Research Output

Filter
Review article
2020

Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage

Zuo, Z. & Liu, J., Jun 2020, In : Current Opinion in Structural Biology. 62, p. 166-174 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Inducible rodent models of glaucoma

Pang, I. H. & Clark, A. F., Mar 2020, In : Progress in Retinal and Eye Research. 75, 100799.

Research output: Contribution to journalReview article

3 Scopus citations

Reductive Stress-Induced Mitochondrial Dysfunction and Cardiomyopathy

Ma, W. X., Li, C. Y., Tao, R., Wang, X. P. & Yan, L. J., 2020, In : Oxidative Medicine and Cellular Longevity. 2020, 5136957.

Research output: Contribution to journalReview article

Open Access
2019

Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases

Ma, J., Gao, B., Zhang, K., Zhang, Q., Jia, G., Li, J., Li, C., Yan, L. J. & Cai, Z., Nov 2019, In : Brain Research Bulletin. 153, p. 15-23 9 p.

Research output: Contribution to journalReview article

Corneal injury: Clinical and molecular aspects

Barrientez, B., Nicholas, S. E., Whelchel, A., Sharif, R., Hjortdal, J. & Karamichos, D., Sep 2019, In : Experimental eye research. 186, 107709.

Research output: Contribution to journalReview article

4 Scopus citations
Open Access
7 Scopus citations

Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke

Ma, J., Qiao, P., Li, Q., Wang, Y., Zhang, L., Yan, L. J. & Cai, Z., Dec 2019, In : Neurochemistry International. 131, 104539.

Research output: Contribution to journalReview article

Wearable Devices for Single-Cell Sensing and Transfection

Chang, L., Wang, Y. C., Ershad, F., Yang, R., Yu, C. & Fan, Y., Nov 2019, In : Trends in Biotechnology. 37, 11, p. 1175-1188 14 p.

Research output: Contribution to journalReview article

4 Scopus citations
2018

Cataract preventive role of isolated phytoconstituents: Findings from a decade of research

Lim, V., Schneider, E., Wu, H. & Pang, I. H., Nov 2018, In : Nutrients. 10, 11, 1580.

Research output: Contribution to journalReview article

3 Scopus citations

Current strategies for brain drug delivery

Dong, X., 2018, In : Theranostics. 8, 6, p. 1481-1493 13 p.

Research output: Contribution to journalReview article

137 Scopus citations

Ligandomics: a paradigm shift in biological drug discovery

Li, W., Pang, I. H., Pacheco, M. T. F. & Tian, H., Mar 2018, In : Drug Discovery Today. 23, 3, p. 636-643 8 p.

Research output: Contribution to journalReview article

6 Scopus citations

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Sharif, R., Bak-Nielsen, S., Hjortdal, J. & Karamichos, D., Nov 2018, In : Progress in Retinal and Eye Research. 67, p. 150-167 18 p.

Research output: Contribution to journalReview article

24 Scopus citations

Role and possible mechanisms of sirt1 in depression

Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L. J. & Yang, X., 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 8596903.

Research output: Contribution to journalReview article

16 Scopus citations
2017

Involvement of Nrf2 in ocular diseases

Batliwala, S., Xavier, C., Liu, Y., Wu, H. & Pang, I. H., 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 1703810.

Research output: Contribution to journalReview article

23 Scopus citations

Metabolic vulnerability in the neurodegenerative disease glaucoma

Inman, D. M. & Harun-Or-Rashid, M., 30 Mar 2017, In : Frontiers in Neuroscience. 11, MAR, 146.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

mGlu5 negative allosteric modulators: a patent review (2013 - 2016)

Emmitte, K. A., 3 Jun 2017, In : Expert Opinion on Therapeutic Patents. 27, 6, p. 691-706 16 p.

Research output: Contribution to journalReview article

15 Scopus citations

Potential biochemical mechanisms of lung injury in diabetes

Zheng, H., Wu, J., Jin, Z. & Yan, L. J., 2017, In : Aging and Disease. 8, 1, p. 7-16 10 p.

Research output: Contribution to journalReview article

19 Scopus citations
2016

Chemical conditioning as an approach to ischemic stroke tolerance: Mitochondria as the target

Jin, Z., Wu, J. & Yan, L. J., 8 Mar 2016, In : International journal of molecular sciences. 17, 3, 351.

