Pharmacology & Neuroscience

Research output

Research output per year 1973 2000 2001 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 114956 Citations
• 147 h-index
• 1977 Article
• 171 Review article
• 50 Chapter
• 49 Comment/debate
• 76 More
  • 27 Editorial
  • 19 Short survey
  • 13 Letter
  • 10 Conference contribution
  • 2 Book
  • 2 Foreword/postscript
  • 2 Conference article
  • 1 Paper

Research output per year

Research output per year

Search results

• Structural basis for the selective activation of rho gtpases by dbl exchange factors

  Snyder, J. T., Worthylakel, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J. & Sondek, J., 2002, In: Nature Structural Biology. 9, 6, p. 468-475 8 p.

  Research output: Contribution to journal › Article › peer-review

  • GDP 100%
  • rho GTP-Binding Proteins 98%
  • intersectin 1 94%
  • Guanine 76%
  • Nucleotide 64%

• Molecular cloning and expression analysis of rat Rgs12 and Rgs14

  Snow, B. E., Antonio, L., Suggs, S., Gutstein, H. B. & Siderovski, D. P., 28 Apr 1997, In: Biochemical and Biophysical Research Communications. 233, 3, p. 770-777 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Cloning 100%
  • Polypeptide 71%
  • rhophilin 59%
  • Protein Domains 57%
  • GTP-Binding Proteins 57%

• Mechanism of manganese dysregulation of dopamine neuronal activity

  Lin, M., Colon-Perez, L. M., Sambo, D. O., Miller, D. R., Lebowitz, J. J., Jimenez-Rondan, F., Cousins, R. J., Horenstein, N., Aydemir, T. B., Febo, M. & Khoshbouei, H., 22 Jul 2020, In: Journal of Neuroscience. 40, 30, p. 5871-5891 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Manganese 100%
  • Dopamine 70%
  • Dopaminergic Neurons 58%
  • Potassium Channels 15%
  • Nifedipine 15%

• Random mutagenesis of the human immunodeficiency virus type-1 frans-activator of transcription (HIV-1 Tat)

  Siderovski, D. P., Matsuyama, T., Frigerio, E., Chui, S., Min, X., Erfle, H., Sumner-smith, M., Bamett, R. W. & Mak, T. W., 25 Oct 1992, In: Nucleic Acids Research. 20, 20, p. 5311-5320 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutagenesis 100%
  • HIV-1 88%
  • Clone Cells 80%
  • tat Genes 56%
  • Nucleotides 54%

• Fluorescence-based assays for RGS box function

  Willard, F. S., Kimple, R. J., Kimple, A. J., Johnston, C. A. & Siderovski, D. P., 2004, In: Methods in Enzymology. 389, p. 56-71 16 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • GTP-Binding Protein Regulators 96%
  • Fluorescence 52%
  • Fluorescence Resonance Energy Transfer 43%
  • Guanosine 40%

• Hydroformylation of methyl methacrylate via "in-situ" phosphinerhodium catalysis

  Prókai-Tátrai, K., Torös, S. & Heil, B., 6 Oct 1987, In: Journal of Organometallic Chemistry. 332, 3, p. 331-335 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Regioselectivity 100%
  • Hydroformylation 88%
  • phosphine 82%
  • Rhodium 74%
  • phosphines 66%

• Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice

  Trexler, K. R., Nass, S. R., Crowe, M. S., Gross, J. D., Jones, M. S., McKitrick, A. W., Siderovski, D. P. & Kinsey, S. G., 1 Oct 2018, In: Drug and Alcohol Dependence. 191, p. 14-24 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabinoid 100%
  • Dronabinol 97%
  • 1-pentyl-3-(1-naphthoyl)indole 62%
  • Suspension 45%
  • Hindlimb Suspension 44%

• Menthol enhances nicotine-induced locomotor sensitization and in vivo functional connectivity in adolescence

  Thompson, M. F., Poirier, G. L., Dávila-García, M. I., Huang, W., Tam, K., Robidoux, M., Dubuke, M. L., Shaffer, S. A., Colon-Perez, L., Febo, M., DiFranza, J. R. & King, J. A., 1 Mar 2018, In: Journal of Psychopharmacology. 32, 3, p. 332-343 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Menthol 100%
  • Nicotine 69%
  • Brain 11%
  • Pharmaceutical Preparations 9%
  • Ventral Tegmental Area 9%

• Involvement of AP-1 and C/EBPβ in upregulation of endothelin B (ET_B) receptor expression in a rodent model of glaucoma

  He, S., Minton, A. Z., Ma, H. Y., Stankowska, D. L., Sun, X. & Krishnamoorthy, R. R., 12 Nov 2013, In: PLoS ONE. 8, 11, e79183.

