Pharmacology & Neuroscience

Research output

Research output per year 1973 2000 2001 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 114956 Citations
• 147 h-index
• 1977 Article
• 171 Review article
• 50 Chapter
• 49 Comment/debate
• 76 More
  • 27 Editorial
  • 19 Short survey
  • 13 Letter
  • 10 Conference contribution
  • 2 Book
  • 2 Foreword/postscript
  • 2 Conference article
  • 1 Paper

Research output per year

Research output per year

Search results

• Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits

  Kimple, R. J., Kimple, M. E., Betts, L., Sondek, J. & Siderovski, D. P., 25 Apr 2002, In: Nature. 416, 6883, p. 878-881 4 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Proteins 100%
  • Nucleotides 80%
  • RGS Proteins 77%
  • Viperidae 67%
  • Heterotrimeric GTP-Binding Proteins 67%

• Are there racial/ethnic differences in indigent inner-city clients with dual diagnoses?

  Nejtek, V. A., Kaiser, K., Vo, H., Hilburn, C., Lea, J. & Vishwanatha, J., 2011, In: Journal of Dual Diagnosis. 7, 1-2, p. 26-38 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dual (Psychiatry) Diagnosis 100%
  • Poverty 75%
  • Hispanic Americans 50%
  • African Americans 49%
  • Psychiatry 39%

• Differential expression and regulation of estrogen receptors (ERs) in rat pituitary and cell lines: Estrogen decreases ERα protein and estrogen responsiveness

  Schreihofer, D. A., Stoler, M. H. & Shupnik, M. A., 2000, In: Endocrinology. 141, 6, p. 2174-2184 11 p.

  Research output: Contribution to journal › Article › peer-review

  • estrophilin 100%
  • TERP-1 76%
  • Estrogen Receptors 64%
  • Estrogens 57%
  • Cell Line 41%

• Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants

  Gross, J. D., Kaski, S. W., Schroer, A. B., Wix, K. A., Siderovski, D. P. & Setola, V., 1 Feb 2018, In: Journal of Psychopharmacology. 32, 2, p. 191-203 13 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Ventral Striatum 88%
  • Dopamine Plasma Membrane Transport Proteins 82%
  • Amphetamine 48%
  • RGS Proteins 34%

• GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg]ZO-1) domain

  Snow, B. E., Hall, R. A., Krumins, A. M., Brothers, G. M., Bouchard, D., Brothers, C. A., Chung, S., Mangion, J., Gilman, A. G., Lefkowitz, R. J. & Siderovski, D. P., 10 Jul 1998, In: Journal of Biological Chemistry. 273, 28, p. 17749-17755 7 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • Guanosine 80%
  • GTP-Binding Proteins 64%
  • Protein Isoforms 52%
  • Protein Domains 43%

• Free-water imaging of the hippocampus is a sensitive marker of Alzheimer's disease

  For the Alzheimer’s Disease Neuroimaging Initiative, 2019, In: NeuroImage: Clinical. 24, 101985.

  Research output: Contribution to journal › Article › peer-review

  • Hippocampus 100%
  • Alzheimer Disease 97%
  • Water 83%
  • Cognitive Dysfunction 82%
  • Positron-Emission Tomography 46%

• A single angiotensin Ii hypertensive stimulus is associated with prolonged neuronal and immune system activation in Wistar-Kyoto rats

  Zubcevic, J., Santisteban, M. M., Perez, P. D., Arocha, R., Hiller, H., Malphurs, W. L., Colon-Perez, L. M., Sharma, R. K., de Kloet, A., Krause, E. G., Febo, M. & Raizada, M. K., 31 Aug 2017, In: Frontiers in Physiology. 8, AUG, p. 592 1 p., 592.

