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2020

Antioxidative and hypoglycemic effect of ta-ermi extracts on streptozotocin-induced diabetes

Jing, S., Zhao, Z., Wu, J. & Yan, L. J., 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13, p. 2147-2155 9 p.

Research output: Contribution to journalArticle

Open Access

C1-CBP-vancomycin: Impact of a Vancomycin C-Terminus Trimethylammonium Cation on Pharmacological Properties and Insights into Its Newly Introduced Mechanism of Action

Wu, Z. C., Isley, N. A., Okano, A., Weiss, W. J. & Boger, D. L., 7 Feb 2020, In : Journal of Organic Chemistry. 85, 3, p. 1365-1375 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Curcumin nanoparticles and their cytotoxicity in docetaxel-resistant castration-resistant prostate cancer cells

Tanaudommongkon, I., Tanaudommongkon, A., Prathipati, P., Nguyen, J. T., Keller, E. T. & Dong, X., Aug 2020, In : Biomedicines. 8, 8, 253.

Research output: Contribution to journalArticle

Open Access

DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

Saint-Lu, N., Burdet, C., Sablier-Gallis, F., Corbel, T., Nevière, A., Sayah-Jeanne, S., Pulse, M., Weiss, W., Ferreira, S., Andremont, A., Mentré, F. & de Gunzburg, J., 2020, In : Antimicrobial agents and chemotherapy. 64, 1, e01196-19.

Research output: Contribution to journalArticle

1 Scopus citations

Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

Chaudhari, K., Wang, J., Xu, Y., Winters, A., Wang, L., Dong, X., Cheng, E. Y., Liu, R. & Yang, S. H., Jun 2020, In : PLoS ONE. 15, 6, e0234571.

Research output: Contribution to journalArticle

Open Access

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Liu, B., Trout, R. E. L., Chu, G. H., Mcgarry, D., Jackson, R. W., Hamrick, J. C., Daigle, D. M., Cusick, S. M., Pozzi, C., De Luca, F., Benvenuti, M., Mangani, S., Docquier, J. D., Weiss, W. J., Pevear, D. C., Xerri, L. & Burns, C. J., 26 Mar 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 2789-2801 13 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke

Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 27 Jan 2020, In : Behavioural Brain Research. 378, 112278.

Research output: Contribution to journalArticle

Effects of mesencephalic astrocyte-derived neurotrophic factor on cerebral angiogenesis in a rat model of cerebral ischemia

Gao, B., Deng, J., Zhang, X., Sun, H., Jia, G., Li, J., Zhang, K., Wan, C., Wang, L., Yan, L. J., Cai, Z. & Ma, J., 10 Jan 2020, In : Neuroscience letters. 715, p. 134657 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Epidemic ribotypes of Clostridium (now Clostridioides) difficile are likely to be more virulent than non-epidemic ribotypes in animal models

Vitucci, J. C., Pulse, M., Tabor-Simecka, L. & Simecka, J., 5 Feb 2020, In : BMC Microbiology. 20, 1, 27.

Research output: Contribution to journalArticle

Open Access

MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma

Harun-Or-Rashid, M., Pappenhagen, N., Zubricky, R., Coughlin, L., Jassim, A. H. & Inman, D. M., Jul 2020, In : Neurobiology of Disease. 141, 104944.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury

Jing, S. Q., Wang, S. S., Zhong, R. M., Zhang, J. Y., Wu, J. Z., Tu, Y. X., Pu, Y. & Yan, L. J., 1 Mar 2020, In : Neural Regeneration Research. 15, 3, p. 548-556 9 p.

Research output: Contribution to journalArticle

Open Access

Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment

Duong, P., Tenkorang, M. A. A., Trieu, J., McCuiston, C., Rybalchenko, N. & Cunningham, R. L., 29 Mar 2020, In : Biology of Sex Differences. 11, 1, 12.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

On-chip multiplexed single-cell patterning and controllable intracellular delivery

Dong, Z., Jiao, Y., Xie, B., Hao, Y., Wang, P., Liu, Y., Shi, J., Chitrakar, C., Black, S., Wang, Y. C., Lee, L. J., Li, M., Fan, Y. & Chang, L., 1 Dec 2020, In : Microsystems and Nanoengineering. 6, 1, 2.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment

Guenter, R., Aweda, T., Carmona Matos, D. M., Jang, S., Whitt, J., Cheng, Y. Q., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jan 2020, In : Surgery (United States). 167, 1, p. 189-196 8 p.

