 1 Aug 2019, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 32, 4, p. 461-471 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Diffusion Tensor Imaging 100%
  • Huntington Disease 98%
  • Corpus Callosum 49%
  • White Matter 26%
  • Anisotropy 16%

• Effects of coenzyme Q₁₀ administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat

  Kwong, L. K., Kamzalov, S., Rebrin, I., Bayne, A. C. V., Jana, C. K., Morris, P., Forster, M. J. & Sohal, R. S., 1 Sep 2002, In: Free Radical Biology and Medicine. 33, 5, p. 627-638 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Coenzyme Q10 100%
  • coenzyme Q10 85%
  • Oxidants 68%
  • Oxidative Stress 64%
  • Antioxidant Agent 49%

• Quantitative structure-activity relationships predicting the antioxidant potency of 17β-estradiol-related polycyclic phenols to inhibit lipid peroxidation

  Prokai, L., Rivera-Portalatin, N. M. & Prokai-Tatrai, K., Jan 2013, In: International journal of molecular sciences. 14, 1, p. 1443-1454 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress 100%
  • antioxidants 79%
  • Quantitative Structure-Activity Relationship 79%
  • Phenols 78%
  • Antioxidants 77%

• Simultaneous measurement of 17β-estradiol, 17α-estradiol and estrone by GC-isotope dilution MS-MS

  Prokai-Tatrai, K., Bonds, D. & Prokai, L., Feb 2010, In: Chromatographia. 71, 3-4, p. 311-315 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrone 100%
  • Isotopes 86%
  • Estrogen 85%
  • Estradiol 69%
  • Tandem Mass Spectrometry 66%

• Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design

  Prokai-Tatrai, K., Prokai, L. & Bodor, N., 22 Nov 1996, In: Journal of Medicinal Chemistry. 39, 24, p. 4775-4782 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucine Enkephalin 100%
  • Peptides 44%
  • Peptide 40%
  • Brain 34%
  • Esters 23%

• 10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

  Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In: ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-androsten-3-one 100%
  • Uterotrophic 85%
  • Epimer 57%
  • 3,16-dihydroxyandrost-5-ene-17,19-dione 55%
  • Estrogen 52%

• Rapid characterization of covalent modifications to rat brain mitochondrial proteins after ex vivo exposure to 4-hydroxy-2-nonenal by liquid chromatography-tandem mass spectrometry using data-dependent and neutral loss-driven MS³ acquisition

  Stevens, S. M., Rauniyar, N. & Prokai, L., Dec 2007, In: Journal of Mass Spectrometry. 42, 12, p. 1599-1605 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Modification 100%
  • Protein 74%
  • Ion-Cyclotron Resonance 64%
  • Adduct 64%
  • High Performance Liquid Chromatography Mass Spectroscopy 61%

• A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: Results from the Western Australia memory study

  Johnson, L. A., Sohrabi, H. R., Hall, J. R., Kevin, T., Edwards, M., O'Bryant, S. E. & Martins, R. N., 1 Aug 2015, In: International Journal of Geriatric Psychiatry. 30, 8, p. 881-886 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Endophenotypes 100%
  • Western Australia 97%
  • Independent Living 77%
  • Cognition 59%
  • Memory 54%

• Supplementation with vitamin E fails to attenuate oxidative damage in aged mice

  Sumien, N., Forster, M. J. & Sohal, R. S., 1 Jun 2003, In: Experimental Gerontology. 38, 6, p. 699-704 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Vitamin E 100%
  • alpha-Tocopherol 97%
  • Tocopherols 82%
  • Acetate 58%
  • Longevity 37%

• Electrospray ionization mass spectrometric and liquid chromatographic- mass spectrometric studies on the metabolism of synthetic dynorphin a peptides in brain tissue in vitro and in vivo

  Prokai, L., Kim, H. S., Zharikova, A., Roboz, J., Ma, L., Deng, L. & Simonsick, W. J., 20 Mar 1998, In: Journal of Chromatography A. 800, 1, p. 59-68 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dynorphins 100%
  • Dynorphin A 94%
  • Electrospray Ionization 67%
  • Pharmacological Metabolism 56%
  • Peptides 46%

• Sex-specific genetic predictors of Alzheimer’s disease biomarkers

  Alzheimer’S Disease Neuroimaging Initiative (Adni) & The Alzheimer Disease Genetics Consortium (Adgc), 1 Dec 2018, In: Acta Neuropathologica. 136, 6, p. 857-872 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer Disease 100%
  • Biomarkers 83%
  • Genome-Wide Association Study 67%
  • Amyloid 61%
  • Endophenotypes 57%

• New insights into the genetic etiology of Alzheimer’s disease and related dementias

  EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC & CHARGE, 1 Apr 2022, In: Nature Genetics. 54, 4, p. 412-436 25 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia 100%
  • Alzheimer Disease 92%
  • Proxy 17%
  • Genome-Wide Association Study 17%
  • Microglia 17%