  Research output: Contribution to journal › Article › peer-review

  • Endothelin B Receptors 100%
  • glaucoma 96%
  • endothelins 88%
  • Transcription Factor AP-1 76%
  • Glaucoma 65%

• Structural basis for nucleotide exchange on Gα_i subunits and receptor coupling specificity

  Johnston, C. A. & Siderovski, D. P., 6 Feb 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 2001-2006 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleotides 100%
  • KB-752 peptide 97%
  • Heterotrimeric GTP-Binding Proteins 55%
  • Peptides 52%
  • Dopamine D2 Receptors 48%

• Digital media use in the 2 h before bedtime is associated with sleep variables in university students

  Orzech, K. M., Grandner, M. A., Roane, B. M. & Carskadon, M. A., 1 Feb 2016, In: Computers in Human Behavior. 55, p. 43-50 8 p., 3676.

  Research output: Contribution to journal › Article › peer-review

  • Digital storage 100%
  • Digital Media 89%
  • sleep 85%
  • Sleep 83%
  • digital media 82%

• Cortical localization of the Gα protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division

  Afshar, K., Willard, F. S., Colombo, K., Siderovski, D. P. & Gönczy, P., Oct 2005, In: Development. 132, 20, p. 4449-4459 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Asymmetric Cell Division 100%
  • GTP-Binding Proteins 67%
  • Embryonic Structures 27%
  • Guanine Nucleotide Dissociation Inhibitors 26%
  • Guanine Nucleotide Exchange Factors 22%

• Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

  Stambolic, V., Suzuki, A., De la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P. & Mak, T. W., 2 Oct 1998, In: Cell. 95, 1, p. 29-39 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Viability 100%
  • Cell Survival 76%
  • phosphatidylinositol 3,4,5-triphosphate 73%
  • Phosphorylation 69%
  • Tensins 65%

• PKC modulation of GABA_A receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor β2 subunit

  Herring, D., Huang, R. Q., Singh, M., Dillon, G. H. & Leidenheimer, N. J., Feb 2005, In: Neuropharmacology. 48, 2, p. 181-194 14 p.

  Research output: Contribution to journal › Article › peer-review

  • GABA-A Receptors 100%
  • Endocytosis 94%
  • Mutation 52%
  • Dynamins 41%
  • Chlorides 33%

• Insomnia and mental health in college students

  Taylor, D. J., Gardner, C. E., Bramoweth, A. D., Williams, J. M., Roane, B. M., Grieser, E. A. & Tatum, J. I., Apr 2011, In: Behavioral Sleep Medicine. 9, 2, p. 107-116 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Sleep Initiation and Maintenance Disorders 100%
  • Mental Health 74%
  • Students 66%
  • mental health 65%
  • young adult 31%

• A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization

  Muller, R. E., Klein, K. R., Hutsell, S. Q., Siderovski, D. P. & Kimple, A. J., 1 Oct 2010, In: Assay and Drug Development Technologies. 8, 5, p. 621-624 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluorescence Polarization 100%
  • Heterotrimeric GTP-Binding Proteins 98%
  • Guanosine 80%
  • Nucleotide 60%
  • Nucleotides 59%

• Antihypertensive Activity of Redox Derivatives of Tryptophan

  Pop, E., Anderson, W., Prokai-Tatrai, K., Brewster, M. E., Bodor, N. & Fregly, M., 1990, In: Journal of Medicinal Chemistry. 33, 8, p. 2216-2221 6 p.

