Pharmacology & Neuroscience

Research output

Research output per year 1973 2000 2001 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 114855 Citations
• 147 h-index
• 1977 Article
• 171 Review article
• 50 Chapter
• 49 Comment/debate
• 76 More
  • 27 Editorial
  • 19 Short survey
  • 13 Letter
  • 10 Conference contribution
  • 2 Book
  • 2 Foreword/postscript
  • 2 Conference article
  • 1 Paper

Research output per year

Research output per year

Search results

• Glucocorticoid receptor transactivation is required for glucocorticoid-induced ocular hypertension and glaucoma

  Patel, G. C., Millar, J. C. & Clark, A. F., May 2019, In: Investigative Ophthalmology and Visual Science. 60, 6, p. 1967-1978 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ocular Hypertension 100%
  • Trabecular Meshwork 90%
  • Glucocorticoid Receptors 88%
  • Glaucoma 75%
  • Glucocorticoids 72%

• Potentiation of Sphingolipids and TGF-β in the human corneal stroma reveals intricate signaling pathway crosstalks

  Nicholas, S. E., Choi, A. J., Lam, T. N., Basu, S. K., Mandal, N. & Karamichos, D., Jun 2023, In: Experimental eye research. 231, 109487.

  Research output: Contribution to journal › Article › peer-review

  • Corneal Stroma 100%
  • Sphingolipids 90%
  • Transforming Growth Factors 77%
  • sphingosine 1-phosphate 45%
  • sphingosine kinase 18%

• Activator of G protein signaling 3 is a guanine dissociation inhibitor for gα subunits

  De Vries, L., Fischer, T., Tronchère, H., Brothers, G. M., Strockbine, B., Siderovski, D. P. & Farquhar, M. G., 19 Dec 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 26, p. 14364-14369 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanine 100%
  • GTP-Binding Proteins 84%
  • Heterotrimeric GTP-Binding Proteins 28%
  • Heart 9%
  • Surface Plasmon Resonance 8%

• Angiopoietin-2 in experimental colitis

  Ganta, V. C., Cromer, W., Mills, G. L., Traylor, J., Jennings, M., Daley, S., Clark, B., Mathis, J. M., Bernas, M., Boktor, M., Jordan, P., Witte, M. & Alexander, J. S., 2010, In: Inflammatory Bowel Diseases. 16, 6, p. 1029-1039 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Angiopoietin-2 100%
  • Colitis 72%
  • Inflammatory Bowel Diseases 27%
  • Leukocytes 13%
  • Capillary Fragility 10%

• Effect of neural precursor proliferation level on neurogenesis in rat brain during aging and after focal ischemia

  Tang, H., Wang, Y., Xie, L., Mao, X. O., Won, S. J., Galvan, V. & Jin, K., Feb 2009, In: Neurobiology of Aging. 30, 2, p. 299-308 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurogenesis 100%
  • Ischemia 71%
  • Brain 46%
  • Caspase 3 23%
  • Young Adult 21%

• Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz

  Dalwadi, D. A., Kim, S., Amdani, S. M., Chen, Z., Huang, R. Q. & Schetz, J. A., 1 Aug 2016, In: Pharmacological Research. 110, p. 10-24 15 p.

  Research output: Contribution to journal › Article › peer-review

  • efavirenz 100%
  • HIV-1 65%
  • serotonin 6 receptor 41%
  • Lysergic Acid Diethylamide 22%
  • Receptor, Serotonin, 5-HT2A 21%

• CB1 cannabinoid receptor induction in experimental stroke

  Jin, K. L., Mao, X. O., Goldsmith, P. C. & Greenberg, D. A., 2000, In: Annals of Neurology. 48, 2, p. 257-261 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabinoid Receptor CB1 100%
  • Cannabinoids 60%
  • Stroke 53%
  • Neurons 32%
  • Middle Cerebral Artery Infarction 28%

• Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum

  Jin, K., Sun, Y., Xie, L., Peel, A., Mao, X. O., Batteur, S. & Greenberg, D. A., 1 Sep 2003, In: Molecular and Cellular Neuroscience. 24, 1, p. 171-189 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Ischemia 100%
  • Cerebral Cortex 93%
  • Neurons 62%
  • Brain 49%
  • Lateral Ventricles 37%

• Sex differences in the pentylenetetrazol-like stimulus induced by ethanol withdrawal

  Jung, M. E., Wallis, C. J., Gatch, M. B. & Lal, H., Nov 1999, In: Journal of Pharmacology and Experimental Therapeutics. 291, 2, p. 576-582 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Pentylenetetrazole 100%
  • Sex Characteristics 73%
  • Ethanol 66%
  • Estradiol 28%
  • Aminobutyrates 9%

• An examination of the Boston Naming Test: Calculation of "estimated" 60-item score from 30- and 15-item scores in a cognitively impaired population

  Hobson, V. L., Hall, J., Harvey, M., Cullum, C. M., Lacritz, L., Massman, P. J., Waring, S. C. & O'Bryant, S., 1 Apr 2011, In: International Journal of Geriatric Psychiatry. 26, 4, p. 351-355 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Language Tests 100%
  • Alzheimer Disease 49%
  • Population 28%
  • Registries 25%
  • Psychological Power 9%

• A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization

  Muller, R. E., Klein, K. R., Hutsell, S. Q., Siderovski, D. P. & Kimple, A. J., 1 Oct 2010, In: Assay and Drug Development Technologies. 8, 5, p. 621-624 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluorescence Polarization 100%
  • Heterotrimeric GTP-Binding Proteins 98%
  • Guanosine 80%
  • Nucleotide 60%
  • Nucleotides 59%

• Hyperparameter Tuning with High Performance Computing Machine Learning for Imbalanced Alzheimer’s Disease Data

  Zhang, F., Petersen, M., Johnson, L., Hall, J. & O’bryant, S. E., 1 Jul 2022, In: Applied Sciences (Switzerland). 12, 13, 6670.

  Research output: Contribution to journal › Article › peer-review

  • machine learning 100%
  • Tuning 61%
  • tuning 59%
  • Machine learning 57%
  • Support vector machines 37%

• Effects of benzodiazepines on acute and chronic ethanol-induced nociception in rats

  Gatch, M. B., Nov 1999, In: Alcoholism: Clinical and Experimental Research. 23, 11, p. 1736-1743 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Nociception 100%
  • Benzodiazepine 97%
  • Benzodiazepines 86%
  • Ethanol 71%
  • Flumazenil 54%

• Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies

  Mach, R. H. & Luedtke, R. T., 1 Mar 2018, In: Journal of Labelled Compounds and Radiopharmaceuticals. 61, 3, p. 291-298 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Positron 100%
  • Dopamine 80%
  • Positron-Emission Tomography 79%
  • Dopamine D2 Receptors 75%
  • Dopamine D3 Receptors 61%

• Cognitive differences among depressed and non-depressed MCI participants: A project FRONTIER study

  Johnson, L. A., Mauer, C., Jahn, D., Song, M., Wyshywaniuk, L., Hall, J. R., Balldin, V. H. & O'Bryant, S. E., Apr 2013, In: International Journal of Geriatric Psychiatry. 28, 4, p. 377-382 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognitive Dysfunction 100%
  • Depression 62%
  • Repression (Psychology) 38%
  • Short-Term Memory 25%
  • Rural Health 17%

• GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling

  Johnston, C. A., Taylor, J. P., Gao, Y., Kimple, A. J., Grigston, J. C., Chen, J. G., Siderovski, D. P., Jones, A. M. & Willard, F. S., 30 Oct 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 44, p. 17317-17322 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Arabidopsis Proteins 100%
  • Heterotrimeric GTP-Binding Proteins 76%
  • GTP Phosphohydrolases 65%
  • Guanosine Triphosphate 60%
  • GTP-Binding Proteins 56%

• Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

  Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S. H., Zhong, Z., Shen, Y., Simpkins, J. W. & Tanzi, R. E., 7 Jun 2007, In: Neuron. 54, 5, p. 721-737 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid Precursor Protein Secretases 100%
  • Alzheimer Disease 62%
  • Brain Ischemia 60%
  • Proteins 22%
  • Caspases 20%

• Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia

  Chen, J., Nagayama, T., Jin, K., Anne Stetler, R., Zhu, R. L., Graham, S. H. & Simon, R. P., 1 Jul 1998, In: Journal of Neuroscience. 18, 13, p. 4914-4928 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Transient Ischemic Attack 100%
  • Caspase 3 80%
  • Peptide Hydrolases 76%
  • Hippocampus 72%
  • Ischemia 26%

• Assessment of blood-born biochemical markers in primary open angle glaucoma

  Goode, S., Lane, D., McNatt, L. & Clark, A., 15 Feb 1996, In: Investigative Ophthalmology and Visual Science. 37, 3

  Research output: Contribution to journal › Article › peer-review

  • Open Angle Glaucoma 100%
  • Hydroxysteroid Dehydrogenases 59%
  • Biomarkers 57%
  • Leukocytes 34%
  • Ouabain 33%

• Histological investigation of human glaucomatous eyes: Extracellular fibrotic changes and galectin 3 expression in the trabecular meshwork and optic nerve head

  Belmares, R., Raychaudhuri, U., Maansson, S. & Clark, A. F., Oct 2018, In: Clinical Anatomy. 31, 7, p. 1031-1049 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabecular Meshwork 100%
  • Galectin 3 98%
  • Optic Disk 83%
  • Eye 46%
  • Collagen 40%

• Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro

  Chaitanya, G. V., Cromer, W. E., Wells, S. R., Jennings, M. H., Couraud, P. O., Romero, I. A., Weksler, B., Erdreich-Epstein, A., Mathis, J. M., Minagar, A. & Alexander, J. S., 23 Nov 2011, In: Journal of neuroinflammation. 8, 162.

  Research output: Contribution to journal › Article › peer-review

  • Cytokines 100%
  • Astrocytes 84%
  • Brain 79%
  • In Vitro Techniques 70%
  • Blood-Brain Barrier 66%

• Transient Focal Cerebral Ischemia Induces Long-term Cerebral Vasculature Dysfunction in a Rodent Experimental Stroke Model

  Winters, A., Taylor, J. C., Ren, M., Ma, R., Liu, R. & Yang, S. H., Jun 2012, In: Translational Stroke Research. 3, 2, p. 279-285 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Transient Ischemic Attack 100%
  • Rodentia 75%
  • Theoretical Models 74%
  • Stroke 62%
  • Phenylephrine 49%

• The utility of a tissue slice model system to determine breast cancer infectivity by oncolytic adenoviruses

  Pennington, K., Chu, Q. D., Curiel, D. T., Li, B. D. L. & Mathis, J. M., Oct 2010, In: Journal of Surgical Research. 163, 2, p. 270-275 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenoviridae 100%
  • Tropism 70%
  • Breast Neoplasms 65%
  • red fluorescent protein 42%
  • Virus Replication 29%

• Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): Genomic structure and chromosomal localization of the human gene

  Snow, B. E., Antonio, L., Suggs, S. & Siderovski, D. P., 12 Jan 1998, In: Gene. 206, 2, p. 247-253 7 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • GTP-Binding Proteins 66%
  • Organism Cloning 61%
  • Genes 26%
  • Chromosomes 15%

• The effect of postmortem time on the RNA quality of human ocular tissues

  Kim, B. J., Sprehe, N., Morganti, A., Wordinger, R. J. & Clark, A., 19 Jun 2013, In: Molecular Vision. 19, p. 1290-1295 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA 100%
  • Eye 89%
  • Trabecular Meshwork 14%
  • Ciliary Body 14%
  • Eye Diseases 11%