  Research output: Contribution to journal › Article › peer-review

  • Inbred WKY Rats 100%
  • Angiotensins 96%
  • Angiotensin II 81%
  • Immune System 66%
  • Neural Pathways 43%

• Structure of Gα_i1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

  Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, Z., Bodor, E. T., Jones, M. B., Blaesius, R., Watts, V. J., Harden, T. K., Sondek, J., Ramer, J. K. & Siderovski, D. P., Jul 2005, In: Structure. 13, 7, p. 1069-1080 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanine Nucleotides 100%
  • Nucleotides 65%
  • Peptides 51%
  • KB-752 peptide 31%
  • GTP-Binding Proteins 26%

• Identification of residues mediating inhibition of glycine receptors by protons

  Chen, Z. & Huang, R., Jun 2007, In: Neuropharmacology. 52, 8, p. 1606-1615 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycine Receptors 100%
  • Protons 74%
  • Histidine 20%
  • Glycine 18%
  • Binding Sites 13%

• Magnetic resonance imaging and volumetric analysis: Novel tools to study the effects of thyroid hormone disruption on white matter development

  Powell, M. H., Nguyen, H. V., Gilbert, M., Parekh, M., Colon-Perez, L. M., Mareci, T. H. & Montie, E., Oct 2012, In: NeuroToxicology. 33, 5, p. 1322-1329 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Volumetric Analysis 100%
  • Thyroid Hormone 84%
  • Propylthiouracil 84%
  • Thyroid Hormones 62%
  • White Matter 56%

• RGS21, a regulator of taste and mucociliary clearance?

  Kimple, A. J., Garland, A. L., Cohen, S. P., Setola, V., Willard, F. S., Zielinski, T., Lowery, R. G., Tarran, R. & Siderovski, D. P., Mar 2014, In: Laryngoscope. 124, 3, p. E56-E63

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Mucociliary Clearance 90%
  • Aversive Agents 49%
  • Mucous Membrane 42%
  • Guanosine Triphosphate 42%

• Current alcohol use is associated with sleep patterns in first-year college students

  Van Reen, E., Roane, B. M., Barker, D. H., McGeary, J. E., Borsari, B. & Carskadon, M. A., 1 Jun 2016, In: Sleep. 39, 6, p. 1321-1326 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Drinking 100%
  • Sleep 85%
  • Alcohols 82%
  • Students 76%
  • HS 6 16%

• Regulators of G-protein signaling and their Gα substrates: Promises and challenges in their use as drug discovery targets

  Kimple, A. J., Bosch, D. E., Giguère, P. M. & Siderovski, D. P., Sep 2011, In: Pharmacological Reviews. 63, 3, p. 728-749 22 p.

  Research output: Contribution to journal › Article › peer-review

  • G-substrate 100%
  • GTP-Binding Protein Regulators 75%
  • Drug Discovery 51%
  • G-Protein-Coupled Receptors 50%
  • RGS Proteins 38%

• PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-κB activation

  Nakamura, K., Kimple, A. J., Siderovski, D. P. & Johnson, G. L., 15 Jan 2010, In: Journal of Biological Chemistry. 285, 3, p. 2077-2089 13 p.

  Research output: Contribution to journal › Article › peer-review

  • P62 100%
  • TNF Receptor-Associated Factor 6 87%
  • Protein Transport 26%
  • Mitogen-Activated Protein Kinase Kinases 26%
  • Proteasome Endopeptidase Complex 25%

• Cooperative interaction between the DNA-binding domains of PU.1 and IRF4

  Yee, A. A., Yin, P., Siderovski, D. P., Mak, T. W., Litchfield, D. W. & Arrowsmith, C. H., 26 Jun 1998, In: Journal of Molecular Biology. 279, 5, p. 1075-1083 9 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA 100%
  • Protein Domains 51%
  • proto-oncogene protein Spi-1 42%
  • Interferon Regulatory Factors 38%
  • Fluorescence Polarization 34%

• A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G_β5 subunits

  Snow, B. E., Krumins, A. M., Brothers, G. M., Lee, S. F., Wall, M. A., Chung, S., Mangion, J., Arya, S., Gilman, A. G. & Siderovski, D. P., 27 Oct 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 22, p. 13307-13312 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • Protein Subunits 73%
  • GTP-Binding Proteins 64%
  • Protein Binding 64%
  • GTPase-Activating Proteins 52%

• A seven-transmembrane RGS protein that modulates plant cell proliferation

  Chen, J. G., Willard, F. S., Huang, J., Liang, J., Chasse, S. A., Jones, A. M. & Siderovski, D. P., 19 Sep 2003, In: Science. 301, 5640, p. 1728-1731 4 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • Plant Cells 88%
  • G-Protein-Coupled Receptors 65%
  • GTP-Binding Protein Regulators 64%
  • Arabidopsis 56%

• The psychoactive designer drug and bath salt constituent MDPV causes widespread disruption of brain functional connectivity

  Colon-Perez, L. M., Tran, K., Thompson, K., Pace, M. C., Blum, K., Goldberger, B. A., Gold, M. S., Bruijnzeel, A. W., Setlow, B. & Febo, M., 1 Aug 2016, In: Neuropsychopharmacology. 41, 9, p. 2352-2365 14 p.