  Research output: Contribution to journal › Article › peer-review

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 100%
  • Antihypertensive 93%
  • Tryptophan 83%
  • Oxidation-Reduction 75%
  • Antihypertensive Agents 72%

• Molecular characterization of mitochodrial apoptosis-inducing factor

  Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D. R., Aebersold, R., Siderovski, D. P., Penninger, J. M. & Kroemer, G., 4 Feb 1999, In: Nature. 397, 6718, p. 441-446 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis Inducing Factor 100%
  • Mitochondria 58%
  • Apoptosis 43%
  • Chromatin 31%
  • Cell Death 26%

• Structural determinants of ubiquitin conjugation in entamoeba histolytica

  Bosch, D. E. & Siderovski, D. P., 25 Jan 2013, In: Journal of Biological Chemistry. 288, 4, p. 2290-2302 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Entamoeba histolytica 100%
  • Thioester 89%
  • Ubiquitin 76%
  • Proteasome Inhibitor 56%
  • Ubiquitination 41%

• Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

  Schiff, M. L., Siderovski, D. P., Jordan, J. D., Brothers, G., Snow, B., De Vries, L., Ortiz, D. F. & Diversé-Pierluissi, M., 7 Dec 2000, In: Nature. 408, 6813, p. 723-727 5 p.

  Research output: Contribution to journal › Article › peer-review

  • N-Type Calcium Channels 100%
  • PDZ Domains 60%
  • Protein-Tyrosine Kinases 59%
  • Psychological Inhibition 53%
  • Calcium Channels 46%

• On random walks and entropy in diffusion-weighted magnetic resonance imaging studies of neural tissue

  Ingo, C., Magin, R. L., Colon-Perez, L., Triplett, W. & Mareci, T. H., Feb 2014, In: Magnetic Resonance in Medicine. 71, 2, p. 617-627 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Entropy 100%
  • Diffusion Magnetic Resonance Imaging 98%
  • White Matter 38%
  • Statistical Models 23%
  • Mechanics 21%

• Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions

  Kosloff, M., Travis, A. M., Bosch, D. E., Siderovski, D. P. & Arshavsky, V. Y., Jul 2011, In: Nature Structural and Molecular Biology. 18, 7, p. 846-853 8 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • GTP-Binding Proteins 64%
  • GTP-Binding Protein Regulators 41%
  • Protein Domains 9%
  • Mutation 5%

• Reduced structural connectivity of the medial temporal lobe including the perforant path is associated with aging and verbal memory impairment

  Granger, S. J., Colon-Perez, L., Larson, M. S., Bennett, I. J., Phelan, M., Keator, D. B., Janecek, J. T., Sathishkumar, M. T., Smith, A. P., McMillan, L., Greenia, D., Corrada, M. M., Kawas, C. H. & Yassa, M. A., Jan 2023, In: Neurobiology of Aging. 121, p. 119-128 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Perforant Pathway 100%
  • Temporal Lobe 66%
  • Memory 52%
  • Entorhinal Cortex 35%
  • Cognitive Dysfunction 23%

• Induction of regulator of G-protein signaling 2 expression by long-acting β₂-adrenoceptor agonists and glucocorticoids in human airway epithelial cellss

  Holden, N. S., George, T., Rider, C. F., Chandrasekhar, A., Shah, S., Kaur, M., Johnson, M., Siderovski, D. P., Leigh, R., Giembycz, M. A. & Newton, R., Jan 2014, In: Journal of Pharmacology and Experimental Therapeutics. 348, 1, p. 12-24 13 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Salmeterol Xinafoate 97%
  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 66%
  • Interleukin-8 63%
  • Adrenergic Receptors 63%

• Structural determinants of rgs-rhogef signaling critical to entamoeba histolytica pathogenesis

  Bosch, D. E., Kimple, A. J., Manning, A. J., Muller, R. E., Willard, F. S., MacHius, M., Rogers, S. L. & Siderovski, D. P., 8 Jan 2013, In: Structure. 21, 1, p. 65-75 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Entamoeba histolytica 85%
  • Heterotrimeric GTP-Binding Proteins 28%
  • GTP-Binding Proteins 21%
  • Amoebic Dysentery 16%