Research output: Contribution to journalReview article

18 Scopus citations

Novel therapeutic targets for reduction of intraocular pressure in primary open angle glaucoma

Mao, W., Liu, Y., Wordinger, R. J., Clark, A. F. & Pang, I. H., 11 Jun 2016, In : Chinese Journal of Ophthalmology. 52, 6, p. 471-475 5 p.

Research output: Contribution to journalReview article

Ocular Complications of Diabetes and Therapeutic Approaches

Vieira-Potter, V. J., Karamichos, D. & Lee, D. J., 2016, In : BioMed Research International. 2016, 3801570.

Research output: Contribution to journalReview article

Open Access
40 Scopus citations

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

Lindsley, C. W., Emmitte, K. A., Hopkins, C. R., Bridges, T. M., Gregory, K. J., Niswender, C. M. & Conn, P. J., 8 Jun 2016, In : Chemical Reviews. 116, 11, p. 6707-6741 35 p.

Research output: Contribution to journalReview article

100 Scopus citations

Role of RAGE in Alzheimer’s Disease

Cai, Z., Liu, N., Wang, C., Qin, B., Zhou, Y., Xiao, M., Chang, L., Yan, L. J. & Zhao, B., 1 May 2016, In : Cellular and Molecular Neurobiology. 36, 4, p. 483-495 13 p.

Research output: Contribution to journalReview article

88 Scopus citations

Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications

Wu, J., Jin, Z., Zheng, H. & Yan, L. J., 10 May 2016, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 9, p. 145-153 9 p.

Research output: Contribution to journalReview article

30 Scopus citations
2015

Advancing biological understanding and therapeutics discovery with small-molecule probes

Schreiber, S. L., Kotz, J. D., Li, M., Aubé, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., Clemons, P. A., De Souza, A., Foley, M. A., Palmer, M., Shamji, A. F., Wawer, M. J., McManus, O., Wu, M. & 26 others, Zou, B., Yu, H., Golden, J. E., Schoenen, F. J., Simeonov, A., Jadhav, A., Jackson, M. R., Pinkerton, A. B., Chung, T. D. Y., Griffin, P. R., Cravatt, B. F., Hodder, P. S., Roush, W. R., Roberts, E., Chung, D. H., Jonsson, C. B., Noah, J. W., Severson, W. E., Ananthan, S., Edwards, B., Oprea, T. I., Conn, P. J., Hopkins, C. R., Wood, M. R., Stauffer, S. R. & Emmitte, K. A., 2015, In : Cell. 161, 6, p. 1252-1265 14 p.

Research output: Contribution to journalReview article

80 Scopus citations

Cerebral small vessel disease and Alzheimer’s disease

Cai, Z., Wang, C., He, W., Tu, H., Tang, Z., Xiao, M. & Yan, L. J., 2015, In : Clinical interventions in aging. 10, p. 1695-1704 10 p., A196.

Research output: Contribution to journalReview article

33 Scopus citations

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M. & 134 others, Haines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. & Glöckner, F. O., 18 Aug 2015, In : Nature Chemical Biology. 11, 9, p. 625-631 7 p.

Research output: Contribution to journalReview article

327 Scopus citations

Role of insulin resistance in Alzheimer’s disease

Cai, Z., Xiao, M., Chang, L. & Yan, L. J., 1 Aug 2015, In : Metabolic Brain Disease. 30, 4, p. 839-851 13 p., A001.

Research output: Contribution to journalReview article

18 Scopus citations
28 Scopus citations
92 Scopus citations

The 'sweet' spot of cellular pluripotency: Protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine

Wang, Y. C., Lin, V., Loring, J. F. & Peterson, S. E., 1 May 2015, In : Expert Opinion on Biological Therapy. 15, 5, p. 679-687 9 p.

Research output: Contribution to journalReview article

3 Scopus citations

Understanding melanocyte stem cells for disease modeling and regenerative medicine applications

Mull, A. N., Zolekar, A. & Wang, Y. C., 21 Dec 2015, In : International journal of molecular sciences. 16, 12, p. 30458-30469 12 p.

Research output: Contribution to journalReview article

15 Scopus citations
2014

Genome-guided discovery of diverse natural products from Burkholderia sp.

Liu, X. & Cheng, Y. Q., Feb 2014, In : Journal of Industrial Microbiology and Biotechnology. 41, 2, p. 275-284 10 p.

