Institute for Healthy Aging

Projects

Projects per year 1986 2012 2013 2014 2015 2016 2017 2019 2024

• 16 Active
• 296 Finished

Projects per year

Search results

• Using rodent behavioral models to identify substance abuse pharmacotherapies

  Forster, M., Gatch, M., Sumien, N. & Shetty, R.

  NIDA: National Institute on Drug Abuse

  20/09/18 → 3/01/23

  Project: Research

• Chronic Lower Leg Heating for the Treatment of Hypertension in Older Women

  Fu, Q., Fu, Q., Romero, S. & Romero, S.

  1/03/19 → 31/12/22

  Project: Research

  • Hypertension 100%
  • Leg 83%
  • Hot Temperature 79%
  • Heating 55%
  • Therapeutics 42%

• Increasing Nigral Tyrosine Hydroxylase Expression as a Mechanism of Exercise-Mediated Recovery: Evaluation in Toxin and Rat Parkinson's Disease Genetic Models

  Salvatore, M.

  Department of Defense

  1/09/19 → 31/08/22

  Project: Research

• Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation

  Liu, J. & Wang, Y.

  NHLBI: Nat Heart, Lung & Blood Institute

  1/08/19 → 31/07/22

  Project: Research

• Confidential

  O'Bryant, S.

  1/08/19 → 31/07/22

  Project: Research

• Improvement of CRISPR-Cas9 specificity through allosteric modulation

  Liu, J.

  National Heart, Lung, and Blood Institute

  1/08/19 → 31/07/22

  Project: Research

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Gene Editing 29%
  • Allosteric Site 11%
  • Technology 10%
  • Hematopoietic System 10%

• HEMAVET 950FS Purchasing for NIGMS R35 Award

  Dong, X. & Dong, X.

  National Institute of General Medical Sciences

  1/07/20 → 30/06/22

  Project: Research

  • purchasing 100%

• Phase II: A Novel Approach for Improving Cerebral Tissue Blood Flow and Oxygenation via Pulsatile Perfusion Therapy

  Rickards, C. & Yurvati, A.

  American Heart Association

  1/07/19 → 30/06/22

  Project: Research

• A Blood Test for Screening into Alzheimer's Prevention Trials

  O'Bryant, S. & Hall, J.

  NIA: National Institute on Aging

  15/09/17 → 30/06/22

  Project: Research

• A Blood Test for Screening into Alzheimer's Prevention Trials

  O'Bryant, S., Hall, J. & Johnson, L.

  NIA: National Institute on Aging

  15/09/17 → 30/06/22

  Project: Research

• Discovery of Functionally Selective Alzheimer's Disease Therapeutics

  Luedtke, R.

  NIA: National Institute on Aging

  15/09/17 → 31/05/22

  Project: Research

• Development of a Clinically-Relevant Test for Assessment of Cerebral Vascular Function (for Dr. Alexander Rosenberg)

  Rickards, C.

  NHLBI: Nat Heart, Lung & Blood Institute

  1/06/19 → 31/05/22

  Project: Research

• Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans

  O'Bryant, S., Hall, J. & Johnson, L.

  NIA: National Institute on Aging

  1/09/17 → 31/05/22

  Project: Research

• Multi-omic Investigation of Exercise Effects in Mild Cognitive Impairment

  O'Bryant, S. & Hall, J.

  University of California - Irvine

  1/07/18 → 28/02/22

  Project: Research

• BN4003 l Version 2, entitled "A MULTICENTER, OPEN-LABEL, LONG-TERM EXTENSION OF PHASE ill STUDIES (BN29552/BN29553) OF CRENEZUMAB IN PATIENTS WITH ALZHEIMER'S DISEASE

  Knebl, J.

  Roche Diagnostics Corporation

  30/11/18 → 30/11/21

  Project: Research

• A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer's Disease Dementia (The DAYBREAK Study)

  Knebl, J.

  Eli Lilly

  13/10/16 → 12/10/21

  Project: Research

• "A PHASE Ill, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, EFFICACY AND SAFETY STUDY OF CRENEZUMAB IN PATIENTS WITH PRODROMAL TO MILD ALZHEIMER'S DISEASE"

  Knebl, J.

  Hoffmann-La Roche Inc.

  18/08/16 → 17/08/21

  Project: Research

• A Novel Neuroprotective Approach for Glaucoma

  Prokai-Tatrai, K. & Prokai, L.

  NEI: National Eye Institute

  1/08/16 → 31/07/21

  Project: Research

• A Novel Neuroprotective Approach for Glaucoma

  Prokai-Tatrai, K.

  NEI: National Eye Institute

  1/08/16 → 31/07/21

  Project: Research

• Interactions between testosterone and oxidative stress in dopamine neurons

  Cunningham, R.

  1/07/15 → 30/06/21

  Project: Research

  • Parkinson Disease 100%
  • Oxidative Stress 87%
  • Disease Progression 23%
  • NADPH Oxidases 22%
  • Animal Models 21%

• Interactions between testosterone and oxidative stress in dopamine neurons

  Cunningham, R.

  National Institute of Neurological Disorders and Stroke

  1/07/15 → 30/06/21

  Project: Research

  • Parkinson Disease 100%
  • Oxidative Stress 87%
  • Disease Progression 23%
  • NADPH Oxidases 22%
  • Animal Models 21%

• ALZHEIMER¿S DISEASE- DONEPEZIL HYDROCHLORIDE AND MEMANTINE HYDROCHLORIDE

  Knebl, J.

  Merck Co.

  31/05/18 → 31/05/21

  Project: Research

• An Alzheimer's Blood Test for Primary Care

  O'Bryant, S., Hall, J., Johnson, L. & Nandy, R.

  NIA: National Institute on Aging

  1/06/18 → 31/05/21

  Project: Research

• Brain-Selective Therapy to Alleviate Hot Flushes of Prostate Cancer Patients

  Prokai, L. & Prókai, L.

  1/04/17 → 31/03/21

  Project: Research

  • Prostatic Neoplasms 100%
  • Androgens 92%
  • Neurotransmitter Agents 88%
  • Estrogens 83%
  • Brain 74%

• A Pro-Inflammatory Endophenotype to Predict Treatment Response to NSAID Therapy in AD

  O'Bryant, S., Hall, J. & Johnson, L.

  NIA: National Institute on Aging

  1/09/16 → 31/03/21

  Project: Research

• Proinflammatory Endophenotype to predict NSAID treatment response Alzheimer's trials

  O'Bryant, S.

  NIA: National Institute on Aging

  1/09/16 → 31/03/21

  Project: Research

• Effects of Aging on Blood Vessels in the Cerebellar Vermis

  Jin, K., Forster, M. & Sumien, N.

  NIA: National Institute on Aging

  1/04/19 → 31/01/21

  Project: Research

• Repositioning Drugs to Treat Ischemic Stroke at Delayed Time Points

  SCHETZ, J. & Schreihofer, D.

  1/07/16 → 31/12/20

  Project: Research

  • Stroke 100%
  • sigma-1 receptor 65%
  • Drug Repositioning 57%
  • Brain 30%
  • In Vitro Techniques 27%

• Blood-Based Biomarker Profiles for a Precision Medicine Approach to Parkinsons Disease

  O'Bryant, S., Hall, J. & Nandy, R.

  Michael J. Fox Fnd for Parkinson's Res

  15/10/19 → 14/10/20

  Project: Research

• Program Evaluation of the Project Towards No Drug Abuse Ground Zero Program

  Nejtek, V.

  Recovery Resource Council

  1/12/17 → 30/09/20

  Project: Research

• Epigenetic Risk Factors for Early Age at Onset of Alzheimer¿s & MCI Among Non-Caribbean Hispanics

  Barber, R., Phillips, N. & Zhou, Z.

  Alzheimer's Disease Program

  22/08/18 → 31/08/20

  Project: Research

• Effectiveness of Psychological & Cognitive Program Interventions in Veterans, Veteran Women, and Their Families

  Nejtek, V.

  Recovery Resource Council

  1/02/15 → 31/08/20

  Project: Research

• Interactions between Testosterone and Oxidative Stress in Dopamine Neurons

  Cunningham, R. & Sumien, N.

  NINDS: Neurological Disorders & Stroke

  1/07/15 → 30/06/20

  Project: Research

• Bi-functional Molecule for Glaucomatous Optic Neuropathy

  Acharya, S. & Stankowska, D.

  BrightFocus Foundation

  1/07/18 → 30/06/20

  Project: Research

• Collective Action to Drive Systems-Level Change

  Severance, J. & Knebl, J.

  United Way of Tarrant County

  1/07/19 → 30/06/20

  Project: Research

• The Effect of Young and Aged Serum Exosomes on Ischemic Stroke Outcome (For: Hongxia Zhang)

  Jin, K.

  American Heart Association

  1/07/18 → 30/06/20

  Project: Research

• Effect of Novel Compound on Auditory Function and on Biochemical Markers in Aged Mice

  Sumien, N.

  Neuronascent, Inc.

  1/06/19 → 30/06/20

  Project: Research

• Blood Biomarkers for Discriminating Amongst Neurodegenerative Diseases

  O'Bryant, S., Hall, J. & Nandy, R.

  Michael J. Fox Fnd for Parkinson's Res

  1/06/19 → 31/05/20

  Project: Research

• Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans - Diversity Supplement

  O'Bryant, S.

  NIA: National Institute on Aging

  15/07/18 → 31/05/20

  Project: Research

• A Novel Mouse Model to Study Motoric Aging Induced by Benzodiazepine Abuse

  Jung, E.

  30/09/16 → 30/04/20

  Project: Research

  • Benzodiazepines 100%
  • Elderly 39%
  • Purkinje Cells 33%
  • Mitochondrial Membranes 21%
  • GABA-A Receptors 20%

• An open-label extension study to evaluate the long-term safety and tolerability of Lu AE58054 as adjunctive treatment to donepezil in patients with mild-moderate Alzheimer¿s disease

  Knebl, J.

  Lundbeck Pharmaceuticals

  3/04/15 → 30/04/20

  Project: Research

• Neurodegeneration in Aging Down Syndrome (NiAD): A Longitudinal Study of Cognition and Biomarkers of Alzheimer's Disease

  O'Bryant, S. & Hall, J.

  University of Pittsburgh

  1/07/18 → 30/04/20

  Project: Research

• Neuroglobin: cell metabolism and neuroprotection

  Yang, S.

  1/07/14 → 30/04/20

  Project: Research

  • Neuroglobin 100%
  • Neurons 20%
  • Lipogenesis 9%
  • Neuroprotection 7%
  • Glycogen 7%

• Biomarkers of Alzheimer's Disease in Adults with Down Syndrome

  O'Bryant, S. & Nandy, R.

  Columbia University Medical Center

  30/09/15 → 30/04/20

  Project: Research

• Biomarkers of Alzheimer's Disease in Down Syndrome

  O'Bryant, S.

  Columbia University Medical Center

  30/09/15 → 30/04/20

  Project: Research

• Brain-Selective Therapy to Alleviate Hot Flushes of Prostate Cancer Patients

  Prokai, L.

  NCI: National Cancer Institute

  1/04/17 → 31/03/20

  Project: Research

• PET Radiotracer for Imaging the Dopamine D3 Receptor

  Luedtke, R.

  University of Pennsylvania

  1/05/16 → 29/02/20

  Project: Research

• Randomized, Double-blind, Parallel Group, Placebo-controlled, Fixed-dose of Lu AE58054 In Patients with Mild - Moderate Alzheimer's Disease Treated with Donepazil; Study 2

  Knebl, J.

  Lundbeck Pharmaceuticals

  8/12/14 → 31/12/19

  Project: Research

• Dietary targeting of dihydrolipoamide dehydrogenase for stroke tolerance

  Yan, L. & Forster, M.

  1/04/13 → 30/09/19

  Project: Research

  • 5-methoxyindole-2-carboxylic acid 100%
  • Dihydrolipoamide Dehydrogenase 83%
  • Stroke 55%
  • Antioxidant Response Elements 19%
  • rat NQO1 protein 15%

• Dietary targeting of dihydrolipoamide dehydrogenase for stroke tolerance

  Forster, M., Yan, L., FORSTER, M. J., YAN, L. & Yan, L.

  National Institute of Neurological Disorders and Stroke

  1/04/13 → 30/09/19

  Project: Research

  • 5-methoxyindole-2-carboxylic acid 100%
  • Dihydrolipoamide Dehydrogenase 83%
  • Stroke 55%
  • Antioxidant Response Elements 19%
  • rat NQO1 protein 15%