Research output: Contribution to journalArticle

Regulation of the SIRT1 signaling pathway in NMDA-induced Excitotoxicity

Yang, X., Sun, X., Wu, J., Ma, J., Si, P., Yin, L., Zhang, Y., Yan, L. J. & Zhang, C., 1 Apr 2020, In : Toxicology Letters. 322, p. 66-76 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses

Lin, V. J. T., Hu, J., Zolekar, A., Yan, L. J. & Wang, Y. C., 14 May 2020, In : Frontiers in Cell and Developmental Biology. 8, 304.

Research output: Contribution to journalArticle

Open Access
2019

A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library

Wang, X. S., Chen, P. H. C., Hampton, J. T., Tharp, J. M., Reed, C. A., Das, S. K., Wang, D. S., Hayatshahi, H. S., Shen, Y., Liu, J. & Liu, W. R., 28 Oct 2019, In : Angewandte Chemie - International Edition. 58, 44, p. 15904-15909 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hypoxia-induced hypertension

Shell, B., Farmer, G. E., Nedungadi, T. P., Wang, L. A., Marciante, A. B., Snyder, B., Cunningham, R. L. & Cunningham, J. T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R651-R665

Research output: Contribution to journalArticle

4 Scopus citations

Assessing the Performance of the Nonbonded Mg2+ Models in a Two-Metal-Dependent Ribonuclease

Zuo, Z. & Liu, J., 28 Jan 2019, In : Journal of Chemical Information and Modeling. 59, 1, p. 399-408 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Association between Diabetes and Keratoconus: A Retrospective Analysis

Whelchel, A. E., McKay, T. B., Priyadarsini, S., Rowsey, T. & Karamichos, D., 1 Dec 2019, In : Scientific Reports. 9, 1, 13808.

Research output: Contribution to journalArticle

Open Access

Bioinspired Nanoparticles Engineered for Enhanced Delivery to the Bone

Gdowski, A. S., Lampe, J. B., Lin, V. J. T., Joshi, R., Wang, Y. C., Mukerjee, A., Vishwanatha, J. K. & Ranjan, A. P., 25 Oct 2019, In : ACS Applied Nano Materials. 2, 10, p. 6249-6257 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, W. P., Simecka, J. W., Raut, S., Ray, A. & Basha, R., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Corneal epithelial–stromal fibroblast constructs to study cell–cell communication in vitro

McKay, T. B., Karamichos, D., Zieske, J. D., Hutcheon, A. E. K. & Guo, X., Dec 2019, In : Bioengineering. 6, 4, 110.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. R., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Felts, A. S., Bollinger, K. A., Brassard, C. J., Rodriguez, A. L., Morrison, R. D., Scott Daniels, J., Blobaum, A. L., Niswender, C. M., Jones, C. K., Jeffrey Conn, P., Emmitte, K. A. & Lindsley, C. W., 1 Jan 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 1, p. 47-50 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu 2 ) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide Cores

Childress, E. S., Wieting, J. M., Felts, A. S., Breiner, M. M., Long, M. F., Luscombe, V. B., Rodriguez, A. L., Cho, H. P., Blobaum, A. L., Niswender, C. M., Emmitte, K. A., Conn, P. J. & Lindsley, C. W., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 378-384 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M 1 Positive Allosteric Modulators

Engers, J. L., Bender, A. M., Kalbfleisch, J. J., Cho, H. P., Lingenfelter, K. S., Luscombe, V. B., Han, C., Melancon, B. J., Blobaum, A. L., Dickerson, J. W., Rook, J. M., Niswender, C. M., Emmitte, K. A., Conn, P. J. & Lindsley, C. W., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1035-1042 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease

Panarese, J. D., Engers, D. W., Wu, Y. J., Bronson, J. J., Macor, J. E., Chun, A., Rodriguez, A. L., Felts, A. S., Engers, J. L., Loch, M. T., Emmitte, K. A., Castelhano, A. L., Kates, M. J., Nader, M. A., Jones, C. K., Blobaum, A. L., Conn, P. J., Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., 14 Mar 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2 Scopus citations

Enhancement of the Antioxidant Activity and Neurotherapeutic Features through Pyridol Addition to Tetraazamacrocyclic Molecules

Johnston, H. M., Pota, K., Barnett, M. M., Kinsinger, O., Braden, P., Schwartz, T. M., Hoffer, E., Sadagopan, N., Nguyen, N., Yu, Y., Gonzalez, P., Tircsó, G., Wu, H., Akkaraju, G., Chumley, M. J. & Green, K. N., 16 Dec 2019, In : Inorganic Chemistry. 58, 24, p. 16771-16784 14 p.