  Research output: Contribution to journal › Article › peer-review

  • 3,4-methylenedioxypyrovalerone 100%
  • Designer Drugs 84%
  • Psychotropic Drugs 64%
  • Baths 57%
  • Salts 48%

• An approach to understanding sleep and depressed mood in adolescents: person-centred sleep classification

  Shochat, T., Barker, D. H., Sharkey, K. M., Van Reen, E., Roane, B. M. & Carskadon, M. A., Dec 2017, In: Journal of Sleep Research. 26, 6, p. 709-717 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sleep 100%
  • Phenotype 51%
  • Sleep Latency 35%
  • Depression 18%
  • Latent Class Analysis 16%

• A bifunctional Gα_i/Gα_s modulatory peptide that attenuates adenylyl cyclase activity

  Johnston, C. A., Ramer, J. K., Blaesius, R., Fredericks, Z., Watts, V. J. & Siderovski, D. P., 24 Oct 2005, In: FEBS Letters. 579, 25, p. 5746-5750 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenylyl Cyclases 100%
  • Nucleotide 80%
  • Nucleotides 79%
  • Peptides 62%
  • GDP 62%

• G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2)

  Willard, F. S., McCudden, C. R. & Siderovski, D. P., Aug 2006, In: Cellular Signalling. 18, 8, p. 1226-1234 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanine Nucleotide Dissociation Inhibitors 100%
  • GTP-Binding Protein alpha Subunits 92%
  • Amino Acid Motifs 81%
  • Purkinje Cells 72%
  • Purkinje cell protein L7 37%

• Effect of extracellular pH on GABA-activated current in rat recombinant receptors and thin hypothalamic slices

  Huang, R. Q. & Dillon, G. H., 1999, In: Journal of Neurophysiology. 82, 3, p. 1233-1243 11 p.

  Research output: Contribution to journal › Article › peer-review

  • gamma-Aminobutyric Acid 100%
  • GABA-A Receptors 18%
  • Aminobutyrates 12%
  • GABA Receptors 10%
  • HEK293 Cells 9%

• Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and hcv co-infection

  Whitmill, A., Kim, S., Rojas, V., Gulraiz, F., Afreen, K., Jain, M., Singh, M. & Park, I. W., Aug 2018, In: PLoS ONE. 13, 8, e0202524.

  Research output: Contribution to journal › Article › peer-review

  • liver diseases 100%
  • Human immunodeficiency virus 1 93%
  • mixed infection 80%
  • Coinfection 73%
  • HIV-1 66%

• Minimal determinants for binding activated Gα from the structure of a Gα_il-peptide dimer

  Johnston, C. A., Lobanova, E. S., Shavkunov, A. S., Low, J., Ramer, J. K., Blaesius, R., Fredericks, Z., Willard, F. S., Kuhlman, B., Arshavsky, V. Y. & Siderovski, D. P., 26 Sep 2006, In: Biochemistry. 45, 38, p. 11390-11400 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Effector 100%
  • RGS Proteins 70%
  • Transducin 67%
  • Peptides 58%
  • Phosphoric Diester Hydrolases 53%

• Spectral analysis by XANES reveals that GPNMB influences the chemical composition of intact melanosomes

  Haraszti, T., Trantow, C. M., Hedberg-Buenz, A., Grunze, M. & Anderson, M. G., Feb 2011, In: Pigment Cell and Melanoma Research. 24, 1, p. 187-196 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Melanosomes 100%
  • X-Ray Absorption Near Edge Structure 88%
  • X-Rays 55%
  • Electron Microscopy 31%
  • Protein 29%