Research output: Contribution to journalReview article

42 Scopus citations

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

Cai, Z., Hussain, M. D. & Yan, L. J., May 2014, In : International Journal of Neuroscience. 124, 5, p. 307-321 15 p.

Research output: Contribution to journalReview article

173 Scopus citations

Pathogenesis of chronic hyperglycemia: From reductive stress to oxidative stress

Yan, L. J., 2014, In : Journal of Diabetes Research. 2014, 137919.

Research output: Contribution to journalReview article

141 Scopus citations

Positive oxidative stress in aging and aging-related disease tolerance

Yan, L. J., Apr 2014, In : Redox Biology. 2, 1, p. 165-169 5 p.

Research output: Contribution to journalReview article

87 Scopus citations

Protein post-translational modifications and regulation of pluripotency in human stem cells

Wang, Y. C., Peterson, S. E. & Loring, J. F., Feb 2014, In : Cell Research. 24, 2, p. 143-160 18 p.

Research output: Contribution to journalReview article

128 Scopus citations
21 Scopus citations
2013

Challenges in the development of glaucoma neuroprotection therapy

Liu, Y. & Pang, I-H., 1 Aug 2013, In : Cell and Tissue Research. 353, 2, p. 253-260 8 p.

Research output: Contribution to journalReview article

10 Scopus citations

MGlu5 negative allosteric modulators: A patent review (2010-2012)

Emmitte, K. A., 1 Apr 2013, In : Expert Opinion on Therapeutic Patents. 23, 4, p. 393-408 16 p.

Research output: Contribution to journalReview article

54 Scopus citations
2 Scopus citations
2012

Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., 23 Feb 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.

Research output: Contribution to journalReview article

169 Scopus citations
2011

Guanylate cyclase activators, cell volume changes and IOP reduction

Ellis, D. Z., 2011, In : Cellular Physiology and Biochemistry. 28, 6, p. 1145-1154 10 p.

Research output: Contribution to journalReview article

15 Scopus citations

Recent advances in the design and development of novel negative allosteric modulators of mGlu 5

Emmitte, K. A., 17 Aug 2011, In : ACS Chemical Neuroscience. 2, 8, p. 411-432 22 p.

Research output: Contribution to journalReview article

55 Scopus citations

Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions

MacHu, T. K., Jun 2011, In : Pharmacology and Therapeutics. 130, 3, p. 338-347 10 p.

Research output: Contribution to journalReview article

50 Scopus citations
2009

Recent progress in the discovery and development of negative allosteric modulators of mGluR5

Lindsley, C. W. & Emmitte, K. A., 1 Jul 2009, In : Current Opinion in Drug Discovery and Development. 12, 4, p. 446-457 12 p.

Research output: Contribution to journalReview article

47 Scopus citations

The multifaceted role of T cell-mediated immunity in pathogenesis and resistance to mycoplasma respiratory disease

Dobbs, N. A., Odeh, A. N., Sun, X. & Simecka, J. W., 1 Dec 2009, In : Current Trends in Immunology. 10, p. 1-19 19 p.

Research output: Contribution to journalReview article

11 Scopus citations
2008

Clinical pharmacy education in China

Ryan, M., Shao, H., Yang, L., Nie, X. Y., Zhai, S. D., Shi, L. W. & Lubawy, W. C., 2008, In : American journal of pharmaceutical education. 72, 6, 129.

Research output: Contribution to journalReview article

24 Scopus citations

Intraocular pressure measurement in rodents

Pang, I. H., Wang, W. H., Millar, J. C. & Clark, A. F., 1 May 2008, In : Chinese Journal of Ophthalmology. 44, 5, p. 465-468 4 p.

Research output: Contribution to journalReview article

2 Scopus citations
2007

Rodent models for glaucoma retinopathy and optic neuropathy

Pang, I-H. & Clark, A., 1 Aug 2007, In : Journal of Glaucoma. 16, 5, p. 483-505 23 p.

Research output: Contribution to journalReview article

117 Scopus citations
2005

Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters.

Shen, B., Chen, M., Cheng, Y., Du, L., Edwards, D. J., George, N. P., Huang, Y., Oh, T., Sanchez, C., Tang, G., Wendt-Pienkowski, E. & Yi, F., 2005, In : Ernst Schering Research Foundation workshop. 51, p. 107-126 20 p.

Research output: Contribution to journalReview article

5 Scopus citations