Research output: Contribution to journalArticle

Evidence of hypoxic glial cells in a model of ocular hypertension

Jassim, A. H. & Inman, D. M., Jan 2019, In : Investigative Ophthalmology and Visual Science. 60, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve

Jassim, A. H., Coughlin, L., Harun-Or-Rashid, M., Kang, P. T., Chen, Y. R. & Inman, D. M., 1 Oct 2019, In : Molecular Neurobiology. 56, 10, p. 7097-7112 16 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S. H., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

In Vivo Efficacy of Novel Monobactam LYS228 in Murine Models of Carbapenemase-Producing Klebsiella pneumoniae Infection

Weiss, W. J., Pulse, M. E., Nguyen, P. & Growcott, E. J., Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e02214-18.

Research output: Contribution to journalArticle

1 Scopus citations

Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections

Goldmann, O., Cern, A., Muesken, M., Rohde, M., Weiss, W., Barenholz, Y. & Medina, E., 28 Dec 2019, In : Journal of Controlled Release. 316, p. 292-301 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

NADPH oxidase mediates membrane androgen receptor-induced neurodegeneration

Tenkorang, M. A. A., Duong, P. & Cunningham, R. L., 2019, In : Endocrinology. 160, 4, p. 947-963 17 p.

Research output: Contribution to journalArticle

1 Scopus citations

Origin and bioactivities of thiosulfinated FK228

Liu, X., Currens, G. C., Xue, L. & Cheng, Y. Q., 2019, In : MedChemComm. 10, 4, p. 538-542 5 p.

Research output: Contribution to journalArticle

Pharmacological, toxicological, and dose range assessment of OG716, a novel lantibiotic for the treatment of clostridium difficile-associated infection

Pulse, M. E., Weiss, W. J., Kers, J. A., DeFusco, A. W., Park, J. H. & Handfield, M., Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e01904-18.

Research output: Contribution to journalArticle

2 Scopus citations

Primary care clinics can be a source of exposure to virulent Clostridium (now Clostridioides) difficile: An environmental screening study of hospitals and clinics in Dallas-Fort Worth region

Simecka, J. W., Fulda, K. G., Pulse, M., Lee, J. H., Vitucci, J., Nguyen, P., Taylor, P., Filipetto, F., Espinoza, A. M. & Sharma, S., 1 Aug 2019, In : PLoS ONE. 14, 8, e0220646.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Probing Protein Allostery as a Residue-Specific Concept via Residue Response Maps

Hayatshahi, H. S., Ahuactzin, E., Tao, P., Wang, S. & Liu, J., 1 Jan 2019, (Accepted/In press) In : Journal of Chemical Information and Modeling.

Research output: Contribution to journalArticle

3 Scopus citations

Prolactin-Induced Protein is a novel biomarker for Keratoconus

Sharif, R., Bak-Nielsen, S., Sejersen, H., Ding, K., Hjortdal, J. & Karamichos, D., Feb 2019, In : Experimental eye research. 179, p. 55-63 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitors

Guenter, R. E., Aweda, T., Matos, D. M. C., Whitt, J., Chang, A. W., Cheng, E. Y., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jun 2019, In : Cancers. 11, 6, 767.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Role of Catalase in Oxidative Stress- And Age-Associated Degenerative Diseases

Nandi, A., Yan, L. J., Jana, C. K. & Das, N., 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 9613090.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Sterilization of Drug-Loaded Composite Coatings for Implantable Glucose Biosensors

Tipnis, N., Kastellorizios, M., Legassey, A., Papadimitrakopoulos, F., Jain, F. & Burgess, D. J., 1 Jan 2019, (Accepted/In press) In : Journal of Diabetes Science and Technology.

Research output: Contribution to journalArticle

Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

Zuo, Z., Zolekar, A., Babu, K., Lin, V. J. T., Hayatshahi, H. S., Rajan, R., Wang, Y. C. & Liu, J., Jul 2019, In : eLife. 8, e46500.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor

Thomy, D., Culp, E., Adamek, M., Cheng, E. Y., Ziemert, N., Wright, G. D., Sass, P. & Brötz-Oesterhelt, H., 2019, In : Applied and Environmental Microbiology. 85, 20, e01292-19.

Research output: Contribution to journalArticle

4 Scopus citations

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate

Panarese, J. D., Engers, D. W., Wu, Y. J., Guernon, J. M., Chun, A., Gregro, A. R., Bender, A. M., Capstick, R. A., Wieting, J. M., Bronson, J. J., Macor, J. E., Westphal, R., Soars, M., Engers, J. E., Felts, A. S., Rodriguez, A. L., Emmitte, K. A., Jones, C. K., Blobaum, A. L., Jeffrey Conn, P. & 3 others, Niswender, C. M., Hopkins, C. R. & Lindsley, C. W., 15 Jan 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 342-346 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Transcriptional profiling of corneal stromal cells derived from patients with keratoconus

Sharif, R., Khaled, M. L., McKay, T. B., Liu, Y. & Karamichos, D., 1 Dec 2019, In : Scientific Reports. 9, 1, 12567.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations